LOCUS       NM_012797                924 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus inhibitor of DNA binding 1 (Id1), mRNA.
ACCESSION   NM_012797
VERSION     NM_012797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Chao,A.C., Chen,C.H., Chang,S.H., Huang,C.T., Hwang,W.C. and
            Yang,D.I.
  TITLE     Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis
            Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons
  JOURNAL   Mol Neurobiol 56 (1), 465-489 (2019)
   PUBMED   29721855
  REMARK    GeneRIF: These results revealed the critical roles of Id1 and SHH
            mediating Abeta-dependent cell cycle reentry and subsequently
            caspase-dependent apoptosis in the fully differentiated
            post-mitotic neurons.
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Wang,J., Qu,D., An,J., Yuan,G. and Liu,Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Patil,M., Sharma,B.K., Elattar,S., Chang,J., Kapil,S., Yuan,J. and
            Satyanarayana,A.
  TITLE     Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and
            White Adipose Browning
  JOURNAL   Diabetes 66 (6), 1611-1625 (2017)
   PUBMED   28270523
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Shahid,M., Spagnolli,E., Ernande,L., Thoonen,R., Kolodziej,S.A.,
            Leyton,P.A., Cheng,J., Tainsh,R.E., Mayeur,C., Rhee,D.K., Wu,M.X.,
            Scherrer-Crosbie,M., Buys,E.S., Zapol,W.M., Bloch,K.D. and
            Bloch,D.B.
  TITLE     BMP type I receptor ALK2 is required for angiotensin II-induced
            cardiac hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 310 (8), H984-H994 (2016)
   PUBMED   26873969
REFERENCE   5  (bases 1 to 924)
  AUTHORS   Wen,D., Zou,Y.F., Gao,Y.H., Zhao,Q., Xie,Y.Y., Shen,P.Y., Xu,Y.W.,
            Xu,J., Chen,Y.X., Feng,X.B., Shi,H. and Zhang,W.
  TITLE     Inhibitor of DNA Binding 1 Is Induced during Kidney
            Ischemia-Reperfusion and Is Critical for the Induction of
            Hypoxia-Inducible Factor-1alpha
  JOURNAL   Biomed Res Int 2016, 4634386 (2016)
   PUBMED   27127787
  REMARK    GeneRIF: Via RNAi, it was found that ID1 induction was inhibited
            with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA
            expression could lead to decreased expression and transcription of
            HIF-1alpha during hypoxia and reoxygenation. In addition, it was
            demonstrated that both ID1 and HIF-1alpha can regulate the
            transcription of twist
REFERENCE   6  (bases 1 to 924)
  AUTHORS   Einarson,M.B. and Chao,M.V.
  TITLE     Regulation of Id1 and its association with basic helix-loop-helix
            proteins during nerve growth factor-induced differentiation of PC12
            cells
  JOURNAL   Mol Cell Biol 15 (8), 4175-4183 (1995)
   PUBMED   7623812
REFERENCE   7  (bases 1 to 924)
  AUTHORS   Nagata,Y., Shoji,W., Obinata,M. and Todokoro,K.
  TITLE     Phosphorylation of helix-loop-helix proteins ID1, ID2 and ID3
  JOURNAL   Biochem Biophys Res Commun 207 (3), 916-926 (1995)
   PUBMED   7864897
REFERENCE   8  (bases 1 to 924)
  AUTHORS   Nagata,Y. and Todokoro,K.
  TITLE     Activation of helix-loop-helix proteins Id1, Id2 and Id3 during
            neural differentiation
  JOURNAL   Biochem Biophys Res Commun 199 (3), 1355-1362 (1994)
   PUBMED   7908517
REFERENCE   9  (bases 1 to 924)
  AUTHORS   Springhorn,J.P., Ellingsen,O., Berger,H.J., Kelly,R.A. and
            Smith,T.W.
  TITLE     Transcriptional regulation in cardiac muscle. Coordinate expression
            of Id with a neonatal phenotype during development and following a
            hypertrophic stimulus in adult rat ventricular myocytes in vitro
  JOURNAL   J Biol Chem 267 (20), 14360-14365 (1992)
   PUBMED   1378442
REFERENCE   10 (bases 1 to 924)
  AUTHORS   Sun,X.H., Copeland,N.G., Jenkins,N.A. and Baltimore,D.
  TITLE     Id proteins Id1 and Id2 selectively inhibit DNA binding by one
            class of helix-loop-helix proteins
  JOURNAL   Mol Cell Biol 11 (11), 5603-5611 (1991)
   PUBMED   1922066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M86708.1 and AI073271.1.
            
            On Nov 23, 2005 this sequence version replaced NM_012797.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M86708.1, BC127448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-902               M86708.1           8-909
            903-924             AI073271.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..924
                     /gene="Id1"
                     /gene_synonym="ID125A; Idb1"
                     /note="inhibitor of DNA binding 1"
                     /db_xref="GeneID:25261"
                     /db_xref="RGD:2858"
     exon            1..465
                     /gene="Id1"
                     /gene_synonym="ID125A; Idb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..507
                     /gene="Id1"
                     /gene_synonym="ID125A; Idb1"
                     /note="inhibitor of DNA binding 1, dominant negative
                     helix-loop-helix protein; Inhibitor of DNA binding 1,
                     helix-loop-helix protein (splice variation); Inhibitor of
                     DNA binding 1 helix-loop-helix protein (splice
                     varaiation); inhibitor of differentiation 1; inhibitor of
                     DNA binding 1, HLH protein"
                     /codon_start=1
                     /product="DNA-binding protein inhibitor ID-1"
                     /protein_id="NP_036929.2"
                     /db_xref="GeneID:25261"
                     /db_xref="RGD:2858"
                     /translation="MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGT
                     RLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL
                     NSESEVATAGGRGLPVRAPLSTLNGEISALAAEAACVPADDRILCR"
     exon            466..907
                     /gene="Id1"
                     /gene_synonym="ID125A; Idb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctcttct aacaccctgt tctcagactc ctccgcgcct ctccgcctgt cctcaggatc
       61 atgaaggtcg ccagtagcag tgccgcggcc accgcaggcc ccagctgttc gctgaaggca
      121 ggcaggacgg cgggcgaagt ggtgcttggt ctgtcggagc aaagcgttgc catctcgcgc
      181 tgcgctggga cgcgcctgcc cgccttgctg gacgaacagc aggtgaacgt tctgctctac
      241 gacatgaacg gctgctactc acgcctcaag gagctggtgc ctaccctgcc tcagaaccgc
      301 aaagtgagca aggtggagat actgcagcat gttatcgact acatcaggga cctgcagctg
      361 gagctgaact ctgagtctga agtcgcgacc gccggaggcc gggggctgcc cgtccgggcc
      421 ccgctcagca ccctgaacgg cgagatcagt gccttggcgg ccgaggcggc atgtgttcca
      481 gccgacgacc gcatcttgtg tcgctgaggc ggcgcactga ggaaccagat ggactccagc
      541 ccttcaggag gcaagaggaa aaaaagtgct ctcggttccc cagagcaacc cggggaaaga
      601 cactaccgcg gccacgggac tcttgacgga tctgtccagg gggtagaggg ttgatcaacg
      661 gagtctcgcc ctctccacct ttcagcctcc agagactttg aggagggggt tattcaaccc
      721 cgtgtgtttc tgtttttttg aaaaagcaga catttttttt aaatggtcac atttcgtgct
      781 tctcagattt ctgagaaaat gttttgtatt gtatattaca atgatcactg gctgagaata
      841 ttgttttaca atagttctta tgggggtggg ttttttgttg ttattaaaca aacactttag
      901 ataacgtaaa aaaaaaaaaa aaaa
//
