LOCUS       XM_039082544            5985 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus inhibitor of Bruton tyrosine kinase
            (Ibtk), transcript variant X1, mRNA.
ACCESSION   XM_039082544
VERSION     XM_039082544.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 3, 2024 this sequence was replaced by
            NM_001427757.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5985
                     /gene="Ibtk"
                     /note="inhibitor of Bruton tyrosine kinase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 46 ESTs, 2 long SRA reads, 3 Proteins, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 148 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:315858"
                     /db_xref="RGD:1311697"
     CDS             905..4963
                     /gene="Ibtk"
                     /codon_start=1
                     /product="inhibitor of Bruton tyrosine kinase isoform X1"
                     /protein_id="XP_038938472.1"
                     /db_xref="GeneID:315858"
                     /db_xref="RGD:1311697"
                     /translation="MDSAAPDCTAKCRSLKHALDVLSVITKGSERQIKIFLSSYCYNA
                     ATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKESGWTALHRSIFYGHINCV
                     WSLLKHGVSLYMQDKEGLSPLDLLMKDRPAHVVFKNTDPTEVYTWGDNTNFTLGHGSQ
                     NSKHHPELLDLFSRSRVYVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCL
                     VPRLVEGLSGHSCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSSCNVPRQI
                     QAKYLKGRTIIGVAAGRFHTVLWTREAVYTLGLNGGQLGHLLDPNGEKCVTTPRQVSA
                     LHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLNLKKVLVSGGCMEYK
                     VDPEHLTENGGQKICILAMDGAGRVFCWRSLSSSLKQCRWAYPRQVSISDIALNRNEI
                     LFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVSDTNSVYERIRLEKLP
                     FAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHD
                     VTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGCHLFVVEKV
                     HPDLFEYLLQFMYTDTCDFLTHGFKPRMIMNKKSEDSKGSPESRLHAVNCHVDDKQKS
                     AFEVYRSNQAHTLSERQKSKPKSSKKGKGVGEDDPVKMLQNVAKKFGLSNLSSRLDGV
                     RYENEKINVIAKKTGNKLKLSQKKCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSM
                     LSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVDFVCSVLVVADQLL
                     ITRLKEMCEVALAENLTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLD
                     VLSEDVLKDLSIFYRKMVPAMERRVITPYQDGPDISCVQAEDGEVFLKEEISLEPNHS
                     ETMFKKAKTRAKKKPRKRSDSSGGYNLSDIIQSPPSAGLLKSAKTNSVESLPELLTSD
                     SEGSYAGVGSPRDLQSPDFTAGFHSDKVEGKAKPYVNGTPLPWTREDLKPWEKSPTTK
                     SAPQFIPSSRVDTSGSSSWVAGSCSPVSPPVVDLRTIMETEANRQKYGAAPKSNLGKI
                     ISHGIKLSQKQRKMMALTTKENNSGTNSMEPILTAPSKSPKPVNAWAPLHSPSSSSFR
                     NFLLEEKKPVPGRGSGDHVKKVCFKGTENSPALNVARCSPHGTPGLESNHVSDFPLVD
                     SPNPWLSSSLAASPAVAPVTFASIVEEERQQEAALIRSREKPLALIQVEEHAIQDLLV
                     FYEAFGNPDEFVIVERTPQGPVAVPMWNKHGC"
ORIGIN      
        1 actactagtg gtccaggagg caacttttct aagatgccta cgtttctacc gagtagtgct
       61 tgggcatcca gctagctcct tgtttcctcc atcccggcct taacctccct tccgagtctc
      121 gacctgaggg agacagatct tttaaggtga ctctggcacc aagagggaca gtactggttc
      181 ttgagtctag ggcagcaggg tcaagctcct ctgggacttt ggggaaaggc cacagctgag
      241 gtactgccac gctaggcctt gtgggcaggc ttcgaccaat cactgtaggg catacacgaa
      301 ctctaaccaa tcagcgcccg tcttattccc gagtcccgcc cgctctagcc caggttcccc
      361 gaaccccgtc ccggcgccga tagtcgcggc tgtcgctttc gctgcagccg cctccggagc
      421 tgactcgggc atcccggctc ctggctccct tcgttgtccc cggtagcttt cactaaggat
      481 gagtccctgc gcggccgcgc gcctgccccg cggagaccgc cggcgcacct tcatctagcg
      541 actggtcacc ctcgcaatta tggctgtttg aaaggcgcag acggtgtgga gggggagttc
      601 ccctcctcac tcccccttgg tgcttgactc caggaataat ttataaactg ggattttttt
      661 aaatgaagaa cttgtatttg atatgaactt tatagaatta tttataaatt tttgatttaa
      721 gtgccaaaag attatacaga gatatatagt tttatataat tgttgtgact acttaaatta
      781 taaccccaaa gggccatctc ttcttgataa ctcttcctga atagtatctt tgtgtcctgg
      841 cttttttaaa aaaaatttac tttggtgact gttctgaagg agtaagcaat ataaagcaat
      901 taggatggat tctgccgccc ccgactgcac ggccaagtgc aggtccctga agcacgctct
      961 ggatgtcctt tctgtgataa caaagggcag tgagaggcag atcaagatct ttctctccag
     1021 ttactgctac aacgcggcaa ctgtcaagga cgccttcggc aggaacgcgc tccacctggt
     1081 ttcctcctgt gggaagaaag cagtgttaga ttggcttatt gagaaaggag tggatttgct
     1141 ggtaaaggac aaggagtcag gctggacagc actgcacaga agcatttttt atggacacat
     1201 caattgtgtt tggtctctgt tgaagcatgg tgttagcttg tatatgcaag ataaagaagg
     1261 attgtcacct ttggatcttc tcatgaagga caggccagct cacgttgtgt ttaagaacac
     1321 tgatcccaca gaagtctata cttggggaga taatacaaac ttcactctgg gccacggaag
     1381 ccagaacagc aaacaccatc cggagctgct ggacctgttt tccaggagca gggtttacgt
     1441 caagcaggtg gtgctttgca aatttcattc agtgtttctg tcccagcaag ggcaggttta
     1501 cacctgtggc catggtcgtg gaggacggtt aggccatgga gatgagcaga catgtttggt
     1561 ccccaggctt gtggaaggac tgtctggtca cagttgttcc caggtggcag ctgccaagga
     1621 tcacactgtt gtgttaactg aagatggatg tgtttataca tttggtctca acacgttcca
     1681 ccaactagga attattcctc caccttccag ttgtaatgta cccagacaga tacaggcaaa
     1741 atatctgaaa ggaaggacga tcattggagt ggcagcaggc aggtttcata cagtgctgtg
     1801 gactcgagaa gccgtttaca cactgggact gaatggtgga cagttgggtc acttactgga
     1861 ccccaatgga gaaaagtgtg tcaccactcc tcgccaagtc tctgccctgc accataagga
     1921 tatcgctgtg tctttggtag ctgcaagcga tggcgccaca gtctgtgtca ccacacgagg
     1981 cgatatttac ttacttgcag actatcagtg caagaagatg gcaactaaac aactaaattt
     2041 gaaaaaggtt cttgtctctg gaggttgtat ggaatacaag gttgatcctg aacacttgac
     2101 agaaaatggg ggtcagaaaa tatgcatcct tgctatggat ggagctggaa gagtattttg
     2161 ctggagatcg ctcagcagtt ctctgaagca gtgcagatgg gcctatcctc gccaggtctc
     2221 aatctccgat atcgctttaa atagaaatga aattctgttt gtcacacagg atggggaagg
     2281 atttaaaggg aaatggtttg aagacaaaag aaagaattct gaaaagaaag cagacatttt
     2341 accaaaccta catcattcct catcagatgt gtcttgtgtc tctgatacaa atagtgtgta
     2401 tgaaagaatt cgacttgaga aacttccttt tgcccataga gctgttagtg tcagcacaga
     2461 tccaagtggg tgcaactttg caatcctaca gtcagaccct aaaacaagcc tttatgaaat
     2521 tccagttgtg tcttcatcct ccttttttga agaatttggc aagctcctga gggagacaga
     2581 tgaaatggac agcttccatg acgtgacctt tcaagttggc aatagactct tccctgcaca
     2641 taaatacgtt ctggcagtgc gctctgactt cttccagaag ttgttccttt cagatggcac
     2701 tcttttagaa ctgacagatg tttaccggaa agacgaagat gctgcagggt gccatctctt
     2761 tgtggtggag aaagttcatc ctgacttatt cgaatacctc ttacagttca tgtatacaga
     2821 tacctgtgac ttcttaacgc atggcttcaa accaagaatg atcatgaaca aaaagtcaga
     2881 agactctaag ggctccccag agtctcgtct gcatgctgtg aattgccatg tggatgataa
     2941 gcagaagtca gcatttgagg tgtacagaag caaccaggct cacacactta gtgaaaggca
     3001 gaagagcaaa cccaagtctt ctaagaaggg aaagggtgtt ggggaagatg atcctgtaaa
     3061 gatgttgcaa aatgtcgcaa agaagtttgg cctcagtaat ttgagtagca ggttagatgg
     3121 agtcagatat gaaaatgaaa aaattaatgt tattgcgaag aaaactggta ataaactgaa
     3181 gctaagtcag aaaaaatgtt cgtttctcta tgatgttacc atgaagtctg tggatggaaa
     3241 ggaattcccc tgtcataagt gtgtgctctg tgcaagactt gagtatttcc acagcatgct
     3301 tagcagatcg tggattgagg cctccagctg tgcagctctg gaaatgccaa tccaggctga
     3361 gatcctgaaa gttattttgg actacctcta tacggatgaa gctgtggtga taaaagagtc
     3421 tcagaatgtg gattttgttt gtagtgttct tgtagtggct gatcaactcc tcataaccag
     3481 gttaaaggag atgtgtgagg tggcactggc tgaaaacctt acccttaaga atgctgctat
     3541 gctgctggag tttgcttcaa tgtacaatgc cgagcagttg aaactctctt gtttacagtt
     3601 cataggactg aatatggcag ctttactcga agcaaggtct cttgatgttc taagtgagga
     3661 tgttttgaag gatctttcca tattttaccg aaaaatggtt ccagcaatgg agaggagagt
     3721 cattacaccg tatcaagatg gaccagacat tagctgtgtg caagcagaag atggggaggt
     3781 ctttcttaaa gaggaaataa gcctggagcc aaatcactcg gaaactatgt tcaagaaggc
     3841 aaaaacaaga gctaaaaaga agccacggaa gcgctcagac agttcaggag gctacaacct
     3901 ttcagatatt atccagagtc caccgtctgc aggactatta aagtctgcaa agaccaactc
     3961 tgtggagtct cttccggaat tgttaacctc agactctgaa gggagctatg caggagtggg
     4021 tagtcccaga gacctacagt cgcctgactt tacagcagga ttccattcgg ataaggttga
     4081 ggggaaagct aagccatatg tgaatggtac acctcttcca tggactaggg aagatttaaa
     4141 accatgggaa aaatcaccaa ctaccaagtc tgctccccag ttcatcccca gtagcagagt
     4201 ggacacttca ggctcttcca gttgggtggc tggttcttgc agtcccgtga gtcctcctgt
     4261 tgtggatctc agaactatca tggaaacaga agcaaacaga caaaaatatg gtgcagcacc
     4321 aaagtcgaac ttgggaaaaa ttatttctca tggaatcaaa ctttctcaga agcaacggaa
     4381 aatgatggca ttgactacca aagaaaacaa ttcaggaaca aatagcatgg agcccattct
     4441 gacagctcct tcaaagtccc ccaagccagt gaacgcatgg gcacctctac actctccttc
     4501 atccagctca ttccggaatt ttttactaga agaaaaaaaa cctgttcctg gccgtggttc
     4561 aggagatcat gtcaaaaaag tttgttttaa aggaactgaa aactctccag ccctaaatgt
     4621 tgcaagatgt tcacctcatg gaactccagg actagaaagc aatcatgtct ctgattttcc
     4681 acttgtagac agtcccaatc cctggctgtc ctcctcactg gcggcatctc ccgcagttgc
     4741 tccagtcacg ttcgcatcca ttgtagaaga agagcggcaa caggaagctg ccctcatcag
     4801 aagccgagag aaacccttgg ctctcattca ggttgaggaa catgcaatac aggacttgct
     4861 ggttttctat gaggcatttg gcaaccctga tgagtttgtc atcgttgaaa ggacaccaca
     4921 gggaccagtg gcagtgccta tgtggaacaa gcatgggtgc tagctcactg gagaggacac
     4981 tgctcctagt tgtggttacc ctgcctacat gaagaaaatg catgtgcaag cgttcttaag
     5041 atttgttagc tcagtgttcc cgtcagagca agagtggata tgatttcttc ccgtagttta
     5101 taatgtttgt atgactaatg agacatttat cagaattgtg attttagtga ctgtcatgtg
     5161 taaatgtgtc aggaaaaatg ttaggctaag gttgcttgga ttgtttcttc taaattacct
     5221 aaggaaaata tgggtgaaat taaagcttag gaatagttca ctaaaaataa tttttcactt
     5281 gagaatatgg gtgatttaga agagcttgcc acatgtgttt ttaaagaaga cattgatgag
     5341 cttaaagcgg agcctcaatc attactgctg attcactgat ggccagaatg ttccgtttgc
     5401 ctgagtagat gtctctcttg ttgctttttc actggactgt tcttaggcct ctctacagtt
     5461 gctggacagt ctatgatcat agcttctgtg ggagatttgg attcatagat cttttttttg
     5521 gttgggtggg aaggtagtaa gagaggacag acctacttgt gaaagattca gtgtcttaag
     5581 gtgttaagtt tctctaaaat aaagcataag attgctgaat agtttatcag agtggttgtt
     5641 tataattact ttttagtatg tataatcaga atttctgtga gcctggatta tatgtataca
     5701 tggaaatttt ggttattttc tttatagtat actgtttggt tttgaatgtt taaaattaaa
     5761 agaaaaacca ttttaaaatg tgtgcttcgg tgtgtagacc atgagaaagc taatgctgaa
     5821 ggcctgggaa agaatcccgg ccagagatag gtcgacagtt cctgcctgac ttcaactaag
     5881 gggaaattgg ttggaagtaa ctaactcggt gttttagctc agttccaccc acaagcagca
     5941 gccatgtgag cagacgtgca ataaaagtaa tgttgatcca cttca
//
