LOCUS       NM_001398962            1733 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus HYLS1, centriolar and ciliogenesis associated
            (Hyls1), transcript variant 2, mRNA.
ACCESSION   NM_001398962 XM_002729924
VERSION     NM_001398962.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Mee,L., Honkala,H., Kopra,O., Vesa,J., Finnila,S., Visapaa,I.,
            Sang,T.K., Jackson,G.R., Salonen,R., Kestila,M. and Peltonen,L.
  TITLE     Hydrolethalus syndrome is caused by a missense mutation in a novel
            gene HYLS1
  JOURNAL   Hum Mol Genet 14 (11), 1475-1488 (2005)
   PUBMED   15843405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 28, 2021 this sequence version replaced XM_002729924.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2986397.1,
                                           SRR26360172.1460285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000008.1  42179024-42179322   c
            300-350             JAXUCZ010000008.1  42177822-42177872   c
            351-469             JAXUCZ010000008.1  42173652-42173770   c
            470-1733            JAXUCZ010000008.1  42170505-42171768   c
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..1733
                     /gene="Hyls1"
                     /note="HYLS1, centriolar and ciliogenesis associated"
                     /db_xref="GeneID:680262"
                     /db_xref="RGD:1594169"
     exon            1..299
                     /gene="Hyls1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..350
                     /gene="Hyls1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..469
                     /gene="Hyls1"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1397
                     /gene="Hyls1"
                     /note="hydrolethalus syndrome 1; hydrolethalus syndrome
                     protein 1"
                     /codon_start=1
                     /product="centriolar and ciliogenesis-associated protein
                     HYLS1"
                     /protein_id="NP_001385891.1"
                     /db_xref="GeneID:680262"
                     /db_xref="RGD:1594169"
                     /translation="MAEKRQAYSVEEAMEQLKGPGGQKWSNMDPEERMLAAATAFTHI
                     CAGQGEGDSRREVQAGQYDPYSKASITPGKRAALPMHLHFPYTGSHVTSSTVSETSQK
                     CRKPVMKRKVLRRKPDGEVLVTDESIISESESGTESDLDLWDLRHRLMNLQFQEGTAS
                     PVDTSQKLNLPCEYQGISQDQLICYLQREEMGPPVYEQDLIVASRPKSFILPRLDQLS
                     RNRGKIDRVARYFEYKRDWDSMRFPGEDNRKELRWSVRGQMLSRPEPQSKPQHLYVPN
                     SYLVPTEKKRSALRWGVRCDLANGVIPKKLPFPLSPS"
     exon            470..1733
                     /gene="Hyls1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaacctgc tgccgggata caggccgctc atacccttgc aggtcacaat gtgatgtaca
       61 cccggcctgc gccacttttg cccggtgggc aagcgagcgg actgagccct ccctgctagc
      121 gtggaagtgg ggacgggtcc ctggggaaga cgagctccca gcacgcctat ggccagatgg
      181 tgcgactggt gttattgttg gaagagcagg gaagtagcct caagtttggg tttcaccttc
      241 cgtggattca tgcgtacaac cagctgtcca taccctttgc ttaggattta ggatagcagg
      301 tttcccgttt gttaactcaa atacagccag tcagtgcaaa ccaaaataag gtggcacagt
      361 agaagctatc ttaattgaag aaatactatc catgacttta tttcccattg ggagtagaac
      421 cgggagacaa attttccttg ctttaagcag ttttaatggc agaaaaaaga caagcttata
      481 gtgtagagga agcaatggag caactgaaag gaccaggtgg acaaaaatgg tccaatatgg
      541 atccagaaga gcgaatgtta gctgctgcta cggcatttac acatatctgt gcagggcagg
      601 gtgaaggaga ttcaaggaga gaagtgcagg ctggccagta tgacccctac agtaaagcct
      661 caataacacc aggaaaaaga gctgctcttc ctatgcacct gcacttccca tatacaggaa
      721 gccatgtcac ttcatcaaca gtttcagaga cttcccaaaa atgcagaaag ccagtaatga
      781 agaggaaggt gctgcgtaga aagccagatg gggaagtgct ggtgacagat gagtctatta
      841 tcagtgagtc tgagtctggt acagaaagcg atttggatct ctgggacttg agacacaggc
      901 tgatgaactt gcaattccaa gaaggcacag catccccagt tgacacttca caaaaactta
      961 acctaccatg tgaataccaa ggaatttcac aagatcagct catttgctat ctacaaaggg
     1021 aagaaatggg ccctcctgtt tatgaacaag acctgattgt tgccagcaga cccaagtcct
     1081 ttattctccc cagactggat caattaagcc gcaaccgagg caagatagac agagtagcca
     1141 gatattttga gtacaaaagg gattgggatt caatgcggtt tcctggtgaa gataacagaa
     1201 aggagttacg ctggagtgtc cgagggcaaa tgctttcccg accagaacct cagtccaagc
     1261 ctcaacactt atatgttcca aacagttatc tagtaccaac ggagaagaaa agatctgccc
     1321 ttcgttgggg tgtccgttgt gaccttgcaa atggtgtcat acccaagaag cttcccttcc
     1381 ctctttctcc ttcttaagtc attttttttt tttttaaaaa acctgtctct cctaacaaag
     1441 gatttaggat aacctagttc tttatctctc ctttaaatac aactaccatg aaaagcaggc
     1501 agaacacaga ataaggactt cagtgttctt cctagtattg ttggtatgtc acatagattt
     1561 catacaccac ttgaattcta aattgccatt ctcaaataca gcaatggggg cggggaggtc
     1621 aaaaactact gaaatccagt aagtgccatt ttaaaaagac ttgtaaactg tggtgttttg
     1681 ttttttttta atttcgtatt aagctcatct attaaagaag tttgaaaaat gaa
//
