LOCUS       NM_001107321            2258 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus HtrA serine peptidase 4 (Htra4), mRNA.
ACCESSION   NM_001107321 XM_001071971 XM_224963
VERSION     NM_001107321.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Ketteler,R., Sun,Z., Kovacs,K.F., He,W.W. and Seed,B.
  TITLE     A pathway sensor for genome-wide screens of intracellular
            proteolytic cleavage
  JOURNAL   Genome Biol 9 (4), R64 (2008)
   PUBMED   18387192
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000283.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001107321.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107321.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               JACYVU010000283.1  16177627-16178242
            617-716             JACYVU010000283.1  16178623-16178722
            717-921             JACYVU010000283.1  16179456-16179660
            922-1116            JACYVU010000283.1  16182526-16182720
            1117-1149           JACYVU010000283.1  16183127-16183159
            1150-1264           JACYVU010000283.1  16185282-16185396
            1265-1322           JACYVU010000283.1  16185739-16185796
            1323-1418           JACYVU010000283.1  16186139-16186234
            1419-2258           JACYVU010000283.1  16190257-16191096
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2258
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="HtrA serine peptidase 4"
                     /db_xref="GeneID:306564"
                     /db_xref="RGD:1306242"
     exon            1..616
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1584
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="probable serine protease HTRA4; high-temperature
                     requirement factor A4; serine protease HTR4"
                     /codon_start=1
                     /product="serine protease HTR4 precursor"
                     /protein_id="NP_001100791.1"
                     /db_xref="GeneID:306564"
                     /db_xref="RGD:1306242"
                     /translation="MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPC
                     PDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPF
                     SREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQK
                     GACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIV
                     SEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLL
                     GRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINH
                     GNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYL
                     GLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQP
                     VTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN"
     exon            617..716
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            717..921
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1116
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1149
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1264
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1322
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1418
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..2258
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgtccttt ataaagtctg gaggccggca gaggcagcat ccaggccagg aaaagaacgt
       61 gttgctcatt tcggcccagt tgtgagccca gagtgaactg gaaaagtaga atcaacgatg
      121 tcaaggagca agatgagctc ccagcggttg tgggctgtgc gagcacagtt tctcttgctg
      181 tggctgctgc tctgggccgc gcctgttccg tgggctgagg ccaggaggtc tagagtctcc
      241 ttgccctgcc cggacgcctg cgatcccacg cgctgcccgc ctctgcctag ctgctcggcc
      301 ggctcggcgc tagtgccaga tcgctgcggc tgctgccaag tgtgcgccgc ggtcgagggc
      361 caggagtgtg gcggggcgcg gggccggccg tgcgtcccgg ggctgcgctg cggcgccccg
      421 ttctcccggg agccctcagg gcgcgcgtgg ctgggcacct gcggttgcgc ggagggtgca
      481 gagggcgcgg cggtgtgcgg cagcgacggg cgcacttacc ccagcctgtg cgcgctccgc
      541 aaggagaacc gagcggctcg ccagcggggt gcgctcccgg ctgtgccagt gcagaaaggt
      601 gcctgcggcg actcagggac cacaagagca gggcggctcc ggacaaagta caacttcatc
      661 gctgccgtgg tggagaaggt ggcaccgtct gtggttcact tgcagctgtt ccgcagatca
      721 cctctcacca accaggaaat cccttcatcc agcggttccg ggttcatagt gtctgaggat
      781 ggcctcattg tcaccaatgc ccatgtcctc accaaccagc agaagatcca ggtagagctc
      841 cagaacgggg ctcagtatga agccactgtc aaagacatcg accataaact ggaccttgca
      901 ctgattaaga tcgagccaga tactgacctt ccagtactgt tgctgggaag atcctctgac
      961 ctccgggccg gagagtttgt ggtggctttg ggtagcccat tttccctgca gaacactgtg
     1021 actgccggga ttgtcagcac cacacagaga ggcggcaaag agttgggact gaaggactca
     1081 gacatagact atatccagac ggacgccatc attaaccacg gaaattctgg gggtccactg
     1141 gtgaacttgg atggcgatgt gatcggtata aacaccctga aggtgaccgc agggatctct
     1201 tttgcaatcc cctcagatag gatcagacag ttcctggcag actatcatga gcgccagttg
     1261 aaaggaaagg ctcccttgca gaagaaatac ctgggtctta gaatgttgcc cctcactctg
     1321 aacctccttc aggaaatgaa gaggcaagat cccgatttcc ctgatgtgag ctctggagtt
     1381 tttgtatatg aagtgattca aggatcggcc gctgcaagct cggggttgag agaccatgat
     1441 gtaattgtca gcataaacgg gcagcctgtc acgaccacaa ccgatgtcat tgaagctgtt
     1501 aaggacaatg cctttctctc catcattgtt cttcgaggaa gccaaacctt gtttctgaca
     1561 gtcacacctg aaataatcaa ttaagcacct tactttgaga aactgcctag caaaaccagt
     1621 tatattacct ggtttctatc gaagacgaac cagagatggc aggttcttct gggtatcaag
     1681 aaaagtggat gctttaaatg tataagtaca tgtgtgtgtg atacacacac tcgtgcacat
     1741 gtgtacacac gtgtatacac acacacacac acacacacac acacacacac acacacacac
     1801 attctcatgg atcctgaggg attaagcatg ctcttctact acaaaaactt tcgtgactca
     1861 agtggccgca gctatggtga tcagagaaaa agtaaagaca gtaagaatgg gaaaacagga
     1921 gactcctaac taaatcttca cagggtgctt tacttaccgt ctatatagcc actaactgat
     1981 atgtcacaca catgtacaaa caatctacct actagatctg aatctggagt aaagaggcaa
     2041 tcatgtttta aataacaccc ctctgtatgc tgaatttccc ggggtatatc cactttgggc
     2101 cagggtttgt ggatagaaag gtcgtcaact ctaagataga ttacaactga tgacgtcaga
     2161 ccaccacaca ggaatatgac cattttagcg gtagaaacta tcctggacct ctggtgtttc
     2221 tgagaatgtc ttctattaaa acaatttttt gaaccatt
//
