LOCUS       NM_001024321            2122 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus hyaluronoglucosaminidase 5 (Hyal5), mRNA.
ACCESSION   NM_001024321 XM_575408
VERSION     NM_001024321.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Reitinger S, Laschober GT, Fehrer C, Greiderer B and Lepperdinger
            G.
  TITLE     Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but
            not HYALP1 degrade hyaluronan
  JOURNAL   Biochem J 401 (1), 79-85 (2007)
   PUBMED   16925524
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Kim E, Baba D, Kimura M, Yamashita M, Kashiwabara S and Baba T.
  TITLE     Identification of a hyaluronidase, Hyal5, involved in penetration
            of mouse sperm through cumulus mass
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 18028-18033 (2005)
   PUBMED   16330764
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091219.1.
            
            On May 27, 2005 this sequence version replaced XM_575408.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2122
                     /gene="Hyal5"
                     /note="hyaluronoglucosaminidase 5"
                     /db_xref="GeneID:500052"
                     /db_xref="RGD:1566275"
     exon            1..111
                     /gene="Hyal5"
                     /inference="alignment:Splign:2.1.0"
     exon            112..1265
                     /gene="Hyal5"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1892
                     /gene="Hyal5"
                     /EC_number="3.2.1.35"
                     /codon_start=1
                     /product="hyaluronidase PH-20"
                     /protein_id="NP_001019492.1"
                     /db_xref="GeneID:500052"
                     /db_xref="RGD:1566275"
                     /translation="MRVLCFKHSFFGSLLESSGLPQTLLVFLLIRCCLTVDFRAPPLI
                     PNVPFLCAWNAPTESCATRFNQPLDLSLFSLVGSPRKTAIGHPVTIFYSDRLGLYPHI
                     DEMHTAFHGGIPQLGSLKSHLEIAKGDIHHYMPIDNVGLAVIDWEDWRPTWSRNWKFK
                     DIYRNKSIEFVQQQNTQLNLTEAVKRAKQEFEEAARNFMEQTLKLGKLLRPNHLWGFY
                     LFPDCYNNNFQDANYKGDCPDIEKQRNDALFWIWKESTALYPSIYLKSSLKSSPLAAL
                     YVRNRVQEAIRMSKVKDPHNPLPIFVYFRPVFTDLTFQYLEQDDLVNTIGETVALGAS
                     GIVMWGTLNLSQTMKSCMNLHDYLKTTLNPYIINVTLAAKMCSQTLCQNQGICSRKDW
                     NSNDYLHLSPRNFQIHFIKHGKYEIIGSPTLDDLQYFSKNFRCSCFSNLDCKERVDIN
                     HVSRVNVCTLEDICINSLVISDRSKLHDNWDHLYFANDKQSGITSSATVSPCVPRKDV
                     SGYLFVLSLYSRHLKYSL"
     exon            1266..1355
                     /gene="Hyal5"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..2085
                     /gene="Hyal5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccggaga ctctagctag gccatggttc acatgaacgt aggaggagta tcttttacta
       61 taatgaaagg gcaggtggtg aggagttctg cataaggtcc tttccagcaa gttatagatt
      121 atacaacttg tcacaaagca tccctgaaaa atgaagcaag acgaataata gttcaatgaa
      181 gagcagccat cccactttca tctcccacag tgacctcata tcagtatctt tctcatcttt
      241 tgcactagat atttgagaga tcaaagtgaa taagaagtaa taagtgcttg gatactaatt
      301 aattctctgc aatgcgagtg ttgtgtttta aacactcctt ctttgggagc cttcttgagt
      361 ccagtggact accccagact ctattagtct tccttttgat tcgatgttgc ttgactgtgg
      421 attttagggc acccccactt atccctaatg tgcctttcct ctgtgcctgg aatgccccaa
      481 ctgagtcttg tgccacgagg tttaatcagc cactagatct tagtctgttc tctttagtag
      541 gaagccccag aaaaactgcc ataggtcatc ctgtcacaat attttattct gatcgtctgg
      601 gtctctatcc tcacatagat gaaatgcaca cagcttttca tggaggtata ccccagctgg
      661 ggtctctaaa atctcatttg gaaatagcta agggtgacat ccatcattac atgccaatag
      721 acaatgtggg cttggctgtc attgactggg aagactggcg gcctacctgg tcaagaaact
      781 ggaaattcaa ggatatttac aggaataagt ctattgagtt cgtccagcaa caaaacacac
      841 aacttaattt gacagaagct gtcaagaggg ctaaacaaga atttgaagag gcagcaagga
      901 attttatgga acagacttta aaattgggaa aattacttcg tccaaatcac ttatggggtt
      961 tttatctttt tcctgattgt tataacaaca attttcaaga tgccaattac aaaggagatt
     1021 gccctgatat agaaaagcaa aggaatgatg ctctcttctg gatatggaag gaaagcacag
     1081 ccctgtaccc atccatctat ttgaagagca gcttaaagtc atccccactg gcagcactct
     1141 acgtcagaaa tcgcgtacaa gaagccattc gcatgtctaa agtaaaagac cctcataatc
     1201 cacttcctat ttttgtatat ttccgccctg tctttactga cctaactttc cagtatctgg
     1261 aacaggatga ccttgtgaat acaattggtg aaacagttgc tctgggtgcc tctggaatag
     1321 taatgtgggg aactcttaat ttatcacaaa ctatgaaatc ttgtatgaac ttacatgatt
     1381 atttgaagac caccctgaat ccttatataa tcaatgtcac ccttgcagcc aaaatgtgta
     1441 gccaaacact ttgccagaat caaggcatat gttcgaggaa agattggaat tcgaatgact
     1501 atctacactt gagccctcgg aattttcaga ttcattttat aaaacatgga aagtatgaaa
     1561 tcattggcag tcccactctt gatgatctgc agtatttttc caaaaacttc cgttgcagct
     1621 gtttctccaa cttggactgt aaggagagag ttgacataaa ccatgtgagc agggtcaatg
     1681 tgtgtactct tgaagacatt tgcattaatt cccttgtaat ttcagaccgt agtaagctac
     1741 atgacaactg ggatcacctt tattttgcta atgacaaaca gtcaggtatt acatcatctg
     1801 ccacagtgag tccatgtgtg ccaagaaaag atgtcagtgg gtacctcttt gttctctctc
     1861 tctattcacg gcatttgaaa tattcactat agggttttga ccactgaaaa actggacact
     1921 atcttttgaa aataattcta tgtaaataat caggattata ctttgaattt tagaggcaaa
     1981 atgtatattc ttctatcaaa aactgattgc aaggctgtca tatttttagg gatatggtct
     2041 tctgagaaga gtgaagatta aataaaatca agttgctata ataaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aa
//
