LOCUS       NM_001034028            4346 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hypoxia up-regulated 1 (Hyou1), transcript
            variant 2, mRNA.
ACCESSION   NM_001034028
VERSION     NM_001034028.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4346)
  AUTHORS   Abu El-Asrar,A.M., Ahmad,A., Alam,K., Bittoun,E., Siddiquei,M.M.,
            Mohammad,G., Mousa,A., De Hertogh,G. and Opdenakker,G.
  TITLE     Association of 150-kDa oxygen-regulated protein with vascular
            endothelial growth factor in proliferative diabetic retinopathy
  JOURNAL   Acta Ophthalmol 96 (4), e460-e467 (2018)
   PUBMED   29098793
  REMARK    GeneRIF: 150-kDa oxygen-regulated protein (ORP150) levels were
            significantly increased in rat retinas after induction of diabetes.
            Vascular endothelial growth factor (VEGF) and the pro-inflammatory
            cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha
            (TNF-alpha) induced upregulation of ORP150 in HRMEC.
REFERENCE   2  (bases 1 to 4346)
  AUTHORS   Cunningham,C.N., He,K., Arunagiri,A., Paton,A.W., Paton,J.C.,
            Arvan,P. and Tsai,B.
  TITLE     Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in
            Parallel With Restoration of Wild-Type Insulin Secretion
  JOURNAL   Diabetes 66 (3), 741-753 (2017)
   PUBMED   28028074
  REMARK    GeneRIF: Data reveal that Grp170 participates in preparing mutant
            proinsulin for degradation while enabling wild-type proinsulin
            escape from the endoplasmic reticulum.
REFERENCE   3  (bases 1 to 4346)
  AUTHORS   Wei,H., Wang,F., Wang,X., Yang,J., Li,Z., Cong,X. and Chen,X.
  TITLE     Lysophosphatidic acid promotes secretion of VEGF by increasing
            expression of 150-kD Oxygen-regulated protein (ORP150) in
            mesenchymal stem cells
  JOURNAL   Biochim Biophys Acta 1831 (8), 1426-1434 (2013)
   PUBMED   23707263
  REMARK    GeneRIF: LPA promotes VEGF secretion at the post-translation level
            by up-regulating ORP150 expression.
REFERENCE   4  (bases 1 to 4346)
  AUTHORS   Jansen,G., Maattanen,P., Denisov,A.Y., Scarffe,L., Schade,B.,
            Balghi,H., Dejgaard,K., Chen,L.Y., Muller,W.J., Gehring,K. and
            Thomas,D.Y.
  TITLE     An interaction map of endoplasmic reticulum chaperones and foldases
  JOURNAL   Mol Cell Proteomics 11 (9), 710-723 (2012)
   PUBMED   22665516
REFERENCE   5  (bases 1 to 4346)
  AUTHORS   Deng,W.H., Chen,C., Wang,W.X., Yu,J., Li,J.Y. and Liu,L.
  TITLE     Effects of ORP150 on appearance and function of pancreatic beta
            cells following acute necrotizing pancreatitis
  JOURNAL   Pathol Res Pract 207 (6), 370-376 (2011)
   PUBMED   21536389
  REMARK    GeneRIF: Results imply a probable role of ORP150 in the changes in
            appearance and function of pancreatic beta cells following acute
            necrotizing pancreatitis, through the pathway of endoplasmic
            reticulum stress.
REFERENCE   6  (bases 1 to 4346)
  AUTHORS   Bando,Y., Ogawa,S., Yamauchi,A., Kuwabara,K., Ozawa,K., Hori,O.,
            Yanagi,H., Tamatani,M. and Tohyama,M.
  TITLE     150-kDa oxygen-regulated protein (ORP150) functions as a novel
            molecular chaperone in MDCK cells
  JOURNAL   Am J Physiol Cell Physiol 278 (6), C1172-C1182 (2000)
   PUBMED   10837345
REFERENCE   7  (bases 1 to 4346)
  AUTHORS   Ozawa,K., Kuwabara,K., Tamatani,M., Takatsuji,K., Tsukamoto,Y.,
            Kaneda,S., Yanagi,H., Stern,D.M., Eguchi,Y., Tsujimoto,Y., Ogawa,S.
            and Tohyama,M.
  TITLE     150-kDa oxygen-regulated protein (ORP150) suppresses
            hypoxia-induced apoptotic cell death
  JOURNAL   J Biol Chem 274 (10), 6397-6404 (1999)
   PUBMED   10037731
REFERENCE   8  (bases 1 to 4346)
  AUTHORS   Matsushita,K., Matsuyama,T., Nishimura,H., Takaoka,T., Kuwabara,K.,
            Tsukamoto,Y., Sugita,M. and Ogawa,S.
  TITLE     Marked, sustained expression of a novel 150-kDa oxygen-regulated
            stress protein, in severely ischemic mouse neurons
  JOURNAL   Brain Res Mol Brain Res 60 (1), 98-106 (1998)
   PUBMED   9748521
REFERENCE   9  (bases 1 to 4346)
  AUTHORS   Ikeda,J., Kaneda,S., Kuwabara,K., Ogawa,S., Kobayashi,T.,
            Matsumoto,M., Yura,T. and Yanagi,H.
  TITLE     Cloning and expression of cDNA encoding the human 150 kDa
            oxygen-regulated protein, ORP150
  JOURNAL   Biochem Biophys Res Commun 230 (1), 94-99 (1997)
   PUBMED   9020069
REFERENCE   10 (bases 1 to 4346)
  AUTHORS   Kuwabara,K., Matsumoto,M., Ikeda,J., Hori,O., Ogawa,S., Maeda,Y.,
            Kitagawa,K., Imuta,N., Kinoshita,T., Stern,D.M., Yanagi,H. and
            Kamada,T.
  TITLE     Purification and characterization of a novel stress protein, the
            150-kDa oxygen-regulated protein (ORP150), from cultured rat
            astrocytes and its expression in ischemic mouse brain
  JOURNAL   J Biol Chem 271 (9), 5025-5032 (1996)
   PUBMED   8617779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB691248.1 and BC065310.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC065310.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               CB691248.1         9-345
            338-4346            BC065310.1         381-4389
FEATURES             Location/Qualifiers
     source          1..4346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..4346
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /note="hypoxia up-regulated 1"
                     /db_xref="GeneID:192235"
                     /db_xref="RGD:621146"
     exon            1..43
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            44..141
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3047
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /note="hypoxia up-regulated protein 1; 150 kDa
                     oxygen-regulated protein; ORP-150; oxygen regulated
                     protein (150kD)"
                     /codon_start=1
                     /product="hypoxia up-regulated protein 1 precursor"
                     /protein_id="NP_001029200.1"
                     /db_xref="GeneID:192235"
                     /db_xref="RGD:621146"
                     /translation="MAATVRRQRPRRLLCWALVAVLLADLLALSDTLAVMSVDLGSES
                     MKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATLRYFQH
                     LLGKQADNPHVALYRSRFPEHELNVDPQRQTVRFQISPQLQFSPEEVLGMVLNYSRSL
                     AEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRR
                     KDINSTAQNIMFYDMGSGSTVCTIVTYQTVKTKEAGTQPQLQIRGVGFDRTLGGLEME
                     LRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLM
                     DDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKV
                     QEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFT
                     REVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDL
                     RVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVED
                     SPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKE
                     EAEAPMEDTSQPPPSEPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGVPPAPE
                     EEKKQKPARKQKMVEEIGVELAVLDLPDLPEDELAHSVQKLEDLTLRDLEKQEREKAA
                     NSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKL
                     AELRKLCQGLFFRVEERRKWPERLSALDNLLNHSSIFLKGARLIPEMDQIFTDVEMTT
                     LEKVINDTWTWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKP
                     RPRPKDKNGTRTEPPLNASAGDQEEKVIPPTGQTEEAKPILEPDKETGTEPADSEPLE
                     LGGPGAESEQAEQTAGQKRPLKNDEL"
     exon            142..235
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            236..314
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            315..469
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            470..546
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            547..728
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            729..844
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1037
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1172
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1255
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1388
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1576
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1715
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1776
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1856
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2042
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2215
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2303
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2426
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2560
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2645
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2886
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2934
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..2985
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..4319
                     /gene="Hyou1"
                     /gene_synonym="Cab140; Orp150"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcgtcc ggggccggct ggtacgcgag acgctgctaa gagggtcaca atggcagcta
       61 cagtaaggag gcagaggcca aggaggctac tctgttgggc cttggtggct gtcctcttgg
      121 cagacctgtt ggcactgagt gacacactgg ctgtgatgtc tgtggacctg ggcagtgaat
      181 ccatgaaggt ggccattgtc aagcctggag tgcccatgga gattgtattg aacaaggaat
      241 ctcggaggaa aactccggtg actgtgacct tgaaggaaaa cgaaaggttt ctaggtgaca
      301 gtgcagctgg catggccatc aagaacccaa aggctacgct ccgttatttc cagcacctcc
      361 ttggaaagca ggcagataac cctcatgtgg ctctttaccg gtcccgtttc ccagaacatg
      421 agctcaatgt tgacccacag aggcagactg tgcgcttcca gatcagtccg cagctgcagt
      481 tctctcccga ggaggtgctg ggcatggttc tcaactactc ccgttccctg gctgaagatt
      541 ttgcagaaca acctattaag gatgcagtga tcaccgtgcc agcctttttc aaccaggccg
      601 agcgccgagc tgtgctgcag gctgctcgta tggctggcct caaggtgctg cagctcatca
      661 atgacaacac tgccacagcc ctcagctatg gtgtcttccg ccggaaagat atcaattcca
      721 ctgcacagaa tatcatgttc tatgacatgg gctcgggcag cactgtgtgt accatcgtga
      781 cctaccaaac ggtgaagact aaggaggctg ggacgcagcc acagctacag atccggggcg
      841 tgggatttga ccgcaccctg ggtggcctgg agatggagct tcggctgcga gagcacctgg
      901 ctaagctctt caatgagcag cgcaagggcc agaaagccaa ggatgttcgg gaaaaccccc
      961 gagccatggc caaactgctt cgggaagcca atcggcttaa aaccgtcctg agtgccaatg
     1021 ctgatcacat ggcacagatt gaaggcttga tggacgatgt ggacttcaag gcaaaagtaa
     1081 ctcgagtgga gtttgaggag ctgtgtgcag atttgtttga tcgagtgcct gggcctgtac
     1141 agcaggccct gcagagtgct gagatgagcc tggatcaaat tgagcaggtg atcctggtgg
     1201 gtggggccac tcgtgttccc aaagttcaag aggtgctgct gaaggctgtg ggcaaggagg
     1261 aactaggaaa gaacatcaat gccgatgaag cagctgccat gggggccgtg taccaggcag
     1321 cggcactgag caaagccttc aaagtgaagc catttgttgt gcgtgatgct gttatttacc
     1381 ccatcctggt ggagttcaca agggaggtgg aggaggagcc tgggcttcga agcctgaagc
     1441 acaataaacg tgtgctcttc tcccgaatgg ggccctaccc tcagcgcaaa gtcatcacct
     1501 ttaaccgata cagccatgat ttcaactttc acatcaacta cggtgacctg ggcttcctgg
     1561 ggcctgagga tcttcgggta tttggctccc agaatctgac cacagtgaaa ctaaaaggtg
     1621 tgggagagag cttcaagaaa tatcctgact atgagtccaa aggcatcaag gcccacttta
     1681 acctagacga gagtggagtg ctcagtttag acagggtgga gtccgtattc gagaccctgg
     1741 tggaggacag cccagaggaa gagtctactc ttaccaaact tggcaacacc atttccagcc
     1801 tgtttggcgg tggtacctca tcagatgcca aagagaatgg tactgatgct gtacaggagg
     1861 aggaggagag ccctgctgag gggagcaagg atgagcctgc agaacagggg gaactcaagg
     1921 aggaagctga agccccaatg gaggatacct cccagcctcc accctctgag cctaaggggg
     1981 atgcagcccg tgagggagaa acacctgatg aaaaagaaag tggggacaag tctgaggccc
     2041 agaagcccaa tgagaagggg caggcagggc ctgagggtgt ccctccagct cccgaggaag
     2101 aaaaaaagca gaaacctgcc cggaagcaga aaatggtgga ggagataggt gtggaactgg
     2161 ctgtcttgga cctgccagac ttgccagagg atgagctggc ccattccgtg cagaaacttg
     2221 aggacttgac cctgcgagac cttgaaaagc aggagaggga gaaagctgcc aacagcttag
     2281 aagcttttat ctttgagacc caggacaaac tgtaccaacc tgagtaccag gaagtgtcca
     2341 ctgaggaaca acgggaggag atctctggaa aactcagtgc cacttctacc tggctggagg
     2401 atgagggatt tggagccacc actgtgatgt tgaaggacaa gctggctgag ctgagaaagc
     2461 tgtgccaagg gctgtttttt cgggtggaag agcgcaggaa atggccagag cggctttcag
     2521 ctctggataa tctcctcaat cactccagca ttttcctcaa gggtgcccga ctcatcccag
     2581 agatggacca gatcttcact gacgtggaga tgacaacgtt ggagaaagtc atcaatgaca
     2641 cctggacctg gaagaatgca accctggccg agcaggccaa gcttcctgcc acagagaaac
     2701 ccgtgctgct ttcaaaagac atcgaggcca aaatgatggc cctggaccgg gaggtgcagt
     2761 atctactcaa taaggccaag tttactaaac cccggccacg gcccaaggac aagaatggca
     2821 cccggacaga gcctcccctc aatgccagtg ctggtgacca agaggaaaag gtcattccac
     2881 ctacaggcca gactgaagag gcgaagccca tcttagaacc tgacaaagag actggtacag
     2941 agccagcaga ctctgagcct ctggaattag gaggtcctgg tgcagaatct gaacaggcag
     3001 agcagacagc agggcagaag cggcctttga agaatgatga gctgtgaccc cgcgcctccg
     3061 ctccacttgc ctccagcccc ttctcctacc acctctattt attatacatc agggttggag
     3121 tggggttggt gtccttaggg gctcaagttc cttctctcag ctgggacagg agatggctgc
     3181 tcaacaggcc tggagtagct ccacaggtga aaccggctct cgttctgtcc ccagccccac
     3241 cctctggtct cccactctct ggccctgtgt ttgagaggaa tcactattct gtcttaattc
     3301 tttgcctgtg ggtaagtgag agaatggccg ccagtggttg ttggagacct ggtcgtggga
     3361 aggatgtcat gttgtgggtc actgaagagt ggccaatctt ctcagcattc tttcatcttt
     3421 tcctcttcta caaaatcagt gtcctgatgg gccagtgtct acagagcctc agtctcactt
     3481 gatttctgag agcctcttct cttctgtgtc ttctcttccc ttgcccttcc tcagctcttc
     3541 tgtccttgcc ttctctgtgc agattaggct gtgggattct tgccctaagc ctttcatcta
     3601 gactgtctgt agagtaaata tgtcctcatg cgacccctgg tggctagagc aagcagggag
     3661 caggcaagaa gggaaaagcc ctgtaacccc ctgtgggttg ttgggtccag gacagtacaa
     3721 gccccaagaa tggttggcag ggtgggagta tactgcaggc actagccatc ctggtcatcc
     3781 ccagttcctg tgatatctac ccttcatgct ctttccttct tccccctggg ctgaccaaaa
     3841 atgtgctatc tactgtgagc ccctttccca agaccctgtg ggacagagat catggtgtga
     3901 atgtaaaaat gccacctcac tctcaggcaa gctttgtggg taaagaaaga ggggtcaggg
     3961 ttcaacttga cagtgtcctt tgccaggaag gagagcccct tgcccactat aaccatgcct
     4021 agagtgcctg tcctccagta ttgcacctgt agcaggaggt agggccaccc cagtgcaggg
     4081 gcaaagcaaa cctgatgtca gttgttttgt cttttctacc ccacccccac ccctctccac
     4141 cttttttttt ttttttttgc cacattggca gaaagactta aaggtcctac acagttcccc
     4201 cctgtgtgtt tgagttcttt cattagcagt tcaggctggt tggacaggtt tgaatcaaat
     4261 tgtactttgt tccattgtta attgagaaac tgtttcaata aaatattctt ttctatagaa
     4321 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
