LOCUS       XM_039091789            8525 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus huntingtin (Htt), transcript variant
            X6, mRNA.
ACCESSION   XM_039091789
VERSION     XM_039091789.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051349.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039091789.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8525
                     /gene="Htt"
                     /gene_synonym="Hd; Hdh"
                     /note="huntingtin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 6 ESTs, 1 long
                     SRA read, 2 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 44 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:29424"
                     /db_xref="RGD:68337"
     CDS             1192..8373
                     /gene="Htt"
                     /gene_synonym="Hd; Hdh"
                     /codon_start=1
                     /product="huntingtin isoform X6"
                     /protein_id="XP_038947717.1"
                     /db_xref="GeneID:29424"
                     /db_xref="RGD:68337"
                     /translation="MATLEKLMKAFESLKSFQQQQQQQQPPPQAPPPPPPPPPQPPQP
                     PPQGQPPPPPPLPGPAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSLRNSPEFQK
                     LLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPR
                     SLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASF
                     GNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRTQYFYNWLLNVLLG
                     LLVPMEEDHPTLLILGVLLTLRCLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLV
                     QVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQALTTPGGLGQLTLVREEAGG
                     RGRSGSIVELLAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSAFAASVK
                     SEIGGELAASSSGVSTPGSVGHDIITEQPRSQHTLQADSVDLSGCDLTSAATDGDEED
                     ILSHSSSQFSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGA
                     DSQYLGVQIGQPQEEDEEEAAGVLSGEVSDVFRNSSLALQQAHLLERMGHSRQPSDSS
                     VDKFVSKDEVAEAGDPESKPCRIKGDIGQPNDDDSAPLVHCVRLLSASFLLTGEKKAL
                     VPDRDVRVSVKALALSCIGAAVALHPESFFSKLYKVPLSTMESTEEQYVSDILNYIDH
                     GDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTGNTFSLVDCIPLLQKTLKD
                     ESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLIDMLPLKNSSYWLVRTELLETLAEI
                     DFRLVSFLEAKAESLHRGAHHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTR
                     LVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYSLLP
                     SVTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAFPVCTWSLGWHCGV
                     PPLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRS
                     SWASEEEGSSAATRQEEIWPALGDRTLVPMVEQLFSHLLKVINICAHVLDDVTPGPAI
                     KAALPSLTNPPSLSPIRRKGKEKEPGEQTSTPMSPKKGGEASTASRQSDTSGPVTASK
                     SSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELA
                     TLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQ
                     CRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQADQEHDASGWFDVLQKV
                     SAQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQL
                     VQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQ
                     IIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVV
                     VSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMHIDSHE
                     ALGVLNTLFEILAPSSLRPVDMLLRSMFITPSTMASVSTVQLWISGILAILRVLISQS
                     TEDIVLSRIQELSFSPYLISCPVINRLRDGDSNPTLGERSEGKQVKNLPEDTFSRFLL
                     QLVGILLEDIVTKQLKVDMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLF
                     TSDGCEGSFYTLDSLNARVRAMVPTHPALVLLWCQILLLINHTDHRWWAEVQQTPKRH
                     SLSCTKSLNPQISAEEDSGSAAQLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLI
                     VNHIQDLISLSHEPPVQDFISAIHRNSAASGLFIQAIQSRCENLSTPTTLKKTLQCLE
                     GIHLSQSGAVLTLYVDRLLGTPFRALARMVDTLACRRVEMLLAANLQSSMAQLPEEEL
                     NRIQEHLQNTGLAQRHQRLYSLLDRFRLSTVQDSLSPLPPVTSHPLDGDGHTSLETVN
                     PDKDWYLQLVRSQCWTRSDSALLEGAELVNRIPAEDMSDFMMSSEFNLSLLAPCLSLG
                     MSEIANGQKSPLFEAARRVTLDRVTNVVQQLPAVHQVFQPFLPTEPTAYWSKLNDLFG
                     DTTSYQSLTTLARALAQYLVVLSKVPAPLHLPPEKEGHTVKFVVMTLEALSWHLIHEQ
                     IPLSLDLQAGLDCCCLALQVPGLWGVLSSPEYVTHTCSLIHCVRFILEAIAVQPGDQL
                     LGPESRSHTPRAVRKEEVDSDIQSGSLGHHCLCRPQSHHFGLRDGGRHGGIPAVGAGP
                     GPQEEQHPTFISHSCAEEHCCQSGPPPPR"
ORIGIN      
        1 ctctgcctcc tgagattaaa ggtgtgctct accattgcct ggcttttttt tttttttctt
       61 ttctttttcc cttttccttt ttcttttgag acaagttctg atatagccca tgctgacttg
      121 aattcactat gaatccaagg ggaaactcta gaactcctga tcctcctccc acctgctgag
      181 tgctgggatt acaggcatga ttaccactcc tggtttataa agtgcaggga ttaaacccag
      241 agcttctgtg catgctactc aaagcattct acaagtgctg tgattaaagg catgcaccac
      301 catacccggc tgaagccaac actttttgct aggcaggctg aaggaacagc ctgggtgtac
      361 tcgcaccatt cttagcttcc tgcttttaat tgtttacctt tgggagatgg aggctctaga
      421 gacaaggacc tcagccctgg tggcaatgag accccccttt tagattctgg ctgatgggta
      481 tagcagttcc cagggtctgg gtctcattgt agtgtgtctg accaaagctc cccagttcgc
      541 tgcgctcggg actgaagctc aggccattgc ctggctagtg gaaaaaagag cctctctgga
      601 ttctgggttc cgagctccac agtcgccttc ccggtgactc caggtgtagt gtggctttat
      661 gcagggaaat ttcttctctt tctttcccct ttccaaccct tccttccttc cgggtctccc
      721 caactcctct gcccaccccc tcaccacttt tctgtcgccg ttgccgcgct cactctcggc
      781 tcagctccgc ccctcatctg gcagcctgcc tcgcccaccg atcctcttgc ttggcttttt
      841 cactcagagg agctttcttc ggccgggaag gggcggggcc tcatcggcgg ggcggagagt
      901 cttaataaac tagcagaggc agggcacgcc cacgaccaaa cgttgagaaa gaggacgacg
      961 catccgcttg tcaattctgc aggtctggcg tggcctcgcc tccgccggca tgacgtcacg
     1021 ggacgcactc gccgcgaggg ttgccgggac gggcccaaga tggctgggag ctttggttcc
     1081 gcttcggtct acctcgtaga gccccattca ttaccttgct gctaagtggc gctgcgtagt
     1141 gcgaataggc tccaagcctt cagggtctgt cctgtcgggc aggaggccgt catggcaacc
     1201 ctggaaaaac tgatgaaggc tttcgagtcg ctcaagtcgt tccagcagca acagcagcag
     1261 cagcagccgc cgccgcaggc gccgccacca ccgccgccgc cgccgcctca accccctcag
     1321 ccgccgcctc aggggcagcc gccgccacca ccgccgctgc caggtccggc cgaggagccg
     1381 ctgcaccgac caaagaagga actctcagcc accaagaagg accgtgtgaa tcactgtcta
     1441 acaatatgtg aaaacattgt ggcacagtct ctcagaaatt ctccagaatt tcagaaactc
     1501 ttgggcattg ctatggaact gtttctgctg tgcagcgacg atgcggagtc agacgtcaga
     1561 atggtggctg atgagtgcct caacaaagtc atcaaagctt tgatggactc taatcttcca
     1621 aggctacagt tagaactcta taaggaaatt aaaaagaatg gtgctcctcg aagtttgcgt
     1681 gcagctctgt ggaggtttgc tgagctggct cacctggttc gacctcagaa gtgcaggcct
     1741 tatctggtga atcttcttcc atgtttgacc cgaacaagca aacgaccgga ggagtcagtt
     1801 caggagactt tggctgcagc tgttcctaaa attatggcct cttttggcaa tttcgcgaat
     1861 gacaatgaaa ttaaggttct attgaaagct ttcatagcaa atctgaagtc aagctctccc
     1921 actgtgcggc ggacagcagc tgggtcagca gtgagtatct gccagcactc taggaggaca
     1981 cagtacttct acaactggct cctgaatgtg ctcctaggtt tgctggttcc catggaggaa
     2041 gaccacccca ctctcctgat ccttggtgtg ttgctcacac tgaggtgtct agtgcccttg
     2101 ctccagcagc aggtcaagga cacaagtcta aagggcagct ttggggtaac acggaaagaa
     2161 atggaagtct ctccttctgc agagcagctt gtccaggttt atgaactgac tttgcatcac
     2221 acacagcacc aagaccataa tgtggtgaca ggggcattgg agctcctgca gcagctcttc
     2281 cgtacccctc cacctgagct gctgcaagca ctgaccacac caggagggct cgggcagctc
     2341 actctggttc gagaggaagc cgggggccga ggccgcagcg ggagtatcgt ggagctttta
     2401 gctggagggg gttcctcatg cagccctgtt ctctcaagaa agcaaaaagg caaagtgctc
     2461 ttaggagagg aagaagcctt ggaggatgac tcggagtcca ggtcagatgt cagcagctca
     2521 gcctttgcag cctctgtgaa gagtgagatt ggtggagagc tcgctgcttc ttcttcgggt
     2581 gtctccactc ccggttctgt aggtcacgac atcatcactg agcagcctcg atcccagcac
     2641 acacttcaag cagactctgt ggatttgtca ggctgtgact tgaccagtgc tgctactgat
     2701 ggagatgagg aagacatctt gagccacagc tccagccagt tcagtgctgt tccatccgac
     2761 cctgccatgg acctgaatga tgggacccag gcctcctcac ccatcagtga cagttctcag
     2821 accaccactg aaggacctga ttcagctgtg actccttctg acagttctga aattgtctta
     2881 gatggtgctg acagccagta tttaggcgtg cagataggac agccacagga ggaagacgag
     2941 gaggaagctg caggtgttct ttctggtgaa gtctcagacg ttttcagaaa ctcttctctg
     3001 gcccttcagc aggcacactt gttggaaaga atgggtcata gccggcagcc ttctgacagc
     3061 agtgttgata agtttgtttc aaaagatgag gttgctgaag ctggggaccc agaaagcaag
     3121 ccttgccgaa tcaaaggtga cataggacag cctaatgatg atgattctgc tcctctggta
     3181 cattgtgtcc gtcttttatc cgcttccttt ttgttaactg gcgaaaagaa agcactggtt
     3241 ccagacagag atgtgagagt cagtgtgaag gccctggccc tcagctgtat tggtgcagct
     3301 gtggcccttc atccagagtc gttcttcagc aaactctaca aagtacctct cagtaccatg
     3361 gaaagtactg aggaacagta tgtctctgac atcctgaact acatcgatca tggagaccct
     3421 caggtgcgag gagctactgc cattctctgt gggacccttg tctactccat cctcagcagg
     3481 tcccgtctcc gtgttggtga ctggctgggc accatcaggg ccctgacagg aaatacattt
     3541 tctctggtgg actgcattcc tttactgcag aaaactttga aggatgaatc ttctgttact
     3601 tgcaagttgg cttgtacagc tgtgaggcac tgtgtcctga gtctttgcag cagcagctac
     3661 agtgacttgg gattacaact gcttattgac atgctgcctc tgaagaacag ctcctactgg
     3721 ctggtgagga ctgaactgct ggaaactctt gcagagattg atttcaggct ggtgagtttt
     3781 ttggaggcaa aagcagaaag tttacaccga ggggctcatc attatacagg gtttctaaaa
     3841 ctacaagaac gagtactcaa taatgtggtc atttatttgc ttggagatga agaccccagg
     3901 gttcgacatg ttgctgcgac gacattgaca agacttgtcc caaagctgtt ttataagtgt
     3961 gaccaaggac aggctgaccc agtcgtggct gtagcaagag atcaaagtag tgtttacctg
     4021 aagctcctca tgcatgagac ccagccacca tcccacttct ccgtcagcac cataaccaga
     4081 atctatagag gctacagctt actaccaagt gtaacagatg tcaccatgga aaacaacctc
     4141 tcaagagtcg ttgccgcagt ttctcatgaa ctcattacgt caactacacg ggcactcaca
     4201 tttgggtgct gtgaagcctt gtgtgttctt tcagccgcct ttccagtttg cacttggagt
     4261 ctaggatggc actgtggagt gcccccactg agtgcctctg atgagtccag gaagagctgc
     4321 actgttggga tggcctccat gattctcacc ttgctttcat cagcttggtt cccactggat
     4381 ctctcagccc atcaggatgc cttgattttg gctggaaact tgctagcagc gagtgccccc
     4441 aagtctctga gaagctcatg ggcctcggaa gaagaaggca gctcagcagc caccagacag
     4501 gaggagatct ggcctgccct gggggatcgg actctggtgc ccatggtgga gcagcttttc
     4561 tcccacctgc tgaaggtgat caatatctgt gctcatgtct tggatgacgt gactcctgga
     4621 ccagcaatca aggcagcttt gccttctctc acaaaccccc cttctctaag tcctattcga
     4681 cggaaaggga aggagaaaga gcccggagaa caaacatcca ctccgatgag tcccaagaaa
     4741 ggtggagagg ccagtacagc ctctcgacag tcagacacct caggacctgt cacagcgagt
     4801 aaatcatctt cacttgggag tttctaccat ctcccttcct acctcagact gcatgatgtc
     4861 ctgaaagcca ctcacgccaa ctataaggtc accttagatc ttcagaacag cactgaaaag
     4921 tttggggggt tcctgcgctc tgccttggac gtcctttctc agattctaga gctggcgaca
     4981 ctgcaggaca ttggaaagtg tgttgaagag gtccttggat acttgaaatc ctgctttagt
     5041 cgagaaccaa tgatggcgac tgtctgtgtt cagcagctat tgaagactct ctttgggaca
     5101 aacttagcct cacagtttga tggcttatct tccaacccca gcaagtctca gtgccgagca
     5161 cagcgccttg gctcttccag tgtgaggccc ggcttatatc actactgctt catggcacca
     5221 tacacgcact tcacgcaggc tttggctgat gccagcctga ggaacatggt acaggcggac
     5281 caggagcacg atgcctcagg gtggtttgat gtactccaga aagtgtctgc tcagttgaag
     5341 acgaacctta caagtgtcac aaagaaccgt gcagataaga acgctattca taaccacatt
     5401 aggttatttg agcctcttgt tataaaagca ttgaagcagt acaccacgac aacatcagta
     5461 caactgcaga agcaggtttt ggatttgctg gcacagctgg ttcagctacg ggtcaattac
     5521 tgtctactgg attcagatca ggtgttcatc gggtttgtgc tgaagcagtt tgagtacatt
     5581 gaagtgggcc agttcaggga atcagaggca attattccaa atatattttt cttcctggta
     5641 ctattatctt atgagcgcta ccattcaaaa cagatcattg gaattcctaa aatcatccag
     5701 ctgtgtgatg gcatcatggc cagtggaagg aaggctgtca cacatgctat tcctgcgctg
     5761 cagcccattg tccatgacct ctttgtgtta agaggaacaa ataaagctga tgcagggaaa
     5821 gagcttgaaa cccagaagga ggtggtggtc tcaatgctgt tacgactcat ccagtaccat
     5881 caggtgctag agatgttcat cctcgtcctg cagcagtgcc acaaagagaa tgaggacaag
     5941 tggaaacggc tctctcggca ggtcgcagac atcatcctgc ccatgttagc caagcagcag
     6001 atgcatattg actctcatga agcccttgga gtattaaata ccttgtttga gattttggct
     6061 ccttcctccc tacgtcctgt ggacatgctt ttgcggagta tgttcatcac tccaagcaca
     6121 atggcatctg taagcactgt gcagctgtgg atatctggaa tcctagccat tctgagggtt
     6181 ctcatttccc agtcaaccga agacattgtt ctttctcgta ttcaggagct ctccttctct
     6241 ccatatttaa tttcctgtcc agtaattaac aggttaaggg atggagacag taatccaaca
     6301 ctaggagaac gcagtgaagg gaaacaagta aagaatttgc cagaagatac attctcaagg
     6361 tttctcttac agctggttgg tattcttctg gaagacattg ttacaaaaca gctcaaagtg
     6421 gacatgagtg aacagcagca tacattctat tgccaagagc tcggcacact gctcatgtgt
     6481 ctgatccaca tattcaaatc tggaatgttc cggagaatca cagccgctgc cactagactc
     6541 ttcaccagtg atggctgtga aggcagcttc tatactctag atagcctgaa tgcacgggtg
     6601 cgagccatgg tgcccacaca cccagctctg gtactgctct ggtgtcagat cctactgctc
     6661 atcaaccaca ctgaccaccg atggtgggcc gaggtgcagc agacgcccaa gagacacagt
     6721 ctgtcctgca cgaagtcact aaacccccag atatctgctg aagaggattc tggctcagca
     6781 gctcagcttg gaatgtgcaa tagagaaata gtacgaagag gggcccttat tctcttctgt
     6841 gattatgtct gtcagaatct ccatgactca gaacacttaa catggctcat tgtgaatcac
     6901 attcaagatc tgatcagctt gtcccacgag cctccagttc aagactttat tagtgccatt
     6961 catcgtaatt ctgcagctag tggtcttttt atccaggcaa ttcagtctcg ctgtgaaaat
     7021 ctttcaactc caaccactct gaagaaaaca cttcagtgct tggaaggcat ccatctcagc
     7081 cagtctggtg ctgtgctcac actgtatgtg gacaggctac tgggcacccc tttccgtgcg
     7141 ctggctcgca tggtcgacac cctggcctgt cgccgagtag aaatgctttt ggctgcaaat
     7201 ttacagagca gcatggccca gttgccagag gaggaactga acagaatcca ggaacacctc
     7261 cagaacactg ggcttgcaca aagacaccaa aggctctatt cactgctgga cagattccga
     7321 ctctctactg tgcaggactc acttagcccc ttgcccccag tcacttccca ccctctggat
     7381 ggggatgggc acacatccct ggaaacagtg aatccggaca aagactggta cctccagctt
     7441 gtcagatccc agtgttggac caggtcagat tctgcactgc tggaaggtgc agagctggtg
     7501 aaccgtatcc ctgctgaaga tatgagtgac ttcatgatga gctcggagtt caacctaagc
     7561 cttttggctc cctgcttaag ccttggcatg agcgagattg ctaatggcca aaagagtccc
     7621 ctttttgaag cggctcgtag ggtgactctg gaccgggtga ccaatgtggt tcagcagctg
     7681 cctgcagtcc atcaagtctt ccagcctttc ctgcctacag aacccacagc ctactggagc
     7741 aagctgaatg atctctttgg tgataccaca tcataccagt ctctgaccac acttgcccgt
     7801 gccctggcac agtacctggt ggtgctctcc aaagtgcctg ctcctttgca ccttcctcct
     7861 gagaaggagg ggcacacggt gaagtttgtg gtaatgacac ttgaggccct gtcatggcat
     7921 ttgatccatg agcagatccc actgagtctg gacctccaag ccggcctaga ctgctgctgc
     7981 ctggcactgc aggtgcctgg cctctggggg gtgctgtcct ccccagagta cgtgactcat
     8041 acttgctccc ttatccactg tgtgcgattc atcctggaag ccattgcagt acaacctgga
     8101 gaccaacttc ttggtccgga aagcaggtca catactccaa gggctgtcag aaaggaggaa
     8161 gtagactcag atatacaaag cggctctctt ggtcaccatt gcctgtgtag acctcagtca
     8221 catcacttcg gcctgcgaga tggtggcaga catggtggaa tccctgcagt cggtgctggc
     8281 cctgggccac aagaggaaca gcaccctacc ttcatttctc acagctgtgc tgaagaacat
     8341 tgttgtcagt ctggcccgcc tccccctcgt taacagctat actcgtgtgc ctcctctggt
     8401 atggaaactc gggtggtcac ccaagcctgg aggggatttc ggcacagtgt ttcctgagat
     8461 ccctgtagag ttcctccagg agaaggaggt cctcaaggag ttcatctacc gcatcaacac
     8521 cctag
//
