LOCUS       NM_013060                733 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus inhibitor of DNA binding 2 (Id2), mRNA.
ACCESSION   NM_013060
VERSION     NM_013060.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 733)
  AUTHORS   Ito,J., Minemura,T., Walchli,S., Niimi,T., Fujihara,Y., Kuroda,S.,
            Takimoto,K. and Maturana,A.D.
  TITLE     Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium
            Channels Expression
  JOURNAL   Int J Mol Sci 22 (7), 3561 (2021)
   PUBMED   33808082
  REMARK    GeneRIF: Id2 Represses Aldosterone-Stimulated Cardiac T-Type
            Calcium Channels Expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 733)
  AUTHORS   Xiao,Y., Jiang,X., Peng,C., Zhang,Y., Xiao,Y., Liang,D., Shi,M.,
            Wang,Y., Zhang,F. and Guo,B.
  TITLE     BMP-7/Smads-induced inhibitor of differentiation 2 (Id2)
            upregulation and Id2/Twist interaction was involved in attenuating
            diabetic renal tubulointerstitial fibrosis
  JOURNAL   Int J Biochem Cell Biol 116, 105613 (2019)
   PUBMED   31539631
  REMARK    GeneRIF: BMP-7/Smads-induced Id2 upregulation and Id2/Twist
            interaction was involved in attenuating diabetic renal
            tubulointerstitial fibrosis.
            Erratum:[Int J Biochem Cell Biol. 2019 Dec;117:105623. doi:
            10.1016/j.biocel.2019.105623.. PMID: 31630925]
REFERENCE   3  (bases 1 to 733)
  AUTHORS   Song,P., Xia,X., Han,T., Fang,H., Wang,Y., Dong,F., Zhang,R., Ge,P.
            and Shen,C.
  TITLE     BMSCs promote the differentiation of NSCs into oligodendrocytes via
            mediating Id2 and Olig expression through BMP/Smad signaling
            pathway
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30143582
  REMARK    GeneRIF: these data strongly suggest that bone marrow stromal cells
            (BMSCs) can promote the differentiation of Neural stem cells (NSCs)
            into oligodendrocytes through mediating Id2 and Olig1/2 expression
            by blocking the BMP/Smad signaling pathway
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 733)
  AUTHORS   Ko,H.R., Kwon,I.S., Hwang,I., Jin,E.J., Shin,J.H.,
            Brennan-Minnella,A.M., Swanson,R., Cho,S.W., Lee,K.H. and Ahn,J.Y.
  TITLE     Akt1-Inhibitor of DNA binding2 is essential for growth cone
            formation and axon growth and promotes central nervous system axon
            regeneration
  JOURNAL   Elife 5, e20799 (2016)
   PUBMED   27938661
  REMARK    GeneRIF: Here, the authors discovered that, in the developing
            neuron from rat, Akt signaling regulates axon growth and growth
            cone formation through phosphorylation of serine 14 (S14) on
            Inhibitor of DNA binding 2 (Id2).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 733)
  AUTHORS   Jiang,L., Wu,Q. and Yang,T.
  TITLE     Silencing of Id2 Alleviates Chronic Neuropathic Pain Following
            Chronic Constriction Injury
  JOURNAL   J Mol Neurosci 59 (1), 99-105 (2016)
   PUBMED   26768262
  REMARK    GeneRIF: Knockdown of Id2 alleviates neuropathic pain by inhibiting
            the NF-kappaB activation.
REFERENCE   6  (bases 1 to 733)
  AUTHORS   Stewart,H.J., Zoidl,G., Rossner,M., Brennan,A., Zoidl,C.,
            Nave,K.A., Mirsky,R. and Jessen,K.R.
  TITLE     Helix-loop-helix proteins in Schwann cells: a study of regulation
            and subcellular localization of Ids, REB, and E12/47 during
            embryonic and postnatal development
  JOURNAL   J Neurosci Res 50 (5), 684-701 (1997)
   PUBMED   9418957
REFERENCE   7  (bases 1 to 733)
  AUTHORS   Nagata,Y., Shoji,W., Obinata,M. and Todokoro,K.
  TITLE     Phosphorylation of helix-loop-helix proteins ID1, ID2 and ID3
  JOURNAL   Biochem Biophys Res Commun 207 (3), 916-926 (1995)
   PUBMED   7864897
REFERENCE   8  (bases 1 to 733)
  AUTHORS   Nagata,Y. and Todokoro,K.
  TITLE     Activation of helix-loop-helix proteins Id1, Id2 and Id3 during
            neural differentiation
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1355-1362 (1994)
   PUBMED   7908517
REFERENCE   9  (bases 1 to 733)
  AUTHORS   Nitta,H. and Ishikawa,I.
  TITLE     Analysis of the genetic control of antibody response to
            Actinobacillus actinomycetemcomitans by immunoblotting inbred
            strains of mice
  JOURNAL   Oral Microbiol Immunol 8 (3), 141-145 (1993)
   PUBMED   8233567
REFERENCE   10 (bases 1 to 733)
  AUTHORS   Sun,X.H., Copeland,N.G., Jenkins,N.A. and Baltimore,D.
  TITLE     Id proteins Id1 and Id2 selectively inhibit DNA binding by one
            class of helix-loop-helix proteins
  JOURNAL   Mol Cell Biol 11 (11), 5603-5611 (1991)
   PUBMED   1922066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013060.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10863.1, BC086391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000006.1  47470584-47470995   c
            413-476             JAXUCZ010000006.1  47470230-47470293   c
            477-733             JAXUCZ010000006.1  47469162-47469418   c
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..733
                     /gene="Id2"
                     /gene_synonym="Ac2-300"
                     /note="inhibitor of DNA binding 2"
                     /db_xref="GeneID:25587"
                     /db_xref="RGD:2859"
     exon            1..412
                     /gene="Id2"
                     /gene_synonym="Ac2-300"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..469
                     /gene="Id2"
                     /gene_synonym="Ac2-300"
                     /note="inhibitor of differentiation 2; inhibitor of DNA
                     binding 2, dominant negative helix-loop-helix protein;
                     inhibitor of DNA binding 2, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-2"
                     /protein_id="NP_037192.1"
                     /db_xref="GeneID:25587"
                     /db_xref="RGD:2859"
                     /translation="MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYS
                     KLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQTSRTP
                     LTTLNTDISILSLQASEFPSELMSNDSKVLCG"
     exon            413..476
                     /gene="Id2"
                     /gene_synonym="Ac2-300"
                     /inference="alignment:Splign:2.1.0"
     exon            477..733
                     /gene="Id2"
                     /gene_synonym="Ac2-300"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcggcgca gccacctcag ccccctgcgg cggctccctc ccggcctttc ctcctacgag
       61 cagcatgaaa gccttcagtc cggtgaggtc cgttaggaaa aacagcctgt cggaccacag
      121 cttgggcatc tcccggagca aaaccccggt ggacgacccg atgagtctgc tctacaacat
      181 gaacgactgc tactccaagc tcaaggaact ggtgcccagc atcccccaga acaagaaggt
      241 gaccaagatg gaaatcctgc agcacgtcat cgattatatc ttggacctgc agatcgccct
      301 ggactcgcac cccactatcg tcagcctgca ccaccagaga cctggacaga accaaacgtc
      361 caggacgccg ctgaccaccc tgaacacgga catcagcatc ctgtccttgc aggcgtctga
      421 attcccttct gagcttatgt cgaatgacag caaagtactc tgtggctaaa taaatggcat
      481 ttggggactt tttccttttt tttttttttt ttttattttt actttctctt tttcttttgc
      541 acaacaagaa gtctacagga tcttttaaga ctgttgtttt gttctgcttt gttatcaacc
      601 atttcaccag gagaacaagt tgaatggacc tttttaaaaa gaaaacggaa ggaaaactaa
      661 gagtgatcat ctcccccagg tgttctccgg cctggactgt gataaccgtt atttatgaga
      721 gactttcaat gcc
//
