LOCUS       NM_012967               2602 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus intercellular adhesion molecule 1 (Icam1), mRNA.
ACCESSION   NM_012967
VERSION     NM_012967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Zeng,J., Gao,W., Tang,Y., Wang,Y., Liu,X., Yin,J., Su,X., Zhang,M.,
            Kang,E., Tian,Y., Ni,B. and He,W.
  TITLE     Hypoxia-sensitive cells trigger NK cell activation via the
            KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat
            epididymis
  JOURNAL   Cell Rep 42 (11), 113442 (2023)
   PUBMED   37952156
  REMARK    GeneRIF: Hypoxia-sensitive cells trigger NK cell activation via the
            KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat
            epididymis.
REFERENCE   2  (bases 1 to 2602)
  AUTHORS   Yang,P., Li,F., Tang,J., Tian,Q. and Zheng,Z.
  TITLE     ET-1 receptor type B (ETBR) overexpression associated with ICAM-1
            downregulation leads to inflammatory attenuation in experimental
            autoimmune myocarditis
  JOURNAL   PeerJ 11, e16320 (2023)
   PUBMED   37901475
  REMARK    GeneRIF: ET-1 receptor type B (ETBR) overexpression associated with
            ICAM-1 downregulation leads to inflammatory attenuation in
            experimental autoimmune myocarditis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2602)
  AUTHORS   Martin,T.M., Burke,S.J., Batdorf,H.M., Burk,D.H., Ghosh,S.,
            Dupuy,S.D., Karlstad,M.D. and Collier,J.J.
  TITLE     ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic
            Female NOD Mice and Is Rapidly Upregulated by NF-kappaB in
            Pancreatic beta-Cells
  JOURNAL   J Immunol 209 (3), 569-581 (2022)
   PUBMED   35851539
  REMARK    GeneRIF: ICAM-1 Abundance Is Increased in Pancreatic Islets of
            Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by
            NF-kappaB in Pancreatic beta-Cells.
REFERENCE   4  (bases 1 to 2602)
  AUTHORS   Tang,X.Y., Chen,P.B., Du,D.J., Qin,Z.Y. and Long,R.J.
  TITLE     [Acupoint catgut embedment may reduce airway inflammation reaction
            by down-regulating ICAM-1 and EOS by suppressing p38MAPK signaling
            in lung tissue of asthmatic rats]
  JOURNAL   Zhen Ci Yan Jiu 47 (2), 129-134 (2022)
   PUBMED   35218622
  REMARK    GeneRIF: [Acupoint catgut embedment may reduce airway inflammation
            reaction by down-regulating ICAM-1 and EOS by suppressing p38MAPK
            signaling in lung tissue of asthmatic rats].
REFERENCE   5  (bases 1 to 2602)
  AUTHORS   Zhang,N., Wang,G. and Sun,G.
  TITLE     Actin-binding protein, IQGAP1, regulates LPS-induced RPMVECs
            hyperpermeability and ICAM-1 upregulation via Rap1/Src signalling
            pathway
  JOURNAL   Cell Signal 85, 110067 (2021)
   PUBMED   34147590
  REMARK    GeneRIF: Actin-binding protein, IQGAP1, regulates LPS-induced
            RPMVECs hyperpermeability and ICAM-1 upregulation via Rap1/Src
            signalling pathway.
REFERENCE   6  (bases 1 to 2602)
  AUTHORS   Fawcett,J., Holness,C.L., Needham,L.A., Turley,H., Gatter,K.C.,
            Mason,D.Y. and Simmons,D.L.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
REFERENCE   7  (bases 1 to 2602)
  AUTHORS   Kita,Y., Takashi,T., Iigo,Y., Tamatani,T., Miyasaka,M. and
            Horiuchi,T.
  TITLE     Sequence and expression of rat ICAM-1
  JOURNAL   Biochim Biophys Acta 1131 (1), 108-110 (1992)
   PUBMED   1349828
REFERENCE   8  (bases 1 to 2602)
  AUTHORS   Sollberg,S., Peltonen,J., Uitto,J. and Jimenez,S.A.
  TITLE     Elevated expression of beta 1 and beta 2 integrins, intercellular
            adhesion molecule 1, and endothelial leukocyte adhesion molecule 1
            in the skin of patients with systemic sclerosis of recent onset
  JOURNAL   Arthritis Rheum 35 (3), 290-298 (1992)
   PUBMED   1371389
REFERENCE   9  (bases 1 to 2602)
  AUTHORS   Karashima,T., Hachisuka,H., Okubo,K. and Sasai,Y.
  TITLE     Epidermal keratinocytes of bullous pemphigoid express intercellular
            adhesion molecule-1 (ICAM-1)
  JOURNAL   J Dermatol 19 (2), 82-86 (1992)
   PUBMED   1377725
REFERENCE   10 (bases 1 to 2602)
  AUTHORS   Burra,P., Hubscher,S.G., Shaw,J., Elias,E. and Adams,D.H.
  TITLE     Is the intercellular adhesion molecule-1/leukocyte function
            associated antigen 1 pathway of leukocyte adhesion involved in the
            tissue damage of alcoholic hepatitis?
  JOURNAL   Gut 33 (2), 268-271 (1992)
   PUBMED   1347281
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D00913.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081837.1, FQ228241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132300, SAMD00155332
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2602
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /note="intercellular adhesion molecule 1"
                     /db_xref="GeneID:25464"
                     /db_xref="RGD:2857"
     exon            1..97
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1668
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /note="ICAM-1"
                     /codon_start=1
                     /product="intercellular adhesion molecule 1 precursor"
                     /protein_id="NP_037099.1"
                     /db_xref="GeneID:25464"
                     /db_xref="RGD:2857"
                     /translation="MASTRARPMLPLLLVLVAVVIPGPVGAQVSIHPTEAFLPRGGSV
                     QVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSS
                     ASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQ
                     AVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRV
                     LKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASV
                     EVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEA
                     HGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKS
                     LFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVP
                     LPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGF
                     VIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP"
     exon            98..361
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     exon            362..667
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     exon            668..955
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1243
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1492
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2602
                     /gene="Icam1"
                     /gene_synonym="CD54; ICAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgcctg cactttgccc tggtcctcca atggcttcaa cccgtgccag gcccatgctg
       61 cctctgctcc tggtcctggt cgccgttgtg atccccgggc ctgtcggtgc tcaggtatcc
      121 atccatccca cagaagcctt cctgcctcgg ggtggatccg tgcaggtgaa ctgctcttcc
      181 tcttgcgaag acgagaacct cggcctgggg ttggagacta actggatgaa agacgaacta
      241 tcgagtggac acaactggaa gctcttcaag ctgagcgaca ttggggaaga cagcagacca
      301 ctgtgctttg agaactgtgg caccacgcag tcctcggctt ctgccaccat cactgtgtat
      361 tcgttcccag agcgagtgga gctggatcct ctgcccgcct ggcagcaggt gggcaagaac
      421 ctcatcctgc gctgcctggt ggaaggcgga gcaccgcgga cacagctctc agtagtgctg
      481 ctccgtggga atgagacact gagccgccag gcagtggatg gggaccccaa ggagatcaca
      541 ttcacggtgc tggccagcag aggcgaccac ggagccaatt tctcatgctt cacagaactg
      601 gacctcaggc cacaagggct gtcactgttc aagaatgtct ccgaggtcag gcagctccgg
      661 actttcgatc ttccgactag ggtcctgaag ctcgacaccc ctgacctcct ggaggtgggc
      721 acccagcaga agttcttgtg ttccctggaa ggcctgtttc ctgcctctga agctcagata
      781 tacctggaga tgggaggcca gatgctgacc ctggagagca caaacagcag agattttgtg
      841 tcagccactg cctcagtgga ggtgactgag aagttggaca gaaccctgca gctgcgctgt
      901 gttttggagc tggcggacca gaccctggag atggagaaga ccttgagaat ctacaacttt
      961 tcagctccca tcctgaccct gagccagccg gaggtctcag aaggggacca agtaactgtg
     1021 aagtgtgaag cccacggtgg ggcacaggtg gtgcttctga acagtacttc ccccaggcca
     1081 cccacctcac agggtacttc ccccaggcca cccacctcac agatccaatt cacactgaat
     1141 gccagcccgg aggatcacaa acgacgcttc ttttgctctg cggccttgga ggtggatggg
     1201 aagtccctgt ttaaaaacca gaccttggaa ctccatgtgc tatatggtcc tcacctggac
     1261 aagaaggact gcttggggaa ctggacctgg caagaggggt ctcagcagac tcttacatgc
     1321 cagccccagg ggaatccagc ccctaatctg acctgcagcc ggaaagcaga tggtgtcccg
     1381 ctgcctatcg ggatggtgaa gtctgtcaaa cgggagatga atggtaccta caagtgccgt
     1441 gcctttagct cccgtgggag tatcaccagg gacgtgcacc tgacagtgct gtaccatgat
     1501 cagaatacct gggtcataat tgttggtgtg ttggtactga tcattgcggg cttcgtgatc
     1561 gtggcgtcca tttacaccta ttaccgccag aggaagatca ggatatacaa gttacagaag
     1621 gctcaggagg aggccctaaa actcaaggta caagccccgc ctccctgagc ccactggaca
     1681 ggacacctgc ctgggccccg ctgctcttga acagatcaat ggacagcatt tacccctcac
     1741 ccacctcctc tggctgtcac aggacaggac agtggcctgg ggatgcatac ttgtagcctc
     1801 aggcctaaga ggactcggag gggcaagact gtgaactcgt gacctggaca cacctacagc
     1861 ctggtgggcc tgcagccaag aaaggctgac ttccttctct attacccctg ctgaggggcc
     1921 ccctacctta ggaaggtgtg atatccggta gacacaagca agagaagaaa aggaacacca
     1981 tgcttcctct gacatgggaa agctgggaca ctgtccccaa ctcttgttga tgtatttatt
     2041 aattcagagt tctgacagtt atttattgag taccctgtac agacactaga ggagtgagca
     2101 ggttaacatg taagttattg cctagaccct ggtgaagggg cacaacagag tctggggaaa
     2161 gatcatacgg gtttgggctt ctccacaggt cagggtgctt tcctcaaaag agctgatttc
     2221 tttcacgagt catataaata ctatgtggac gagcagtggc cctctgctcg tagacctctc
     2281 tgggacccct gcctcctccc acagcctgga gtctcccagc accagcatgg gtgaccacct
     2341 ccccacctac atacattcct acctttgttc ccaatgtcaa ccaccatgcc taaatatgga
     2401 cgctcacctt tagcagctca acaatggagt ctcatgcccg tgaaattatg gtcaatccct
     2461 gcatgcctcc acccggctcc acctcaaaga gaatgcctgg gagaaaatgt tccaaccact
     2521 tagaagggtc ctgcaagctg ttgtgggagg gtaggcaccc ctcccagcgc agaagccttt
     2581 cctttgaatc aataaagttt ta
//
