LOCUS       NM_022938               1493 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 7 (Htr7), mRNA.
ACCESSION   NM_022938
VERSION     NM_022938.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1493)
  AUTHORS   Korlatowicz,A., Pabian,P., Solich,J., Kolasa,M., Latocha,K.,
            Dziedzicka-Wasylewska,M. and Faron-Gorecka,A.
  TITLE     Habenula as a Possible Target for Treatment-Resistant Depression
            Phenotype in Wistar Kyoto Rats
  JOURNAL   Mol Neurobiol 60 (2), 643-654 (2023)
   PUBMED   36344870
  REMARK    GeneRIF: Habenula as a Possible Target for Treatment-Resistant
            Depression Phenotype in Wistar Kyoto Rats.
REFERENCE   2  (bases 1 to 1493)
  AUTHORS   Slawinska,U., Majczynski,H., Kwasniewska,A., Miazga,K., Cabaj,A.M.,
            Bekisz,M., Jordan,L.M. and Zawadzka,M.
  TITLE     Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar
            Spinal Blockade of 5-HT7 Receptors
  JOURNAL   Int J Mol Sci 22 (11), 6007 (2021)
   PUBMED   34199392
  REMARK    GeneRIF: Unusual Quadrupedal Locomotion in Rat during Recovery from
            Lumbar Spinal Blockade of 5-HT7 Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1493)
  AUTHORS   Cinar,I., Halici,Z., Dincer,B., Sirin,B. and Cadirci,E.
  TITLE     The role of 5-HT7 receptors on isoproterenol-induced myocardial
            infarction in rats with high-fat diet exacerbated coronary
            endothelial dysfunction
  JOURNAL   Hum Exp Toxicol 39 (8), 1005-1018 (2020)
   PUBMED   32329363
  REMARK    GeneRIF: The role of 5-HT7 receptors on isoproterenol-induced
            myocardial infarction in rats with high-fat diet exacerbated
            coronary endothelial dysfunction.
REFERENCE   4  (bases 1 to 1493)
  AUTHORS   Hernandez-Abreu,O.I., Garcia-Pedraza,J.A., Rivera-Mancilla,E.,
            Villanueva-Castillo,B., Moran,A., Garcia-Domingo,M.,
            Manrique-Maldonado,G., Altamirano-Espinoza,A.H. and Villalon,C.M.
  TITLE     Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7
            receptors inhibiting the tachycardic sympathetic drive in pithed
            rats
  JOURNAL   Clin Exp Pharmacol Physiol 47 (3), 403-411 (2020)
   PUBMED   31846086
  REMARK    GeneRIF: Blockade of 5-HT2 receptors with sarpogrelate uncovers
            5-HT7 receptors inhibiting the tachycardic sympathetic drive in
            pithed rats.
REFERENCE   5  (bases 1 to 1493)
  AUTHORS   Seitz,B.M., Demireva,E.Y., Xie,H., Fink,G.D., Krieger-Burke,T.,
            Burke,W.M. and Watts,S.W.
  TITLE     5-HT does not lower blood pressure in the 5-HT7 knockout rat
  JOURNAL   Physiol Genomics 51 (7), 302-310 (2019)
   PUBMED   31125292
REFERENCE   6  (bases 1 to 1493)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (bases 1 to 1493)
  AUTHORS   Ruat,M., Traiffort,E., Leurs,R., Tardivel-Lacombe,J., Diaz,J.,
            Arrang,J.M. and Schwartz,J.C.
  TITLE     Molecular cloning, characterization, and localization of a
            high-affinity serotonin receptor (5-HT7) activating cAMP formation
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8547-8551 (1993)
   PUBMED   8397408
REFERENCE   8  (bases 1 to 1493)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
REFERENCE   9  (bases 1 to 1493)
  AUTHORS   Shen,Y., Monsma,F.J. Jr., Metcalf,M.A., Jose,P.A., Hamblin,M.W. and
            Sibley,D.R.
  TITLE     Molecular cloning and expression of a 5-hydroxytryptamine7
            serotonin receptor subtype
  JOURNAL   J Biol Chem 268 (24), 18200-18204 (1993)
   PUBMED   8394362
REFERENCE   10 (bases 1 to 1493)
  AUTHORS   Meyerhof,W., Obermuller,F., Fehr,S. and Richter,D.
  TITLE     A novel rat serotonin receptor: primary structure, pharmacology,
            and expression pattern in distinct brain regions
  JOURNAL   DNA Cell Biol 12 (5), 401-409 (1993)
   PUBMED   8517926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U68489.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022938.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68489.1, L22558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1493
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="5-hydroxytryptamine receptor 7"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
     exon            1..663
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1423
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /note="serotonin receptor 7; GPRFO; 5-HT-7; 5-HT-X; 5-HT7;
                     high affinity serotonin receptor (5HT7);
                     5-hydroxytryptamine (serotonin) receptor 7, adenylate
                     cyclase-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 7"
                     /protein_id="NP_075227.1"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
                     /translation="MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSW
                     MPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGN
                     CLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNV
                     FIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL
                     PPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH
                     KFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGI
                     IVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNR
                     DLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVL"
     exon            664..1424
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1493
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccccatg gctgggccgc gcggagccga gcgggcaagg tgaatccagc cccggggccg
       61 gctgccggag cgcttggcgg ggtcgccggc tccatgggca gcggcgctcg gcacgatgat
      121 ggacgttaac agcagcggcc gccccgacct ctacggccat ctccgttcac tcatcctgcc
      181 ggaggtgggg cgcgggctgc aggacctgag ccccgacggt ggcgcccacc ctgtggtgag
      241 ctcctggatg ccgcacctgc tgagtggctt cctagaggtg acggctagcc cggcgcccac
      301 ctgggacgcg ccaccggaca atgtctcagg ctgcggggag cagatcaact atggcagagt
      361 ggagaaagtt gtgatcggct ccatcctgac gctcatcacg ctgctgacga tcgcaggcaa
      421 ctgcctggtg gtgatctcgg tgtgcttcgt caagaagctc cgccagccct ccaactacct
      481 gattgtgtcc ctggcgctgg ctgacctctc ggtggccgtg gcggtcatgc ctttcgttag
      541 tgtcaccgac ctcatcgggg gcaagtggat cttcggccac ttcttctgca acgtcttcat
      601 cgccatggac gtcatgtgct gcacggcctc gatcatgacc ctgtgcgtga tcagcatcga
      661 caggtacctt gggatcacga gacccctcac gtacccggtg aggcaaaatg ggaaatgtat
      721 ggccaaaatg attctgtcgg tctggctgct ctctgcctcc atcaccttac ctcctctctt
      781 cggatgggct cagaatgtga acgatgacaa agtgtgcttg atcagccagg attttggcta
      841 cacgatctac tccactgcgg tggcgtttta tatccccatg tcggtcatgc tgttcatgta
      901 ctatcagatt tacaaggccg ccaggaagag tgcagccaaa cacaagttcc caggcttccc
      961 acgcgtgcag ccggagagtg tcatctccct gaatggtgtg gtgaagctcc agaaggaggt
     1021 ggaagagtgt gcgaaccttt cgagactgct caaacacgaa aggaaaaaca tctccatctt
     1081 caagcgggaa cagaaagcag ccactacctt ggggatcatc gtgggagcct tcactgtgtg
     1141 ctggctgccg tttttcctct tgtccacagc ccgccccttt atctgtggca cctcctgtag
     1201 ctgcattcct ctgtgggtgg agaggacatg tctgtggctg ggctatgcaa actctctcat
     1261 taatcctttt atatatgcct tcttcaaccg ggacctgagg accacctatc gtagcctact
     1321 ccagtgccag taccggaata tcaaccggaa gctctctgct gcaggcatgc atgaagccct
     1381 gaaacttgct gagaggcccg agagatccga gtttgtgctg taagacaaaa ctctgaccac
     1441 tgtgggaaaa agggtcatga tacatgatcc agagtggaac cctggatgaa ttc
//
