LOCUS       NM_001106599            1607 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus HtrA serine peptidase 2 (Htra2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001106599 XM_001054494 XM_001066414
VERSION     NM_001106599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Du Y, Yang D, Dong X, Du Q, Wang D, Shen Y and Yu W.
  TITLE     Omi inhibition ameliorates neuron apoptosis and neurological
            deficit after subarachnoid hemorrhage in rats
  JOURNAL   Genes Genomics 43 (12), 1423-1432 (2021)
   PUBMED   34677809
  REMARK    GeneRIF: Omi inhibition ameliorates neuron apoptosis and
            neurological deficit after subarachnoid hemorrhage in rats.
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Wang X.
  TITLE     Inhibition of HtrA2 alleviates inflammatory response and cell
            apoptosis in lipopolysaccharide-induced acute pneumonia in rats
  JOURNAL   Mol Med Rep 22 (4), 3127-3134 (2020)
   PUBMED   32945404
  REMARK    GeneRIF: Inhibition of HtrA2 alleviates inflammatory response and
            cell apoptosis in lipopolysaccharideinduced acute pneumonia in
            rats.
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Zurawa-Janicka D, Kobiela J, Slebioda T, Peksa R, Stanislawowski M,
            Wierzbicki PM, Wenta T, Lipinska B, Kmiec Z, Biernat W, Lachinski
            AJ and Sledzinski Z.
  TITLE     Expression of HTRA Genes and Its Association with Microsatellite
            Instability and Survival of Patients with Colorectal Cancer
  JOURNAL   Int J Mol Sci 21 (11), 3947 (2020)
   PUBMED   32486357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Li F, Li X, Yang J, Guo X, Zheng X, Lv Z and Shi C.
  TITLE     Increased Expression of Apo-J and Omi/HtrA2 After Intracerebral
            Hemorrhage in Rats
  JOURNAL   World Neurosurg 116, e26-e34 (2018)
   PUBMED   29581019
  REMARK    GeneRIF: Local high expression of Apo-J in the peripheral regions
            may play a neuroprotective role by inhibiting apoptosis via the
            Omi/HtrA2 pathway after hemorrhage
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Wang P, Hu Y, Yao D and Li Y.
  TITLE     Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a
            Murine Model of Septic Encephalopathy
  JOURNAL   Cell Physiol Biochem 49 (6), 2163-2173 (2018)
   PUBMED   30286467
  REMARK    GeneRIF: The inhibition of Omi/HtrA2 by UCF-101 leads to
            neuroprotection by inhibiting the cytosolic translocation of
            Omi/HtrA2 and antagonizing the caspase-dependent apoptosis pathway.
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM,
            Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ and Vaux
            DL.
  TITLE     HtrA2 promotes cell death through its serine protease activity and
            its ability to antagonize inhibitor of apoptosis proteins
  JOURNAL   J Biol Chem 277 (1), 445-454 (2002)
   PUBMED   11604410
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine
            NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C and Downward J.
  TITLE     The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP
            through a reaper-like motif
  JOURNAL   J Biol Chem 277 (1), 439-444 (2002)
   PUBMED   11602612
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K and Takahashi R.
  TITLE     A serine protease, HtrA2, is released from the mitochondria and
            interacts with XIAP, inducing cell death
  JOURNAL   Mol Cell 8 (3), 613-621 (2001)
   PUBMED   11583623
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D,
            Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ,
            Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi
            GP and Creasy CL.
  TITLE     Characterization of human HtrA2, a novel serine protease involved
            in the mammalian cellular stress response
  JOURNAL   Eur J Biochem 267 (18), 5699-5710 (2000)
   PUBMED   10971580
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Jones JM, Albin RL, Feldman EL, Simin K, Schuster TG, Dunnick WA,
            Collins JT, Chrisp CE, Taylor BA and Meisler MH.
  TITLE     mnd2: a new mouse model of inherited motor neuron disease
  JOURNAL   Genomics 16 (3), 669-677 (1993)
   PUBMED   8325640
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158760.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001106599.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158760.1, SRR8487227.300632.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1607
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /note="HtrA serine peptidase 2"
                     /db_xref="GeneID:297376"
                     /db_xref="RGD:1308906"
     exon            1..530
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1401
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /EC_number="2.4.21.-"
                     /note="protease, serine, 25; high temperature requirement
                     protein A2"
                     /codon_start=1
                     /product="serine protease HTRA2, mitochondrial"
                     /protein_id="NP_001100069.1"
                     /db_xref="GeneID:297376"
                     /db_xref="RGD:1308906"
                     /translation="MAALKAGRGANWSLRAWRALGGIFWRKGPLLAPDLRALLTSGTP
                     DPQARMTYGTPSLPARVPLGVLASRANLTSGTPDLWVRLTVGTPGSSDQEDCGSPGSR
                     RREWLAVALGAGGAVLLLLWGWGRGPSTVLAAVPAPPPTSPRSQYNFIADVVEKTAPA
                     VVYIEILDRHPFSGREVPISNGSGFIVASDGLIVTNAHVVADRRRVRVRLPSGDTYEA
                     MVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVS
                     SAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIP
                     SDRLREFLHRGEKKNSWFGISGSQRRYIGVMMLTLTPSILAELQLREPSFPDVQHGVL
                     IHKVILGSPAHRAGLRPADVILAIGEKMIQNAEDVYEAVRTQSQLAVRIRRGPETLTL
                     YVTPEVTE"
     exon            531..735
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            736..930
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            931..963
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1069
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1139
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1235
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1584
                     /gene="Htra2"
                     /gene_synonym="Prss25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggagag ccgaggcgga gcagatggct gcgctgaagg cggggcgggg tgcaaactgg
       61 agccttcggg catggcgggc tttggggggc atcttctgga ggaagggccc cctgttagcc
      121 cctgacctcc gggctctgct gacgtcagga actcctgacc ctcaggcccg gatgacttat
      181 gggaccccca gtctcccggc ccgggtgcct ttgggggtcc ttgcatcacg ggcaaatctg
      241 acgtctggga ccccggatct ctgggtacga ctgactgtgg ggactccagg ctctagtgac
      301 caggaggact gcgggagccc tggaagccgt cggcgcgaat ggctagcggt ggcgttgggc
      361 gcagggggtg cagtgctgct gttgttgtgg ggttgggggc ggggtccttc cacggtgctg
      421 gctgctgttc ctgctccgcc acccacctct ccccggagcc agtacaattt catcgcagac
      481 gtggtggaga agacagcccc tgctgtggtc tatatcgaga tcctagaccg gcaccctttc
      541 tccggccgtg aagtccccat ctcaaacggt tcaggattca tagtggcttc agatgggctc
      601 atcgtaacca acgcccacgt ggtggctgat cggcgccgag tgcgagtgag gctacctagc
      661 ggagacactt atgaggccat ggtcacagct gtggatcctg tagcagacat tgccacatta
      721 aggattcaaa ccaaggagcc tcttcccaca ctgcccctcg gccgctccgc tgatgtccgg
      781 caaggggagt ttgttgttgc catgggaagt cccttcgctc tgcagaacac catcacgtcc
      841 ggcattgtca gctctgctca gcgaccagcc agggacctgg ggctccctca gaccaacgtg
      901 gaatacattc agaccgatgc agctattgac tttggaaatt ctggtggtcc cctggttaac
      961 ctggatgggg aggtgattgg agtgaacacc atgaaggtga cagctggaat ctcctttgcc
     1021 atcccttctg atcgccttag ggagttcctg catcgcgggg agaagaaaaa ttcctggttt
     1081 ggaatcagtg ggtcccaacg ccgctacatt ggagtgatga tgctgactct gacccccagc
     1141 atccttgctg agctacagct ccgagagcca agtttccctg atgttcagca tggtgtcctc
     1201 attcataaag ttatcctggg ctcccctgca cacagggctg gcctgcggcc tgctgatgtg
     1261 atcttggcca ttggggagaa aatgatacaa aatgctgaag atgtttatga ggctgttcga
     1321 acccaatcac agctggcagt gcggatccgg cgtggaccag aaacgctgac cttatacgtg
     1381 accccagagg tcacagaata actggattgg caagggtttg aagctcttgc tctgatttcc
     1441 tccttgcttt tctagtctag gttctgaacg catgtgggaa gaggaggagt gactagacct
     1501 acggagggca ggtccctcta accactgcag cagtcctggg ctctgaagaa cacattttat
     1561 ataaaataaa attataccta gcaaaaaaaa aaaaaaaaaa aaaaaaa
//
