LOCUS       NM_001408927           14063 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus HECT, UBA and WWE domain containing E3 ubiquitin
            protein ligase 1 (Huwe1), mRNA.
ACCESSION   NM_001408927
VERSION     NM_001408927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 14063)
  AUTHORS   Jiang,X., Yang,J., Li,H., Qu,Y., Xu,W., Yu,H. and Tong,Y.
  TITLE     Huwe1 is a novel mediator of protection of neural progenitor L2.3
            cells against oxygen-glucose deprivation injury
  JOURNAL   Mol Med Rep 18 (5), 4595-4602 (2018)
   PUBMED   30221657
  REMARK    GeneRIF: the effects of Huwe1 on Notch1 signaling were completely
            abolished by knockdown of NMyc, indicating that Huwe1 may require
            NMyc to suppress the activation of the Notch1 signaling in L2.3
            cells.
REFERENCE   2  (bases 1 to 14063)
  AUTHORS   Di Rita,A., Peschiaroli,A., D Acunzo,P., Strobbe,D., Hu,Z.,
            Gruber,J., Nygaard,M., Lambrughi,M., Melino,G., Papaleo,E.,
            Dengjel,J., El Alaoui,S., Campanella,M., Dotsch,V., Rogov,V.V.,
            Strappazzon,F. and Cecconi,F.
  TITLE     HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by
            regulating AMBRA1 activation via IKKalpha
  JOURNAL   Nat Commun 9 (1), 3755 (2018)
   PUBMED   30217973
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14063)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14063)
  AUTHORS   He,G.Q., Xu,W.M., Li,J.F., Li,S.S., Liu,B., Tan,X.D. and Li,C.Q.
  TITLE     Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and
            reperfusion injury in primary Rat cortical neuronal cells
  JOURNAL   Mol Brain 8, 88 (2015)
   PUBMED   26698301
  REMARK    GeneRIF: Huwe1 knockdown increased Gadd45b, p-CREB and BDNF
            expression after brain neuron oxygen-glucose deprivation and
            reperfusion. It decreased methylation of the 5th CpG island (123 bp
            apart form BDNF IXa).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14063)
  AUTHORS   Senyilmaz,D., Virtue,S., Xu,X., Tan,C.Y., Griffin,J.L.,
            Miller,A.K., Vidal-Puig,A. and Teleman,A.A.
  TITLE     Regulation of mitochondrial morphology and function by
            stearoylation of TFR1
  JOURNAL   Nature 525 (7567), 124-128 (2015)
   PUBMED   26214738
REFERENCE   6  (bases 1 to 14063)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   7  (bases 1 to 14063)
  AUTHORS   Zhong,Q., Gao,W., Du,F. and Wang,X.
  TITLE     Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the
            polyubiquitination of Mcl-1 and regulates apoptosis
  JOURNAL   Cell 121 (7), 1085-1095 (2005)
   PUBMED   15989957
REFERENCE   8  (bases 1 to 14063)
  AUTHORS   Liu,Z., Oughtred,R. and Wing,S.S.
  TITLE     Characterization of E3Histone, a novel testis ubiquitin protein
            ligase which ubiquitinates histones
  JOURNAL   Mol Cell Biol 25 (7), 2819-2831 (2005)
   PUBMED   15767685
REFERENCE   9  (bases 1 to 14063)
  AUTHORS   Gu,J., Dubner,R., Fornace,A.J. Jr. and Iadarola,M.J.
  TITLE     UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53
            transactivation
  JOURNAL   Oncogene 11 (10), 2175-2178 (1995)
   PUBMED   7478539
REFERENCE   10 (bases 1 to 14063)
  AUTHORS   Gu,J., Ren,K., Dubner,R. and Iadarola,M.J.
  TITLE     Cloning of a DNA binding protein that is a tyrosine kinase
            substrate and recognizes an upstream initiator-like sequence in the
            promoter of the preprodynorphin gene
  JOURNAL   Brain Res Mol Brain Res 24 (1-4), 77-88 (1994)
   PUBMED   7968380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000021.1  24353217-24353459
            244-391             JAXUCZ010000021.1  24356649-24356796
            392-460             JAXUCZ010000021.1  24378647-24378715
            461-559             JAXUCZ010000021.1  24383450-24383548
            560-766             JAXUCZ010000021.1  24384257-24384463
            767-919             JAXUCZ010000021.1  24386122-24386274
            920-982             JAXUCZ010000021.1  24395008-24395070
            983-1060            JAXUCZ010000021.1  24396950-24397027
            1061-1108           JAXUCZ010000021.1  24398085-24398132
            1109-1177           JAXUCZ010000021.1  24398211-24398279
            1178-1277           JAXUCZ010000021.1  24398837-24398936
            1278-1378           JAXUCZ010000021.1  24402264-24402364
            1379-1529           JAXUCZ010000021.1  24402647-24402797
            1530-1657           JAXUCZ010000021.1  24402930-24403057
            1658-1798           JAXUCZ010000021.1  24403565-24403705
            1799-1904           JAXUCZ010000021.1  24403905-24404010
            1905-2006           JAXUCZ010000021.1  24406240-24406341
            2007-2087           JAXUCZ010000021.1  24406733-24406813
            2088-2194           JAXUCZ010000021.1  24410585-24410691
            2195-2372           JAXUCZ010000021.1  24410934-24411111
            2373-2464           JAXUCZ010000021.1  24412004-24412095
            2465-2676           JAXUCZ010000021.1  24412675-24412886
            2677-2734           JAXUCZ010000021.1  24417657-24417714
            2735-2911           JAXUCZ010000021.1  24418393-24418569
            2912-3157           JAXUCZ010000021.1  24421192-24421437
            3158-3291           JAXUCZ010000021.1  24422793-24422926
            3292-3386           JAXUCZ010000021.1  24423303-24423397
            3387-3578           JAXUCZ010000021.1  24426268-24426459
            3579-3795           JAXUCZ010000021.1  24427974-24428190
            3796-3918           JAXUCZ010000021.1  24428516-24428638
            3919-4156           JAXUCZ010000021.1  24429971-24430208
            4157-4387           JAXUCZ010000021.1  24430642-24430872
            4388-4510           JAXUCZ010000021.1  24433142-24433264
            4511-4606           JAXUCZ010000021.1  24433640-24433735
            4607-4876           JAXUCZ010000021.1  24434375-24434644
            4877-5029           JAXUCZ010000021.1  24435218-24435370
            5030-5157           JAXUCZ010000021.1  24436583-24436710
            5158-5239           JAXUCZ010000021.1  24436907-24436988
            5240-5416           JAXUCZ010000021.1  24437834-24438010
            5417-5576           JAXUCZ010000021.1  24438271-24438430
            5577-5935           JAXUCZ010000021.1  24439013-24439371
            5936-6131           JAXUCZ010000021.1  24442200-24442395
            6132-6299           JAXUCZ010000021.1  24443141-24443308
            6300-6445           JAXUCZ010000021.1  24444603-24444748
            6446-6512           JAXUCZ010000021.1  24445190-24445256
            6513-6730           JAXUCZ010000021.1  24446544-24446761
            6731-6942           JAXUCZ010000021.1  24448948-24449159
            6943-7125           JAXUCZ010000021.1  24449516-24449698
            7126-7298           JAXUCZ010000021.1  24451724-24451896
            7299-7447           JAXUCZ010000021.1  24452228-24452376
            7448-7523           JAXUCZ010000021.1  24453088-24453163
            7524-7622           JAXUCZ010000021.1  24454004-24454102
            7623-7756           JAXUCZ010000021.1  24454690-24454823
            7757-7925           JAXUCZ010000021.1  24455015-24455183
            7926-8154           JAXUCZ010000021.1  24456470-24456698
            8155-8333           JAXUCZ010000021.1  24457136-24457314
            8334-8423           JAXUCZ010000021.1  24457584-24457673
            8424-8578           JAXUCZ010000021.1  24457828-24457982
            8579-8624           JAXUCZ010000021.1  24459912-24459957
            8625-8912           JAXUCZ010000021.1  24461534-24461821
            8913-9168           JAXUCZ010000021.1  24463076-24463331
            9169-9299           JAXUCZ010000021.1  24463553-24463683
            9300-9514           JAXUCZ010000021.1  24464341-24464555
            9515-9803           JAXUCZ010000021.1  24464638-24464926
            9804-9906           JAXUCZ010000021.1  24465066-24465168
            9907-10453          JAXUCZ010000021.1  24465932-24466478
            10454-11060         JAXUCZ010000021.1  24467140-24467746
            11061-11179         JAXUCZ010000021.1  24468687-24468805
            11180-11336         JAXUCZ010000021.1  24468906-24469062
            11337-11469         JAXUCZ010000021.1  24469760-24469892
            11470-11672         JAXUCZ010000021.1  24470142-24470344
            11673-11800         JAXUCZ010000021.1  24471021-24471148
            11801-11900         JAXUCZ010000021.1  24472215-24472314
            11901-12059         JAXUCZ010000021.1  24474175-24474333
            12060-12305         JAXUCZ010000021.1  24474691-24474936
            12306-12423         JAXUCZ010000021.1  24475318-24475435
            12424-12564         JAXUCZ010000021.1  24475874-24476014
            12565-12852         JAXUCZ010000021.1  24476566-24476853
            12853-12958         JAXUCZ010000021.1  24476969-24477074
            12959-13076         JAXUCZ010000021.1  24478190-24478307
            13077-13258         JAXUCZ010000021.1  24478543-24478724
            13259-13449         JAXUCZ010000021.1  24479004-24479194
            13450-14063         JAXUCZ010000021.1  24480185-24480798
FEATURES             Location/Qualifiers
     source          1..14063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..14063
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /note="HECT, UBA and WWE domain containing E3 ubiquitin
                     protein ligase 1"
                     /db_xref="GeneID:501546"
                     /db_xref="RGD:1561763"
     exon            1..243
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..391
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..460
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..13552
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /EC_number="2.3.2.26"
                     /note="HECT, UBA and WWE domain containing 1, E3 ubiquitin
                     protein ligase; URE-binding protein 1; HECT-type E3
                     ubiquitin transferase HUWE1; HECT, UBA and WWE
                     domain-containing protein 1; upstream regulatory
                     element-binding protein 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HUWE1"
                     /protein_id="NP_001395856.1"
                     /db_xref="GeneID:501546"
                     /db_xref="RGD:1561763"
                     /translation="MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTW
                     NIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEKEQLKMLLLAVLNFTAL
                     LIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLL
                     TRLQHLAESWGGKENGFGLAECCRDLQMLKYPPSATTLHFEFYADPGAEVKIEKRTTS
                     NTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQA
                     VQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSI
                     VHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYH
                     LASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSH
                     SGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPSTTQEGEEMETDMDGVQCIPQRAALL
                     KSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFV
                     FQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQC
                     QPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAII
                     KLLEEICNLGRDPKYICQKPSIQKADGTTSAPPPRSNHAAEEASSEDEEEEEVQAMQS
                     FNSAQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKG
                     LLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDLILSSLE
                     PLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQ
                     SEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQ
                     KLVPKDEKAGTTQGGKRSDGEQDGTAGSMDASAQGLLEGIELDGDTLAPMETDEPSSS
                     DSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAA
                     STTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDER
                     KYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLM
                     LVEKMVNPTTVLESPHSLPAKLPGGVQSFPQFSALRFLVVTQKAAFTCIKNLWNRKPL
                     KVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEEAGQEEGGSRREPQVNQQ
                     QLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIIGGVVRDLSMSEEDQMMRA
                     IAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDEL
                     HTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADV
                     LIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSG
                     ILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYL
                     QSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQV
                     NEETGNRRPVMLTLLRVPRLSKNSKSSNGQELEKTLEESKETDIKRKENKGNDIPLAL
                     ESTNTEKDASLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLR
                     LTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVV
                     RSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAP
                     RGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSSLPVIPDTIKEVIYDMLNALAAYHA
                     PEEADKSDPKPGGMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSLNSQVFAA
                     DGAPAETSTTGTSQGEGASTPEETREGKKDKEGDRTSEEGKQKGKGSKPLMPTSTILR
                     LLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPAL
                     ARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMES
                     CPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAAL
                     KPLETLSRIVNQPSSLFGSKSASSKSKSEQDAQGASQDSSSHQQDPGEPGEAEVQEED
                     HDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSG
                     NSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDS
                     SGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPL
                     VRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTT
                     RLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSS
                     LPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTE
                     ECKVLDAESMHDCVSVVKVPIVNHLEFLRDEELEERREKRRKQLAEEETKIIDKGKED
                     KENRDQSAQCTVSKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSESKETLGTLQPSQ
                     QQPTLPPPPSLGEISQELQSPAEEVGNSTQLLMPIELEELGPTRPSGEAETTQMELSP
                     APTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSEQPTA
                     GSSTPGDAPSVGADVQGRPDVSRESTQPPEDSSPPASSESSSTRDSAVAISGADSRGI
                     LEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPST
                     NSSTPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPV
                     TFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSS
                     TSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRL
                     RGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRS
                     SESELCIETPKLSTSEERGKKSSKSCASSSHENRPLDLLHKMESKSSNQLSWLSVSMD
                     AALGCRTNIFQIQRSGGRKHTEKHASSGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPS
                     HFTQQRTKETNCESDRERGSKQACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKN
                     SVKSVPVSAGGEGETSLHSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIAL
                     PENKVSEVQTNSSNSGSSTAATSNTSTTTTTTTATAPTPTPPAATTPVTSAPALVAAT
                     AISTITVAASTTVTTPTTATTTVSTSTTKGNKSPAKVGEGGSSSVDFKMVSSGLTENQ
                     LQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQI
                     GTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQ
                     KRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSG
                     LGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSNQSETSVRREESPMD
                     VDQPSPSAQDTQSIVVSDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELE
                     ESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPA
                     TPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAV
                     LVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM
                     KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCN
                     PNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLV
                     YLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMT
                     GAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSN
                     SIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRST
                     DRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA"
     exon            461..559
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..766
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..919
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..982
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1060
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1108
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1177
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1277
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1378
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1529
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1657
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1798
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1904
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2006
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2087
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2194
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2372
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2464
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2676
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2734
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2911
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3157
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3291
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3386
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3578
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3795
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3918
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4156
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            4157..4387
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4510
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4606
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4876
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..5029
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5030..5157
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5158..5239
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5240..5416
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5417..5576
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5577..5935
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            5936..6131
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6132..6299
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6300..6445
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6446..6512
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6513..6730
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6731..6942
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            6943..7125
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7126..7298
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7299..7447
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7448..7523
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7524..7622
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7756
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7757..7925
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            7926..8154
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8155..8333
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8334..8423
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8424..8578
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8579..8624
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8625..8912
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            8913..9168
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            9169..9299
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            9300..9514
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            9515..9803
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            9804..9906
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            9907..10453
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            10454..11060
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11061..11179
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11180..11336
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11337..11469
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11470..11672
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11673..11800
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11801..11900
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            11901..12059
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12060..12305
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12306..12423
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12424..12564
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12565..12852
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12853..12958
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            12959..13076
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            13077..13258
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            13259..13449
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
     exon            13450..14063
                     /gene="Huwe1"
                     /gene_synonym="URE-B1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctccgccc cgtagtgctc cgtgaggttg tgcgtcattt gcttttcgct tcgcgtgggg
       61 tgagagctga gcagtagcga tttcggcttt ggtggaagga gaggtctggg acgggctggg
      121 ctcaattttt cctggtctgg tggaggttct cctgggatca cgcgaaggcg gcagaggttg
      181 gctactgagt gcaggagctg cggaggcgcg agcagcgttt tctggtgctg ccgttcttag
      241 ccggtcctcc agtagcctga cctgagtgtc tttattagtg cttcagagga acaaaaacag
      301 gagaccagaa tttggtcagg aagtttcagg aagctgttgg agcagtgttg ggatttccca
      361 ccaggatgac tatgattggc tgtgatttta gatcttaaag ctgaaaactg aaaacatgaa
      421 agtagacagg actaaactca aaaagacacc tactgaggct cctgcagact gcagagcctt
      481 aatagacaaa ctcaaagttt gtaacgatga gcaactcctc ttggaactgc agcaaatcaa
      541 aacatggaac attggcaagt gtgagttata tcactgggtg gatctgttgg accgctttga
      601 tggaattctg gcagatgctg gacaaacagt ggagaatatg tcatggatgc ttgtatgtga
      661 taggccagaa aaagaacagc tgaaaatgct tctgttggct gtattgaact tcacagcctt
      721 gctcattgag tacagctttt ctcggcatct gtacagttcc atagagcatt tgacaacatt
      781 attggcttcc tctgatatgc aagtggtgct ggctgtcctt aaccttctat atgtatttag
      841 caaaagatca aactatatca cacgtcttgg atctgacaag aggactccac tactgacaag
      901 gctgcaacat ttggcagaga gctggggtgg aaaggagaat ggctttggat tggcagaatg
      961 ttgcagagat ttgcaaatgt tgaaatatcc acccagtgca accacactac actttgaatt
     1021 ttatgcagat cctggagctg aggtcaaaat agagaagagg acaactagta atacactaca
     1081 ttatattcac atagaacaac ttgacaagat ttcagaaagt ccttctgaaa taatggaatc
     1141 tcttaccaaa atgtacagca ttcctaagga taaacagatg ctgttattta ctcatatacg
     1201 actggcccat ggcttttcta atcacaggaa gcgattacaa gctgttcagg ccagactgca
     1261 tgcaatatct atattagtct attctaatgc cttgcaagag tcagcaaaca gtatcttgta
     1321 taatgggttg atagaggagt tggttgatgt ccttcaaata acagataagc agcttatgga
     1381 aattaaagct gcttctttac gaacattaac atcaattgtt catttggaga gaactcccaa
     1441 gctcagcagt attattgact gtactggaac tgcctcctac catggttttt tgcctgtact
     1501 tgtgcggaac tgtattcagg ccatgattga tccttccatg gacccatacc cccaccagtt
     1561 tgccacagct cttttctcct ttttgtacca tctggccagc tatgatgctg gtggcgaagc
     1621 cttggtctct tgtggaatga tggaagcctt actaaaggtc ataaaatttc ttggtgatga
     1681 gcaggaccag ataacatttg taaccagagc tgtcagagtg gttgacctga tcaccaacct
     1741 ggacatggca gcttttcagt ctcatagtgg tctttctatc ttcatctata gacttgagca
     1801 cgaagtagat ttgtgtcgta aagaatgccc ttttgtgatc aagccaaaga tccagagacc
     1861 tagtaccact caagaaggag aagaaatgga aactgatatg gatggagttc agtgtattcc
     1921 acaacgagca gcacttctca agtccatgtt gaatttcctc aagaaggcca ttcaagaccc
     1981 tgctttttca gatggcatac gacatgtgat ggatggttct ttacctacct ctctgaaaca
     2041 catcatcagc aatgcagaat actatggccc atcactcttc ctcctagcta ctgaagtggt
     2101 gactgtgttt gtatttcaag agccgtcact gctgtcctca ctccaggaca atggactgac
     2161 agatgtcatg ctgcatgcac tgcttatcaa agatgttcct gctacaaggg aagtccttgg
     2221 ttccctccca aatgtattca gtgcactttg cttgaatgcc cgaggtcttc agtcttttgt
     2281 acaatgtcaa ccatttgaac gtctcttcaa agttcttctg tctcctgatt acctcccagc
     2341 catgcggagg aggagaagtt ctgatcccct tggggatact gcatccaacc tggggagtgc
     2401 tgttgacgag ctcatgagac atcagcccac cctcaaaaca gatgcaacaa ctgccatcat
     2461 caagttactt gaagaaatct gtaatcttgg aagagatcca aaatacattt gtcagaagcc
     2521 atctattcag aaagcagatg gtactactag tgctcctcct ccaaggtcta atcatgctgc
     2581 agaagaggct tctagtgaag atgaggagga agaggaagta caggccatgc agagctttaa
     2641 ttctgcccag cagaatgaaa ccgagcctaa tcagcaggtt gttggtacag aggaacgtat
     2701 acctatcccc ctcatggatt acatccttaa tgtgatgaaa tttgtggaat ctattctgag
     2761 caacaataca acagatgacc actgccaaga atttgtaaat cagaaaggac tcttaccttt
     2821 ggttaccatt ttgggtcttc ccaatctgcc cattgacttt cccacatctg ctgcctgtca
     2881 ggctgttgca ggtgtctgca aatccatatt gaccctgtca catgaaccca aagttcttca
     2941 agaaggtctc cttcagttag acttgatcct ttcctccttg gagcctttac atcggcccat
     3001 tgaatcccct gggggctcgg tgttactgag agaattggca tgtgcaggca atgttgctga
     3061 tgctaccctc tcagctcagg ctacgcctct gttgcatgct ctcactgctg cccatgccta
     3121 catcatgatg tttgttcaca cttgcagagt tggacagagt gaaattcgtt ctatctcagt
     3181 aaaccagtgg ggttctcagt tgggtttgag tgttctgagc aagctaagcc agttatactg
     3241 ttctcttgtg tgggaaagca ctgtcctcct ctctttatgt acccccaaca gcttaccatc
     3301 tggatgtgaa tttggccaag cggacatgca gaaacttgtt ccaaaggatg agaaggcagg
     3361 tacgacccag ggaggaaaaa gatcagatgg agaacaggat gggactgctg gaagtatgga
     3421 tgcttctgcc caggggttat tggaaggaat tgagctagat ggtgacacat tggcacccat
     3481 ggagacagat gaaccttctt cttcagattc taagggcaaa tctaaaatca cacctgccat
     3541 ggctgcaaga attaaacaaa tcaagccatt gctgtcagct tcttccagat taggccgagc
     3601 gcttgctgaa ctctttggac tccttgttaa actgtgtgtg ggttctcctg tccgccaaag
     3661 aaggagccat catgctgcca gtaccaccac tgcaccaaca cctgctgcta gatcaacagc
     3721 ttcagccctc actaagctac tcacaaaagg cttatcatgg cagcccccac catatacacc
     3781 tactccccgc ttcagactga cattcttcat ctgttcagtt ggattcacct ctccaatgct
     3841 ctttgatgag agaaagtatc cttaccatct tatgctgcag aaatttctct gctctggtgg
     3901 tcacaatgct ctttttgaaa cgttcaactg ggctctatcc atgggaggaa aagttcccgt
     3961 ttctgaggga ttggaacatt cagacttacc tgatggcaca ggagaattcc tagatgcctg
     4021 gcttatgctt gtagaaaaga tggtaaatcc cactacggtg cttgaatctc cacattcgtt
     4081 gcctgccaaa ttgcctggag gggtccagag ctttccacaa tttagtgccc ttcgcttcct
     4141 tgtagtaacc caaaaagcag cctttacttg tatcaagaac ctgtggaacc ggaaacccct
     4201 taaagtatat gggggacgaa tggctgagtc tatgctggcc attctgtgcc acattctccg
     4261 aggggaacct gtgattcgag aaagactgag caaagagaag gaaggatctc gaggggaaga
     4321 agaagcaggc caggaagaag gtggctcgcg cagagaacct caagtcaacc agcaacagct
     4381 acaacagctc atggacatgg gtttcacaag agaacatgcc atggaggcac tgttgaatac
     4441 cagtacaatg gaacaagcaa cagagtatct tttaacccac cctcctccga tcataggagg
     4501 agttgttcgg gatcttagca tgtcagaaga ggaccagatg atgagagcaa ttgctatgtc
     4561 tctgggacag gatattccaa tggatcaaag ggcagagtca cctgaggaag ttgcttgccg
     4621 gaaggaggaa gaagaacgta aagctcgaga aaaacaagaa gaggaagaag ctaaatgtct
     4681 agagaagttt caagatgctg atccattgga acaagatgag ctccacactt tcacagatac
     4741 aatgttacca ggctgcttcc atcttcttga tgagttgcct gatacagtgt accgcgtttg
     4801 tgatctgatc atgacagcca tcaaacgtaa tggagctgac tatcgtgata tgattctgaa
     4861 gcaggttgtc aaccaggttt gggaagctgc tgatgtattg atcaaagccg cccttcctct
     4921 aacaacaagt gacacaaaaa cagtttcaga atggatcagt cagatggcta ccctgccaca
     4981 ggcctccaat ttggctacta gaatcttgct tttaacacta ctttttgagg agttgaagct
     5041 accttgtgcc tgggtggttg aatcaagtgg cattcttaat gtcctaatca agctcttaga
     5101 agtggttcag ccctgcctac aggctgccaa agagcaaaag gaagtccaga ccccaaagtg
     5161 gatcacccca gtgttgcttc ttattgattt ttatgaaaag actgccatct catcaaagag
     5221 aagggctcaa atgactaagt acctacagtc caacagcaac aactggcgct ggtttgatga
     5281 ccgctctggg cgttggtgta gttacagtgc tagcaacaac agcaccattg attctgcctg
     5341 gaaatctgga gaaacaagtg taagattcac tgcaggccga cgaagataca ctgttcagtt
     5401 cactacaatg gtgcaggtta atgaagaaac aggaaaccga cgtcctgtga tgctaactct
     5461 cctcagggtg ccaagactga gtaagaactc aaaaagcagc aatggacagg aactagagaa
     5521 gacactggaa gaaagcaagg agaccgatat caaacgtaaa gaaaataaag gcaatgatat
     5581 ccccttagct ctagagagta cgaacactga aaaagatgca agcctagaag aaacaaaaat
     5641 tggggagatc ctaatccagg gcctgacaga agatatggtg accgttctaa tccgagcctg
     5701 tgtgagcatg ctgggagtcc ctgtggaccc agacactttg catgccaccc ttcgcctctg
     5761 tttgaggctc actcgagacc acaaatatgc catgatgttt gcagagctga agagtacccg
     5821 aatgatcttg aatttgaccc agagctcagg tttcaatggg tttaccccct tagttaccct
     5881 tctcttaaga cacatcattg aggatccttg cactcttcgt catacaatgg aaaaggttgt
     5941 tcgctcagca gctacaagtg gagctggaag tactacatct ggtgtggtat ctggcagcct
     6001 cggctctcgg gagatcaact acatccttcg agtccttgga ccagcagcct gccgcaatcc
     6061 agacatattc acagaagtag ccaattgctg catccgcatt gcccttccag cccctcgagg
     6121 ctcaggaact gcttcagatg atgaatttga gaatcttaga attaaaggtc ctaatgctgt
     6181 gcagctggta aagacaacac ctttgaagcc ttcatctctg cctgtcattc ctgatactat
     6241 taaggaagtt atctatgata tgctgaatgc tttggctgcg taccatgctc cagaggaagc
     6301 agacaaatct gatcctaaac ctgggggaat gacccaagag gttggccagc tcctacaaga
     6361 catgggtgac gatgtatacc agcagtaccg gtcacttact cgtcagagca gtgactttga
     6421 tacacagtca ggtttttcct taaatagtca ggtctttgct gcagatggtg cccctgctga
     6481 aacttccaca actggaacct cccaaggaga gggagcttca actccagagg agactcgaga
     6541 aggaaagaag gataaagaag gggaccggac ttctgaggaa ggcaagcaga aaggcaaggg
     6601 cagcaaaccc ttaatgccta cctctactat ccttcgtctt ctggcagagt tggtgaggtc
     6661 ctatgttggt attgctacac tgattgcaaa ctacagctat accgtgggcc agtctgagtt
     6721 gatcaaagag gactgcagtg tgctagcttt tgtcctggac cacctcctcc cacacaccca
     6781 gaatgcagaa gacaaggaca cacctgccct ggcccgtctg ttccttgcaa gtctggctgc
     6841 tgccgggagc ggcacagatg cccaggtggc cctagtgaat gaagtaaaag cagccctggg
     6901 gcgggcgctt gctatggctg agagtacaga gaaacatgcc agacttcagg cagtgatgtg
     6961 tatcatcagt actatcatgg aatcctgccc ttccacctcc agcttctaca gtagtgccac
     7021 cgccaaaact cagcataatg gcatgaacaa catcattcga ctgttcctga aaaagggact
     7081 agtcaatgac ctggccagag ttcctcacag cctagacttg tccagtccca atatggccaa
     7141 cacagtcaat gctgccctaa aacccttgga aacactttcc cggattgtaa accaacccag
     7201 tagccttttt ggcagcaaga gtgcttctag caagagcaag tctgagcagg atgcccaagg
     7261 agcttctcag gactcaagta gccatcagca agatccaggc gagcctgggg aggcagaagt
     7321 acaggaggag gatcatgatg tcactcagac agaggtggca gatggggata tcatggatgg
     7381 ggaggctgaa accgactcag tggtgattgc tgggcagcct gaggtgctca gttcacaaga
     7441 gatgcaggtt gagaatgaac tggaggacct gatagatgag ttgcttgaga gggatggcgg
     7501 atctgggaac agtacaatta tagtgagcag aagtggagag gatgaatcac aagaggacgt
     7561 gctgatggat gaagctcctt ccaacctcag ccaagcttcc accttgcagg ccaaccgaga
     7621 agattccatg aatatcctgg accctgagga tgaggaggag cacactcagg aagaggacag
     7681 cagtggcagt aacgaggatg aggatgatag tcaggatgaa gaggaggagg aggaggaaga
     7741 tgaggaagat gatcaggagg atgatgaagg tgaagaagga gatgaagatg atgacgatga
     7801 tggttctgag atggaattgg atgaggatta ccctgatatg aacgcttctc ccttggtccg
     7861 atttgagcgc tttgaccggg aggatgatct catcattgag tttgacaaca tgttctccag
     7921 tgctacagac attcccccat ccccaggaaa tatccctact acccacccat tgatggtacg
     7981 ccatgcagat cacagttctc tgacactggg cagtggctct tctacaactc gtcttaccca
     8041 gggcatcggt cgcagtcaaa ggaccctaag acagctcaca gccaatacag gacataccat
     8101 tcatgttcac taccctggga atcgccagcc taaccctcct cttatactcc agaggttgct
     8161 tggtccctct gctgctgctg acattcttca gctaagcagc agccttccct tacaaagccg
     8221 aggccgggcc cgccttctag ttggcaatga tgacgtccat atcatcgcca ggtctgatga
     8281 cgagctgctg gatgactttt ttcatgacca gagtacagcc actagccaag caggaaccct
     8341 gtctagcatc ccaacagctc tgacacgatg gacagaggaa tgcaaagttc ttgatgccga
     8401 gagtatgcat gactgtgttt cagtggttaa agtgcccatt gtcaatcacc tggaattctt
     8461 gagagatgag gagctagaag agagaaggga gaaacgcagg aaacaactgg ctgaggaaga
     8521 aacaaaaata atagacaaag gcaaagaaga caaggagaac agagatcaga gcgcacagtg
     8581 tactgtatct aagacaaatg actccactga acagaatgtc tcagatggga ctcctatgcc
     8641 tgacagctat ccaacaaccc cctcttcaac ggatgcacct acatctgagt ccaaggagac
     8701 acttggtacc ctacaaccct cccagcagca gccaacactt ccacccccac catccttagg
     8761 agagatttct caggaactgc agtcgcctgc tgaagaagtg ggaaactcta cacagctatt
     8821 gatgcctata gagttggagg agttgggtcc cacaagacca agtggagaag cagaaacaac
     8881 tcaaatggaa ttgtctccag ctcccaccat aacctctctt tccccagaga gagctgaaga
     8941 ttcagatgca ttaacagctg tcagcagtca actggaaggt tctcccatgg acactagcag
     9001 cctggcttcc tgtacattag aagaggctgt gggtgatact ccagcagctg gcagttctga
     9061 gcagcccaca gcaggtagct ccactcctgg agatgcccca tcagttgggg cagatgtgca
     9121 aggcagacct gatgtgtcaa gagaatccac ccagccacct gaggacagct ccccacctgc
     9181 atcctctgag agttcttcca ccagagattc tgccgtggct atctctgggg cagactctcg
     9241 tggaatttta gaagagccac taccttcaac aagcagtgaa gaagaagatc ccctggctgg
     9301 tatcagtctt cctgaaggtg tggatccctc ctttctggct gctctccctg atgatatccg
     9361 tcgggaagtc cttcagaatc agctgggcat acgtccacca acgcgaactg ctccctccac
     9421 aaatagctca actcctgcag tagtggggaa ccctggtgtg actgaagtga gccctgagtt
     9481 cctggctgct ctacctccag caattcaaga ggaagtgcta gcacagcaga gagctgaaca
     9541 gcagcgacgg gaactggctc agaatgccag ctcagacacc cccatggacc ctgtgacctt
     9601 cattcagact ctaccctcag atctgcgccg gagtgtccta gaggacatgg aagacagtgt
     9661 gttagctgtg atgccacctg acattgcagc tgaggctcaa gctctaaggc gagaacaaga
     9721 agcccggcag cgacagctca tgcatgagcg tctctttgga cacagcagta cttctgcact
     9781 ctctgccatt ctccgaagcc cagcttttac cagtcgcctg agtggcaacc gtggggtcca
     9841 gtatactcgc cttgctgtac agaggggtgg aaccttccag atggggggta gcagcagcca
     9901 taataggcct tctggcagta atgtggacac actcctccgc ctccgaggac gactccttct
     9961 agaccatgaa gccctatctt gccttttggt cctacttttt gtggatgagc caaagctcaa
    10021 tactagccgt ctacaccgag tactgagaaa tctctgctat catgcccaga cccgccactg
    10081 ggtcatccgc agcctcctgt ccattttgca gcgcagcagt gagagtgagt tgtgcattga
    10141 gacacccaag ctttccacga gcgaagaaag gggcaagaag tcaagcaaga gctgtgcatc
    10201 aagcagccat gaaaaccgtc ccctggatct gctccacaag atggagtcca aaagttccaa
    10261 tcagctctcc tggctctcag tatcaatgga tgctgcttta ggctgtagga ctaacatatt
    10321 ccagattcag cgttctggag ggcgtaaaca tacagagaag catgcaagca gtggttccac
    10381 tgtccacatc cacccccagg ctgctcctgt tgtctgcaga catgttttgg atacactcat
    10441 tcagttggcc aaggtatttc ccagccactt tacacagcag cggaccaaag aaacaaactg
    10501 tgagagtgat cgggaacggg gcagtaagca ggcctgcagc ccttgctcct cacagtcctc
    10561 cagcagtggc atctgtacag acttctggga cttattggta aaactggata acatgaatgt
    10621 tagccgaaaa ggcaagaact ccgtgaagtc agtaccagtg agcgctggtg gtgaagggga
    10681 aacgtcccta cacagccttg aagcctctcc actggggcag ctcatgaaca tgttgtcaca
    10741 tccagtcatc cgccggagtt ctctcttaac tgagaaactc ctaagactcc tctctctcat
    10801 ctcaattgct ctcccagaaa acaaagtatc agaagtgcaa actaactcca gcaacagtgg
    10861 ttcctccact gctgccacct caaatacatc tactaccacc accaccacta ctgccactgc
    10921 tcccacgccc acacctcctg ctgcaactac ccctgtcact tctgctcccg ctctggttgc
    10981 tgctacagct atttccacca ttactgtagc tgcttctacc acagtgacta cccccacaac
    11041 tgctaccact actgtttcaa cttccactac taaaggcaac aaatctccag caaaggttgg
    11101 tgaaggaggc agcagtagtg tagacttcaa aatggtatcc tctggcctca ctgaaaacca
    11161 gctacagctc tctgtggagg tgttgacatc ccactcttgt tctgaagaag ggttggaaga
    11221 tgcagccaat gtgttactgc agctctctcg aggggactct gggacgcgag acactgttct
    11281 taagctgcta ctgaatggag cccgtcattt gggttatacc ctttgtaaac agatcggtac
    11341 cctactcgct gaactacggg aatacaatct ggaacagcag cggcgagccc aatgtgagac
    11401 cctctcgcct gatggcctac ctgaggagca gccacagacc accaaactga aaggcaaaat
    11461 gcagagcagg tttgacatgg ctgagaatgt ggtaattgtg gcatctcaga agcgaccctt
    11521 gggtggccgg gagctccaac tgccttctat gtccatgttg acatccaaga catccaccca
    11581 gaagttcttc ttgagggtac tacaggtcat catccagctg cgggatgaca cacgacgagc
    11641 taacaaaaaa gccaagcaga caggcaggct aggttcctcc ggtttaggct cagctagcag
    11701 catccaggca gctgttcggc agctggaggc tgaggctgat gccattatac aaatggtacg
    11761 tgagggtcaa agggcgcgga gacagcaaca agcagcaacg tcggagtctt ctaaccagtc
    11821 agagacatct gtccggagag aggaatcacc catggatgtg gaccagccat ctcccagtgc
    11881 tcaagatact cagtccattg tagtctcaga tggaacacca cagggagaga aggagaaaga
    11941 ggagagacca cctgagttac ccctgctcag tgagcaactg agcctagatg agctatggga
    12001 catgctaggg gaatgtttaa aggaactgga agaatctcat gatcagcatg cagtattagt
    12061 gctacagcct gctgtcgagg ccttcttttt ggtccatgcc acagagcggg agagcaagcc
    12121 tcctgttcga gatacccgtg agagccagct ggcacacatc aaggatgagc ctcctccact
    12181 ttcccctgcc cccttaaccc cagccactcc atcctccctt gacccattct tctccaggga
    12241 gccctcatct atgcacatct catcaagcct gccccctgac acacagaagt tccttcgttt
    12301 tgcagagact caccgcactg tgttaaacca gatacttcgg cagtccacca cccatctcgc
    12361 tgatggacct ttcgctgtct tagtagatta cattcgtgtc ctcgactttg atgtcaagcg
    12421 caaatatttc cgccaagagc tggaacgttt ggacgaaggg ctccggaaag aagacatggc
    12481 cgtgcatgtc cgccgtgacc atgtatttga agactcctat cgtgagctgc atcgcaaatc
    12541 tcctgaagaa atgaagaatc gattgtatat agtgtttgaa ggagaagaag ggcaggatgc
    12601 tgggggtcta ctgcgagagt ggtacatgat catctctcga gagatgttca accctatgta
    12661 tgccttgttc cgtacctcac ctggtgaccg ggtcacctac acgatcaatc catcttccca
    12721 ctgtaacccc aaccacctca gctacttcaa gtttgttgga cgaattgtag ccaaagctgt
    12781 atatgacaac cgcctcctgg agtgctactt tactaggtct ttctacaaac acatcttggg
    12841 caaatctgtc aggtatacag atatggagag tgaggattac cacttctacc agggtctagt
    12901 ttatctgctt gaaaatgatg tctctacatt aggttatgac ctcaccttca gcactgaggt
    12961 tcaagaattt ggagtatgtg aggttcgtga cctcaaaccc aatggagcca acatcttagt
    13021 aacagaggag aacaagaagg aatatgtaca cctggtttgc cagatgagaa tgacaggagc
    13081 catccgcaaa cagctggcag ccttcttaga aggcttctat gaaatcattc caaagcgcct
    13141 catatccatc tttactgagc aggagttaga gctgctcata tcagggctgc ctaccatcga
    13201 catagatgac ctaaaatcta acactgagta ccacaagtac cagtccaact ccattcagat
    13261 ccaatggttc tggagagcat tgcgttcctt tgaccaagca gaccgtgcca agttcctcca
    13321 gtttgtcaca ggtacttcca aggtgcccct gcaaggattt gctgcccttg aaggcatgaa
    13381 tggcattcag aagtttcaga ttcatcgaga cgacagatcc acagatcgcc tgccttcagc
    13441 tcacacatgt tttaatcaac tggacctgcc tgcctatgag agctttgaga agctccgcca
    13501 catgctacta ttggccatcc aggagtgctc tgaaggcttt gggctggcct aataaataag
    13561 gccctgccta cttctgtggg gtttttctac catttttgga cctggggagg ggggggggtt
    13621 taaaagatcc agaaagaaaa tgtcaaaatc caataaatga aattcaccaa ctcaccatgt
    13681 gtgtgtccca gctgcccatc ttccctagtg catacctgtt cgcttctcat tctctttcct
    13741 ctaccctttc cttgcctttc ccttttccat gccgtccatg atccccaccc catgtgttaa
    13801 gaaggcagtt gcctttgcag ggacctgttt gtcccaactg aacagtgtgc tcctcagatt
    13861 ctgtgttcag aaggatttgc tgcattgaga cttgaaacct ttggataggg gaaaaattat
    13921 atatatatat atttttttgt tctgtttgca tttcttaatt tgtgcttgga atgtgttgat
    13981 gtgcacagct aatgattcaa tgcgagacaa gattggcatc tgtgttgtgg aggtttcaaa
    14041 taaagagcac tcttcataac tca
//
