LOCUS       NP_075227                435 aa            linear   ROD 04-OCT-2024
DEFINITION  5-hydroxytryptamine receptor 7 [Rattus norvegicus].
ACCESSION   NP_075227
VERSION     NP_075227.1
DBSOURCE    REFSEQ: accession NM_022938.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 435)
  AUTHORS   Korlatowicz,A., Pabian,P., Solich,J., Kolasa,M., Latocha,K.,
            Dziedzicka-Wasylewska,M. and Faron-Gorecka,A.
  TITLE     Habenula as a Possible Target for Treatment-Resistant Depression
            Phenotype in Wistar Kyoto Rats
  JOURNAL   Mol Neurobiol 60 (2), 643-654 (2023)
   PUBMED   36344870
  REMARK    GeneRIF: Habenula as a Possible Target for Treatment-Resistant
            Depression Phenotype in Wistar Kyoto Rats.
REFERENCE   2  (residues 1 to 435)
  AUTHORS   Slawinska,U., Majczynski,H., Kwasniewska,A., Miazga,K., Cabaj,A.M.,
            Bekisz,M., Jordan,L.M. and Zawadzka,M.
  TITLE     Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar
            Spinal Blockade of 5-HT7 Receptors
  JOURNAL   Int J Mol Sci 22 (11), 6007 (2021)
   PUBMED   34199392
  REMARK    GeneRIF: Unusual Quadrupedal Locomotion in Rat during Recovery from
            Lumbar Spinal Blockade of 5-HT7 Receptors.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 435)
  AUTHORS   Cinar,I., Halici,Z., Dincer,B., Sirin,B. and Cadirci,E.
  TITLE     The role of 5-HT7 receptors on isoproterenol-induced myocardial
            infarction in rats with high-fat diet exacerbated coronary
            endothelial dysfunction
  JOURNAL   Hum Exp Toxicol 39 (8), 1005-1018 (2020)
   PUBMED   32329363
  REMARK    GeneRIF: The role of 5-HT7 receptors on isoproterenol-induced
            myocardial infarction in rats with high-fat diet exacerbated
            coronary endothelial dysfunction.
REFERENCE   4  (residues 1 to 435)
  AUTHORS   Hernandez-Abreu,O.I., Garcia-Pedraza,J.A., Rivera-Mancilla,E.,
            Villanueva-Castillo,B., Moran,A., Garcia-Domingo,M.,
            Manrique-Maldonado,G., Altamirano-Espinoza,A.H. and Villalon,C.M.
  TITLE     Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7
            receptors inhibiting the tachycardic sympathetic drive in pithed
            rats
  JOURNAL   Clin Exp Pharmacol Physiol 47 (3), 403-411 (2020)
   PUBMED   31846086
  REMARK    GeneRIF: Blockade of 5-HT2 receptors with sarpogrelate uncovers
            5-HT7 receptors inhibiting the tachycardic sympathetic drive in
            pithed rats.
REFERENCE   5  (residues 1 to 435)
  AUTHORS   Seitz,B.M., Demireva,E.Y., Xie,H., Fink,G.D., Krieger-Burke,T.,
            Burke,W.M. and Watts,S.W.
  TITLE     5-HT does not lower blood pressure in the 5-HT7 knockout rat
  JOURNAL   Physiol Genomics 51 (7), 302-310 (2019)
   PUBMED   31125292
REFERENCE   6  (residues 1 to 435)
  AUTHORS   Heidmann,D.E., Metcalf,M.A., Kohen,R. and Hamblin,M.W.
  TITLE     Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and
            rat produced by alternative splicing: species differences due to
            altered intron-exon organization
  JOURNAL   J Neurochem 68 (4), 1372-1381 (1997)
   PUBMED   9084407
REFERENCE   7  (residues 1 to 435)
  AUTHORS   Ruat,M., Traiffort,E., Leurs,R., Tardivel-Lacombe,J., Diaz,J.,
            Arrang,J.M. and Schwartz,J.C.
  TITLE     Molecular cloning, characterization, and localization of a
            high-affinity serotonin receptor (5-HT7) activating cAMP formation
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8547-8551 (1993)
   PUBMED   8397408
REFERENCE   8  (residues 1 to 435)
  AUTHORS   Lovenberg,T.W., Baron,B.M., de Lecea,L., Miller,J.D., Prosser,R.A.,
            Rea,M.A., Foye,P.E., Racke,M., Slone,A.L., Siegel,B.W. et al.
  TITLE     A novel adenylyl cyclase-activating serotonin receptor (5-HT7)
            implicated in the regulation of mammalian circadian rhythms
  JOURNAL   Neuron 11 (3), 449-458 (1993)
   PUBMED   8398139
REFERENCE   9  (residues 1 to 435)
  AUTHORS   Shen,Y., Monsma,F.J. Jr., Metcalf,M.A., Jose,P.A., Hamblin,M.W. and
            Sibley,D.R.
  TITLE     Molecular cloning and expression of a 5-hydroxytryptamine7
            serotonin receptor subtype
  JOURNAL   J Biol Chem 268 (24), 18200-18204 (1993)
   PUBMED   8394362
REFERENCE   10 (residues 1 to 435)
  AUTHORS   Meyerhof,W., Obermuller,F., Fehr,S. and Richter,D.
  TITLE     A novel rat serotonin receptor: primary structure, pharmacology,
            and expression pattern in distinct brain regions
  JOURNAL   DNA Cell Biol 12 (5), 401-409 (1993)
   PUBMED   8517926
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U68489.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U68489.1, L22558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     Protein         1..435
                     /product="5-hydroxytryptamine receptor 7"
                     /note="serotonin receptor 7; GPRFO; 5-HT-7; 5-HT-X; 5-HT7;
                     high affinity serotonin receptor (5HT7);
                     5-hydroxytryptamine (serotonin) receptor 7, adenylate
                     cyclase-coupled"
                     /calculated_mol_wt=48297
     Site            5
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32305.2)"
     Site            87..111
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Region          100..398
                     /region_name="7tmA_5-HT7"
                     /note="serotonin receptor subtype 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15329"
                     /db_xref="CDD:320452"
     Region          119..145
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320452"
     Site            122..143
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Site            156..181
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Region          158..188
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320452"
     Site            order(161..162,165..166,169..170,234,246,250,343,346..347,
                     353,366,369..370,373,377)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320452"
     Region          200..222
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320452"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Region          239..268
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320452"
     Site            241..263
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Region          323..353
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320452"
     Site            330..355
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320452"
     Site            367..390
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32305.2)"
     CDS             1..435
                     /gene="Htr7"
                     /gene_synonym="5Ht7"
                     /coded_by="NM_022938.2:116..1423"
                     /db_xref="GeneID:65032"
                     /db_xref="RGD:71034"
ORIGIN      
        1 mmdvnssgrp dlyghlrsli lpevgrglqd lspdggahpv vsswmphlls gflevtaspa
       61 ptwdappdnv sgcgeqinyg rvekvvigsi ltlitlltia gnclvvisvc fvkklrqpsn
      121 ylivslalad lsvavavmpf vsvtdliggk wifghffcnv fiamdvmcct asimtlcvis
      181 idrylgitrp ltypvrqngk cmakmilsvw llsasitlpp lfgwaqnvnd dkvclisqdf
      241 gytiystava fyipmsvmlf myyqiykaar ksaakhkfpg fprvqpesvi slngvvklqk
      301 eveecanlsr llkherknis ifkreqkaat tlgiivgaft vcwlpfflls tarpficgts
      361 csciplwver tclwlgyans linpfiyaff nrdlrttyrs llqcqyrnin rklsaagmhe
      421 alklaerper sefvl
//
