LOCUS       NM_172040               1940 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus hyaluronidase 2 (Hyal2), mRNA.
ACCESSION   NM_172040 XM_001072871 XM_001072909 XM_001072933
VERSION     NM_172040.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Decleves,A.E., Caron,N., Voisin,V., Legrand,A., Bouby,N.,
            Kultti,A., Tammi,M.I. and Flamion,B.
  TITLE     Synthesis and fragmentation of hyaluronan in renal ischaemia
  JOURNAL   Nephrol Dial Transplant 27 (10), 3771-3781 (2012)
   PUBMED   22529164
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Kurdykowski,S., Mine,S., Bardey,V., Danoux,L., Jeanmaire,C.,
            Pauly,G., Brabencova,E., Wegrowski,Y. and Maquart,F.X.
  TITLE     Ultraviolet-B irradiation induces differential regulations of
            hyaluronidase expression and activity in normal human keratinocytes
  JOURNAL   Photochem Photobiol 87 (5), 1105-1112 (2011)
   PUBMED   21699545
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Andre,B., Duterme,C., Van Moer,K., Mertens-Strijthagen,J., Jadot,M.
            and Flamion,B.
  TITLE     Hyal2 is a glycosylphosphatidylinositol-anchored, lipid
            raft-associated hyaluronidase
  JOURNAL   Biochem Biophys Res Commun 411 (1), 175-179 (2011)
   PUBMED   21740893
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Monzon,M.E., Fregien,N., Schmid,N., Falcon,N.S., Campos,M.,
            Casalino-Matsuda,S.M. and Forteza,R.M.
  TITLE     Reactive oxygen species and hyaluronidase 2 regulate airway
            epithelial hyaluronan fragmentation
  JOURNAL   J Biol Chem 285 (34), 26126-26134 (2010)
   PUBMED   20554532
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Ormiston,M.L., Slaughter,G.R., Deng,Y., Stewart,D.J. and
            Courtman,D.W.
  TITLE     The enzymatic degradation of hyaluronan is associated with disease
            progression in experimental pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 298 (2), L148-L157 (2010)
   PUBMED   19915162
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Danilkovitch-Miagkova,A., Duh,F.M., Kuzmin,I., Angeloni,D.,
            Liu,S.L., Miller,A.D. and Lerman,M.I.
  TITLE     Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase
            and mediates transformation of epithelial cells by jaagsiekte sheep
            retrovirus
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4580-4585 (2003)
   PUBMED   12676986
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Liu,S.L., Duh,F.M., Lerman,M.I. and Miller,A.D.
  TITLE     Role of virus receptor Hyal2 in oncogenic transformation of rodent
            fibroblasts by sheep betaretrovirus env proteins
  JOURNAL   J Virol 77 (5), 2850-2858 (2003)
   PUBMED   12584308
  REMARK    GeneRIF: May degrade hyaluronan by analogy to human HYAL2. Serves
            as an entry receptor for jaagsiekte sheep retrovirus but not for
            enzootic nasal tumor virus. Suppresses transformation by the
            envelope proteins of these viruses in rodent fibroblasts.
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Nicoll,S.B., Barak,O., Csoka,A.B., Bhatnagar,R.S. and Stern,R.
  TITLE     Hyaluronidases and CD44 undergo differential modulation during
            chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 292 (4), 819-825 (2002)
   PUBMED   11944887
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Lepperdinger,G., Strobl,B. and Kreil,G.
  TITLE     HYAL2, a human gene expressed in many cells, encodes a lysosomal
            hyaluronidase with a novel type of specificity
  JOURNAL   J Biol Chem 273 (35), 22466-22470 (1998)
   PUBMED   9712871
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062410.1.
            
            On Aug 28, 2007 this sequence version replaced NM_172040.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062410.1, AF034218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1940
                     /gene="Hyal2"
                     /note="hyaluronidase 2"
                     /db_xref="GeneID:64468"
                     /db_xref="RGD:620321"
     exon            1..98
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..1065
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1566
                     /gene="Hyal2"
                     /EC_number="3.2.1.35"
                     /note="hyal-2; hyaluronoglucosaminidase 2"
                     /codon_start=1
                     /product="hyaluronidase-2 precursor"
                     /protein_id="NP_742037.2"
                     /db_xref="GeneID:64468"
                     /db_xref="RGD:620321"
                     /translation="MRAGLGPIITLALVLEVAWASELKPTAPPIFTGRPFVVAWNVPT
                     QECAPRHKVPLDLRAFDVEATPNEGFFNQNITTFYYDRLGLYPRFDAAGMSVHGGVPQ
                     NGSLCAHLPMLKEAVERYIQTQEPAGLAVIDWEEWRPVWVRNWQEKDVYRQSSRQLVA
                     SRHPDWPSDRIVKQAQYEFEFAARQFMLNTLRYVKAVRPQHLWGFYLFPDCYNHDYVQ
                     NWDSYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSKHSRNFVSFRVQEAL
                     RVAHTHHANHALPVYVFTRPTYTRGLTELSQMDLISTIGESAALGSAGVIFWGDSVYA
                     SSMENCQNLKKYLTQTLVPYIVNVSWATQYCSWTQCHGHGRCVRRNPSASTFLHLSPS
                     SFRLVPGRTPSEPQLRPEGELSEDDLSYLQMHFRCHCYLGWGGEQCQWNHKRAAGDAS
                     RAWAGAHLASLLGLVAMTLTWTL"
     exon            1066..1155
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1880
                     /gene="Hyal2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagctgggg cagtgcttgg gcgaagggcc ggagcgggct tagctggtac caggatggcg
       61 gcggccctgg cgtgggtcct ggcggcgcct ggtgcgagtt cctgagctgc taccaggcag
      121 gtgacacttc ctgtagcccc cagcatgcgg gcaggactgg gtcccatcat cacactggcc
      181 ctagtgctgg aggtagcatg ggcctcggag cttaagccca cagcgccgcc catcttcacc
      241 ggccgaccct ttgtggtagc atggaatgta cccacacaag aatgtgctcc gcgccacaaa
      301 gtgcccctgg accttagggc cttcgatgtg gaggctacac ctaacgaggg ttttttcaac
      361 cagaatatca ccaccttcta ctatgaccgt ctaggcctgt atccacgttt tgatgcagct
      421 gggatgtctg tgcatggtgg cgtgcctcag aacggtagcc tctgtgcaca cctgcccatg
      481 ctgaaggaag ctgtggaacg ctacattcag acccaggagc ctgcggggct ggcggtcatt
      541 gactgggagg aatggcgacc agtgtgggtt cgaaactggc aggagaaaga tgtgtaccgg
      601 cagtcttcac gccagctggt ggccagtcga caccctgact ggccatcaga ccgaatagtg
      661 aagcaggcgc agtacgaatt cgagttcgct gctcggcagt tcatgttgaa cacactccgt
      721 tacgtcaagg cagtcagacc tcagcacctg tggggcttct acctctttcc tgactgctat
      781 aatcatgatt acgtacagaa ctgggatagc tacacaggcc gctgtcctga cgtggaggtg
      841 gcacgaaatg accagttggc ctggctctgg gctgagagta cagctctctt tccctccgtg
      901 tacctggacg agacgctggc atcctccaaa cacagccgca actttgtcag cttccgtgtt
      961 caggaggccc ttcgtgtggc tcacacccac catgcaaacc atgcactccc cgtgtatgtc
     1021 ttcacgcgtc ccacatatac ccgagggctc acagaactta gccagatgga cctcatctct
     1081 accatcggtg agagcgccgc cctgggctca gctggtgtta tcttctgggg cgactcagtg
     1141 tacgcttcaa gtatggagaa ctgccagaac ctcaagaagt acctaacgca gacgctggtc
     1201 ccctacatag tcaatgtgtc ctgggccacc cagtactgca gttggaccca gtgccatggc
     1261 catgggcgct gtgtgcgccg caatcccagc gccagtacct tcttgcacct cagtcccagc
     1321 agcttccgcc tggtgcctgg ccgcacgccc agtgaacccc agcttcgacc tgagggggag
     1381 ctcagcgaag atgacctcag ctacctgcag atgcactttc gctgccactg ctatctgggc
     1441 tggggtggtg agcagtgcca gtggaaccat aaacgggcag ctggggatgc cagtagagcc
     1501 tgggctggag cccacctcgc cagtctcctg ggtttggtag ctatgactct cacctggacc
     1561 ttataaggga tctctccccg cagatagcag tccagctggc ctctggcaca aggatctcct
     1621 tggcacaagg agcctgttag ggggtaggca aatgagtctg gagttggagt gggcagtacc
     1681 cccaggatgc ctagaagagc atccatacca cctgtcaccc ccctgttcta agggggagag
     1741 aaacatcccc tgagatgccc tcatcttgcc agagaagacg aggatacagc taggccgggg
     1801 aaggcctacc tctactctct gttcctggat agtttataat cttggggtct cttttgtaaa
     1861 ttaaatacaa aacaactgcg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa
//
