LOCUS       NM_001191108            3155 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interactor of little elongation complex ELL
            subunit 2 (Ice2), mRNA.
ACCESSION   NM_001191108 XM_001075498
VERSION     NM_001191108.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3155)
  AUTHORS   Hu,D., Smith,E.R., Garruss,A.S., Mohaghegh,N., Varberg,J.M.,
            Lin,C., Jackson,J., Gao,X., Saraf,A., Florens,L., Washburn,M.P.,
            Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex functions at initiation and
            elongation phases of snRNA gene transcription
  JOURNAL   Mol Cell 51 (4), 493-505 (2013)
   PUBMED   23932780
REFERENCE   2  (bases 1 to 3155)
  AUTHORS   Smith,E.R., Lin,C., Garrett,A.S., Thornton,J., Mohaghegh,N., Hu,D.,
            Jackson,J., Saraf,A., Swanson,S.K., Seidel,C., Florens,L.,
            Washburn,M.P., Eissenberg,J.C. and Shilatifard,A.
  TITLE     The little elongation complex regulates small nuclear RNA
            transcription
  JOURNAL   Mol Cell 44 (6), 954-965 (2011)
   PUBMED   22195968
REFERENCE   3  (bases 1 to 3155)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   4  (bases 1 to 3155)
  AUTHORS   Sugiura,N., Dadashev,V. and Corriveau,R.A.
  TITLE     NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is
            expressed during development
  JOURNAL   Eur J Biochem 271 (23-24), 4629-4637 (2004)
   PUBMED   15606750
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            [WARNING] On Mar 14, 2025 this sequence was replaced by
            NM_001191108.2.
            
            On Jul 17, 2010 this sequence version replaced XM_001075498.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.32317.1,
                                           SRR26643299.35942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000008.1  78925559-78925599
            42-146              JAXUCZ010000008.1  78926729-78926833
            147-396             JAXUCZ010000008.1  78937486-78937735
            397-516             JAXUCZ010000008.1  78939132-78939251
            517-654             JAXUCZ010000008.1  78941077-78941214
            655-771             JAXUCZ010000008.1  78941741-78941857
            772-931             JAXUCZ010000008.1  78942065-78942224
            932-1113            JAXUCZ010000008.1  78943368-78943549
            1114-2164           JAXUCZ010000008.1  78948157-78949207
            2165-2340           JAXUCZ010000008.1  78949789-78949964
            2341-2470           JAXUCZ010000008.1  78954353-78954482
            2471-2555           JAXUCZ010000008.1  78958365-78958449
            2556-2606           JAXUCZ010000008.1  78959554-78959604
            2607-2865           JAXUCZ010000008.1  78961076-78961334
            2866-3155           JAXUCZ010000008.1  78964963-78965252
FEATURES             Location/Qualifiers
     source          1..3155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3155
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="interactor of little elongation complex ELL subunit
                     2"
                     /db_xref="GeneID:691379"
                     /db_xref="RGD:1585038"
     CDS             1..2994
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /note="NMDA receptor-regulated gene 2; NMDA
                     receptor-regulated protein 2; NMDA receptor regulated 2;
                     interactor of little elongator complex ELL subunit 2"
                     /codon_start=1
                     /product="little elongation complex subunit 2"
                     /protein_id="NP_001178037.1"
                     /db_xref="GeneID:691379"
                     /db_xref="RGD:1585038"
                     /translation="MSSGITMSEPRLNWDVTPKNGLKVFFSPENYKDHSMAPSLKELY
                     ILSNRRIGENVSVSANSVENEPAVSSATQAKEKVGMILLPKPRVPYPRFSRFSQREQR
                     TFVDLLVKYAKIPSSSKTVGTNTNEFLQYLDMKKHVNEEVNEFLKFLQNSAKKCAQDY
                     NMLSDEARLFTEQILRACIEQVKKYPEFYTLHEVTSLMGFFPFKIEMGLKLEKTLLVL
                     GSAKFVKTAFPSMPVKLQLSKEDMSSIENPQQQAEAMHCDISKDPNAEKLVSRYHPQI
                     ALTSQALFTLLNNHGPSYKEQWEIPVCVQMIAVEGSKPVKVIYINSPLPRKQMTMRER
                     NQIFHEVPLKHIFSKTTSVPVSAVFMDKPEEYTSEVDISTEASECRKIETLENLDLDF
                     DGDVTELETFGVTTTSPSRSPSSESDSSAPIMTDVHTAPKVTAIPVAPAAPVTPAAPV
                     APVVAPVAPVVAPVAPAAPVTPVTPEASAIPNITDDSRSLCQILMKQLQKEKQLFSGV
                     ESGPEACKNKDDQGLEPCAEEGPSANAKSLTQDSEVHRTEEISNESDVGALCTSDERQ
                     SVQKNADNPNETATASETADTEKGIPCGSDTDEDCLIIDTESKSNSDGRTAGLGSSPN
                     SSAQASVENQTTTTVSEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPVSRTIPELP
                     LTNSEESKQPSASEQPSATLDASTWPKSSWPSAFQKPKGRLPYELQDYVEDTSEYVAP
                     QEGNFVYKLFSLQDLLLLVRCSVQRVETRPRSKKRKKIRRQFPVYVLPKVEYQGCYGV
                     EALTESELCRFWTESLLHSNCSFYVGHIDAFTSKLFMLEEITSEELKEKLAALKISSL
                     FNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKAHCDLPGVP
                     SSLSVPWVPLDPSYLLPYHIHHGRIPCTFPPKSLRPAAQPKVGATRMPTRNHRNPVSR
                     ETKSSCLPVQQVENEGVAQNKRKIM"
     exon            1..41
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            42..146
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..396
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..516
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..654
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..771
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..931
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1113
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2164
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2340
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2470
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2555
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2606
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2865
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3155
                     /gene="Ice2"
                     /gene_synonym="Narg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagctctg gcataaccat gagtgaacca aggctgaact gggatgttac acccaaaaat
       61 ggccttaaag tctttttctc tccagaaaat tataaagatc attccatggc tccaagttta
      121 aaagaactct atattttgtc caacagacgt ataggagaaa atgtgagtgt ctcagcaaat
      181 tctgtagaaa atgagcctgc agttagttca gcaactcaag caaaggaaaa agttgggatg
      241 attctccttc ccaaaccaag agttccttat cctcgtttct ctcggttctc acagagagag
      301 cagaggactt ttgtggattt gttggttaaa tatgcaaaga tcccctcaag ttccaagact
      361 gttggaacaa atacaaatga atttctacag tatctggata tgaaaaaaca tgtgaatgaa
      421 gaagttaatg aattcctaaa gtttttacag aattctgcaa agaaatgtgc acaggattat
      481 aacatgctct ctgatgaggc ccgtctcttc acggagcaaa tcctaagagc ttgcattgag
      541 caagtgaaaa agtacccaga attttatacg cttcatgaag ttaccagcct aatgggattc
      601 ttccccttca aaatagagat gggactgaag ttagaaaaga ctcttcttgt tttgggcagt
      661 gcaaagtttg taaaaacagc atttccctcg atgcctgtga aactgcagct ctccaaagag
      721 gacatgtctt ccattgagaa cccacagcaa caagccgaag cgatgcactg cgatattagt
      781 aaagacccga atgcagagaa acttgtttca agataccatc ctcagatcgc tctgactagc
      841 caagcattat tcaccttgct caataaccat ggaccaagct acaaggagca gtgggagatc
      901 ccagtgtgtg ttcagatgat agctgtggaa ggttccaaac cagttaaagt aatttatatc
      961 aattcgccac ttccccgaaa gcaaatgaca atgagagaaa gaaatcaaat cttccatgaa
     1021 gttccattaa aacatatatt ctcaaaaacc acatctgttc cagtctctgc tgtctttatg
     1081 gacaaacctg aagagtacac ctctgaggtg gatatatcca ctgaagctag tgagtgccga
     1141 aaaattgaga ctctggaaaa tttggatctg gactttgatg gtgatgtcac agaacttgaa
     1201 acctttggag taactactac tagtccatcc aggtcaccaa gttcagaaag tgactcctct
     1261 gcacccatca tgacagatgt ccacacagcc cccaaagtaa cagctatacc tgtggcacca
     1321 gctgctcctg tgacaccagc tgctcctgtg gcaccagttg ttgctcctgt ggcaccagtt
     1381 gttgctcctg tggcaccagc tgctcctgta acaccagtta cacctgaggc atcagctata
     1441 ccaaacatta ctgatgattc tagaagttta tgtcagattc tgatgaaaca gttacagaag
     1501 gagaaacagc tattctctgg tgtggaaagt ggtcctgaag catgcaaaaa taaagatgat
     1561 caagggcttg aaccatgtgc tgaagagggt cccagtgcca atgcaaagtc tttaacacaa
     1621 gacagtgaag tccacagaac tgaggaaatt tctaatgaga gtgatgtagg tgcgctgtgt
     1681 accagtgatg aaagacaaag tgttcagaag aacgcagaca atcccaacga aacagccact
     1741 gcatcagaaa cagctgacac tgagaaaggg ataccttgtg gcagtgatac agatgaggac
     1801 tgcttaatca ttgatacaga gagtaaaagt aatagtgatg gaaggacagc tggtttgggt
     1861 tctagtccaa attcttcagc acaggcttct gtggaaaacc agaccactac tactgtttct
     1921 gaggaatctt gtgttttaaa gaaacctatc aaaagagtct ataaaaaatt tgatccagtt
     1981 ggagaaattc taaaaatgca ggatgagctt ttaaaaccag tttccaggac aatacctgag
     2041 ttgcccttga ctaattcaga agaatctaaa cagccatctg cttctgagca accctctgct
     2101 actttggacg cctccacctg gccaaaatcc agttggccct ctgcatttca gaagcctaaa
     2161 ggacgattgc catatgaact tcaagactat gtggaagaca catcagaata tgtagctcct
     2221 caagaaggaa actttgtcta taagttgttc agcctacaag acctgttgtt acttgtgcgg
     2281 tgcagtgtcc agagggtaga gacaagacca cgctccaaaa aacggaagaa gatcagaaga
     2341 caatttccag tttacgtgct accaaaagta gagtatcaag gttgttatgg agttgaagct
     2401 ctgactgaaa gcgagctctg tcgcttctgg actgaaagtt tattgcattc caactgctcg
     2461 ttttatgttg gtcatattga tgcgtttact tcaaagcttt tcatgctaga agaaatcacc
     2521 tcagaagaat taaaagaaaa acttgcagca ctcaagattt caagtttatt taacattctc
     2581 cagcacattt taaagaaatt atgtagcttg caggaagggt cctacttgct gtctcacgca
     2641 gcagaagatt cttcactcct gatctacaag acctcagatg gaaaagttac tagaacagcg
     2701 tataatttgc ataaggcaca ttgtgacctt cctggtgtac cctccagtct ctcggttcct
     2761 tgggtcccat tagatcccag ttacctgtta ccatatcaca tccatcatgg acgaatacct
     2821 tgtacttttc cacctaaatc actgcgccct gcagcacaac caaaggttgg tgcgacaaga
     2881 atgcctaccc ggaaccacag gaatccagtt tccagggaaa ccaaaagcag ttgcctgcct
     2941 gttcagcaag ttgaaaatga aggagtggct cagaataaaa ggaaaataat gtaagggctg
     3001 gaccaccgaa agtaaagttt cagaaaactc agttataaca gtgtttaatg ttgaacttta
     3061 agggaaacat gcccaaaaga ccggctagca agaatgtttc tcctcgctat cctggagttc
     3121 ttacaaagtg ccttggaaac ctactgactg cggga
//
