LOCUS       NM_013058                983 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus inhibitor of DNA binding 3 (Id3), mRNA.
ACCESSION   NM_013058
VERSION     NM_013058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 983)
  AUTHORS   Li,J., Fang,J., Qin,Y., Liao,W., Liu,H., Zhou,Y. and Ding,K.
  TITLE     GLCE regulates PC12 cell neuritogenesis induced by nerve growth
            factor through activating SMAD/ID3 signalling
  JOURNAL   Biochem J 459 (2), 405-415 (2014)
   PUBMED   24499487
  REMARK    GeneRIF: The function of GLCE in neuritogenesis via SMAD/ID3
            signalling was studied via mutagenesis and gene silencing studies.
REFERENCE   2  (bases 1 to 983)
  AUTHORS   Mohamed,J.S., Lopez,M.A., Cox,G.A. and Boriek,A.M.
  TITLE     Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3
            cooperatively inhibit myoblast differentiation by physical
            interaction
  JOURNAL   J Biol Chem 288 (34), 24560-24568 (2013)
   PUBMED   23824195
REFERENCE   3  (bases 1 to 983)
  AUTHORS   Kurooka,H., Sugai,M., Mori,K. and Yokota,Y.
  TITLE     The metalloid arsenite induces nuclear export of Id3 possibly via
            binding to the N-terminal cysteine residues
  JOURNAL   Biochem Biophys Res Commun 433 (4), 579-585 (2013)
   PUBMED   23523789
REFERENCE   4  (bases 1 to 983)
  AUTHORS   Wassmann,K., Mueller,C.F., Becher,U.M., Werner,C., Jung,A.,
            Zimmer,S., Steinmetz,M., Nickenig,G. and Wassmann,S.
  TITLE     Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched
            Kruppel-like factor (GKLF) and p53 regulates proliferation of
            vascular smooth muscle cells
  JOURNAL   Mol Cell Biochem 333 (1-2), 33-39 (2010)
   PUBMED   19618124
  REMARK    GeneRIF: relevant interaction of GKLF, Id3, and p53 for VSMC
            proliferation
REFERENCE   5  (bases 1 to 983)
  AUTHORS   Duffield,G.E., Watson,N.P., Mantani,A., Peirson,S.N.,
            Robles-Murguia,M., Loros,J.J., Israel,M.A. and Dunlap,J.C.
  TITLE     A role for Id2 in regulating photic entrainment of the mammalian
            circadian system
  JOURNAL   Curr Biol 19 (4), 297-304 (2009)
   PUBMED   19217292
REFERENCE   6  (bases 1 to 983)
  AUTHORS   Ellmeier,W. and Weith,A.
  TITLE     Expression of the helix-loop-helix gene Id3 during murine embryonic
            development
  JOURNAL   Dev Dyn 203 (2), 163-173 (1995)
   PUBMED   7655079
REFERENCE   7  (bases 1 to 983)
  AUTHORS   Nagata,Y., Shoji,W., Obinata,M. and Todokoro,K.
  TITLE     Phosphorylation of helix-loop-helix proteins ID1, ID2 and ID3
  JOURNAL   Biochem Biophys Res Commun 207 (3), 916-926 (1995)
   PUBMED   7864897
REFERENCE   8  (bases 1 to 983)
  AUTHORS   Menezes,J.R. and Luskin,M.B.
  TITLE     Expression of neuron-specific tubulin defines a novel population in
            the proliferative layers of the developing telencephalon
  JOURNAL   J Neurosci 14 (9), 5399-5416 (1994)
   PUBMED   8083744
REFERENCE   9  (bases 1 to 983)
  AUTHORS   Nagata,Y. and Todokoro,K.
  TITLE     Activation of helix-loop-helix proteins Id1, Id2 and Id3 during
            neural differentiation
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1355-1362 (1994)
   PUBMED   7908517
REFERENCE   10 (bases 1 to 983)
  AUTHORS   Christy,B.A., Sanders,L.K., Lau,L.F., Copeland,N.G., Jenkins,N.A.
            and Nathans,D.
  TITLE     An Id-related helix-loop-helix protein encoded by a growth
            factor-inducible gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1815-1819 (1991)
   PUBMED   2000388
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064658.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013058.3.
            
            On Feb 22, 2004 this sequence version replaced NM_013058.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064658.1, DV724169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..983
                     /gene="Id3"
                     /note="inhibitor of DNA binding 3"
                     /db_xref="GeneID:25585"
                     /db_xref="RGD:2860"
     exon            1..337
                     /gene="Id3"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..397
                     /gene="Id3"
                     /note="inhibitor of differentiation 3; inhibitor of DNA
                     binding 3, dominant negative helix-loop-helix protein;
                     inhibitor of DNA binding 3, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-3"
                     /protein_id="NP_037190.1"
                     /db_xref="GeneID:25585"
                     /db_xref="RGD:2860"
                     /translation="MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSAEEPLSLLDDM
                     NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTA
                     ELTPELVISKDKRSFCH"
     exon            338..420
                     /gene="Id3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..942
                     /gene="Id3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttctgtt cttaaacttt gctctccaac ctccaacatg aaggcgctga gcccggtgcg
       61 cggctgctac gaggcggtgt gctgcctgtc ggaacgtagc ctagccattg cgcgaggccg
      121 gggtaagagc ccgtcggcgg aggagccgct tagcctcttg gacgacatga accactgcta
      181 ctcgcgcctg cgggaactgg tgccgggagt cccgcggggc actcagctta gccaggtgga
      241 aatcctgcag cgtgtcatag actacatcct cgaccttcaa gtggttctgg cagagcccgc
      301 gcctggaccc ccggatggtc cgcatctccc gatccagaca gctgagctca ctccggaact
      361 tgtgatctcc aaggacaaga ggagtttttg ccactgaccc ggtcgtcctg gcacctcccg
      421 aacgcaggtg ctggcgcccg ttccgcttgg gaccctggga ctctgggacc ctctctccag
      481 ccggaagcct gaggggcatg gatgagcttc gatcttgcca cagccctctt catttaccct
      541 gaactcatgc ctcgaggctg gacctggagc ccgagagcga aggactgaac ttgggtggcc
      601 tgaagagcta gctagcactc gctggtcagc agctgggcaa cgtcactctg tccccaccct
      661 gactcaagtc ttaaaaagac tggctttttt ccgaaaatgg ggtgtcgaga agggtgtggg
      721 gggtacacga gtggctgccc tgcacacact gccaaggcag cataagagct ggtcttctgg
      781 tttccttgga gaaaagctct gttgccctga ttatgaactc tataatagag tatatagctt
      841 ttgtaccttt tttttacagg aaggtgactt tctgtaacca tgtgatgtat attaaacttt
      901 ttataaaagt taacattttg cataataaac aatttttgaa caaaaaaaaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaa
//
