LOCUS       NM_001172079            3117 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus intercellular adhesion molecule 5 (Icam5), mRNA.
ACCESSION   NM_001172079
VERSION     NM_001172079.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Ohgomori,T., Nanao,T., Morita,A. and Ikekita,M.
  TITLE     Asn54-linked glycan is critical for functional folding of
            intercellular adhesion molecule-5
  JOURNAL   Glycoconj J 29 (1), 47-55 (2012)
   PUBMED   22187327
  REMARK    GeneRIF: The Asn54-linked glycan is necessary for normal
            trafficking and function of ICAM-5, but is unassociated with
            ER-associated degradation of it.
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Ohgomori,T., Funatsu,O., Nakaya,S., Morita,A. and Ikekita,M.
  TITLE     Structural study of the N-glycans of intercellular adhesion
            molecule-5 (telencephalin)
  JOURNAL   Biochim Biophys Acta 1790 (12), 1611-1623 (2009)
   PUBMED   19733219
  REMARK    GeneRIF: Elucidation of the roles of the N-glycans expressed in
            neural cells, including those present on ICAM-5.
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Tian,L., Lappalainen,J., Autero,M., Hanninen,S., Rauvala,H. and
            Gahmberg,C.G.
  TITLE     Shedded neuronal ICAM-5 suppresses T-cell activation
  JOURNAL   Blood 111 (7), 3615-3625 (2008)
   PUBMED   18223167
  REMARK    GeneRIF: ICAM-5 is involved in immune privilege of the brain and
            acts as an anti-inflammatory agent.
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Esselens,C., Oorschot,V., Baert,V., Raemaekers,T., Spittaels,K.,
            Serneels,L., Zheng,H., Saftig,P., De Strooper,B., Klumperman,J. and
            Annaert,W.
  TITLE     Presenilin 1 mediates the turnover of telencephalin in hippocampal
            neurons via an autophagic degradative pathway
  JOURNAL   J Cell Biol 166 (7), 1041-1054 (2004)
   PUBMED   15452145
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Annaert,W.G., Esselens,C., Baert,V., Boeve,C., Snellings,G.,
            Cupers,P., Craessaerts,K. and De Strooper,B.
  TITLE     Interaction with telencephalin and the amyloid precursor protein
            predicts a ring structure for presenilins
  JOURNAL   Neuron 32 (4), 579-589 (2001)
   PUBMED   11719200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.3034956.1,
                                           SRR21887622.3034965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000008.1  27844780-27845090
            312-581             JAXUCZ010000008.1  27845964-27846233
            582-902             JAXUCZ010000008.1  27846366-27846686
            903-1190            JAXUCZ010000008.1  27847220-27847507
            1191-1445           JAXUCZ010000008.1  27847738-27847992
            1446-1694           JAXUCZ010000008.1  27848089-27848337
            1695-1937           JAXUCZ010000008.1  27848902-27849144
            1938-2216           JAXUCZ010000008.1  27849224-27849502
            2217-2456           JAXUCZ010000008.1  27849593-27849832
            2457-2720           JAXUCZ010000008.1  27850355-27850618
            2721-3117           JAXUCZ010000008.1  27851371-27851767
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3117
                     /gene="Icam5"
                     /note="intercellular adhesion molecule 5"
                     /db_xref="GeneID:313785"
                     /db_xref="RGD:1305039"
     exon            1..311
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..2983
                     /gene="Icam5"
                     /note="intercellular adhesion molecule 5, telencephalin"
                     /codon_start=1
                     /product="intercellular adhesion molecule 5"
                     /protein_id="NP_001165550.1"
                     /db_xref="GeneID:313785"
                     /db_xref="RGD:1305039"
                     /translation="MPGPSPGLRRTLLGLWAALGLGILGISAVALEPFWADLQPRVAL
                     VERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFR
                     CARRTLQARGLIRTFQRPDRVELVPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRG
                     GQELIRRSFVGEPPRARGAMLTATVLARREDHRANFSCLAELDLRPHGLGLFANSSAP
                     RQLRTFAMPPLSPSLIAPRFLEVGSERPVTCTLDGLFPAPEAGVYLSLGDQRLHPNVT
                     LDGESLVATATATASEEQEGTKQLMCIVTLGGESRETQENLTVYSFPAPLLTLSEPEA
                     PEGKMVTVSCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVDGE
                     TLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPDGGA
                     VLALGLLGPVTRALAGTYRCTAINGQGQAVKDVTLTVEYAPALDSVGCPERITWLEGT
                     EASLSCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAV
                     TVEYGPSFEELGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGVVLPLVSS
                     NSGSRNSMTPGNLSPGIYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGA
                     EATALACSARGRPSPRVRCSREGAARLERLQVSREDAGTYLCVATNAHGTDSRTVTVG
                     VEYRPVVAELAASPPSVRPGGNFTLTCRAEAWPPAQISWRAPPGALNLGLSSNNSTLS
                     VAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAF
                     YVQSTACKKGEYNVQEAESSGEAVCLNGAGGTPGAEGGAETPGTAESPADGEVFAIQL
                     TSS"
     exon            312..581
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            582..902
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1190
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1445
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1694
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1937
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2216
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2456
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2720
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..3117
                     /gene="Icam5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggagcag cccagtgcgc gctcgcctcc agtcagctcg cccccgatca ccgcctctgt
       61 caccgccccc tccttggaaa ccaagttacc aacgtttaaa ccaatccctg ggcgcaattc
      121 tgccaccccc acactccacc cgctgcgctg cgcggtcctc ccagcccagc tctccatcac
      181 tcgcgctccc ctcgccttct gcgctctccc ctccctggca gcggcggcaa tgccggggcc
      241 ttcaccaggg ctgcgccgaa cgctcctcgg cctctgggct gccctgggcc tggggatcct
      301 aggcatctca gcggtcgcgc tagaaccttt ctgggcggac cttcagcccc gcgtggcgct
      361 cgtggagcgc gggggctcgc tgtggctcaa ctgcagcact aactgtccga ggccggagcg
      421 cggtggcctg gagacctcgc tacgccgaaa cgggacccag aggggtctgc gctggctggc
      481 tcgacagctg gtggacatcc gagagcctga aacccagccg gtctgcttct tccgctgcgc
      541 gcgccgcaca ctccaagcgc gtgggctcat ccgaactttc cagcgaccgg atcgggtaga
      601 gctagtgcct ctgcctcctt ggcagcctgt aggtgagaac ttcaccttga gctgcagggt
      661 cccgggggca ggaccccgag cgagcctcac attgaccttg ctgcgaggcg gccaggagct
      721 gattcgccga agtttcgtag gcgagccacc ccgagctcgg ggtgcgatgc tcaccgccac
      781 ggtcctggcg cgcagagagg atcacagggc caatttctca tgcctcgcgg agcttgacct
      841 gcggccacac ggcttgggac tgtttgcaaa cagctcagcc cccagacagc tccgcacgtt
      901 tgccatgcct ccactttccc cgagccttat tgccccacga ttcttagaag tgggctcaga
      961 aaggccggtg acttgcactt tggatggact gtttcctgcc ccagaagccg gggtttacct
     1021 ctctctggga gatcagaggc ttcatcctaa tgtgaccctc gacggggaga gccttgtggc
     1081 cactgccaca gctacagcaa gtgaagaaca ggaaggcacc aaacagctga tgtgcatcgt
     1141 gaccctcggg ggcgaaagca gggagaccca ggaaaacctg actgtctaca gcttcccggc
     1201 tcctcttctg actttaagtg agccagaagc ccccgaggga aagatggtga ccgtaagctg
     1261 ctgggcaggg gcccgagccc ttgtcacctt ggagggaatt ccagctgcgg tccctgggca
     1321 gcccgctgag ctccagttaa atgtcacaaa gaatgacgac aagcggggct tcttctgcga
     1381 cgctgccctc gatgtggacg gggaaactct gagaaagaac cagagctctg agcttcgtgt
     1441 tctgtacgca cctcggctgg atgacttgga ctgtcccagg agctggacgt ggccagaggg
     1501 tccagagcag accctccact gcgaggcccg tggaaaccct gagccctccg tgcactgtgc
     1561 aaggcctgac ggtggggcgg tgctagcgct gggcctgttg ggtccagtga cccgtgccct
     1621 cgcgggcact taccgatgta cagcaatcaa tgggcaaggc caggcggtca aggatgtgac
     1681 cctgactgtg gaatatgccc cagcgctgga cagtgtaggc tgcccagaac gtattacttg
     1741 gctggagggg acagaggcat cgcttagctg tgtggcacac ggggtcccac cacctagcgt
     1801 gagctgtgtg cgctctggaa aggaggaagt catggaaggg cccctgcgtg tggcccggga
     1861 gcacgctggc acttaccgat gcgaagccat caacgccagg ggatcagcgg ccaaaaatgt
     1921 ggctgtcacg gtggaatatg gtcccagttt tgaggagttg ggctgcccca gcaactggac
     1981 ttgggtagaa ggatctggaa aactgttttc ctgtgaagtt gatgggaagc cggaaccacg
     2041 cgtggagtgc gtgggctcgg agggtgcaag cgaaggggta gtgttgcccc tggtgtcctc
     2101 gaactctggt tccagaaact ctatgactcc tggtaacctg tcaccgggta tttacctctg
     2161 caacgccacc aaccggcatg gctccacagt caaaacagtc gtcgtgagcg cggaatcacc
     2221 gccacagatg gatgaatcca gttgcccgag tcaccagaca tggctggaag gagccgaggc
     2281 tactgcgctg gcctgcagtg ccagaggccg cccctctcca cgcgtgcgct gttccaggga
     2341 aggtgcagcc aggctggaga ggctacaggt gtcccgagag gatgcgggga cctacctgtg
     2401 tgtggctacc aacgcgcatg gcacggattc acggaccgtc actgtgggtg tggaataccg
     2461 gcctgtggtg gctgagctgg cagcctcgcc cccaagcgtg cggcctggcg gaaacttcac
     2521 tctgacctgc cgtgcagagg cctggcctcc agcccagatc agctggcgcg cgcccccggg
     2581 agctctcaac ctcggtctct ccagcaacaa cagcacgctg agcgtggcgg gtgccatggg
     2641 cagccatggt ggcgagtatg agtgcgcagc caccaatgcg catgggcgcc acgcacggcg
     2701 catcacggtg cgcgtggccg gtccatggct gtgggtcgct gtgggcggtg cggcaggggg
     2761 cgcggcgctg ctggccgcag gggccggcct ggccttctac gtgcagtcca ccgcttgcaa
     2821 gaagggagag tacaacgtcc aggaggctga gagctcaggc gaggcggtgt gtctcaatgg
     2881 cgcgggcggg acaccgggtg cagaaggcgg agcagagacc cccggcactg ccgagtcacc
     2941 tgcagatggc gaggttttcg ccatccagct gacatcttcc tgagcctgta tccagctccc
     3001 ccaggggcct cgaaagcaca ggggtggacg tatgtattgt tcactctcta tttattcaac
     3061 tccaggggcg tcgtccccgt tttctaccca ttcccttaat aaagttttta taaagga
//
