LOCUS       NM_001100780            3266 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hyaluronidase 4 (Hyal4), mRNA.
ACCESSION   NM_001100780 XM_001062033 XM_578235
VERSION     NM_001100780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3266)
  AUTHORS   Kaneiwa,T., Miyazaki,A., Kogawa,R., Mizumoto,S., Sugahara,K. and
            Yamada,S.
  TITLE     Identification of amino acid residues required for the substrate
            specificity of human and mouse chondroitin sulfate hydrolase
            (conventional hyaluronidase-4)
  JOURNAL   J Biol Chem 287 (50), 42119-42128 (2012)
   PUBMED   23086929
REFERENCE   2  (bases 1 to 3266)
  AUTHORS   Fiszer-Szafarz,B., Litynska,A. and Zou,L.
  TITLE     Human hyaluronidases: electrophoretic multiple forms in somatic
            tissues and body fluids. Evidence for conserved hyaluronidase
            potential N-glycosylation sites in different mammalian species
  JOURNAL   J Biochem Biophys Methods 45 (2), 103-116 (2000)
   PUBMED   10989127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_578235.1, XM_001062033.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3266
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3266
                     /gene="Hyal4"
                     /note="hyaluronidase 4"
                     /db_xref="GeneID:404783"
                     /db_xref="RGD:1303194"
     exon            1..48
                     /gene="Hyal4"
                     /inference="alignment:Splign:2.1.0"
     exon            49..193
                     /gene="Hyal4"
                     /inference="alignment:Splign:2.1.0"
     exon            194..1196
                     /gene="Hyal4"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1688
                     /gene="Hyal4"
                     /EC_number="3.2.1.35"
                     /note="hyaluronoglucosaminidase 4"
                     /codon_start=1
                     /product="hyaluronidase-4"
                     /protein_id="NP_001094250.1"
                     /db_xref="GeneID:404783"
                     /db_xref="RGD:1303194"
                     /translation="MQLLSEGQLRRCVVQPVHLTSGLLIFFILKSISSLKPARLPVYQ
                     RKPFIAAWNAPTDLCLIKYNLAVNLKVFQMVGSPRLKDRRQNVVIFYANKLGSYPWYT
                     SEGVPINGGLPQNTSLQVHLEKAYQDINYYIPSENFSGLAVIDWEYWRPQWARNWNTK
                     DIYRQKSRTLISDMKENISTADIEYLAKATFEKSAKAFMEETIKLGIKSRPKGFWGYY
                     LYPDCHNYNFYATNYTGSCPEEEVLRNNDLSWLWNSSTALYPAVSIRKSFADSENTLH
                     FSQFRVRESLRISTMTSHDYALPVFVYTRLGYKEEPLLFLSKQDLISTIGESAALGAA
                     GIVVWGDMNLTSSAENCTKVNRFVNSDFGSYVINVTTAAEVCSRHLCKNNGRCARKTW
                     KAAHYLHLNPASYHIEASADREFVVKGRASDADLAAMAENFLCHCYEGYEGADCRDMT
                     EASGPSGVSVSSSSVITLCLIALAGHQSIQL"
     exon            1197..1286
                     /gene="Hyal4"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..3266
                     /gene="Hyal4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctctggag caggtgaata aaggaccagc aggcaaacaa aagcaaaggt tttaaacata
       61 gtttatcaca actgttctgc tgagaggaat agaggagagt ggcttcttcg ctgacccctg
      121 tctgtatgtg gcagactcca cccaagggcc acgtactcgc cgtcttcact atctggaaga
      181 gtaaaccaaa gaggcctttt ggattacgtt gaagaagagg tagtgtaagt ttctatctta
      241 tcatgcaact attgtctgaa ggacaattaa gacgctgtgt tgttcaacca gtacatctta
      301 catcagggct gctcatattt tttatcctga agtctatctc atccctaaaa cctgctcgac
      361 ttccagttta tcaaaggaaa ccttttatag ctgcttggaa tgctccaaca gacctgtgtt
      421 tgataaaata taatttggca gtgaacttaa aagtgtttca gatggttgga agccctcggc
      481 tcaaagacag gaggcaaaat gttgttatat tttatgccaa caaattggga tcttacccat
      541 ggtatacatc agaaggggta cccatcaatg gtggtcttcc ccaaaacaca agcttacagg
      601 tacacctgga aaaggcttac caggatatta attattacat cccttctgaa aatttcagtg
      661 gacttgctgt tatagactgg gaatattggc gcccacagtg ggcccggaac tggaacacca
      721 aggatatcta cagacagaag tcaagaactc ttatttctga tatgaaggag aacatatcca
      781 ctgctgatat tgaatattta gccaaagcaa cttttgagaa aagtgcaaaa gctttcatgg
      841 aggaaactat caaattggga attaagagca gacccaaggg cttttggggt tattacttgt
      901 atcctgactg ccacaattac aatttttatg ctacaaacta taccgggtca tgcccagaag
      961 aggaagtttt gaggaacaat gacctctctt ggctctggaa cagcagtact gctctgtatc
     1021 ctgctgttag tattaggaaa tcctttgcag acagtgaaaa tactttgcac ttctcacaat
     1081 ttcgggtgcg tgaatcactg aggatctcta ctatgacatc acatgattat gctctgcccg
     1141 tatttgtcta cacacggctg ggctacaaag aggaaccttt gcttttcctt tctaagcaag
     1201 atctaattag taccatagga gaaagtgctg cgttgggagc tgcaggcatt gttgtttggg
     1261 gagacatgaa tttaacttca tctgcggaga actgtacaaa ggtgaaccgc tttgtgaact
     1321 ctgattttgg tagctacgta atcaatgtga ccacagcagc tgaagtgtgc agtcgtcatc
     1381 tttgcaagaa caatgggagg tgtgcacgga agacatggaa agcagctcat tacctccact
     1441 tgaaccctgc gagttaccac atagaggcct ctgcagatag agaattcgta gtgaagggaa
     1501 gagcgtcaga tgctgaccta gccgccatgg cagagaattt tctatgtcac tgttatgagg
     1561 gctatgaggg ggctgactgt agagatatga cagaggccag tggcccctcg ggggtttccg
     1621 tttcctctag ttcagtaata acactgtgtc tgatagctct agcaggtcat caaagcattc
     1681 agctgtgaca taattgactt taaagggaat tgtgtccttt taagtagggt attatggagc
     1741 agatggattt cacatgctcc tctgagttcc tctgagagcc attataaatc aacattatgt
     1801 cacaacatga ataggaacct cttaccttct ttgctacact ttggttggaa gccaggtcta
     1861 agagaataaa gcagtgcact ctgttctctt acttgaatgt ttcaatggca tttaaatcaa
     1921 agtttattct ttttctaatt atataggcac aagtgtgcaa atgaatagta agcttattat
     1981 ttcaagcaca ttttctagga aagcagttca tttacaggca ggttacaacg taagcacctg
     2041 gttcaacagt cgtgacccgg tcaactaatt catcagagga ggtgaaccgc cgtgctactg
     2101 ggccagcctc cgcctcactt gcgtctgttt ccctgatgaa ctcatggagg acaggattac
     2161 tactggtgtg gtttctcaag agaaagaatt caggttgctg actccaactc atcacaacca
     2221 tcaacctctt ccttctcaga ccttaccagt ctgcaaaaca aaaaggtcca ggatccactg
     2281 aactatagat ccaaaagctg aagtcctgtt gacgtttgaa agtggaacct ttctttcttt
     2341 cttttctttt ttatgaaaag aaagtgtata aggaaaatca gctactttgt cttcctctgt
     2401 tccccatata aattttgagt agtagatttg ggtttagaat cactttgaac ctgatttgaa
     2461 ttacgctgtt cactctttat gtggggttat aaatcttaac aagttcttta cagccctctt
     2521 tatcttctgg aatttggtag tataattctt gtctcagcga attagcacag taatttgcct
     2581 tgcactcctg ggttcttagt aatgtagctg atccaggaca atctcttgaa cactaaagca
     2641 acagtcaagc tgtttccttc tgtggacagc gaccatttat aatcacttag acattgtgct
     2701 gtgttccttg agggatactc tcaggggata cagttttctc tccataaaga taatttaata
     2761 ggaagagaaa ctcaagaaag atatgatgat actaataaag aagggatacc acttgagtct
     2821 tctcttcttt cttaactctt tcaactcagg atccctgctt gccagaggtg actgtgaaag
     2881 tttaattctg aaatgtacac tagaaacaaa caaagcctta attatactgt gaatgaaagg
     2941 catgattata tatatgtata tatatgctat ttaaaaatta aattcatttt tatatgaaag
     3001 ttgatgtgat tagcattaca gagcatttac aaaattttaa caataaccaa agaaatcacc
     3061 aataaacacc ttactgtaag ctggtaactt tttatgtagt ttttactaat atttcttata
     3121 aaatgatttt tgtatggcta taattatatt ttatattctg tttcaattaa tgatgtgttt
     3181 tcatagcatt ttgtaatctt cacgcatgtt tttaaaaatc tttttctctt ccagtagagg
     3241 gattaaaggt taggattaat gcaaac
//
