LOCUS       NM_207599               1426 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus hyaluronidase 3 (Hyal3), mRNA.
ACCESSION   NM_207599 XM_217256
VERSION     NM_207599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1426)
  AUTHORS   Kurdykowski,S., Mine,S., Bardey,V., Danoux,L., Jeanmaire,C.,
            Pauly,G., Brabencova,E., Wegrowski,Y. and Maquart,F.X.
  TITLE     Ultraviolet-B irradiation induces differential regulations of
            hyaluronidase expression and activity in normal human keratinocytes
  JOURNAL   Photochem Photobiol 87 (5), 1105-1112 (2011)
   PUBMED   21699545
REFERENCE   2  (bases 1 to 1426)
  AUTHORS   Reese,K.L., Aravindan,R.G., Griffiths,G.S., Shao,M., Wang,Y.,
            Galileo,D.S., Atmuri,V., Triggs-Raine,B.L. and Martin-Deleon,P.A.
  TITLE     Acidic hyaluronidase activity is present in mouse sperm and is
            reduced in the absence of SPAM1: evidence for a role for
            hyaluronidase 3 in mouse and human sperm
  JOURNAL   Mol Reprod Dev 77 (9), 759-772 (2010)
   PUBMED   20586096
REFERENCE   3  (bases 1 to 1426)
  AUTHORS   Orimoto,A.M., Dumaresq-Doiron,K., Jiang,J.Y., Tanphaichitr,N.,
            Tsang,B.K. and Carmona,E.
  TITLE     Mammalian hyaluronidase induces ovarian granulosa cell apoptosis
            and is involved in follicular atresia
  JOURNAL   Endocrinology 149 (11), 5835-5847 (2008)
   PUBMED   18653706
REFERENCE   4  (bases 1 to 1426)
  AUTHORS   Monzon,M.E., Manzanares,D., Schmid,N., Casalino-Matsuda,S.M. and
            Forteza,R.M.
  TITLE     Hyaluronidase expression and activity is regulated by
            pro-inflammatory cytokines in human airway epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 39 (3), 289-295 (2008)
   PUBMED   18390475
REFERENCE   5  (bases 1 to 1426)
  AUTHORS   Hemming,R., Martin,D.C., Slominski,E., Nagy,J.I., Halayko,A.J.,
            Pind,S. and Triggs-Raine,B.
  TITLE     Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose
            overexpression increases hyaluronidase 1 activity in cultured cells
  JOURNAL   Glycobiology 18 (4), 280-289 (2008)
   PUBMED   18234732
REFERENCE   6  (bases 1 to 1426)
  AUTHORS   Chow,G., Knudson,C.B. and Knudson,W.
  TITLE     Expression and cellular localization of human hyaluronidase-2 in
            articular chondrocytes and cultured cell lines
  JOURNAL   Osteoarthritis Cartilage 14 (9), 849-858 (2006)
   PUBMED   16600643
REFERENCE   7  (bases 1 to 1426)
  AUTHORS   Lokeshwar,V.B., Schroeder,G.L., Carey,R.I., Soloway,M.S. and
            Iida,N.
  TITLE     Regulation of hyaluronidase activity by alternative mRNA splicing
  JOURNAL   J Biol Chem 277 (37), 33654-33663 (2002)
   PUBMED   12084718
REFERENCE   8  (bases 1 to 1426)
  AUTHORS   Shuttleworth,T.L., Wilson,M.D., Wicklow,B.A., Wilkins,J.A. and
            Triggs-Raine,B.L.
  TITLE     Characterization of the murine hyaluronidase gene region reveals
            complex organization and cotranscription of Hyal1 with downstream
            genes, Fus2 and Hyal3
  JOURNAL   J Biol Chem 277 (25), 23008-23018 (2002)
   PUBMED   11929860
REFERENCE   9  (bases 1 to 1426)
  AUTHORS   Nicoll,S.B., Barak,O., Csoka,A.B., Bhatnagar,R.S. and Stern,R.
  TITLE     Hyaluronidases and CD44 undergo differential modulation during
            chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 292 (4), 819-825 (2002)
   PUBMED   11944887
REFERENCE   10 (bases 1 to 1426)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097259.1.
            
            On Jun 12, 2005 this sequence version replaced NM_207599.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1426
                     /gene="Hyal3"
                     /note="hyaluronidase 3"
                     /db_xref="GeneID:300993"
                     /db_xref="RGD:1303334"
     exon            1..119
                     /gene="Hyal3"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1033
                     /gene="Hyal3"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1375
                     /gene="Hyal3"
                     /EC_number="3.2.1.35"
                     /note="hyal-3; hyaluronoglucosaminidase 3"
                     /codon_start=1
                     /product="hyaluronidase-3 precursor"
                     /protein_id="NP_997482.2"
                     /db_xref="GeneID:300993"
                     /db_xref="RGD:1303334"
                     /translation="MITQLGLTLVVGLTLCLVHVQALLQVPELPFSVLWNVPSARCKT
                     RFGVHLPLDALGIIANHGQRFHGQNITIFYKNQFGLYPYFGPRGTAHNGGIPQAVSLD
                     HHLAQAAHQILHNLGSSFAGLAVLDWEEWYPLWAGNWGTHRQVYQAASWAWAQQMFPD
                     LNPQEQLHKAQTGFEQAARALMEHTLRLGQMLRPHGLWGFYRYPVCGNGWHNMASNYT
                     GHCHPAIITRNTQLRWLWAASSALFPSIYLPPRLPPAYHQTFVRHRLEEAFRVALTGH
                     AHPLPVLAYVRLTHRSSGRFLSLDDLMQTIGVSAALGAAGVVLWGDLSVSSSEEECWR
                     LHDYLVGTLGPYVINVTKAATACSHQRCHGHGRCSWKDPGQMEAFLHLQPDDNLGAWK
                     SFRCRCYLGWSGPTCLEPKP"
     exon            1034..1123
                     /gene="Hyal3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1402
                     /gene="Hyal3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagtcctcc gtactgctgg gaccagcgta ggcagaccga agagttggag ccagagacag
       61 cgagttaacc aaccgtgcgc aggcaggacg cggagcatct tggaactcga cttgaacatg
      121 ttcccatctc tgtggcatga tcacgcagct aggcctaacc ctggtggtgg ggttaaccct
      181 atgcttggta cacgtccagg ctttgctgca ggttcctgag cttccctttt ctgtgctgtg
      241 gaatgtaccc tcagcaagat gtaagacccg ctttggtgtg catctgcctc tcgatgctct
      301 tggcatcata gccaaccatg gccagcgttt tcatggccaa aacatcacca tcttctataa
      361 gaaccagttc ggtctttatc cttactttgg acctagaggc acagcccaca atgggggaat
      421 ccctcaggct gtgtccctag accaccactt ggcacaagct gcccaccaga tcctccacaa
      481 cctaggatct agctttgctg gcttggcagt gctggactgg gaagaatggt acccactctg
      541 ggctgggaac tggggcaccc atcgacaagt ctaccaggca gcctcctggg cttgggcaca
      601 gcagatgttc cctgacttga accctcagga acagctccac aaagcccaaa ctggctttga
      661 gcaggctgcc cgtgcactga tggaacacac actgcggctg ggccagatgc ttcgcccaca
      721 tgggctctgg ggcttttatc gatacccagt ctgtggcaat ggctggcata atatggcttc
      781 caactacaca ggccactgcc atccagccat cattacccga aacacccagc tgcgttggct
      841 ctgggctgcc tccagtgctc tcttccctag catctacctc ccacccagac ttccacctgc
      901 ctaccatcag acctttgtac gacaccgcct ggaggaggcc ttccgtgtag ccctcactgg
      961 gcatgcccat cccctacctg ttctggctta tgttcgcctc acacaccgga gctctgggag
     1021 attcttgtct ctggatgacc taatgcagac tattggtgtg agtgcagcac tgggagcagc
     1081 tggcgtagtg ctctgggggg acctgagtgt ttctagctct gaggaagagt gctggcgtct
     1141 ccatgactac ctagtgggca ctttaggccc ctatgtgatc aacgtgacca aggctgccac
     1201 agcctgcagt caccagcgat gccatggcca cggtcgctgt tcctggaaag acccaggaca
     1261 aatggaagcc tttctacatc tgcagccaga tgacaatctt ggagcttgga agtccttcag
     1321 atgccgttgt tacttgggct ggtctggccc tacctgcctg gagcctaaac cctgagccca
     1381 agaaaacaac atggattcag gaaaaaaaaa aaaaaaaaaa aaaaaa
//
