LOCUS       NM_030844               1916 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus islet cell autoantigen 1 (Ica1), mRNA.
ACCESSION   NM_030844
VERSION     NM_030844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Herlo,R., Lund,V.K., Lycas,M.D., Jansen,A.M., Khelashvili,G.,
            Andersen,R.C., Bhatia,V., Pedersen,T.S., Albornoz,P.B.C.,
            Johner,N., Ammendrup-Johnsen,I., Christensen,N.R., Erlendsson,S.,
            Stoklund,M., Larsen,J.B., Weinstein,H., Kjaerulff,O., Stamou,D.,
            Gether,U. and Madsen,K.L.
  TITLE     An Amphipathic Helix Directs Cellular Membrane Curvature Sensing
            and Function of the BAR Domain Protein PICK1
  JOURNAL   Cell Rep 23 (7), 2056-2069 (2018)
   PUBMED   29768204
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Xu,J., Kam,C., Luo,J.H. and Xia,J.
  TITLE     PICK1 mediates synaptic recruitment of AMPA receptors at
            neurexin-induced postsynaptic sites
  JOURNAL   J Neurosci 34 (46), 15415-15424 (2014)
   PUBMED   25392508
  REMARK    GeneRIF: study showed that PICK1, being negatively regulated by
            ICA69, could facilitate synapse maturation.
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Barkalifa,R., Yagil,Y. and Yagil,C.
  TITLE     Sex-specific genetic dissection of diabetes in a rodent model
            identifies Ica1 and Ndufa4 as major candidate genes
  JOURNAL   Physiol Genomics 42 (3), 445-455 (2010)
   PUBMED   20530722
  REMARK    GeneRIF: Sex-specific genetic dissection of diabetes in a rodent
            model identifies Ica1 and Ndufa4 as major candidate genes.
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Cao,M., Xu,J., Shen,C., Kam,C., Huganir,R.L. and Xia,J.
  TITLE     PICK1-ICA69 heteromeric BAR domain complex regulates synaptic
            targeting and surface expression of AMPA receptors
  JOURNAL   J Neurosci 27 (47), 12945-12956 (2007)
   PUBMED   18032668
  REMARK    GeneRIF: Islet cell autoantigen 69 kDa (ICA69) regulates AMPA
            receptor trafficking by preventing formation of homomeric protein
            interacting with C kinase 1 (PICK1) Bin/amphiphysin/Rvs (BAR)
            domain complexes.
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Yagil,C., Barkalifa,R., Sapojnikov,M., Wechsler,A., Ben-Dor,D.,
            Weksler-Zangen,S., Kaiser,N., Raz,I. and Yagil,Y.
  TITLE     Metabolic and genomic dissection of diabetes in the Cohen rat
  JOURNAL   Physiol Genomics 29 (2), 181-192 (2007)
   PUBMED   17213368
  REMARK    GeneRIF: Ica1, on chromosome 4, is a high priority candidate gene
            for the development of diet-induced diabetes in the Cohen rat.
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Spitzenberger,F., Pietropaolo,S., Verkade,P., Habermann,B.,
            Lacas-Gervais,S., Mziaut,H., Pietropaolo,M. and Solimena,M.
  TITLE     Islet cell autoantigen of 69 kDa is an arfaptin-related protein
            associated with the Golgi complex of insulinoma INS-1 cells
  JOURNAL   J Biol Chem 278 (28), 26166-26173 (2003)
   PUBMED   12682071
  REMARK    GeneRIF: ICA69 is an arfaptin-related protein that is likely to
            play a role in membrane trafficking at the Golgi complex and
            immature secretory granules in neurosecretory cells
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Winer,S., Astsaturov,I., Gaedigk,R., Hammond-McKibben,D., Pilon,M.,
            Song,A., Kubiak,V., Karges,W., Arpaia,E., McKerlie,C., Zucker,P.,
            Singh,B. and Dosch,H.M.
  TITLE     ICA69(null) nonobese diabetic mice develop diabetes, but resist
            disease acceleration by cyclophosphamide
  JOURNAL   J Immunol 168 (1), 475-482 (2002)
   PUBMED   11751995
REFERENCE   8  (bases 1 to 1916)
  AUTHORS   Pilon,M., Peng,X.R., Spence,A.M., Plasterk,R.H. and Dosch,H.M.
  TITLE     The diabetes autoantigen ICA69 and its Caenorhabditis elegans
            homologue, ric-19, are conserved regulators of neuroendocrine
            secretion
  JOURNAL   Mol Biol Cell 11 (10), 3277-3288 (2000)
   PUBMED   11029035
REFERENCE   9  (bases 1 to 1916)
  AUTHORS   Roep,B.O., Duinkerken,G., Schreuder,G.M., Kolb,H., de Vries,R.R.
            and Martin,S.
  TITLE     HLA-associated inverse correlation between T cell and antibody
            responsiveness to islet autoantigen in recent-onset
            insulin-dependent diabetes mellitus
  JOURNAL   Eur J Immunol 26 (6), 1285-1289 (1996)
   PUBMED   8647206
REFERENCE   10 (bases 1 to 1916)
  AUTHORS   Miyazaki,I., Gaedigk,R., Hui,M.F., Cheung,R.K., Morkowski,J.,
            Rajotte,R.V. and Dosch,H.M.
  TITLE     Cloning of human and rat p69 cDNA, a candidate autoimmune target in
            type 1 diabetes
  JOURNAL   Biochim Biophys Acta 1227 (1-2), 101-104 (1994)
   PUBMED   7918678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078812.1.
            
            On Jun 10, 2007 this sequence version replaced NM_030844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1916
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /note="islet cell autoantigen 1"
                     /db_xref="GeneID:81024"
                     /db_xref="RGD:621465"
     exon            1..67
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            68..217
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            218..310
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1736
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /note="p69; ICAp69; islet cell autoantigen p69; 69 kDa
                     islet cell autoantigen; islet cell autoantigen 1, 69 kDa"
                     /codon_start=1
                     /product="islet cell autoantigen 1"
                     /protein_id="NP_110471.2"
                     /db_xref="GeneID:81024"
                     /db_xref="RGD:621465"
                     /translation="MSGHKCYSWELQDRFAQDKSVVNKMQQKYWETKQAFIKATGKKE
                     DEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQGF
                     QDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRMEQ
                     CRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDLL
                     GASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKKL
                     VEKEKKKSSRRENREAVAQEPRQLISLEEENQHKESSTCQTEEGKSVPSSVDKSSADD
                     ACSGPIDELLDVKPEEACLGPMAGTPEPESGDKDDLLLLNEIFSTSSLDEGEFSREWA
                     AVFGDDRLKEPAPMGAQGEPDPKPQIGSAFLPSQLLDQNMKDLQASLQEPAKAASDLT
                     AWFSLFADLDPLSNPDAIGKTDKEHELLNA"
     exon            311..473
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            474..546
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            547..670
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            671..869
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            870..995
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1094
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1189
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1242
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1305
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1344
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1614
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1886
                     /gene="Ica1"
                     /gene_synonym="Ica69"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaagacc ccagggagta gagagaggga cactcacgcc tctcatccct gatccgcccc
       61 aaacaaggaa aatggttcga tgttattaaa aatgaatctt aagaagaaaa atgaatcaca
      121 gcagttaaac tatggagttc tgctacttgt aagaagtgga gaagcctgag attacatcac
      181 tgacccttga tcctccactg agctaaaaca ccagctggtt taatagaaca tatcctatca
      241 tgctttttct ctgccccttc tcaaatcatc agcagtagaa aagagaagaa aacatgtcag
      301 gacacaaatg ttattcctgg gagttgcagg atcggtttgc tcaagataag tcagttgtca
      361 ataagatgca acagaaatat tgggaaacga agcaggcctt tatcaaagcc acagggaaga
      421 aggaagatga acatgtcgtt gcttctgatg cagacctgga tgccaagcta gagctgtttc
      481 attcgattca gagaacctgt ttggacttgt ctaaagcaat tgtgctctat caaaagagaa
      541 tatgtttctt gtctcaagaa gaaaatgaac tgggaaaatt tctccgatcc caaggcttcc
      601 aggacaaaac ccgagcagga aaaatgatgc aagccacagg aaaggccctc tgcttttcct
      661 cccagcaaag gttggccttg agaaaccctt tgtgtcgatt tcaccaagaa gtagagactt
      721 ttagacatcg ggccatctcc gatacctggc tgacagtgaa ccgcatggag cagtgccgga
      781 cagaatatag aggggcgtta ttgtggatga aggacgtgtc tcaggaactg gatccagacc
      841 tctacaagca aatggagaag ttcaggaagg tacagacaca agtccgcctc gcgaagaaga
      901 actttgacaa attgaagatg gatgtgtgtc aaaaggtgga tcttcttgga gcaagcagat
      961 gtaacctctt atctcacatg ctagcaacat atcagaccac tctgctccac ttttgggaga
     1021 aaacttctca caccatggca gccatccatg agagcttcaa aggctatcaa ccatatgaat
     1081 tcacaacgtt aaagagctta caagacccta tgaaaaagct agtcgagaaa gaaaagaaga
     1141 agagctcccg gagggaaaac cgggaggctg tggcacagga gccgaggcag ttaatttcat
     1201 tggaggaaga gaaccagcac aaagaatcct ctacttgcca gacggaggag ggaaaaagcg
     1261 ttccgtcttc tgtagacaaa agttctgcag atgatgcatg ctcaggaccc atagatgaac
     1321 tattagacgt gaaacctgag gaagcttgcc tgggtcccat ggcagggacc ccagaacctg
     1381 aaagtgggga caaggacgac ctcctgctgt tgaacgagat cttcagcact tccagcctgg
     1441 atgaagggga gttcagcagg gagtgggctg cggtgttcgg agacgaccgg ctgaaggaac
     1501 cagcccccat gggggcccag ggagagccag accccaagcc ccagataggc tctgcgttcc
     1561 ttccttcaca gcttttagac caaaacatga aagatctcca ggcctctctc caagagcctg
     1621 ccaaggctgc ctcggacctg actgcctggt tcagcctctt tgctgacctc gaccccctat
     1681 caaatcctga tgctattggg aaaaccgata aagaacacga attgctcaat gcatgagtct
     1741 gcaaccttca acaggggagc cctccggcca ctccgcaaca cctcatccag ggcttgcaga
     1801 agtctaacgt gctcagtacg ctgttttaat atttacatgc cattttaata aaacgagagg
     1861 gtcaaggccc tgtttctatc gctataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
