LOCUS       NM_022610               2049 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus inducible T-cell co-stimulator (Icos), mRNA.
ACCESSION   NM_022610
VERSION     NM_022610.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Tao,Y.W., Xing,Q., Li,D., Quan,J., Gao,Y., Hu,X. and Zhang,X.
  TITLE     Association between Increased Inducible Costimulator/Inducible
            Costimulator Ligand Expression with Bone Destruction in Apical
            Periodontitis
  JOURNAL   J Endod 45 (7), 890-897 (2019)
   PUBMED   31153660
  REMARK    GeneRIF: the increased expression of ICOS/ICOS ligand in periapical
            lesions was associated with the inflammatory infiltration and
            alveolar bone destruction of apical periodontitis
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Wang,W.M., Liu,Z. and Chen,G.
  TITLE     Effect of siRNA silencing of inducible co-stimulatory molecule on
            myocardial cell hypertrophy after cardiac infarction in rats
  JOURNAL   Genet Mol Res 15 (2) (2016)
   PUBMED   27323062
  REMARK    GeneRIF: ICOS-targeted siRNA can effectively silence gene
            expression of ICOS, and provided satisfactory treatment efficacy
            for myocardial cell hypertrophy after infarction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Luo,Y., Yang,Y., Zhang,H., Zhang,T., Wang,Y., Tan,S., Xu,Y., Li,D.,
            Ye,L. and Chen,P.
  TITLE     Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral
            Infarction Rat Models
  JOURNAL   Med Sci Monit 21, 3003-3007 (2015)
   PUBMED   26436531
  REMARK    GeneRIF: ICOS siRNA can protect brain tissues from ischemia
            injuries after cerebral infarction, improve limb movement and
            coordination, lower the mortality rate of rats, and inhibit T
            cell-induced cytokines
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Araujo,L.M., Fert,I., Jouhault,Q., Labroquere,K., Andrieu,M.,
            Chiocchia,G. and Breban,M.
  TITLE     Increased production of interleukin-17 over interleukin-10 by treg
            cells implicates inducible costimulator molecule in experimental
            spondyloarthritis
  JOURNAL   Arthritis Rheumatol 66 (9), 2412-2422 (2014)
   PUBMED   24909668
  REMARK    GeneRIF: our data highlight a key role for ICOS signaling in the
            generation of imbalanced production of IL-10 and IL-17 by Treg
            cells in a rat model of spondyloarthritis.
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Vogel,K.U., Edelmann,S.L., Jeltsch,K.M., Bertossi,A., Heger,K.,
            Heinz,G.A., Zoller,J., Warth,S.C., Hoefig,K.P., Lohs,C., Neff,F.,
            Kremmer,E., Schick,J., Repsilber,D., Geerlof,A., Blum,H., Wurst,W.,
            Heikenwalder,M., Schmidt-Supprian,M. and Heissmeyer,V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Futamatsu,H., Suzuki,J., Kosuge,H., Yokoseki,O., Kamada,M., Ito,H.,
            Inobe,M., Isobe,M. and Uede,T.
  TITLE     Attenuation of experimental autoimmune myocarditis by blocking
            activated T cells through inducible costimulatory molecule pathway
  JOURNAL   Cardiovasc Res 59 (1), 95-104 (2003)
   PUBMED   12829180
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Mittrucker,H.W., Kursar,M., Kohler,A., Yanagihara,D.,
            Yoshinaga,S.K. and Kaufmann,S.H.
  TITLE     Inducible costimulator protein controls the protective T cell
            response against Listeria monocytogenes
  JOURNAL   J Immunol 169 (10), 5813-5817 (2002)
   PUBMED   12421962
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Tezuka,K., Tsuji,T., Hirano,D., Tamatani,T., Sakamaki,K.,
            Kobayashi,Y. and Kamada,M.
  TITLE     Identification and characterization of rat AILIM/ICOS, a novel
            T-cell costimulatory molecule, related to the CD28/CTLA4 family
  JOURNAL   Biochem Biophys Res Commun 276 (1), 335-345 (2000)
   PUBMED   11006126
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Mages,H.W., Hutloff,A., Heuck,C., Buchner,K., Himmelbauer,H.,
            Oliveri,F. and Kroczek,R.A.
  TITLE     Molecular cloning and characterization of murine ICOS and
            identification of B7h as ICOS ligand
  JOURNAL   Eur J Immunol 30 (4), 1040-1047 (2000)
   PUBMED   10760791
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Tamatani,T., Tezuka,K. and Hanzawa-Higuchi,N.
  TITLE     AILIM/ICOS: a novel lymphocyte adhesion molecule
  JOURNAL   Int Immunol 12 (1), 51-55 (2000)
   PUBMED   10607749
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_022610.3.
            
            On Nov 26, 2020 this sequence version replaced NM_022610.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023134.1, SRR26643284.12397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000009.1  69877799-69877890
            93-431              JAXUCZ010000009.1  69893978-69894316
            432-538             JAXUCZ010000009.1  69894934-69895040
            539-623             JAXUCZ010000009.1  69895960-69896044
            624-2049            JAXUCZ010000009.1  69898224-69899649
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2049
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /note="inducible T-cell co-stimulator"
                     /db_xref="GeneID:64545"
                     /db_xref="RGD:620123"
     exon            1..92
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..637
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /note="inducible T-cell costimulator; activation-inducible
                     lymphocyte immunomediatory molecule"
                     /codon_start=1
                     /product="inducible T-cell costimulator precursor"
                     /protein_id="NP_072132.1"
                     /db_xref="GeneID:64545"
                     /db_xref="RGD:620123"
                     /translation="MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNY
                     PETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSS
                     QGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCI
                     FIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS"
     exon            93..431
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /inference="alignment:Splign:2.1.0"
     exon            432..538
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /inference="alignment:Splign:2.1.0"
     exon            539..623
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /inference="alignment:Splign:2.1.0"
     exon            624..2049
                     /gene="Icos"
                     /gene_synonym="Ailim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggagggga agagtgcagc tgttcctggc agacatgaag ccctacttct cgtgcgtctt
       61 tgtcttctgc ttcctaatca aacttttaac aggagaactc aatgacttgg ccaatcacag
      121 gatgttttcg tttcacgatg gaggtgtaca gatttcttgt aactaccctg agactgtcca
      181 gcagttaaaa atgcagttgt tcaaagacag agaagtcctc tgcgacctca ccaagaccaa
      241 gggaagcgga aacaccgtgt ccatcaagaa tccgatgtcc tgtccatatc agctgtccaa
      301 caacagtgtc tcttttttcc tagacaacgc agacagctcc cagggcagct actttttatg
      361 cagcctgtcg attttcgacc cacccccttt tcaagaaaag aaccttagtg gaggatattt
      421 gcttatttat gaatcccagc tttgttgcca gctgaagctt tggttacccg tagggtgtgc
      481 agcttttgtg gcagcgctcc tttttggatg catatttatc gtctggtttg caaaaaagaa
      541 gtacagatcc agtgtgcacg accctaatag cgagtacatg ttcatggcgg cagtcaacac
      601 aaacaaaaag tccagacttg caggtatgac ctcataatct ggaacacggg aacccatgga
      661 ggaactacac tgtctagttc ccctgaaact tgaatggaga aagtcttcta ttttctggac
      721 cacagggcat ctgacttgat taactactga tacctccttt tggtgttttg tttgtctgga
      781 tcagtgacta tcagtcactc ggaatttcag cagactgccc tgggtttgct gagtcctttt
      841 aaggcaaacc ccttcttata gaagacccgg ctcatatgta ttcaacaaac agacctcact
      901 gggatacaat cccctctttc tgcgcctgct tctagctatg caccggccag caagacaaac
      961 atatctccag catttttaca aaaatgccag ggtatgaatc tgtaaagtac acaggcagcc
     1021 attgaccacc gtctgtcctc gttttttcag attctatttt tttccataga gatcagcatt
     1081 ccttctagaa tcagacagta gagggagatg cttcacaaca gaagctctta tgtttctgag
     1141 atgttgatga attcatgctt tagtaccacc atgttctcta acaacttcta tattccagct
     1201 gatcactgct tcagggctta gatgcctgct tttgccttca agtctcccct taaagatact
     1261 cccacaggtc tacttggtgg cctgcagcca ctctgaatag gaagtttggt ctacaatttc
     1321 ccccctctgc tgctcaaaaa aaaaattagt agatatgatt ttcccatatt ctccctgcca
     1381 aagtaatttt ttccagcaaa gacatctaaa ttcagttaat atggtttact gtgttgatat
     1441 tagtggcagt aaacatttct cagaatcaaa agcaaattaa ttttgcggtg gtgtttttct
     1501 accattatct gggtttccat ggtgctatta ctcacaagtt tagctatttt tatgcatcat
     1561 attaaagttg caagcaagca gagcaaccct cggttaatgg gcaaacattc tcctggggta
     1621 gaatgaattg tctatttagc ccgaaaactg cagtttctgt gggtggctgc cagactacag
     1681 ccgtgctttg ctctggcttt gacaggttga aatagtcccc atgagcctgg aacagtactc
     1741 cagactgtgc tggagtccca aagttaggag ggccatggag cctgggacag gctgctgctt
     1801 tggtctttag gatctaggaa gaattacaga ggggccaaga cagagttccc tcccctagaa
     1861 actgtgcagc ctggaagtca gccctggcac tttaagatag ccttctttag aacatgagtt
     1921 agttggtagt attctgacgt gtaaacagcc tatgattgct cggagctgga ccattttctc
     1981 cacttccctg tctgcatgcc taagacttct agagcagcca acgtatatgc aacattaaag
     2041 aaaaaaaaa
//
