LOCUS       XM_006245038            3520 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus inducible T-cell co-stimulator (Icos),
            transcript variant X3, mRNA.
ACCESSION   XM_006245038
VERSION     XM_006245038.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051344.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006245038.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006245038.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3520
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /note="inducible T-cell co-stimulator; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 13 ESTs, 1 long SRA read, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 37 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:64545"
                     /db_xref="RGD:620123"
     CDS             291..893
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /codon_start=1
                     /product="inducible T-cell costimulator isoform X2"
                     /protein_id="XP_006245100.1"
                     /db_xref="GeneID:64545"
                     /db_xref="RGD:620123"
                     /translation="MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNY
                     PETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSS
                     QGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCI
                     FIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS"
ORIGIN      
        1 agggtcagtc tgacgaggca ggatagagcc tttcccagga agcctttcac ttcctgccga
       61 tccggaggga agaggatgga gttacaagga ccttctgaca gtcaaacaat ggtcctttga
      121 ggtcacagat aaaataattt ctgagcagag aagttagact tctttcccaa gttcctggac
      181 ctggtaaatg atggagccga ctctagaata aaacagaaaa caactgagaa catgatttca
      241 ctgccacttt tgagcactgg aggggaagag tgcagctgtt cctggcagac atgaagccct
      301 acttctcgtg cgtctttgtc ttctgcttcc taatcaaact tttaacagga gaactcaatg
      361 acttggccaa tcacaggatg ttttcgtttc acgatggagg tgtacagatt tcttgtaact
      421 accctgagac tgtccagcag ttaaaaatgc agttgttcaa agacagagaa gtcctctgcg
      481 acctcaccaa gaccaaggga agcggaaaca ccgtgtccat caagaatccg atgtcctgtc
      541 catatcagct gtccaacaac agtgtctctt ttttcctaga caacgcagac agctcccagg
      601 gcagctactt tttatgcagc ctgtcgattt tcgacccacc cccttttcaa gaaaagaacc
      661 ttagtggagg atatttgctt atttatgaat cccagctttg ttgccagctg aagctttggt
      721 tacccgtagg gtgtgcagct tttgtggcag cgctcctttt tggatgcata tttatcgtct
      781 ggtttgcaaa aaagaagtac agatccagtg tgcacgaccc taatagcgag tacatgttca
      841 tggcggcagt caacacaaac aaaaagtcca gacttgcagg tatgacctca taatctggaa
      901 cacgggaacc catggaggaa ctacactgtc tagttcccct gaaacttgaa tggagaaagt
      961 cttctatttt ctggaccaca gggcatctga cttgattaac tactgatacc tccttttggt
     1021 gttttgtttg tctggatcag tgactatcag tcactcggaa tttcagcaga ctgccctggg
     1081 tttgctgagt ccttttaagg caaacccctt cttatagaag acccggctca tatgtattca
     1141 acaaacagac ctcactggga tacaatcccc tctttctgcg cctgcttcta gctatgcacc
     1201 ggccagcaag acaaacatat ctccagcatt tttacaaaaa tgccagggta tgaatctgta
     1261 aagtacacag gcagccattg accaccgtct gtcctcgttt tttcagattc tatttttttc
     1321 catagagatc agcattcctt ctagaatcag acagtagagg gagatgcttc acaacagaag
     1381 ctcttatgtt tctgagatgt tgatgaattc atgctttagt accaccatgt tctctaacaa
     1441 cttctatatt ccagctgatc actgcttcag ggcttagatg cctgcttttg ccttcaagtc
     1501 tccccttaaa gatactccca caggtctact tggtggcctg cagccactct gaataggaag
     1561 tttggtctac aatttccccc ctctgctgct caaaaaaaaa attagtagat atgattttcc
     1621 catattctcc ctgccaaagt aattttttcc agcaaagaca tctaaattca gttaatatgg
     1681 tttactgtgt tgatattagt ggcagtaaac atttctcaga atcaaaagca aattaatttt
     1741 gcggtggtgt ttttctacca ttatctgggt ttccatggtg ctattactca caagtttagc
     1801 tatttttatg catcatatta aagttgcaag caagcagagc aaccctcggt taatgggcaa
     1861 acattctcct ggggtagaat gaattgtcta tttagcccga aaactgcagt ttctgtgggt
     1921 ggctgccaga ctacagccgt gctttgctct ggctttgaca ggttgaaata gtccccatga
     1981 gcctggaaca gtactccaga ctgtgctgga gtcccaaagt taggagggcc atggagcctg
     2041 ggacaggctg ctgctttggt ctttaggatc taggaagaat tacagagggg ccaagacaga
     2101 gttccctccc ctagaaactg tgcagcctgg aagtcagccc tggcacttta agatagcctt
     2161 ctttagaaca tgagttagtt ggtagtattc tgacgtgtaa acagcctatg attgctcgga
     2221 gctggaccat tttctccact tccctgtctg catgcctaag acttctagag cagccaacgt
     2281 atatgcaaca ttaaagaaaa aaaaagaaaa gaaaagaaac agcaaaaagc agacaaacaa
     2341 gataaacccc aaacttaaat aaaatagggc tgcttcctag ttttaagtta tagttgctta
     2401 ctcagtttgc tttacaagtg aactgggtat caacggatac ttattacatt aagcatgtgt
     2461 aatgctggct atgtacagta cagtactgac cttaagtatg gtgttctctc tcttccaatg
     2521 actcaggcag cctggctggc tctgtgaggg catcccctga gttggatgga cctctttgtt
     2581 tagggggtga gggtacttta ctccggtcct tgaaggatcc ccatcccaac actgaacacc
     2641 taccaatgaa ttcttgaaga acaaaatttc tgtgaaataa aatctggctt acagaggagc
     2701 catgtgctaa agatgttagc aataatacca agtcacggct aagcacgagt gtgcagcaat
     2761 gggatagaac cttgctgtgt tttctggggg cgaagaagtg atgaccttag ctaccacatg
     2821 caaattagcc cttgctctcc catgaccttg tgtgctgcat aagatagttg ctccctttgc
     2881 ctcgctttcc cccttttaaa ctctaaaata gccacaaact tataaaagag tcagaagcac
     2941 aggaaaaagt gtgttctgcg cctgacttag tttctgcctt gacccccccg gccccacaga
     3001 atggtgccta tttcctatgg aaatgaaggc tgtattcttt gatgacttga cagtcaccaa
     3061 tgtcagaaaa ttatcgttga tatgtcacta ttctctattc tttggtctgc attcaagatc
     3121 ttcccctcgg ttctaggatg tctgtaggag ccgaaggttc tgctggagac ttccccctgt
     3181 gtttggctgt ccagtctctg gagtattctt cagtctggac agttctcttc agtctgtagt
     3241 ctgggctctt tgtctgatcg tgggccattg ttttgtagaa tgtttctttt gggggggtca
     3301 ctctgatgtt tcttcatgaa tgaaatgaag ttatttgtct ttagcagaaa taatacagaa
     3361 gtggtgttgc gccctgtagg gcagctcaca tttcggttcg tcaagttact gccaatgttt
     3421 gttttcatct cttgactaag ctcctgtcaa gcttctccat tgcgaagtga ttctgcccct
     3481 ccacccccaa cagccaataa atatgctttg tgagaaagta
//
