LOCUS       NM_001191969            1798 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus hyccin PI4KA lipid kinase complex subunit 1
            (Hycc1), mRNA.
ACCESSION   NM_001191969 XM_575330
VERSION     NM_001191969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Baskin,J.M., Wu,X., Christiano,R., Oh,M.S., Schauder,C.M.,
            Gazzerro,E., Messa,M., Baldassari,S., Assereto,S., Biancheri,R.,
            Zara,F., Minetti,C., Raimondi,A., Simons,M., Walther,T.C.,
            Reinisch,K.M. and De Camilli,P.
  TITLE     The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P
            synthesis at the plasma membrane
  JOURNAL   Nat Cell Biol 18 (1), 132-138 (2016)
   PUBMED   26571211
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Gazzerro,E., Baldassari,S., Giacomini,C., Musante,V., Fruscione,F.,
            La Padula,V., Biancheri,R., Scarfi,S., Prada,V., Sotgia,F.,
            Duncan,I.D., Zara,F., Werner,H.B., Lisanti,M.P., Nobbio,L.,
            Corradi,A. and Minetti,C.
  TITLE     Hyccin, the molecule mutated in the leukodystrophy hypomyelination
            and congenital cataract (HCC), is a neuronal protein
  JOURNAL   PLoS One 7 (3), e32180 (2012)
   PUBMED   22461884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575330.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.17930.1,
                                           SRR26643298.21290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               JAXUCZ010000004.1  12024780-12024983
            205-283             JAXUCZ010000004.1  12048010-12048088
            284-385             JAXUCZ010000004.1  12057398-12057499
            386-565             JAXUCZ010000004.1  12061022-12061201
            566-646             JAXUCZ010000004.1  12061843-12061923
            647-762             JAXUCZ010000004.1  12062401-12062516
            763-858             JAXUCZ010000004.1  12062803-12062898
            859-975             JAXUCZ010000004.1  12064596-12064712
            976-1063            JAXUCZ010000004.1  12068458-12068545
            1064-1223           JAXUCZ010000004.1  12069377-12069536
            1224-1798           JAXUCZ010000004.1  12084023-12084597
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="hyccin PI4KA lipid kinase complex subunit 1"
                     /db_xref="GeneID:499975"
                     /db_xref="RGD:1562906"
     exon            1..204
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            205..283
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /note="down-regulated by Ctnnb1, A; family with sequence
                     similarity 126, member A"
                     /codon_start=1
                     /product="hyccin"
                     /protein_id="NP_001178898.1"
                     /db_xref="GeneID:499975"
                     /db_xref="RGD:1562906"
                     /translation="MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKV
                     IQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELIWCYLAVSASRNVHSSGCIE
                     ALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKV
                     VYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQ
                     HVRKYGGASSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPL
                     LVANAIKASLPPGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTE
                     LTGQEELTEITEVDEGFYSRAASSTSQSGLSISSHNCSHKTSVGKNQRRSGGSKAGAK
                     ERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSHGLAQTAATVF
                     SKSFEQVSGVPGPRSPSPAIGCVAGADAHRFSACSLQEEKLIYGSERIDLPLKCQAGQ
                     RGPPSVSITLSAD"
     exon            284..385
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            386..565
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            566..646
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            647..762
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            763..858
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            859..975
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1063
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1223
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1798
                     /gene="Hycc1"
                     /gene_synonym="Drctnnb1a; Fam126a; RGD1562906"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagcggct ggcggcagtg gcggctgtcc gggctgggtt gtcagtcaga gagaggaggg
       61 aagatggctc gcccggactc gtgctgctag aaggagaggg gcaggtggct cagctgccgg
      121 cggagcgccg tcgccgggtc gccgtagtcg cagtggtcgc cgtggtcgtg aggggaggcc
      181 gcggtgggtt ccggagctgc tctggttgaa ggtttggaac aaatgtggaa aaatgttcac
      241 ctcagagata ggggttgtag aagaatggct gtcagaattt aagacactcc cagaaacatc
      301 tttgccaaat tatgccacaa atttgaaaga caagagttct ttagtttcat ctctctataa
      361 agttatccag gagccacaga gtgagttact agagcctgtg tgtcaccagc tctttgagtt
      421 ctaccgcagt ggggaggaac agctgctgcg gttcactctg cagtttctcc ccgagctgat
      481 ctggtgctac cttgccgtgt cagccagcag aaatgtgcac agcagcggct gcattgaggc
      541 ccttcttctg ggggtttaca acctggaaat agttgacaaa catggacata gtaaagtact
      601 gagttttaca attccgtctt tatccaaacc atctgtatac catgaacctt ccagcattgg
      661 gtctatggca ctgaccgaga gtgcactctc ccagcatggc ttatcaaaag tcgtgtacag
      721 tggcccccat cctcaacggg agatgctgac agcacagaac aggtttgaag tgctgacatt
      781 ccttctgctg tgttacaacg ctgccttaac ctacatgccc agtgtttctc tccagtcact
      841 gtgtcagatc tgttcaagaa tctgtgtgtg tggatatccc cgacaacacg taagaaagta
      901 cggaggtgca agcagcagga taccgatctc atctggcttc atggtacaga tgctaacagg
      961 cgtgtatttt gccatataca atggagaatg ggatctagct cagaaagcac tggatgacat
     1021 tatatacaga gcccagctag aactataccc agagccactg ctggttgcta atgcaataaa
     1081 ggcttcattg cctccgggtg ccatgaaatc tagtaaggaa ggtacacggt gtattcaagt
     1141 ggagatcaca ccaacgtcct ccagaatatc aaggaatgca gttaccagca tgtcaataag
     1201 aggtcacagg tggaaaagac atggagatac agagttaaca ggtcaagaag aactgacgga
     1261 gataactgaa gttgacgagg gattttattc cagggctgcg tctagcacca gccagtcggg
     1321 tctatcaatc agtagtcaca attgtagtca caagacaagt gtaggaaaga accagagacg
     1381 gtcgggagga agcaaagctg gagcaaagga gagagaaact gcaggggaat cttgcagaga
     1441 tcactttgct cgcaaacaaa cccagagagc ccagagcgag aaccttgagc ttctctctct
     1501 gaagagactg accttgacct ccagccagtc cctgcccaag cccagcagcc acggcttggc
     1561 tcagactgcg gccactgtat ttagtaaatc ctttgaacaa gtgagtgggg tcccaggccc
     1621 acgtagccct tctcctgcca ttggctgtgt tgctggggca gatgcccata gattttctgc
     1681 ttgtagtctc caagaagaga agcttattta cgggtcagaa aggattgacc ttccactgaa
     1741 gtgtcaagca ggccagcggg ggcctcctag tgttagcatc actctgtctg cagattaa
//
