LOCUS       NM_013159               4276 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus insulin degrading enzyme (Ide), mRNA.
ACCESSION   NM_013159
VERSION     NM_013159.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Kim,D.H., Lee,D., Lim,H., Choi,S.J., Oh,W., Yang,Y.S., Chang,J.H.
            and Jeon,H.B.
  TITLE     Effect of growth differentiation factor-15 secreted by human
            umbilical cord blood-derived mesenchymal stem cells on amyloid beta
            levels in in vitro and in vivo models of Alzheimer's disease
  JOURNAL   Biochem Biophys Res Commun 504 (4), 933-940 (2018)
   PUBMED   30224067
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Khodadadi,D., Gharakhanlou,R., Naghdi,N., Salimi,M., Azimi,M.,
            Shahed,A. and Heysieattalab,S.
  TITLE     Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits
            Through Improving the Clearance of Peripheral and Central
            Amyloid-Beta Levels
  JOURNAL   Neurochem Res 43 (8), 1561-1574 (2018)
   PUBMED   29948724
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Kazkayasi,I., Burul-Bozkurt,N., Ismail,M.A., Merino-Serrais,P.,
            Pekiner,C., Cedazo-Minguez,A. and Uma,S.
  TITLE     Insulin deprivation decreases insulin degrading enzyme levels in
            primary cultured cortical neurons and in the cerebral cortex of
            rats with streptozotocin-induced diabetes
  JOURNAL   Pharmacol Rep 70 (4), 677-683 (2018)
   PUBMED   29940507
  REMARK    GeneRIF: data suggest that insulin deprivation, rather than high
            glucose, is a significant determinant of IDE regulation; as
            evidence indicates potential roles for IDE in diabetes and
            Alzheimer's disease, understanding the mechanisms regulating IDE
            expression may be important in developing new treatment strategies
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Li,H., Cao,L., Ren,Y., Jiang,Y., Xie,W. and Li,D.
  TITLE     GLP-1 receptor regulates cell growth through regulating IDE
            expression level in Abeta1-42-treated PC12 cells
  JOURNAL   Biosci Rep 38 (4) (2018)
   PUBMED   29263141
  REMARK    GeneRIF: GLP-1R regulates cell growth, at least partially, through
            regulating cAMP/PKA/IDE signaling pathway in ABETA(1-42)-treated
            PC12 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Wang,N., Jia,Y.M., Zhang,B., Xue,D., Reeju,M., Li,Y., Huang,S.M.
            and Liu,X.W.
  TITLE     Neuroprotective mechanism of Kai Xin San: upregulation of
            hippocampal insulin-degrading enzyme protein expression and
            acceleration of amyloid-beta degradation
  JOURNAL   Neural Regen Res 12 (4), 654-659 (2017)
   PUBMED   28553348
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Bennett,R.G., Hamel,F.G. and Duckworth,W.C.
  TITLE     Characterization of the insulin inhibition of the peptidolytic
            activities of the insulin-degrading enzyme-proteasome complex
  JOURNAL   Diabetes 46 (2), 197-203 (1997)
   PUBMED   9000694
  REMARK    Erratum:[Diabetes 1997 Sep;46(9):1532]
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Baumeister,H., Muller,D., Rehbein,M. and Richter,D.
  TITLE     The rat insulin-degrading enzyme. Molecular cloning and
            characterization of tissue-specific transcripts
  JOURNAL   FEBS Lett 317 (3), 250-254 (1993)
   PUBMED   8425612
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Kuo,W.L., Montag,A.G. and Rosner,M.R.
  TITLE     Insulin-degrading enzyme is differentially expressed and
            developmentally regulated in various rat tissues
  JOURNAL   Endocrinology 132 (2), 604-611 (1993)
   PUBMED   7678795
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Muller,D., Schulze,C., Baumeister,H., Buck,F. and Richter,D.
  TITLE     Rat insulin-degrading enzyme: cleavage pattern of the natriuretic
            peptide hormones ANP, BNP, and CNP revealed by HPLC and mass
            spectrometry
  JOURNAL   Biochemistry 31 (45), 11138-11143 (1992)
   PUBMED   1445854
  REMARK    Erratum:[Biochemistry 1993 Apr 13;32(14):3830]
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Muller,D., Baumeister,H., Buck,F. and Richter,D.
  TITLE     Atrial natriuretic peptide (ANP) is a high-affinity substrate for
            rat insulin-degrading enzyme
  JOURNAL   Eur J Biochem 202 (2), 285-292 (1991)
   PUBMED   1836994
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013159.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X67269.1, SRR26643293.8660.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000001.1  244514413-244514526 c
            115-299             JAXUCZ010000001.1  244477275-244477459 c
            300-507             JAXUCZ010000001.1  244475507-244475714 c
            508-677             JAXUCZ010000001.1  244471980-244472149 c
            678-800             JAXUCZ010000001.1  244466278-244466400 c
            801-913             JAXUCZ010000001.1  244463518-244463630 c
            914-1076            JAXUCZ010000001.1  244462951-244463113 c
            1077-1169           JAXUCZ010000001.1  244461781-244461873 c
            1170-1261           JAXUCZ010000001.1  244461306-244461397 c
            1262-1342           JAXUCZ010000001.1  244459786-244459866 c
            1343-1446           JAXUCZ010000001.1  244457615-244457718 c
            1447-1549           JAXUCZ010000001.1  244448928-244449030 c
            1550-1672           JAXUCZ010000001.1  244445800-244445922 c
            1673-1755           JAXUCZ010000001.1  244443398-244443480 c
            1756-1900           JAXUCZ010000001.1  244438851-244438995 c
            1901-2011           JAXUCZ010000001.1  244436197-244436307 c
            2012-2132           JAXUCZ010000001.1  244435256-244435376 c
            2133-2224           JAXUCZ010000001.1  244433478-244433569 c
            2225-2336           JAXUCZ010000001.1  244432387-244432498 c
            2337-2504           JAXUCZ010000001.1  244428595-244428762 c
            2505-2777           JAXUCZ010000001.1  244425646-244425918 c
            2778-2839           JAXUCZ010000001.1  244424304-244424365 c
            2840-2912           JAXUCZ010000001.1  244418890-244418962 c
            2913-2980           JAXUCZ010000001.1  244418281-244418348 c
            2981-4276           JAXUCZ010000001.1  244416343-244417638 c
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..4276
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /note="insulin degrading enzyme"
                     /db_xref="GeneID:25700"
                     /db_xref="RGD:2861"
     exon            1..114
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3076
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /EC_number="3.4.24.56"
                     /note="insulysin; insulinase; insulin protease"
                     /codon_start=1
                     /product="insulin-degrading enzyme"
                     /protein_id="NP_037291.1"
                     /db_xref="GeneID:25700"
                     /db_xref="RGD:2861"
                     /translation="MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNN
                     PAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPN
                     IPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEG
                     ALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKF
                     GTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFS
                     EVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYL
                     GHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIIL
                     HMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVL
                     TAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPED
                     VIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDK
                     FFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTI
                     YGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHA
                     MYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALG
                     VMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTD
                     MQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPP
                     HYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQ
                     QYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEF
                     PSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL"
     exon            115..299
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            300..507
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            508..677
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            678..800
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            801..913
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1076
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1169
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1261
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1342
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1446
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1549
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1672
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1755
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1900
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2011
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2132
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2224
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2336
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2504
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2777
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2839
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2912
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2980
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..4276
                     /gene="Ide"
                     /gene_synonym="INSDEGM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctgcgc cggggtatgc ggaacgggct cgtgtggctg ctgcaccccg cgctgcccag
       61 caccttgcac tccatcctcg gcgctcgccc gcctcccgtg aagcgactgt gtggattccc
      121 aaaacaaatt tacagcacaa tgaataatcc ggccatccag agaatagaag accatattgt
      181 caagtctcct gaagacaaac gggaatatcg tggactagaa ctggccaatg gtatcaaagt
      241 gcttctcatc agtgatccca ccacggacaa gtcatcagca gcactcgacg tgcacatagg
      301 gtcactgtca gaccctccaa atattcctgg cttaagccat ttttgtgagc atatgctgtt
      361 tttgggaaca aagaaatatc ctaaggaaaa tgaatacagc cagtttctca gtgaacatgc
      421 tgggagttca aatgcattta ccagcggaga acacaccaat tattatttcg atgtttccca
      481 tgaacacttg gaaggagccc tggacaggtt tgcccagttt ttcctgtgcc ccttgtttga
      541 tgcaagttgt aaggacagag aggtgaacgc tgtcgattca gagcatgaaa agaatgtgat
      601 gaatgatgcc tggagactct tccagctgga aaaggctaca gggaatccca agcacccctt
      661 cagcaaattc gggacaggaa acaaatatac tctagagact cgacccaacc aagaaggcat
      721 cgatgtaagg gaagaactct tgaaatttca ctctacgtat tattcgtcca atctgatggc
      781 gatttgtgtt ttaggtcgag aatctttaga tgacctgact aatctggtgg tgaagttatt
      841 ttctgaagta gagaataaaa atgtcccttt gcctgaattt cctgagcacc ctttccaaga
      901 agaacatctt aaacaacttt ataaaatagt acccattaag gatattagga atctttatgt
      961 gacatttccc ataccagacc ttcaacagta ctacaaatcc aatcccggtc attatctcgg
     1021 tcatctgatc gggcatgaag gtcctggaag cctgttgtca gagctcaagt caaagggctg
     1081 ggtaaacacc ctggttgggg gacagaagga aggagcccga ggttttatgt tttttatcat
     1141 taatgtggac ttaactgaag aagggttatt acatgttgaa gatataattt tgcacatgtt
     1201 tcaatacatt cagaagctac gtgctgaagg acctcaagaa tgggttttcc aagagtgcaa
     1261 ggacttgaac gctgtcgctt tcaggtttaa agataaagag aggccacgag gctacacatc
     1321 taagattgca gggaaattgc actattatcc cctaaatgga gtgctcacag ctgaatattt
     1381 actggaagaa tttagacccg acttgataga catggttctt gataaactca gaccagaaaa
     1441 tgtccgggtg gcaatagttt ctaaatcatt tgaagggaaa actgaccgca cagagcagtg
     1501 gtatggaacc cagtacaagc aagaagctat cccagaggac gtcattcaga aatggcaaaa
     1561 tgctgacctg aatgggaaat ttaaacttcc aacaaagaat gaattcattc ctacaaattt
     1621 tgagattttg gcattagaaa aagatgcaac accataccct gctcttatta aggatacagc
     1681 catgagtaag ctgtggttca aacaagatga taaatttttc ttgccgaaag cttgtctcaa
     1741 ctttgaattt ttcagcccgt ttgcttatgt ggaccccttg cactgtaaca tggcctattt
     1801 gtaccttgaa ctcctcaaag actcactcaa cgagtatgca tatgcagcag agctagcagg
     1861 cctgagctat gatctccaaa acaccatcta tgggatgtat ctctcagtga aaggttacaa
     1921 tgacaaacag ccaattttgc taaagaagat caccgagaaa atggctactt ttgagattga
     1981 taaaaaaaga tttgaaatta tcaaagaggc gtacatgcga tctcttaata atttccgggc
     2041 tgagcagcct caccagcacg ccatgtacta cctccgtctg ctgatgactg aagtggcctg
     2101 gaccaaagat gagttaaaag aagccctcga tgatgtgacc ctcccccgtc ttaaggcctt
     2161 catacctcag ctgctgtccc ggctgcatat tgaagccctt ctccatggca acataacaaa
     2221 gcaggctgcc ttaggagtta tgcagatggt agaagacacc cttattgagc atgctcacac
     2281 caaacctctc cttccaagtc agctagtccg gtacagagaa gttcagctcc ccgaccgagg
     2341 atggtttgtt taccagcgga ggaacgaagt ccacaataac tgtggcattg agatttacta
     2401 ccagacagac atgcagagca cctcggagaa catgttcctg gagctcttct gccagattat
     2461 ctctgagcct tgcttcaaca ctctgcgtac caaggagcag cttggctata ttgtcttcag
     2521 tggacctcgt cgggccaacg gcatccaggg cttgcgattc atcatccagt cagaaaaacc
     2581 acctcactac ctggaaagca gagtggaagc cttcttgatc accatggaaa aggccataga
     2641 ggacatgaca gaggaggctt tccaaaaaca cattcaggcg ttagcgattc gccgactcga
     2701 caaaccaaag aaactctctg cagagtgcgc gaagtactgg ggggagatca tctcccagca
     2761 gtacaattat gacagagata acatagaggt tgcatattta aagacactca gcaaggatga
     2821 tatcatcaaa ttctacaagg aaatgttggc tgtggacgca ccaaggagac ataaagtatc
     2881 cgtccacgtt cttgccaggg aaatggattc ttgtcctgtg gttggagagt tcccctctca
     2941 gaatgatata aacctttccg aagcgccacc cttgccacaa cctgaggtga ttcataacat
     3001 gactgaattc aagcgcggcc tgccgctgtt cccccttgtg aagccacaca ttaacttcat
     3061 ggcggcaaaa ctctgaagaa gcagctgcgc ccctgtgcct tccggggcca ggaaagcagt
     3121 ctcagctttg agtagtttct ggcttgcaat tagagagaca aacagaaaag agttatcagg
     3181 cattattatg tagaatgtta aaaacccaaa gtaataaaat tataaagtct tatagatgta
     3241 gaatattttt aaaatctctt aaatatttta atgtttttct ttttattcct aaaagaaatt
     3301 tccttatatt aactgcttaa tctgaagaaa gatatctcag tacaatcttt cttccttatt
     3361 ctgtaaaata gtcacttgtc tgaaaaaaaa ataagagctt ttttttctta aaggcttcag
     3421 aacacttaga aaggattacc tttttaagac gcgatcaagc tcagatctgc ttctgtcgat
     3481 ggttcctgtg aaccagcaga gcatcgcggt gggcagatag tgcacaaagc ggttccgcgt
     3541 tcctttacta gtgaacctgc tgattaacta aggcatggtt ttaatgtttt tataaaactt
     3601 gggtatgttt tttaaccttc ttagtcaaat gctagaaaac ccagaatacc caatttacag
     3661 tgctagaaat gcagattaac cttgaatcaa gttcggaatt tctcaggatt cctgtgggtt
     3721 ctctctcatc gaattctgtt gacatttctg tttctcgtag ttggtctgct gggttccatc
     3781 agcagacaca tactgctgta cagcgtgtga gacatgctgt gctgacatca gctgttgtga
     3841 ctccccgtaa ctcctagggt gaagttgtga tccgtgtgtg aactaaaaca tttgcccctt
     3901 tagggactca aaaggcagca aatacaaagc cacctccttg gagatacaaa actgtggcgt
     3961 tcttaaacag ccagtctccg taagactcta aactccccac tgcttccggt ctcatcttgc
     4021 cttaagtgtt attttttgaa tatatgaata taaacataca gatgatgact ggagtggact
     4081 tttaaaaaat atttttttca caagatacta ttttaggtga aaatgttact gtagatttaa
     4141 cagctgtttt aaagtatttg ctattattaa aacttcttca agaacaagcg tggctatgct
     4201 cccacacaca ggcaatagta acagaaagtg ctcctgtttg tccaccagct caggcaaagt
     4261 acagaatggc gtttcc
//
