LOCUS       NM_175582               1626 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus inhibitor of DNA binding 4 (Id4), mRNA.
ACCESSION   NM_175582 XM_214444
VERSION     NM_175582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Liu,Z., Xu,D., Wang,S., Chen,Y., Li,Z., Gao,X., Jiang,L., Tang,Y.
            and Peng,Y.
  TITLE     Astrocytes induce proliferation of oligodendrocyte progenitor cells
            via connexin 47-mediated activation of the ERK/Id4 pathway
  JOURNAL   Cell Cycle 16 (7), 714-722 (2017)
   PUBMED   28278052
  REMARK    GeneRIF: Astrocytes can cause Ca(2+) signaling activation, ERK1/2
            phosphorylation, and Id4 expression stimulation in oligodendrocyte
            progenitor cells inducing proliferation of these cells, mainly
            through Cx47.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Sharma,P., Knowell,A.E., Chinaranagari,S., Komaragiri,S.,
            Nagappan,P., Patel,D., Havrda,M.C. and Chaudhary,J.
  TITLE     Id4 deficiency attenuates prostate development and promotes
            PIN-like lesions by regulating androgen receptor activity and
            expression of NKX3.1 and PTEN
  JOURNAL   Mol Cancer 12, 67 (2013)
   PUBMED   23786676
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Huang,J., Vogel,G., Yu,Z., Almazan,G. and Richard,S.
  TITLE     Type II arginine methyltransferase PRMT5 regulates gene expression
            of inhibitors of differentiation/DNA binding Id2 and Id4 during
            glial cell differentiation
  JOURNAL   J Biol Chem 286 (52), 44424-44432 (2011)
   PUBMED   22041901
  REMARK    GeneRIF: CpG-rich islands within the Id2 and Id4 genes were bound
            by PRMT5 and were hypomethylated in PRMT5-deficient cells,
            suggesting that PRMT5 plays a role in gene silencing during glial
            cell
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Guo,S.J., Hu,J.G., Zhao,B.M., Shen,L., Wang,R., Zhou,J.S. and
            Lu,H.Z.
  TITLE     Olig1 and ID4 interactions in living cells visualized by
            bimolecular fluorescence complementation technique
  JOURNAL   Mol Biol Rep 38 (7), 4637-4642 (2011)
   PUBMED   21132377
  REMARK    GeneRIF: Bimolecular fluorescence complementation (BiFC) analysis
            was performed to further characterize the distinct subcellular
            localization of olig1, ID4 and their dimer.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Oatley,M.J., Kaucher,A.V., Racicot,K.E. and Oatley,J.M.
  TITLE     Inhibitor of DNA binding 4 is expressed selectively by single
            spermatogonia in the male germline and regulates the self-renewal
            of spermatogonial stem cells in mice
  JOURNAL   Biol Reprod 85 (2), 347-356 (2011)
   PUBMED   21543770
  REMARK    GeneRIF: These results indicate that ID4 is a distinguishing marker
            of spermatogonial stem cells in the mammalian germline and plays an
            important role in the regulation of self-renewal.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Bedford,L., Walker,R., Kondo,T., van Cruchten,I., King,E.R. and
            Sablitzky,F.
  TITLE     Id4 is required for the correct timing of neural differentiation
  JOURNAL   Dev Biol 280 (2), 386-395 (2005)
   PUBMED   15882580
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Yun,K., Mantani,A., Garel,S., Rubenstein,J. and Israel,M.A.
  TITLE     Id4 regulates neural progenitor proliferation and differentiation
            in vivo
  JOURNAL   Development 131 (21), 5441-5448 (2004)
   PUBMED   15469968
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Shan,L., Yu,M., Qiu,C. and Snyderwine,E.G.
  TITLE     Id4 regulates mammary epithelial cell growth and differentiation
            and is overexpressed in rat mammary gland carcinomas
  JOURNAL   Am J Pathol 163 (6), 2495-2502 (2003)
   PUBMED   14633621
  REMARK    GeneRIF: Id4 may contribute to carcinogenesis by inhibiting mammary
            epithelial cell differentiation and stimulating mammary epithelial
            cell growth
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Beger,C., Pierce,L.N., Kruger,M., Marcusson,E.G., Robbins,J.M.,
            Welcsh,P., Welch,P.J., Welte,K., King,M.C., Barber,J.R. and
            Wong-Staal,F.
  TITLE     Identification of Id4 as a regulator of BRCA1 expression by using a
            ribozyme-library-based inverse genomics approach
  JOURNAL   Proc Natl Acad Sci U S A 98 (1), 130-135 (2001)
   PUBMED   11136250
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Stewart,H.J., Zoidl,G., Rossner,M., Brennan,A., Zoidl,C.,
            Nave,K.A., Mirsky,R. and Jessen,K.R.
  TITLE     Helix-loop-helix proteins in Schwann cells: a study of regulation
            and subcellular localization of Ids, REB, and E12/47 during
            embryonic and postnatal development
  JOURNAL   J Neurosci Res 50 (5), 684-701 (1997)
   PUBMED   9418957
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_175582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ780284.1, SRR26643297.48240.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               JAXUCZ010000017.1  16597853-16598293   c
            442-500             JAXUCZ010000017.1  16597449-16597507   c
            501-1626            JAXUCZ010000017.1  16595724-16596849   c
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1626
                     /gene="Id4"
                     /gene_synonym="Idb4"
                     /note="inhibitor of DNA binding 4"
                     /db_xref="GeneID:291023"
                     /db_xref="RGD:631428"
     CDS             1..486
                     /gene="Id4"
                     /gene_synonym="Idb4"
                     /note="inhibitor of DNA binding 4, dominant negative
                     helix-loop-helix protein; inhibitor of DNA binding 4, HLH
                     protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-4"
                     /protein_id="NP_783172.2"
                     /db_xref="GeneID:291023"
                     /db_xref="RGD:631428"
                     /translation="MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAA
                     AAAARCKAAEAAADEPALCLQCDMNDCYTRLRRLVPTIPPNKKVSKVEILQHVIDYIL
                     DLQLALETHPALLRQPPPPAPPLHSAGACPVAPQRTPLTALNTDPAGAVNKQGDSILC
                     R"
     exon            1..441
                     /gene="Id4"
                     /gene_synonym="Idb4"
                     /inference="alignment:Splign:2.1.0"
     exon            442..500
                     /gene="Id4"
                     /gene_synonym="Idb4"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1626
                     /gene="Id4"
                     /gene_synonym="Idb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaggcgg tgagcccggt gcgcccctct ggccgcaagg cgccgtcggg ctgcggcggc
       61 ggggagctgg cgctacgttg cctggcggag catggccata gcctaggtgg ctcggcagcc
      121 gcggcggcgg cggcggcggc agcgcgctgc aaggcggccg aggcggcggc cgacgagccg
      181 gcactgtgcc tgcagtgcga tatgaacgac tgctacactc gcctgcggag gctcgtgccc
      241 accatcccgc ccaacaagaa agtcagcaaa gtggagatcc tgcagcacgt tatcgactac
      301 atcctggacc tgcagctggc gctggagacg caccctgctc tgctgagaca gccgccaccg
      361 cccgcgccac cgctccactc ggccggggct tgcccggtcg cgccgcagcg gaccccgctt
      421 acggcgctca acactgaccc ggccggcgcc gtgaacaagc agggcgacag cattctctgc
      481 cgctgagctg cgttggccag gtgtgcggcc gcctgagcac cagcgagcca ggagccctag
      541 aaagggaggg ccagagcaga aattaagaga aaaaagccac cagaggaaag gaaaaaaaaa
      601 tcttcagcaa atctagaaac gttgtctcgg cttgtcattc caagagagag agagaaagaa
      661 ggggaaaaat aataaaactt aaattcactt ttactttttt gcacgttcac aagcattcac
      721 cgtacgtatt ctcttttagt tttttttttt cttttataac cgctgtgaat tgtacatttc
      781 tgtggttatt tttatcaccc ttttggagat gcagttaaac tttgaagctt aagtgtgacc
      841 agactgtaag cggaagagct atagtgaatc caactttaga ggttacgttg tgacaagcga
      901 actgtttttg tttctgaagc tttactaata taccagagca ttggcgacgt tgttttacat
      961 ctgttgttta aaatagatga ttataacagg gcggggaact ttttctctgc aagaatgtta
     1021 catattgtac agataagtga gtgacatttc ataccctgta tatatagaga tgttctataa
     1081 gtgtgagaaa gtatatgcgc tttaatagac tactgtaatt ataagatatt tttaattaaa
     1141 tattttttgt aaatattatg tgtgtgtttt tttaaatcta tgggaatatt tcttttggaa
     1201 aattattttt cagctccatg gcagagctct taaaatctat ctggatgttt tctgtttggc
     1261 caagctgttt gatttgtttt gttgttttgc ccagtatcta gtatctgagg ctcagaagta
     1321 acagctctct ggtactggtt tgcatgattg catgagatgt tcaatcacaa aataaacccg
     1381 ttatgagtcc tttcaaatgt gctttcctga cctagatggg aacctttgta tttgaagtgt
     1441 acatgttgaa aacatacctt atccggtttt aagtacaggg ttttatagtg taatatataa
     1501 agaattaagt gtgtgaggtt tttttttttt tcctttttga actgaggtca aaaatagatt
     1561 gagtgaattt gcatatagga tggagaaata cttggacctt taaggagtct acagaactgc
     1621 tgtctt
//
