LOCUS       NM_207616               2888 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus hyaluronidase 1 (Hyal1), transcript variant 1,
            mRNA.
ACCESSION   NM_207616 XM_345980
VERSION     NM_207616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Dai,Y.P. and Gao,X.Q.
  TITLE     Effects of silencing epididymal vascular endothelial growth factor
            (VEGF) expression on hyaluronidase (HYD) activity in arsenic
            poisoning rats through downregulating VEGF receptor 2 (VEGFR2)
  JOURNAL   Bioengineered 12 (1), 1351-1359 (2021)
   PUBMED   33904385
  REMARK    GeneRIF: Effects of silencing epididymal vascular endothelial
            growth factor (VEGF) expression on hyaluronidase (HYD) activity in
            arsenic poisoning rats through downregulating VEGF receptor 2
            (VEGFR2).
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Decleves,A.E., Caron,N., Voisin,V., Legrand,A., Bouby,N.,
            Kultti,A., Tammi,M.I. and Flamion,B.
  TITLE     Synthesis and fragmentation of hyaluronan in renal ischaemia
  JOURNAL   Nephrol Dial Transplant 27 (10), 3771-3781 (2012)
   PUBMED   22529164
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Kurdykowski,S., Mine,S., Bardey,V., Danoux,L., Jeanmaire,C.,
            Pauly,G., Brabencova,E., Wegrowski,Y. and Maquart,F.X.
  TITLE     Ultraviolet-B irradiation induces differential regulations of
            hyaluronidase expression and activity in normal human keratinocytes
  JOURNAL   Photochem Photobiol 87 (5), 1105-1112 (2011)
   PUBMED   21699545
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Yoffou,P.H., Edjekouane,L., Meunier,L., Tremblay,A.,
            Provencher,D.M., Mes-Masson,A.M. and Carmona,E.
  TITLE     Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in
            epithelial ovarian cancer
  JOURNAL   PLoS One 6 (6), e20705 (2011)
   PUBMED   21695196
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Gasingirwa,M.C., Thirion,J., Mertens-Strijthagen,J., Wattiaux-De
            Coninck,S., Flamion,B., Wattiaux,R. and Jadot,M.
  TITLE     Endocytosis of hyaluronidase-1 by the liver
  JOURNAL   Biochem J 430 (2), 305-313 (2010)
   PUBMED   20572808
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   Lokeshwar,V.B., Schroeder,G.L., Carey,R.I., Soloway,M.S. and
            Iida,N.
  TITLE     Regulation of hyaluronidase activity by alternative mRNA splicing
  JOURNAL   J Biol Chem 277 (37), 33654-33663 (2002)
   PUBMED   12084718
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   Nicoll,S.B., Barak,O., Csoka,A.B., Bhatnagar,R.S. and Stern,R.
  TITLE     Hyaluronidases and CD44 undergo differential modulation during
            chondrogenesis
  JOURNAL   Biochem Biophys Res Commun 292 (4), 819-825 (2002)
   PUBMED   11944887
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Rai,S.K., Duh,F.M., Vigdorovich,V., Danilkovitch-Miagkova,A.,
            Lerman,M.I. and Miller,A.D.
  TITLE     Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol
            (GPI)-anchored cell-surface receptor for jaagsiekte sheep
            retrovirus, the envelope protein of which mediates oncogenic
            transformation
  JOURNAL   Proc Natl Acad Sci U S A 98 (8), 4443-4448 (2001)
   PUBMED   11296287
REFERENCE   9  (bases 1 to 2888)
  AUTHORS   Triggs-Raine,B., Salo,T.J., Zhang,H., Wicklow,B.A. and
            Natowicz,M.R.
  TITLE     Mutations in HYAL1, a member of a tandemly distributed multigene
            family encoding disparate hyaluronidase activities, cause a newly
            described lysosomal disorder, mucopolysaccharidosis IX
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6296-6300 (1999)
   PUBMED   10339581
REFERENCE   10 (bases 1 to 2888)
  AUTHORS   Frost,G.I., Csoka,A.B., Wong,T. and Stern,R.
  TITLE     Purification, cloning, and expression of human plasma hyaluronidase
  JOURNAL   Biochem Biophys Res Commun 236 (1), 10-15 (1997)
   PUBMED   9223416
  REMARK    Erratum:[Biochem Biophys Res Commun. 2004 Jun 25;319(2):705..
            Csoka, T B [corrected to Csoka, A B]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 3, 2022 this sequence version replaced NM_207616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.32023.1,
                                           SRR26643298.46453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000008.1  117129311-117129460
            151-1074            JAXUCZ010000008.1  117129939-117130862
            1075-1164           JAXUCZ010000008.1  117131218-117131307
            1165-2888           JAXUCZ010000008.1  117131439-117133162
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2888
                     /gene="Hyal1"
                     /note="hyaluronidase 1"
                     /db_xref="GeneID:367166"
                     /db_xref="RGD:1303060"
     exon            1..150
                     /gene="Hyal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1479
                     /gene="Hyal1"
                     /EC_number="3.2.1.35"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hyal-1; hyaluronoglucosaminidase 1"
                     /codon_start=1
                     /product="hyaluronidase-1 isoform 1 precursor"
                     /protein_id="NP_997499.2"
                     /db_xref="GeneID:367166"
                     /db_xref="RGD:1303060"
                     /translation="MKPFSPEVSPDPCPATAAHLLRTYTLFLTLLELAQGCRGSMVSN
                     RPFITVWNADTHWCLKDHGVDVDVSVFDVVANKEQNFQGPNMTIFYREELGTYPYYTP
                     TGEPVFGGLPQNASLVTHLAHAFQDIKAAMPEPDFSGLAVIDWEAWRPRWAFNWDSKD
                     IYQQRSMELVRAEHPDWPETLVEAEAQDQFQEAAQAWMAGTLQLGQVLRPRGLWGYYG
                     FPDCYNYDFLSPNYTGQCSLSIHDQNDQLGWLWNQSYALYPSIYLPAALMGTGKSQMY
                     VRYRVQEAFRLALVSRDPHVPIMPYVQIFYEKTDYLLPLEELEHSLGESAAQGAAGAV
                     LWISSEKTSTKESCQAIKAYMDSTLGPFILNVTSAALLCSEALCSGRGRCVRHPSYPE
                     ALLTLSPASFSIEPTHDGRPLSLKGTLSLKDRAQMAMKFKCRCYRGWSGEWCKKQDM"
     exon            151..1074
                     /gene="Hyal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1164
                     /gene="Hyal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..2888
                     /gene="Hyal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactttccc tgagcagcag aggcagcagc agcagcctct ctaagctggt gcaactagga
       61 ccaacttgtg ggacagaatc cagccaagcc atattccggc ttacacagtg tgctcagaaa
      121 gtttggagaa tgaagccctt cagtcctgag gtttccccag acccatgccc tgctactgca
      181 gcccacctgc ttcgcaccta cacgctcttc ctgaccttgc tggagttggc ccaaggttgc
      241 agaggttcca tggtatccaa ccggccgttc atcactgttt ggaatgcaga cactcactgg
      301 tgcctgaagg accacggagt ggatgtggat gtcagtgtct tcgacgtggt tgccaacaag
      361 gagcagaatt tccaaggccc caacatgact attttctacc gagaggagtt gggcacctac
      421 ccctactata cacccaccgg ggaacccgta tttggtggtc tgccccagaa tgccagcctg
      481 gttacccacc ttgctcacgc attccaggac atcaaggctg ccatgcctga acctgacttc
      541 tcgggactgg cggtcattga ttgggaggct tggcgcccac gatgggcctt caactgggac
      601 agcaaggaca tttatcagca gcgctcaatg gaactggtcc gggcagaaca ccctgactgg
      661 ccagaaactt tagtggaagc agaagcccaa gaccagttcc aggaagctgc acaggcctgg
      721 atggcaggca ccctccaact ggggcaggta ctgcgtcccc gtggcctctg gggctactat
      781 ggcttccctg actgctacaa ctacgacttt ctaagtccca actacacagg ccagtgctca
      841 ctgagcatcc atgatcagaa tgaccagcta gggtggttgt ggaaccagag ctatgccctt
      901 taccccagta tttacttgcc tgcagcactg atgggcacag ggaagtcaca gatgtatgtt
      961 cgataccgtg tgcaagaggc gttccgtttg gctttagttt ccagagaccc tcatgtgccc
     1021 ataatgccct acgtccaaat cttctatgaa aagacagatt atcttctacc cctggaggag
     1081 ctggagcaca gcctgggaga gagtgcagcc cagggagcgg caggagcagt gctctggata
     1141 agctcagaaa aaacaagtac caaggagtca tgccaagcca ttaaagcata catggattcc
     1201 acactcggac cctttatcct gaacgtaacc agtgcagctc ttttgtgcag cgaagctctg
     1261 tgttctggcc gtggtcgttg tgtccgccat cccagttacc ctgaggctct cctcaccctc
     1321 agccctgcca gcttctccat tgagccaaca catgatggca gacccctgag cctcaagggt
     1381 accctctcgc ttaaggatcg ggcacagatg gctatgaaat tcaagtgtcg atgctaccgt
     1441 ggatggagtg gagagtggtg taagaagcag gatatgtagt gatttgctgc accaggctgc
     1501 atatactgaa cacgggacat acccagggcc tacctatgac ttccttacat acagtcacac
     1561 gcgcacaaat cacagtcagg agtacactca agcgctgtca tggccgcaat cacacgggca
     1621 cattcacggg gatagtcaca tagtgaatca gaatttaggc taggtactat caactctgta
     1681 tctataagga cctactcata ggcagttcct ccagaaccta tgagtcagca gtcacaaaag
     1741 ctgacatttg ctctgtgcca agccctgtgc taagcaaaca ctagaagtgg gccaactcat
     1801 tcagtcttta caatcgacat gctgggaaga tgagtacttt tttatttact tactctggga
     1861 gataaactta ggacctcaca cacactaggc aagtgctcca acactaagct atattcccag
     1921 ccactgtcca atgttgccca gcaagaatag acaagcaagg ccaggcattg atgatgctca
     1981 cccttgatcc cagtactcag gaggcaaggc cagcctggtc tacatattga gctccaggac
     2041 agccaggact acacagagca aatttcagct gtctcaaaac aaaatgacac tgtctcaaaa
     2101 caaaacagcc aggagagatg catattgaaa tctaggctat ctagctctaa agatagaaca
     2161 ttgcacacct actgtgtgtt gatggtgccc taaaaggatt agggaacaca acaacatcac
     2221 tgtaagggtc cctgaatctg ctcagagtac tagcattccc caatccagca aacgaagctg
     2281 tcctatagta cttagctgtt taattagctc ctaaaatagg caggccccag aacacagaag
     2341 gtactggagc tctacacttt catccaattg tgttgtctga agacgactgc ttctcatgat
     2401 caggaggaag tcccgcctga tcggaccatt tccaccgacc cactaggatt ggagacgcta
     2461 ctagagcaga aacaaaacga aactcccatt tctttgaggc tggagttggg agagctgcag
     2521 gcggagctga acacaggaaa gccgctagaa gccagaggct gagcggagag gaggcggagc
     2581 caacgagagg aaactacggg cctagtcgcc accggaaggg aagaagtcag ggacagaatg
     2641 ggcctacact agttctgttg tgacgctcag aaccaggggc gggtgtctag gtggtgacat
     2701 tccgggcact gagaacatag gaggaggtgc gctgtctcct gcaaagactg caacgagtcc
     2761 tccgtactgc tgggaccagc gtaggcagac cgaagagttg gagccagaga cagcgagtta
     2821 accaaccgtg cgcaggcagg acgcggagca tcttggaact cgacttgaac atgtcagtat
     2881 caccctca
//
