LOCUS       NM_031721               2012 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus HtrA serine peptidase 1 (Htra1), mRNA.
ACCESSION   NM_031721
VERSION     NM_031721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Tavarna,T., Wolfe,B., Wu,X.J. and Reyes,L.
  TITLE     Porphyromonas gingivalis-mediated disruption in spiral artery
            remodeling is associated with altered uterine NK cell populations
            and dysregulated IL-18 and Htra1
  JOURNAL   Sci Rep 12 (1), 14799 (2022)
   PUBMED   36042379
  REMARK    GeneRIF: Porphyromonas gingivalis-mediated disruption in spiral
            artery remodeling is associated with altered uterine NK cell
            populations and dysregulated IL-18 and Htra1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Wang,W., Zhao,M., Cui,L., Ren,Y., Zhang,J., Chen,J., Jia,L.,
            Zhang,J., Yang,J., Chen,G., Ashby,C.R. Jr., Wu,C., Chen,Z.S. and
            Wang,L.
  TITLE     Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a
            novel target to overcome cisplatin resistance in human non-small
            cell lung cancer
  JOURNAL   Mol Cancer 19 (1), 134 (2020)
   PUBMED   32878625
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Zurawa-Janicka,D., Kobiela,J., Slebioda,T., Peksa,R.,
            Stanislawowski,M., Wierzbicki,P.M., Wenta,T., Lipinska,B.,
            Kmiec,Z., Biernat,W., Lachinski,A.J. and Sledzinski,Z.
  TITLE     Expression of HTRA Genes and Its Association with Microsatellite
            Instability and Survival of Patients with Colorectal Cancer
  JOURNAL   Int J Mol Sci 21 (11), 3947 (2020)
   PUBMED   32486357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Yao,Y. and Li,N.
  TITLE     Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in
            Patients with Colon Cancer
  JOURNAL   Med Sci Monit 26, e921933 (2020)
   PUBMED   32218415
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Xiong,Z., Fu,Z., Shi,J., Jiang,X. and Wan,H.
  TITLE     HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer
            by Increasing XIAP and Activating PI3K/Akt Pathway
  JOURNAL   Ann Clin Lab Sci 47 (3), 264-270 (2017)
   PUBMED   28667026
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Cameron,D.J., Yang,Z., Gibbs,D., Chen,H., Kaminoh,Y., Jorgensen,A.,
            Zeng,J., Luo,L., Brinton,E., Brinton,G., Brand,J.M.,
            Bernstein,P.S., Zabriskie,N.A., Tang,S., Constantine,R., Tong,Z.
            and Zhang,K.
  TITLE     HTRA1 variant confers similar risks to geographic atrophy and
            neovascular age-related macular degeneration
  JOURNAL   Cell Cycle 6 (9), 1122-1125 (2007)
   PUBMED   17426452
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Sheng,J., Organ,E.L., Hao,C., Wells,K.S., Ruley,H.E. and Rubin,D.H.
  TITLE     Mutations in the IGF-II pathway that confer resistance to lytic
            reovirus infection
  JOURNAL   BMC Cell Biol 5, 32 (2004)
   PUBMED   15333144
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Tocharus,J., Tsuchiya,A., Kajikawa,M., Ueta,Y., Oka,C. and
            Kawaichi,M.
  TITLE     Developmentally regulated expression of mouse HtrA3 and its role as
            an inhibitor of TGF-beta signaling
  JOURNAL   Dev Growth Differ 46 (3), 257-274 (2004)
   PUBMED   15206957
REFERENCE   9  (bases 1 to 2012)
  AUTHORS   Oka,C., Tsujimoto,R., Kajikawa,M., Koshiba-Takeuchi,K., Ina,J.,
            Yano,M., Tsuchiya,A., Ueta,Y., Soma,A., Kanda,H., Matsumoto,M. and
            Kawaichi,M.
  TITLE     HtrA1 serine protease inhibits signaling mediated by Tgfbeta family
            proteins
  JOURNAL   Development 131 (5), 1041-1053 (2004)
   PUBMED   14973287
REFERENCE   10 (bases 1 to 2012)
  AUTHORS   Hu,S.I., Carozza,M., Klein,M., Nantermet,P., Luk,D. and Crowl,R.M.
  TITLE     Human HtrA, an evolutionarily conserved serine protease identified
            as a differentially expressed gene product in osteoarthritic
            cartilage
  JOURNAL   J Biol Chem 273 (51), 34406-34412 (1998)
   PUBMED   9852107
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF179370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF179370.1, BC081767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2012
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /note="HtrA serine peptidase 1"
                     /db_xref="GeneID:65164"
                     /db_xref="RGD:69235"
     exon            1..512
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1483
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /EC_number="3.4.21.-"
                     /note="protease, serine, 11 (Igf binding); protease serine
                     11; serine protease HTRA1; serine protease 11;
                     high-temperature requirement A serine peptidase 1"
                     /codon_start=1
                     /product="serine protease HTRA1 precursor"
                     /protein_id="NP_113909.1"
                     /db_xref="GeneID:65164"
                     /db_xref="RGD:69235"
                     /translation="MQFLRTALLSLLLLLLAAPSLALPSGISRSAPAATVCPEHCDPT
                     RCAPPPTDCEGGRVRDACGCCEVCGALEGAVCGLQEGPCGEGLQCVVPFGVPASATVR
                     RRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQE
                     DPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTN
                     AHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPG
                     EFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVN
                     LDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKTVTKKKYIGIRMMSLTS
                     SKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSD
                     VIKKENTLNMVVRRGNEDIVITVVPEEIDP"
     exon            513..612
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            613..817
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1012
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1045
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1160
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1218
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1314
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..2012
                     /gene="Htra1"
                     /gene_synonym="Prss11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttcggct gtggtccagc ccgtggccgt cggagtcgcc atgcagttcc tgcgtaccgc
       61 gctcctgtct ttgctactgc tgctgctggc ggctccctct ttggcgttgc cgtcggggat
      121 cagccgctcg gcccccgctg ccactgtctg tccggagcac tgcgatccta cccgctgcgc
      181 cccgccaccc acggactgcg agggtggccg cgtccgcgac gcgtgcggct gctgcgaggt
      241 gtgcggcgcg ctcgagggtg cagtgtgcgg cctgcaggag ggtccctgcg gcgaggggct
      301 gcaatgcgta gtgcccttcg gggtgccggc ctccgccaca gtacgacggc gcgcacaggc
      361 cggtctgtgc gtgtgtgcca gcagcgagcc ggtgtgcggc agcgacgcca agacgtacac
      421 caacctgtgc cagctgcgcg ccgccagccg ccgttccgag aagcttcgcc agcctccggt
      481 catcgtcctg cagcgcggcg cctgcggcca agggcaggaa gatcccaaca gtttgcgtca
      541 taagtacaac tttatcgctg atgtggtgga gaagatcgcc cctgctgtgg ttcacattga
      601 actttatcgc aagcttcctt tctcgaagag ggaggtgcca gtggcgagtg ggtcaggatt
      661 cattgtgtcg gaggatggac tgattgtgac aaatgctcac gtggtgacca acaaaaaccg
      721 ggtcaaggtt gagctgaaga atggagcgac ttatgaagcc aaaatcaagg atgtggatga
      781 aaaggccgac attgcgctta tcaagattga ccaccagggt aagctgccag tcctgctgct
      841 tggccgctcc tccgagctgc ggccaggaga atttgtggtt gccatcggaa gccccttctc
      901 tcttcaaaac acggtcacca ctgggatcgt cagcaccacc cagcgaggcg gcaaagaact
      961 ggggctccgg aactccgata tggactacat tcagacagac gccatcatca attatggaaa
     1021 ctccggaggc ccgttagtaa acctggatgg cgaggtgatt gggattaaca ccttgaaggt
     1081 gacggcgggc atctccttcg caattccatc cgataagata aaaaagttct tgacagagtc
     1141 ccatgatcga caggccaaag ggaaaactgt caccaagaag aagtatattg ggatacgaat
     1201 gatgtcgctt acatctagca aagccaaaga actgaaggat cgtcaccgag acttcccgga
     1261 tgtaatctcc ggagcatata tcattgaagt catccccgac acccccgcag aagctggagg
     1321 gctcaaggaa aatgacgtca tcatcagcat caatggacag tctgtggtca ctgccaatga
     1381 tgtcagtgat gtcatcaaaa aggagaacac cctgaacatg gttgtccgca gagggaatga
     1441 agacattgtg attacggtgg ttcctgaaga aattgatccc taggcagagg caggagctgg
     1501 acttcatgtt tccctcaaag actccaggag atggcgcatg agaactgagc tggtgacgca
     1561 ggacacccag gactttgtcc aacattttgc ttgttcgggg aacacccctg tcgacagaat
     1621 cctccttgat agtttgcggg caaaacaaat gtaatgttgg aggtgcacag gccgaagccc
     1681 tgccctctgt atgctacgca tgcagcctgc tttttcttac aagcttgggc tattcctgct
     1741 taagcagtca acatctgtcc ctgcccttag ccccagttgt ccgactaatg cacttgacag
     1801 acgcatagat ggatgagagg acagtccttg cagccttggt cttgggtgtg tttacacttt
     1861 tactccgagt cagcactcag aggaaattga tgccctgaga ccacaggtgg gtgaccctgg
     1921 cttctgagat ggccaaaaaa tgcctcttag gaatcctgga atcaggagta caatgacttt
     1981 gagtttcagc tattaaaata cttcttcata ct
//
