LOCUS       NM_012587               1948 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus integrin-binding sialoprotein (Ibsp), mRNA.
ACCESSION   NM_012587
VERSION     NM_012587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. doi:
            10.3389/fphar.2020.635927.. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Choe,J., Sasaki,Y., Zhou,L., Takai,H., Nakayama,Y. and Ogata,Y.
  TITLE     Insulin-like growth factor-II regulates bone sialoprotein gene
            transcription
  JOURNAL   Odontology 104 (3), 271-281 (2016)
   PUBMED   25895664
  REMARK    GeneRIF: IGF-II increased BSP transcription by targeting CRE, FRE
            and HOX elements in the proximal promoter of the rat BSP gene.
            Moreover, phospho-CREB1, c-Fos, c-Jun, Dlx5 and Runx2 transcription
            factors appear to be key regulators of IGF-II effects on BSP
            transcription.
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Holm,E., Aubin,J.E., Hunter,G.K., Beier,F. and Goldberg,H.A.
  TITLE     Loss of bone sialoprotein leads to impaired endochondral bone
            development and mineralization
  JOURNAL   Bone 71, 145-154 (2015)
   PUBMED   25464126
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Takai,H., Matsumura,H., Matsui,S., Kim,K.M., Mezawa,M., Nakayama,Y.
            and Ogata,Y.
  TITLE     Unliganded estrogen receptor alpha stimulates bone sialoprotein
            gene expression
  JOURNAL   Gene 539 (1), 50-57 (2014)
   PUBMED   24495337
  REMARK    GeneRIF: ERalpha stimulates BSP gene transcription in a
            ligand-independent manner by targeting the cAMP response element
            and AP1/glucocorticoid response elements in the rat BSP gene
            promoter.
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Rapuano,B.E. and MacDonald,D.E.
  TITLE     Structure-activity relationship of human bone sialoprotein peptides
  JOURNAL   Eur J Oral Sci 121 (6), 600-609 (2013)
   PUBMED   24103036
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Tye,C.E., Rattray,K.R., Warner,K.J., Gordon,J.A., Sodek,J.,
            Hunter,G.K. and Goldberg,H.A.
  TITLE     Delineation of the hydroxyapatite-nucleating domains of bone
            sialoprotein
  JOURNAL   J Biol Chem 278 (10), 7949-7955 (2003)
   PUBMED   12493752
  REMARK    GeneRIF: delineation of the hydroxyapatite-nucleating domains
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Shimizu,E. and Ogata,Y.
  TITLE     Activation of bone sialoprotein gene transcription by flavonoids is
            mediated through an inverted CCAAT box in ROS 17/2.8 cells
  JOURNAL   J Cell Biochem 86 (1), 35-44 (2002)
   PUBMED   12112014
  REMARK    GeneRIF: Activation of bone sialoprotein gene transcription by
            flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8
            cells
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Shimizu-Sasaki,E., Yamazaki,M., Furuyama,S., Sugiya,H., Sodek,J.
            and Ogata,Y.
  TITLE     Identification of a novel response element in the rat bone
            sialoprotein (BSP) gene promoter that mediates constitutive and
            fibroblast growth factor 2-induced expression of BSP
  JOURNAL   J Biol Chem 276 (8), 5459-5466 (2001)
   PUBMED   11087753
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Begue-Kirn,C., Smith,A.J., Loriot,M., Kupferle,C., Ruch,J.V. and
            Lesot,H.
  TITLE     Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin,
            osteonectin and bone sialoprotein gene expression during normal and
            in vitro-induced odontoblast differentiation
  JOURNAL   Int J Dev Biol 38 (3), 405-420 (1994)
   PUBMED   7848824
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Oldberg,A., Franzen,A. and Heinegard,D.
  TITLE     The primary structure of a cell-binding bone sialoprotein
  JOURNAL   J Biol Chem 263 (36), 19430-19432 (1988)
   PUBMED   3198635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY314698.1, DY313346.1, BC127506.1 and CB324054.1.
            
            On Oct 16, 2007 this sequence version replaced NM_012587.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY314698.1, BC127506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680417, SAMN06680437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               DY314698.1         1-525
            526-1034            DY313346.1         202-710
            1035-1544           BC127506.1         1031-1540
            1545-1948           CB324054.1         4-407               c
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1948
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /note="integrin-binding sialoprotein"
                     /db_xref="GeneID:24477"
                     /db_xref="RGD:2855"
     exon            1..60
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     exon            61..127
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1033
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /note="bone sialoprotein 2; BSP II; bone sialoprotein II;
                     cell-binding sialoprotein"
                     /codon_start=1
                     /product="integrin-binding sialoprotein precursor"
                     /protein_id="NP_036719.2"
                     /db_xref="GeneID:24477"
                     /db_xref="RGD:2855"
                     /translation="MKTALILLCILGMASAFSMKNFHRRIKAEDSEENGVFKYRPRYF
                     LYKHAYFYPPLKRFPVQGGSDSSEENGDGDSSEEEGEEEETSNEEENNEDSEGNEDQE
                     AEAENATLSGVTASYGVETTADAGKLELAALQLPKKAGDAEGKAPKMKESDEEEEEEE
                     EEENENEEAEVDENEQVVNGTSTNSTEVDGGNGPSGGDNGEEAEEASVTEAGAEGTTA
                     GARELTSYGTTTAVLLNGFQQTTPPPEAYGTTSPPARKSSTVEYGEEYEQIGNEYNTA
                     YETYDENNGEPRGDTYRAYEDEYSYYKGHGYEGYEGQDYYYHQ"
     exon            128..178
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     exon            179..256
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     exon            257..322
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     exon            323..487
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1934
                     /gene="Ibsp"
                     /gene_synonym="Bsp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggagaa caatccgtgc cactcactca cttgctctct ccagccagga ctgccgaagg
       61 aagaaattgc aaaatgaaga ctgctttaat cttgctctgc attttgggga tggcgagtgc
      121 tttctcgatg aaaaatttcc atagaagaat caaagcagag gattctgaag aaaacggggt
      181 ctttaagtac cggccacgct actttcttta taagcatgcc tacttttatc ctcctctgaa
      241 acggtttcca gtccagggag gcagcgactc ttcggaagaa aatggagatg gcgatagttc
      301 ggaggaggag ggggaggaag aggagacttc aaatgaagag gaaaacaacg aagactctga
      361 ggggaatgaa gaccaggagg cggaggcaga gaacgccaca ctctcagggg taaccgctag
      421 ctacggggta gagaccacag ctgacgctgg aaagttggag ttagctgcgc tccagctacc
      481 caagaaggct ggagatgcag agggcaaggc tccaaaaatg aaggaaagcg acgaggaaga
      541 ggaagaggaa gaggaggaag aaaacgagaa cgaagaagca gaagtggatg aaaatgagca
      601 ggtcgtcaac ggcaccagca ccaactccac ggaggtggac ggggggaatg gccccagcgg
      661 aggagacaac ggagaagaag ccgaggaggc aagcgtcact gaagcaggtg cagaaggaac
      721 aacagcaggg gccagggagc tgaccagtta tggcaccacg acagctgtcc ttctgaacgg
      781 gtttcagcag acgaccccgc cacccgaagc ctatgggacc acctccccac cagccagaaa
      841 gagcagcacg gttgagtatg gggaagaata cgaacaaata ggcaacgagt acaacactgc
      901 gtatgaaacc tatgacgaga acaacgggga gcctcgcggg gacacttacc gagcttatga
      961 ggacgaatac agctactaca aggggcatgg ctatgaaggc tacgagggtc aggattatta
     1021 ctaccaccag tgaaggcccc tccggggagg actccccatt ctgtctttgc atctggatac
     1081 cattttcaaa gctcaactca ggaaggtgca atatatatat ataacagatg tgcattttat
     1141 agtgtggaat ggtgctacgg tctcagagtg atttccacaa atgcttccgt ttgtagcggc
     1201 cttttttttt ttttttttaa tttttccagg tgcgtcattg aagggtcatc gtaaatcagg
     1261 gctgttgatc aagtagcaca cagatctatg agctgggacc aggtggaatg cttcgaggtt
     1321 gtttttctat agtgtttgtg ctgtgtacac cattgctaac caccctaaca taccctgtac
     1381 aagaagactc ctaacgagag atttattaac aacactgtat acgatgtgtg tagttccttt
     1441 atcacacccc ctacctaata ctgtattagg tttgattttc atcctcatgt attttacgtg
     1501 acttgtgcac atgcgttttt atcataaata aatatgcaat cattcacgtg tgttataatt
     1561 aaaaagaaag ggagagtgtt ggaatgagtg tgggtctaag gagcagggaa caatttggct
     1621 aaaaagaaac gcttatctcc atcagggttt aaaactcaga ggatccggaa acactcttta
     1681 ttcagtacat ctgaacggct aaggttcgac tacggagggc agaatcatct gtatacagga
     1741 gggagtaaat gacccctttt agagttgcca gatttaccaa acatgaatac acggtgtgag
     1801 acgcccacct cagcttgaat tccagatgaa caatggctgg tttttaatac aacccctccc
     1861 ctacagataa tttgtctctg tgaaacattt ggaacaaact tatgctaaat aaatgactta
     1921 ttctttatct aataaaaaaa aaaaaaaa
//
