LOCUS       XM_039098232           15758 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Hydin, axonemal central pair apparatus
            protein (Hydin), transcript variant X1, mRNA.
ACCESSION   XM_039098232
VERSION     XM_039098232.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051354.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039098232.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15758
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15758
                     /gene="Hydin"
                     /note="Hydin, axonemal central pair apparatus protein;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 9 ESTs, 6 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 16 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:292017"
                     /db_xref="RGD:1562254"
     CDS             73..15546
                     /gene="Hydin"
                     /codon_start=1
                     /product="hydrocephalus-inducing protein homolog isoform
                     X1"
                     /protein_id="XP_038954160.1"
                     /db_xref="GeneID:292017"
                     /db_xref="RGD:1562254"
                     /translation="MDTAVHEKVDHKKCRECGQRKYFKPASKRLEEPMGTVHRKMAKV
                     ISGLQSKVLPPMSPKVVTEEEVNRMMSPSEFLKEMSLTTEQKLASTRIICRPQITELL
                     DMGETTHQKFSRVDLDQALFQPFPSEIIFQNYSPCEVYEVPLVLRNNDKIPRMVKVVE
                     ESSPYFKIISPKDIGHKVAPGVPSIFRILFTPEENKDYAHMLTCITEREKFIVPVKAR
                     GARAILDFPDELNFSTCPVKYSTQKVLLVRNIGNKDSMFHLKTRSPYSVEPTGGILNV
                     GESMQLEVNFEPQTVGNHSGKLIVIYDTGEMVFVCLYGAAIDVNIRLDKNSLIMERTY
                     ISLSNQRSITIHNRTNIIAHFQWKVFATQEEEDKEKHRVCDDLHREEKQETSMILEDC
                     ILDPSLRERLSIISRTFENQRKLVQGNSMLFLDHIFTIDPLEGDVWPNSTAEITVYFN
                     PLEARLYQQTVYCDISGREIRLPLRIRGEGMGPKIHFNFELLDIGKVFIGSAHCYEAI
                     LSNKGSIDALFNVIPKTSALGACFVFNPKEGIIEPSGVQAVQIAFSSTSLGHFEEEFL
                     IDVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGNVSYGFPHTLTCSLNNTSLVSMTFK
                     LRVRGDGEGMSSIPSYSQDSDSKRRSWINTEISTTKPKEFTITPNSGTIRAQGFAAIK
                     VTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVPKLQLMTTEVDFGRCFLKYPY
                     EKTIQLVNHDDLPGCYKVLPQIYETSPTMLLSSPSPCGVISPHSTVNIPLALETQVTG
                     AHRSTVYISVFGSQEAPLACHVQSIGEGPVIFIHPTQIDFGNIYVLKDTSRILQLSNQ
                     SFIPAEFRARLANKKSLWTVKPSEGSVPAEDDIPLTLTANLNDIVTFKDTVILEIKHS
                     NTYRIPIQATGIGSTIVSDKPFAPELNLGSHFSLDTHYYRFKLTNKGRRVQQLFWMND
                     DFNPKEKQSKKGSTGSSRRQSKVSQESTDSGNPVFQLHPVRMELYPGQTIDVILEGYS
                     ATPKKVKEKLVCQAIVGAQKGKSLLMSVTIICEFIAPVIQLSTRQLIYRLEKKPNMVL
                     EPDYQPLVIKNVTTLPVRMLLSTSGPFFICETDKSLLPATPKPIKLEVDEEKNFLVKF
                     DPSYRHDLNNWVAEEVLSIKYTEHPQVDNLSLRGEVHYPNLCFEVMEVDFGCILNDTE
                     VIRYIMITNCSPLVVKFRWFFLVDDEENQIRFAPCMKPYSAFLSQMESIPATSVTASS
                     LAAPPMPEYTEMDFSDSIKTILMDDEAGPEETKKPMTSAMVSEAIKYSSAGTERSQSQ
                     PDYPECLWVYDPDEMLSIGIEEVFDILPLYGVLRPYSNHQISFTFYGHCDIVARAKAL
                     CEVEGGPTYEIILKGEASLVNYSFDTKDINYGLQLFDHITEREITLKNIGKVGFEFKV
                     LTNYRSSPRNLLPGMPLILPLSGFIQSNKEQVLKVYYLPGIPEVFQRNFQIQIAHLVP
                     ENITLYGEGIFPRISLDLHRNLRGNEKYQHFLEQAKKNIEKEYSKYETVNHYEVITEE
                     IPEEETAELSAHLQMEVERLIVQDYALEHQRGISSSTTEDTYFSHRSCRKLAKVQLPE
                     YILDFGYIVLGDVRTHIIKITNTSHFPVSFHAEKHVLHETGFSTELDRVKNLPYCETE
                     TFEVRCDPQGANLSVGNKEVILPIKVSGGPTIHICLQATVTIPSMTLSCNKIEFATIQ
                     CGQCMVETIQLSNHLQVPCEWFVYTPKSTNKMDKHIPKYLRRKLRAEMTPKSRIFEIQ
                     PTSGVLDPDERANVQVKFMPKEEKFYSQSLMFQIGQSNQKLTLLAQGQGLEPRLEFSP
                     SVLELGPLLPYASGDEAEVIVRNPCSFPIEFYSLEFDQQYLLEEKMLRQLKGYDSYNT
                     LLLPPRNPGEKLPQEVYDYFKEVKKSKEEHMKAKYLENLAQENAEEEEMNTSDQGTAS
                     TKRTSLSRGISVTSNMEERHLPTEAKNYPDEDDYEESLEKLTFQTDKMQSTDSHSVEE
                     VGEVESNPVSKAIARHLGIDISAEGRLAKNRKGIAIIVYGTPVSGKTANAISMAKFYN
                     TACLNIDSIVLEALSDSNNVLGIRARELCIRAAIEQSMREAEESAQESSVTQNLGAPA
                     RLSTENLGRFTSDLTLLTQEYKIPKSMRGSVMLSKGKTESHWSGSQKQQGQQQQQQQQ
                     QQPQQQQQPQQQQQQQHHQHQSETPQISSSPLLGGPTQRRLSVSASIGGETGLMSCVL
                     PDDLLIQILAERIQLSDCFRGVVFDGLDTLFARNAPSALICLLKAIGSREHIYVINMS
                     QDYVAMKAQEKAKKELEETKRQEALAKEKERLQTLDEEEYDALTAEQKIAFDREVRQA
                     LRERKKRELERLAREMHEKKLQQELERQKEEDELKRKVKRPKPGPVAKEEPPLKKSQG
                     PTNKQLPSVAKLEMKMESIERKVSVREHGLLEETTRKKKATTEYAFGFPITQEQEESE
                     GDFLKDSDKNLAQKFKVYDTCLKDVQNILMYWDRKQGMMVPHTGPDEIPHEVDDQRQA
                     PSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLEKLRAMEERSDGEGEGEEEH
                     EGKKDLGVPFINIQTPDFEGISWKQALESDKLPKGDQILNILGLGSSGPPIPPPVLFS
                     IISYPAKRQSLVATEILKHFVFVIPPNDDLPLSDEKKDMEGDSDLFLNTIVTKAQEEQ
                     PSPPAKGSKQKSKDKTEQARETQKDKRRTYSGRKGLSGGASGNLAPMSDIDQNNFDGE
                     HSQEKFIRLNHFRWIVPPNGEVTLRMHFSSFDVGNYDQTFNFELLGTRRQYQLYCRGV
                     CTYPYICKDPKIVYPQRKKDMKLKEVVVKKYVVSMDKFYFGPLLCGKSRDKYKSSLYP
                     DNMETLTILNDSPMVVEAYFCFQHDVKASTYFLEPVNMTLKPNEKQILNVWAYPTAVG
                     VFEDSIVCCIKENPEPAIFKICCQGIRPEIEVEPRQLHFDRLLLHRKESKSLVLRNVT
                     SLPVAWRISSLEHLGEDFTVSMMQGTMLPKGEFGLQVHFQPSKPVNIKKAIRIEVLDA
                     ENLVGVVQIENILIFAESYDIALDITFPKGTEGGLDFGTLRVLEEVKQPLQLKNRGKY
                     EIIFSFTVDSVGILPTNLSSMIWIQPKRGTLASIDKPTTVQVFFRARKEVKVESQPIL
                     RCQIIEPALSEGEIIASIPIKFSVNAVYSKFTISPSSIINFGALICGTRKSITFTIEN
                     QGIIDFKYALYRLTGESPILQKKATSHMRHGRTRESESFYKPGAPKMAKFSDIVQKDM
                     NIANQARFTHGMFTVYPGFGSVSSGGQQVITVECVADPVGRCEEFLAIDISDRDPREN
                     PAGIPYTLLAEACLPAFVTDNNILIFEEHQICTSPNLYHIQQTIQSGGLFVEDENKFI
                     FCNVLVGHKAKARFKISNVGKISCDVNIIVRPISNKVVNRIIDIFDVDPNKMCIGSRS
                     HAFATVLFTPQAMQTYQCIFEATLDGLPSTLARSRGLVFDIIGEGTLPRVTVIRPTLY
                     NQHGNPLLLFKRLLLGHSEKLPLILKNNGTIPAQLHVDLRDQLGVFSLKGRPTTSYIY
                     IMEENKPNEKVKKAHTASLVVSPGDTAEFDVFFHSNKIGRMTGTIHLTVINNQYEETM
                     IHLVGESYEDDITLDNIHGLINTTSQETSEMSEVIEIAEESAMEDLVTAALLDHIQFG
                     YCHIGISYNVSFTITNHSQANVIRFEWPLLATLSFSPQIGHLHPGCSKDVVVTLKSES
                     PITLKKMCVKCKLSKIMFQLPVDQVPDWDDRMRTVKWVDAPRNTPGNLTTKRKVIETD
                     PEPAHSVVEENYRELRIQFSANVDFASYKCETSEVFFKETLVYQTRVFEFDLVNTGQV
                     LLEFCWISEEVSKIVSFAMPENPGSSQKDQLSQGTGSSLDSALDHWTEASPSPFSVEP
                     SSGFVPVGKTQKLKLKFSPMDIGEFESSLYCQIPNLPLGEQGPLLITKGRSVLPFCHF
                     DLKESDYISGHRRNPELRGPGSGPLEPNTRVIEFTSVGIGGKNLRTFTILNPTNSTYS
                     FCWTSEETESLQNPPAFVCLTEKGIIHPEKKAEIIFQFLPAHLDITEAFWTFSIPEHN
                     ISVPFLLVGKTTDPLISLDKSHLNFSSLLIGREARETVKIINKEEQGFNFAFQDSSRY
                     SEGFNNSLIVCPMEGWIPPLSRFPVDIFFTPKQEGDVNFNLICNIKKKAHPLTLNVKA
                     EGYTMNAEVKCRDRMGSTTLLTSTQVNTINFYEVELNECVQCEFNFINTGKFNFSYQA
                     ELSGPKFLLQYLDFTPTDNSVDVGQSEPASLSFQPYQKCVLKGLELKIKISHGPTFIC
                     NVVGCAVSPAVHFSFTSHNFGTCFIYQAGMPPYKQNLVVTNREETSMSLDCLYTNTPH
                     VEVNFSVDVIKPGKTLEIPITFYPREAINYRELIPFEINGLSQQTVEIKGKGTEMKLL
                     VLDPANRIVKLGAVLPGQVVKKTVSLVNNSLAQLTFNHSIMFSIPELQEAKVITVEPF
                     HSITMKPKEVCKLEITFAPKKRVPPFSEEVFMEWMGLLRPLFLLSGCCQALEISLDQE
                     HLPFGPVVYQTQATRRILMMNTGDVGARFKWDVKKLKPHFTISPEEGYITSGTEIALE
                     VTYHPTEIGKESLYKNILCFIQGGSPLCLTLSGICVGPPVVKEVVNFNCQVRSRHTQT
                     ILLSNRSNQTWNLHPIFEGEHWEGPEFITLEAHQQNKPYEITYKPRTMNLENRKHQGT
                     LFFPLPDGTGWLYALHGTAELPKAVANIYREVPCKTPYTELLPISNWLNKPQRFRVIV
                     EILKPEKPDLSVTLKGLDYIDVLSGSKKDYKLNFFAYKEGLYTAKVIFRNEVTNEFLY
                     YTVSFRVTPSGIIKSIQMTSPVRQSVSASIKLENPLPYSVTFSTECKLNDISLPSQFA
                     VPPNSEGTFSFEFQPLKAGEICGRLTLHNGDLGYYQYELLLKALPAPPEKPVHFQTVL
                     GSSQSILAKFTNYTRLKTEYYCKTDCSDFHTEKIINAAPGAQGGTEVSVEVIFEPSHL
                     GETKGILCLSSLIGGEYIIPLFGIALPPKPQGPFLIRAGYNIIIPFKNIFLHATNFSF
                     IVENPAFTIRAAESVRPKKINNITVYFEGNPSGSKTPITTKLIVTCPQCEGTESGIKW
                     VYYLKGITP"
ORIGIN      
        1 tctccaatca acgttgctct tgttagagtg tgagccaccc tagcggttgc tgtggcaaca
       61 gatggtaaca agatggacac agcagtgcac gaaaaagtgg atcacaaaaa atgcagagag
      121 tgtggacaaa ggaaatattt caaaccagca agtaaaaggc ttgaggaacc catggggact
      181 gtgcatcgga agatggccaa agtgatctcc ggactgcaga gcaaagtctt gccacccatg
      241 agcccgaagg tggtcacaga ggaggaagtg aaccggatga tgtcgccctc agaattcctg
      301 aaggagatgt ccctcactac ggagcagaaa ctggcaagta cacgaatcat atgccgacca
      361 cagatcaccg aactcctaga tatgggagaa acaacgcatc aaaagttttc cagagttgac
      421 ttggatcagg ccttgttcca gccctttcca tcagaaatca tattccagaa ctattctccc
      481 tgtgaagtct atgaagtgcc attggttttg aggaacaacg acaaaatccc aaggatggta
      541 aaagttgttg aagaaagctc accttacttt aaaatcatca gccccaaaga catcggccac
      601 aaggtagccc cgggagtgcc gtccatattc cgaatcctct tcactccaga ggagaacaag
      661 gattatgccc acatgctgac ctgtatcacc gaaagagaga agttcattgt gcccgtcaaa
      721 gctagagggg ctcgagccat cctggacttt cccgatgagc tgaatttttc cacttgccct
      781 gtgaaataca gcacccagaa ggttctgctg gtccgcaaca ttggcaacaa agactccatg
      841 ttccacctca aaactcgaag cccttactca gtagagccaa cgggcgggat tcttaacgtg
      901 ggggaatcca tgcaactgga agtgaacttt gagccgcaga ctgtgggcaa tcacagtgga
      961 aaactcatcg tgatttacga cacaggggaa atggtctttg tgtgtctcta tggagctgcc
     1021 atagacgtga atataagact agacaaaaat tctttgatca tggagagaac ctacatatcg
     1081 ctgtccaacc aacggtctat caccatccac aaccgcacta atataattgc ccatttccag
     1141 tggaaggtgt ttgctaccca agaagaagag gacaaagaaa aacatagggt ctgtgatgat
     1201 ctccacaggg aggaaaagca ggaaaccagc atgatacttg aagactgcat cttggatccc
     1261 tcgctccgag aacgcctgtc cattatctcc cgtacgtttg agaaccagag gaagctggtt
     1321 caaggaaaca gcatgctctt tctggatcac attttcacga tagatcccct ggaaggcgat
     1381 gtctggccta actcaacagc tgaaatcact gtgtacttta accccctaga agccaggctc
     1441 taccagcaga cggtttactg tgacatctca ggccgagaga tccgcttgcc cctccgaatc
     1501 agaggagaag gaatggggcc caagattcac ttcaacttcg aattactgga cattggcaaa
     1561 gttttcattg gatctgccca ctgctatgag gcgatccttt ccaacaaagg cagcatcgat
     1621 gccctcttca acgtcatccc caaaacttca gccttggggg cctgctttgt tttcaatcct
     1681 aaagaaggca tcattgaacc gagtggggtc caagccgtcc agatcgcctt cagttccacc
     1741 agcctggggc acttcgaaga agagttcctg atcgatgtca acgggtcccc tgagcccgtg
     1801 aaactgacca ttcgaggctg tgtgattgga cctacattcc attttaatgt ccctgctctg
     1861 cactttggga atgtttccta tggatttccc catactttga cgtgttccct caataatacg
     1921 tctttggtct ccatgacctt caaactgcgt gtccgtggcg atggcgaagg catgagtagc
     1981 atcccaagtt actctcagga ttcggacagc aaacgacggt catggattaa tacagaaata
     2041 tccacaacaa aacccaaaga atttaccatc actcccaaca gtggcaccat ccgtgcccag
     2101 ggttttgctg ccatcaaggt gaccttgtgc tccaacaccg tgcagaaata cgagctggcg
     2161 ctggtggtag atgtggaggg catcggagag gaagtgctgg cgctcttgat tacagccaga
     2221 tgtgttgtgc ccaagctcca gttgatgact acagaggtgg acttcgggcg ctgcttcctg
     2281 aagtacccat acgagaagac catccagctt gtcaaccatg atgaccttcc tgggtgctat
     2341 aaggtcctgc ctcagatata tgagacttca cccaccatgc tgctttctag cccctccccc
     2401 tgtggagtca tctcccccca cagcactgta aacataccac tagcgttgga gacccaggtc
     2461 actggtgcac acagatccac ggtttacatc tcagtcttcg ggagccagga agcccctctg
     2521 gcatgtcacg tacagagtat tggagaaggg cccgttatct tcatacaccc cactcagatc
     2581 gacttcggca atatctacgt cctgaaggac acgtccagaa ttctccagct ctctaaccag
     2641 tccttcatcc ctgcagaatt ccgggctcgc ctggcaaaca aaaagtccct ttggacggtt
     2701 aaacccagtg agggctcagt tcctgcagaa gatgacatcc cactgacgct gactgccaac
     2761 ctgaatgaca tagtgacgtt caaagacacg gtcatcctgg agattaagca cagtaacacc
     2821 taccggatcc ccatccaggc cactgggatt ggttcgacca ttgtttccga caaaccgttt
     2881 gctccagaac tcaacttggg atcgcatttt agcctggata cccactatta ccgcttcaag
     2941 ctgaccaaca aaggacggcg ggtccagcaa ctgttctgga tgaatgacga cttcaacccc
     3001 aaagaaaagc agagtaagaa gggctctact ggtagtagcc gtcgccagtc caaggtctcc
     3061 caggaatcca cagatagcgg gaaccccgtg tttcaactcc accctgtcag gatggagttg
     3121 tacccagggc agacaatcga cgtgatactc gaaggctatt ccgccacgcc caagaaagtc
     3181 aaagaaaagc tggtgtgcca ggccatcgtc ggagcccaga aggggaaaag cttgttgatg
     3241 tctgtgacca tcatctgcga gtttatagct ccagtgatcc agctatccac caggcagctc
     3301 atatatcggc tggaaaagaa gcctaacatg gtcctggagc ctgactacca gcccctggtg
     3361 ataaagaatg tgaccaccct gcctgtgagg atgctgctct ccacctccgg gcccttcttc
     3421 atctgtgaaa ctgataaatc cctgctgcct gcaactccga agcccataaa actggaggtt
     3481 gatgaggaga aaaacttcct ggtcaagttt gatccgtcct acagacacga cctgaacaac
     3541 tgggttgcag aagaggttct atccattaag tacacggaac accctcaggt ggacaacctg
     3601 agcttgcgtg gagaagtgca ttaccccaac ctctgttttg aggtgatgga ggtggatttc
     3661 ggctgcatcc tgaatgatac cgaggtcatt cgctacatca tgatcaccaa ttgcagcccc
     3721 ttggttgtga aattccgctg gttcttcctg gtggatgatg aggaaaatca gatcaggttt
     3781 gcaccatgta tgaagcccta cagcgccttc ttgtcccaga tggagtccat cccagcaacg
     3841 tcagtcaccg ctagctctct ggcggcccca ccgatgccag agtacactga gatggacttc
     3901 agtgattcta tcaagaccat ccttatggac gacgaagctg gacctgaaga aaccaaaaag
     3961 cccatgacgt ccgctatggt ctcagaagca ataaaataca gctccgcggg aacagaaaga
     4021 agccagagcc agccggacta cccagaatgc ctgtgggtct atgacccgga tgagatgctt
     4081 tctattggga tagaagaagt cttcgacatt ttgcccctct acggagttct gcggccctac
     4141 agcaaccatc aaatatcgtt taccttctac ggacactgtg acatcgtcgc ccgggccaaa
     4201 gctctgtgtg aagtggaagg agggcccacc tatgaaataa tcctgaaggg ggaggcgtcc
     4261 ctggtcaact actcctttga cacgaaggac attaactatg gattgcagct gtttgaccat
     4321 atcacagaac gtgaaatcac actgaaaaac atcgggaaag ttggctttga gttcaaagtt
     4381 ctgactaatt accggtcttc cccaaggaac cttctccctg gaatgccact tatcctgcct
     4441 ctgtcgggtt ttatccagtc gaataaggag caggtgctga aagtttacta cttgcctgga
     4501 ataccagaag tcttccaaag aaacttccag atacaaatcg cccacctggt cccagaaaac
     4561 atcactctgt acggagaggg catcttccca cgaatcagcc ttgacctaca caggaacctc
     4621 cgaggcaatg aaaagtacca acacttctta gaacaagcga agaaaaacat agaaaaagag
     4681 tacagtaaat acgagactgt caatcactat gaggtgatta cagaggaaat ccccgaggag
     4741 gagaccgcag agttaagtgc tcatctccag atggaggtag aacgacttat agtccaagac
     4801 tacgccctgg aacaccagag aggcatctcc tccagtacca cagaggacac ctacttcagc
     4861 caccggagct gccgcaaact agccaaagtc cagctgccag agtacatcct ggactttggc
     4921 tacattgtgc ttggtgacgt ccgaacccac atcatcaaga tcaccaacac cagtcacttt
     4981 cctgtgtcct tccatgcaga aaagcatgtc cttcatgaaa caggcttcag cactgagcta
     5041 gaccgtgtaa agaacctacc ttactgtgag acagaaacat tcgaagtgag atgtgaccca
     5101 caaggggcta atctttctgt gggcaacaaa gaagtcattc tccccatcaa ggtgtctgga
     5161 gggccaacca ttcacatctg cctccaagcc actgtgacca ttccaagtat gaccctgtcg
     5221 tgcaacaaaa tagaatttgc tacaatccag tgtgggcagt gcatggtaga aaccattcag
     5281 ctttccaacc atctccaagt cccttgtgaa tggtttgtct acaccccgaa gtctactaac
     5341 aagatggata aacacatacc aaagtattta aggcgaaagc tgcgagctga gatgacgccc
     5401 aagtctcgga tctttgagat ccaacccact tccggagtct tggatcctga cgagagggcc
     5461 aacgtgcaag tgaaattcat gcctaaagaa gagaaattct acagccaatc tctgatgttc
     5521 cagattggcc agagcaatca gaagcttact cttctagcgc agggtcaagg tctggagcca
     5581 cgcctggaat tcagcccttc agttctggaa ctggggcccc tcctgcctta tgcatcagga
     5641 gatgaggccg aggtgattgt gaggaaccct tgcagcttcc ccattgagtt ttactctcta
     5701 gaatttgacc agcagtatct cttagaagaa aagatgctgc ggcagctgaa aggctatgac
     5761 tcctacaaca ctttgctgct gcctccccgg aacccggggg agaagctgcc ccaggaagtc
     5821 tacgattact ttaaggaggt aaagaaatca aaagaggagc acatgaaggc caagtacctg
     5881 gagaacctgg cgcaggagaa tgcagaagag gaagaaatga acacatctga ccaaggaacc
     5941 gccagcacaa agaggacatc acttagccga gggatctctg tcacatccaa catggaagag
     6001 cggcatcttc cgactgaagc caagaactac ccagatgagg acgactatga agaaagcctg
     6061 gagaaactaa cgtttcaaac cgacaagatg cagagcacag acagccactc cgtggaggag
     6121 gttggagaag tggagagcaa cccagtgagc aaagcaatag cgcgccacct gggcatcgac
     6181 atttctgcag aaggccgcct ggccaagaac cggaaaggaa tcgccattat cgtctacggg
     6241 acgccggtgt caggaaagac agccaatgcc atcagcatgg ccaagttcta caacacagcc
     6301 tgcctgaaca ttgactccat tgtcttagaa gccctgtcag actctaacaa cgtccttggg
     6361 atacgggccc gggaactgtg catccgagct gccatagagc agtccatgag ggaagccgag
     6421 gagtcagccc aggagtcttc agtgactcaa aaccttgggg caccagcacg actaagcact
     6481 gagaacttgg gcaggtttac ctccgatctc actctactga cccaggaata caaaatcccg
     6541 aagagcatgc gtgggagcgt gatgctctcc aaaggcaaga cggaaagcca ctggtctggg
     6601 tctcagaagc agcaggggca gcagcagcag cagcagcagc agcaacaacc acaacagcag
     6661 caacagccac aacagcagca acagcagcaa catcatcagc accaatctga aacaccgcag
     6721 atctcctcca gccctctcct cggcggcccc acccagcggc ggctcagcgt cagcgccagt
     6781 atcggagggg agactgggct gatgagctgt gtgctcccag atgaccttct cattcagatc
     6841 ctggctgagc ggatacagct gagcgactgt ttcagaggtg tggtgttcga tggcctagac
     6901 acgctctttg cacggaacgc accttctgcc ctcatctgcc tgctaaaggc catcggtagc
     6961 cgggagcaca tatatgtcat caacatgtct caggattatg tggccatgaa agcccaggag
     7021 aaagctaaaa aggagctaga agagaccaaa cgccaggaag ctcttgcgaa ggagaaggag
     7081 cgtctccaga cacttgatga ggaagagtat gatgccctaa cagcagaaca gaaaattgca
     7141 tttgaccgcg aggttcggca ggcactccgg gagagaaaga agagggagct agaaagactc
     7201 gccagggaga tgcatgaaaa gaagctgcag caggagttgg agaggcagaa ggaggaggac
     7261 gagctaaaac ggaaggtcaa aagacctaaa ccgggccctg tggcaaagga ggagccaccc
     7321 ctaaagaagt cacaaggacc cacaaacaag cagcttccct ctgtcgccaa attagaaatg
     7381 aagatggagt caatcgaaag gaaagtttct gtcagagagc atggattact tgaagaaacc
     7441 accaggaaaa agaaagccac gaccgaatac gcgtttggat tcccaattac ccaggaacag
     7501 gaggagagcg aaggagactt cctgaaggac tctgacaaga acctggcaca aaagtttaaa
     7561 gtctatgaca cgtgtctgaa ggatgtgcaa aacatcctca tgtattggga ccgcaagcaa
     7621 gggatgatgg tacctcacac tggcccagat gagatcccac acgaggttga cgaccagcgc
     7681 caggcgcctt cagggggcgg ggggcgcaag ggccgcaagg accgggagag ggagcgcttg
     7741 gagaaggaga gggctgagaa ggagcgcctg gaaagggaga aggctgagag ggagcgcctg
     7801 gagaagctgc gggccatgga ggagagaagc gatggggaag gggaaggaga agaggagcat
     7861 gagggaaaga aggatctcgg ggtgcccttt atcaacatcc agactccgga ctttgaaggc
     7921 ataagctgga agcaagccct ggagagtgac aagcttccca aaggagatca gatcctgaac
     7981 atcctaggcc tgggatcctc aggaccaccc atccctcctc cagtcttgtt ctccatcatc
     8041 tcttacccag cgaagcggca gtctttggtc gccactgaga tcctgaagca ttttgtgttt
     8101 gtgattccac caaatgatga cctccccctg tcggatgaga aaaaagacat ggaaggagac
     8161 tcagatctct tcctcaacac catcgtcacc aaggctcagg aggaacagcc ctccccacct
     8221 gctaagggaa gcaagcagaa atcgaaagac aaaacagaac aagctcgcga aactcagaag
     8281 gataaacgtc gcacgtattc cggcaggaaa ggcctctctg gcggggcatc agggaacctt
     8341 gctccgatgt ctgacataga ccaaaacaac ttcgatggag aacactccca ggagaagttc
     8401 atcaggctga atcacttccg gtggattgtg cctccaaatg gagaggtaac cttgagaatg
     8461 cacttctcct ctttcgacgt tggaaactat gaccaaacat ttaattttga gctccttggg
     8521 acccgccgtc aataccagct ctactgccgt ggggtgtgca cctacccata catctgcaaa
     8581 gacccaaaaa ttgtgtaccc tcagaggaag aaggacatga agttaaagga agtcgtcgtt
     8641 aagaagtatg tagtgagcat ggataagttt tactttggcc cactgctctg tggcaagtca
     8701 agagacaagt ataagtcatc cttgtaccct gacaacatgg agacactgac aatcctgaat
     8761 gattccccaa tggtggtaga ggcatacttc tgtttccagc acgacgtaaa agcgagcacc
     8821 tactttctag agcccgtcaa catgactctg aaacccaatg aaaagcagat cctaaatgta
     8881 tgggcctacc ctactgcagt cggtgtcttt gaagacagca ttgtctgctg catcaaggag
     8941 aacccagagc cagccatctt taagatatgc tgccaaggaa tccgcccaga aattgaagtg
     9001 gagcccaggc agttacattt tgaccggctc ttgcttcata gaaaagaatc caagtcacta
     9061 gttctccgta atgtcacgtc tcttcctgtg gcctggagga tctccagcct ggaacaccta
     9121 ggggaggact tcactgtatc catgatgcag ggcactatgc tgcctaaggg agagtttggg
     9181 ctacaagtgc acttccagcc ctccaaacct gtcaacatca agaaggccat tcggattgag
     9241 gttttagatg cagagaatct tgtgggtgtc gttcagatcg aaaacatctt gatctttgca
     9301 gaatcctatg atatcgcttt ggacatcacc ttccccaaag gaactgaagg aggtctggac
     9361 tttgggactc tgagggtcct ggaggaagta aagcagcccc ttcaactgaa gaaccgtgga
     9421 aaatacgaga tcatattcag tttcactgtg gactccgtag gcattttgcc aacaaactta
     9481 agttccatga tctggatcca acccaaaagg gggacactgg cctcaataga taagcccacg
     9541 accgtgcaag tgttcttccg agcaagaaag gaagtgaagg tcgagtccca gcccatcctg
     9601 cgctgccaga ttattgagcc agctctctca gaaggtgaga tcattgccag catccctatc
     9661 aagttttctg tgaatgcggt gtactccaaa ttcaccatca gcccctcctc catcatcaat
     9721 tttggggctt tgatctgcgg tacaaggaaa agcatcacct tcactataga aaaccaaggc
     9781 ataatcgact tcaaatatgc cctctacagg ctgactgggg agagtccaat tctccaaaag
     9841 aaagcgacca gccacatgag gcatgggaga acccgagaaa gtgagagctt ctacaagccc
     9901 ggagccccta aaatggccaa gttctcggac atagtccaga aagacatgaa catagcaaac
     9961 caggcccgct tcacccatgg catgttcact gtatacccgg gatttggctc cgtttcttcc
    10021 ggaggacaac aggtcatcac tgtggagtgt gtggccgatc ctgtggggag gtgtgaggag
    10081 tttctggcca tcgatatctc tgaccgagac cctagagaaa accctgccgg catcccttac
    10141 actctgcttg ccgaagcttg tctaccagcc tttgtgaccg acaacaacat cttgatattt
    10201 gaagaacatc agatctgtac cagccccaac ctgtaccaca tccaacagac catacagagt
    10261 ggggggctat tcgtggagga tgagaacaag ttcatcttct gcaatgtcct ggtgggtcat
    10321 aaggccaagg ctcggttcaa gatcagcaac gtgggaaaga tctcctgtga tgtcaacatt
    10381 atcgtcaggc ccatctccaa caaggtagtc aaccgcatca ttgacatctt tgacgtggat
    10441 cccaacaaga tgtgcattgg gagccgctca catgccttcg ccacagtgtt gttcacacca
    10501 caggccatgc agacctacca gtgcatcttc gaggccacct tggatggcct tcccagcacc
    10561 ctggcaagga gccgaggtct tgtgtttgat attattggtg aggggaccct ccctcgagtg
    10621 actgtcatcc ggccaactct ctataaccaa cacggaaacc ccttgctcct gtttaagagg
    10681 cttctgcttg gtcattcaga gaaactgcct ctcatcctca agaacaacgg caccatcccc
    10741 gcccagcttc atgtagacct gcgagaccaa ctaggagtct tctctctgaa agggagaccc
    10801 accacctcct atatctacat catggaggaa aacaaaccga atgaaaaagt taaaaaagcc
    10861 cacacagcct ccctggtggt ttctcctgga gacacagccg aattcgatgt ctttttccac
    10921 tccaataaga ttgggagaat gacaggcacc atccacttaa cagtgatcaa caaccagtat
    10981 gaggagacca tgatccacct ggttggagaa agctatgaag atgacatcac cttggacaac
    11041 atccatgggc tgatcaatac cactagccag gagacctcgg agatgtctga ggtcatagag
    11101 attgcagagg agagcgccat ggaggactta gtgacagccg ccctgctgga tcacatccag
    11161 tttgggtact gtcacatcgg aatcagctac aatgtgagct tcaccatcac caatcacagc
    11221 caagcgaatg tgattcgctt tgagtggccc cttttagcaa cactgtcttt ctccccacag
    11281 atagggcatc tccaccctgg ctgttccaag gacgtagtgg tgaccttgaa gtcagagtcg
    11341 cccatcaccc tgaagaagat gtgtgtgaag tgcaagcttt ccaagatcat gtttcagctc
    11401 cctgtagacc aggtccccga ctgggatgac cgcatgcgca cagtcaagtg ggtggatgct
    11461 ccccgaaata cacctgggaa cctgactaca aaacgaaagg tcatagagac ggaccccgag
    11521 ccagcccact cggtggtaga agaaaattac cgagagttgc ggatccagtt cagtgccaac
    11581 gtggattttg cttcctataa gtgtgaaacg agtgaagtgt tctttaagga aacactggtt
    11641 taccagaccc gagtatttga gtttgacctt gttaacacag gacaggtgct gttagaattc
    11701 tgctggatct cagaagaagt ctccaagata gtcagtttcg ccatgccaga gaatccaggt
    11761 tccagtcaaa aagatcagct aagtcagggg acgggcagct ccctagacag tgccctggac
    11821 cactggactg aagcctctcc atcacccttc tcggtggaac cctcctcggg ctttgtgcct
    11881 gtaggcaaga ctcagaagct caaactgaag ttctccccaa tggacattgg agagttcgag
    11941 agctccctgt actgccaaat tcccaacctg ccactcggag aacaaggccc tcttctgata
    12001 acgaaagggc ggagcgtcct tccattctgc catttcgacc tgaaggaatc agactacatc
    12061 agtggtcatc ggcgcaaccc agagctccga ggaccaggtt ctgggcctct cgaacctaac
    12121 acccgagtga tcgagttcac cagcgtgggc ataggcggaa agaatctcag gaccttcacg
    12181 attctgaacc caaccaacag cacttactct ttctgctgga cctctgaaga gacagagagt
    12241 ctccagaatc ctccggcctt cgtgtgtctc acagagaagg gtattatcca ccccgagaag
    12301 aaagctgaga ttatattcca gttcctgccg gctcacctgg acatcacgga agcattctgg
    12361 actttctcta tcccagagca caatatctca gtgcccttcc tgctggtggg caagaccaca
    12421 gaccccctca tctctcttga caaatcacac ctcaacttca gctctctcct cataggcaga
    12481 gaagcccgag agacggtaaa gatcatcaac aaggaggagc aaggattcaa tttcgccttc
    12541 caggacagct cccgctattc tgaaggattc aacaacagcc tcatcgtctg tcccatggaa
    12601 ggctggatcc caccactgtc caggttccca gttgatatct tcttcacacc aaagcaagaa
    12661 ggagatgtga actttaattt gatctgcaac ataaaaaaga aagctcaccc tctgacactc
    12721 aacgtcaagg cggagggcta cactatgaac gctgaggtca agtgcagaga ccggatgggc
    12781 tccaccaccc tcctaacgtc cacccaggtc aacaccatca acttctacga ggtggagttg
    12841 aatgagtgcg ttcagtgtga attcaatttc atcaacactg gcaagttcaa tttcagctac
    12901 caggcagagc tctctgggcc caaattcctg ttgcagtatt tggacttcac gcccaccgac
    12961 aatagtgtag atgtgggtca gtcagaacca gccagcctgt ctttccaacc gtatcagaag
    13021 tgtgtcttga agggcctgga actcaaaatc aagatcagcc atggcccaac attcatatgc
    13081 aacgtcgtag gctgtgctgt gagcccagct gtccatttct ccttcaccag ccacaacttt
    13141 gggacttgct tcatctacca agctgggatg cccccataca aacaaaacct cgtcgtcacc
    13201 aacagggaag aaacatctat gagcctagat tgtttataca ccaacacccc acacgtcgag
    13261 gtgaacttca gtgtggatgt gataaagcca gggaagacac tggagatccc aatcaccttt
    13321 tacccccggg aagctatcaa ctaccgagaa ctcatcccct ttgaaatcaa tgggctctct
    13381 caacagacag tggagatcaa agggaaaggc acagaaatga agcttttagt cctagatcca
    13441 gccaacagga ttgtaaagtt gggagctgtc ctgccagggc aggtcgtaaa gaaaacagtt
    13501 tccctcgtca acaatagcct tgcccagctc acctttaatc actcaatcat gttctccatt
    13561 ccagagctcc aggaagccaa ggtcatcacc gtggagccct tccacagtat caccatgaag
    13621 cctaaggaag tctgtaaact agagattacc tttgccccca agaagcgagt ccctcctttc
    13681 tctgaggaag tcttcatgga atggatgggg ctactgcgtc ccctcttcct cctcagtggc
    13741 tgttgtcagg ccctggagat ttccctggac caagaacatc ttcccttcgg tcctgttgtg
    13801 tatcagacac aagccacacg gcgcattctc atgatgaaca caggcgatgt gggtgcaagg
    13861 tttaaatggg atgtcaagaa gctcaagccc cacttcacca ttagccctga agaaggttac
    13921 atcacctcag gcacagagat tgctctagaa gtaacctacc accccaccga gatagggaag
    13981 gagagtctct ataaaaacat tctctgcttc atccaaggag gaagtcctct gtgcctcacc
    14041 ctgtctggaa tctgcgtggg accacctgta gtaaaagagg tggtgaattt caactgccaa
    14101 gtgcgctcca ggcacacaca gactatcctg ctctcaaacc gttccaacca gacctggaac
    14161 ctgcacccca tctttgaggg tgagcactgg gaggggcctg agttcatcac cttggaggcc
    14221 catcagcaaa acaagcccta cgagatcacc tacaagcccc gaaccatgaa cctggagaac
    14281 cgcaagcacc agggcactct atttttccca ctcccggatg ggactggctg gctatatgcc
    14341 ctgcatggga ctgccgaact ccccaaagct gttgccaata tctaccgtga ggttccatgt
    14401 aagactccct atactgagct cctgcccatc agcaactggc tgaacaagcc ccagagattc
    14461 cgagtcattg tggaaatatt gaaaccagag aagccagacc taagtgtcac tctgaagggc
    14521 cttgactaca ttgatgttct gtctggctcc aagaaagact acaagctgaa cttctttgcc
    14581 tacaaggagg gactgtacac ggcaaaggtg atcttccgga acgaggtgac caacgagttc
    14641 ttgtactaca ctgtgagttt cagggtcacc ccttctggca tcataaaatc catccagatg
    14701 acaagcccag tccgccagag cgtatcagcc tccatcaagt tggagaaccc cctgccttat
    14761 tcggtgacct tctcaacaga gtgcaagttg aatgacatca gcctgccttc ccagtttgct
    14821 gtacctccaa actctgaggg aacgttctcg tttgaattcc agcccttgaa agctggagaa
    14881 atctgcggga gactgacctt gcacaatggt gacttgggct actaccagta tgagctcctg
    14941 ctgaaggcct tgcctgcacc ccctgagaaa cctgtccact tccagaccgt tcttggcagc
    15001 agccaaagca tcttagcgaa gttcaccaat tatacccggc tgaagactga gtactactgc
    15061 aagactgact gttctgactt ccacacagaa aaaattatta atgcagcccc aggagcccag
    15121 ggtggcactg aagtcagcgt ggaagtcatc tttgagccca gccatctggg tgagaccaaa
    15181 ggcatcctgt gcctgtcgtc actcataggt ggggaatata tcatcccact ctttggaatt
    15241 gctctgcccc ccaagcccca aggccccttc ctgatcagag ctggatacaa catcatcatc
    15301 cccttcaaga acatcttctt gcatgcaaca aacttctcct tcattgtgga gaacccagcc
    15361 ttcaccatcc gggctgcaga atctgtgcgg cccaagaaga tcaacaacat cacagtctat
    15421 tttgagggga acccgtcagg cagtaaaacc cctatcacca ctaagctgat tgtcacctgc
    15481 cctcagtgtg aaggcactga atctggaatc aaatgggttt attatctgaa ggggatcaca
    15541 ccttaagtta caactgcatc aactggcagc tgtcctctca gactataagc catgcctcgt
    15601 gctgtcccaa caaagaatag agaagaaaag gagaattttc cagggacttt attgtatgtg
    15661 tttaattgta ggagaagtga ttttatatta tattttacaa atacagatgt gaaatttatg
    15721 ctccacatta aaatttatag tgacacacaa cagatcta
//
