LOCUS       NM_001305263             609 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Huntingtin interacting protein K (Hypk), mRNA.
ACCESSION   NM_001305263 XM_006224580 XM_006234873
VERSION     NM_001305263.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 609)
  AUTHORS   Choudhury,K.R. and Bhattacharyya,N.P.
  TITLE     Chaperone protein HYPK interacts with the first 17 amino acid
            region of Huntingtin and modulates mutant HTT-mediated aggregation
            and cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 456 (1), 66-73 (2015)
   PUBMED   25446099
REFERENCE   2  (bases 1 to 609)
  AUTHORS   Arnesen,T., Starheim,K.K., Van Damme,P., Evjenth,R., Dinh,H.,
            Betts,M.J., Ryningen,A., Vandekerckhove,J., Gevaert,K. and
            Anderson,D.
  TITLE     The chaperone-like protein HYPK acts together with NatA in
            cotranslational N-terminal acetylation and prevention of Huntingtin
            aggregation
  JOURNAL   Mol Cell Biol 30 (8), 1898-1909 (2010)
   PUBMED   20154145
  REMARK    GeneRIF: Data indicate that the physical interaction between HYPK
            and NatA Naa10/15 seems to be of functional importance both for
            huntingtin aggregation and for N-terminal acetylation.
REFERENCE   3  (bases 1 to 609)
  AUTHORS   Raychaudhuri,S., Sinha,M., Mukhopadhyay,D. and Bhattacharyya,N.P.
  TITLE     HYPK, a Huntingtin interacting protein, reduces aggregates and
            apoptosis induced by N-terminal Huntingtin with 40 glutamines in
            Neuro2a cells and exhibits chaperone-like activity
  JOURNAL   Hum Mol Genet 17 (2), 240-255 (2008)
   PUBMED   17947297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and FM113709.1.
            
            On or before Mar 6, 2015 this sequence version replaced
            XM_006234873.2, XM_006224580.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK844494.1, CB583061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000003.1  128888717-128888811
            96-604              FM113709.1         35-543
            605-609             JAXUCZ010000003.1  128890085-128890089
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..609
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /note="Huntingtin interacting protein K"
                     /db_xref="GeneID:311359"
                     /db_xref="RGD:1311457"
     exon            1..187
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..391
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /codon_start=1
                     /product="huntingtin-interacting protein K"
                     /protein_id="NP_001292192.1"
                     /db_xref="GeneID:311359"
                     /db_xref="RGD:1311457"
                     /translation="MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEE
                     KEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAE
                     RSLREHMGNVVEALIALTN"
     exon            188..243
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /inference="alignment:Splign:2.1.0"
     exon            244..295
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /inference="alignment:Splign:2.1.0"
     exon            296..609
                     /gene="Hypk"
                     /gene_synonym="RGD1311457"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgcggcgg cgcggtgaga tcgaaatggc gaccgaggga gacgtggagc tcgagttaga
       61 gactgagacc agcggccctg agcggcctcc cgagaagcca aggaaacatg acagtggtgc
      121 tgctgaccta gagcgggtta ctgactatgc ggaggagaaa gagatccaga gttcgaatct
      181 tgagacggct atgtccgtca ttggagacag acggtccagg gagcaaaagg ccaaacagga
      241 gcgggagaag gaactggcga aggtcactat caagaaggaa gatctggagt tgataatgac
      301 agaaatggag atctctcgag cagcagccga aaggagcttg agggaacaca tgggcaatgt
      361 ggtggaggct cttattgccc taaccaactg ataaagtgtg tttagacatt ctggactgat
      421 ttacggaaat aaagtgttct gttttgctgt tttttttttt tttttttttc cagttttatc
      481 ccagatcaaa tgcattatat atcctatttt attgtcagtt tctatgttgg accttgatga
      541 aaccgtatga acaatcagtg taaagaagta cctaatgttc aaatacaggc tctgttttta
      601 ttaccctta
//
