LOCUS       NM_024365               1925 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 6 (Htr6), mRNA.
ACCESSION   NM_024365
VERSION     NM_024365.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Farias,C.P., Leite,A.K.O., Schmidt,B.E., de Carvalho Myskiw,J. and
            Wyse,A.T.S.
  TITLE     The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial
            prefrontal cortex behave differently in extinction learning: Does
            social support play a role?
  JOURNAL   Behav Brain Res 463, 114922 (2024)
   PUBMED   38408524
  REMARK    GeneRIF: The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in
            the medial prefrontal cortex behave differently in extinction
            learning: Does social support play a role?
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Rychtyk,J., Partyka,A., Gdula-Argasinska,J., Myslowska,K.,
            Wilczynska,N., Jastrzebska-Wiesek,M. and Wesolowska,A.
  TITLE     5-HT6 receptor agonist and antagonist improve memory impairments
            and hippocampal BDNF signaling alterations induced by MK-801
  JOURNAL   Brain Res 1722, 146375 (2019)
   PUBMED   31412259
  REMARK    GeneRIF: 5-HT6 receptor agonist and antagonist improve memory
            impairments and hippocampal BDNF signaling alterations induced by
            MK-801.
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Rahman,M.A., Kim,H., Lee,K.H., Yun,H.M., Hong,J.H., Kim,Y.,
            Choo,H., Park,M. and Rhim,H.
  TITLE     5-Hydroxytryptamine 6 Receptor (5-HT6R)-Mediated Morphological
            Changes via RhoA-Dependent Pathways
  JOURNAL   Mol Cells 40 (7), 495-502 (2017)
   PUBMED   28681593
  REMARK    GeneRIF: 5-HT6R plays an important role in the regulation of cell
            morphology via a RhoA-dependent pathway in mammalian cell lines and
            primary neurons.
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Jastrzebska-Wiesek,M., Siwek,A., Partyka,A.,
            Antkiewicz-Michaluk,L., Michaluk,J., Romanska,I., Kolaczkowski,M.
            and Wesolowska,A.
  TITLE     Study of a mechanism responsible for potential antidepressant
            activity of EMD 386088, a 5-HT6 partial agonist in rats
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 389 (8), 839-849 (2016)
   PUBMED   27106213
  REMARK    GeneRIF: Dopaminergic system is involved in antidepressant-like
            activity of Htr6 partial agonist EMD386088.
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Brodsky,M., Gibson,A.W., Smirnov,D., Nair,S.G. and Neumaier,J.F.
  TITLE     Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a
            Pathway-Selective Manner
  JOURNAL   Neuropsychopharmacology 41 (9), 2377-2387 (2016)
   PUBMED   27032690
  REMARK    GeneRIF: Study concludes that 5-HT6 receptors in medium spiny
            neurons in the direct and indirect pathway of the nucleus accumbens
            shell increase the sensitivity to the reinforcing properties of
            cocaine, particularly at low doses.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Grimaldi,B., Bonnin,A., Fillion,M.P., Ruat,M., Traiffort,E. and
            Fillion,G.
  TITLE     Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in
            the rat brain during ontogenetic development
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 357 (4), 393-400 (1998)
   PUBMED   9606024
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Boess,F.G., Monsma,F.J. Jr., Carolo,C., Meyer,V., Rudler,A.,
            Zwingelstein,C. and Sleight,A.J.
  TITLE     Functional and radioligand binding characterization of rat 5-HT6
            receptors stably expressed in HEK293 cells
  JOURNAL   Neuropharmacology 36 (4-5), 713-720 (1997)
   PUBMED   9225298
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Kohen,R., Metcalf,M.A., Khan,N., Druck,T., Huebner,K.,
            Lachowicz,J.E., Meltzer,H.Y., Sibley,D.R., Roth,B.L. and
            Hamblin,M.W.
  TITLE     Cloning, characterization, and chromosomal localization of a human
            5-HT6 serotonin receptor
  JOURNAL   J Neurochem 66 (1), 47-56 (1996)
   PUBMED   8522988
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Ruat,M., Traiffort,E., Arrang,J.M., Tardivel-Lacombe,J., Diaz,J.,
            Leurs,R. and Schwartz,J.C.
  TITLE     A novel rat serotonin (5-HT6) receptor: molecular cloning,
            localization and stimulation of cAMP accumulation
  JOURNAL   Biochem Biophys Res Commun 193 (1), 268-276 (1993)
   PUBMED   8389146
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Monsma,F.J. Jr., Shen,Y., Ward,R.P., Hamblin,M.W. and Sibley,D.R.
  TITLE     Cloning and expression of a novel serotonin receptor with high
            affinity for tricyclic psychotropic drugs
  JOURNAL   Mol Pharmacol 43 (3), 320-327 (1993)
   PUBMED   7680751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 30, 2015 this sequence version replaced NM_024365.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L19656.1, L03202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              JAXUCZ010000005.1  156594116-156595147 c
            1033-1191           JAXUCZ010000005.1  156580829-156580987 c
            1192-1925           JAXUCZ010000005.1  156579901-156580634 c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1925
                     /gene="Htr6"
                     /note="5-hydroxytryptamine receptor 6"
                     /db_xref="GeneID:64354"
                     /db_xref="RGD:62044"
     exon            1..1032
                     /gene="Htr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1635
                     /gene="Htr6"
                     /note="5-HT-6; ST-B17; serotonin receptor 6; 5-HT6;
                     5-hydroxytryptamine (serotonin) receptor 6, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 6"
                     /protein_id="NP_077341.2"
                     /db_xref="GeneID:64354"
                     /db_xref="RGD:62044"
                     /translation="MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAAN
                     SLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLW
                     TAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFL
                     PLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQ
                     AVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGM
                     FFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRF
                     LPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQL
                     TAQLLLPGEATRDPPPPTRATTVVNFFVTDSVEPEIRPHPLSSPVN"
     exon            1033..1191
                     /gene="Htr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1925
                     /gene="Htr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagccaggaa ccccaccccc atcttatggc atccccggtg gccctattcc atcccagggc
       61 tctcatccag ccccaagcta actttcattg actcgtcaca tcagtacccc tccccaaact
      121 tcttacccga gtactccagg tggccctgcc gtaggaggca cccctacaac tcctcccgat
      181 ctcttgaaat cgctgctcga tgacctaaga accccgtttt gccaatacta ctctaaggtg
      241 cagcttcctt tctcctcctt tgccttcacc ctgtacctgc agtcaccata tcccgtcttg
      301 gtcctcaacc cagtccccat ggttccagag ccaggccctg tcaacagtag caccccagcc
      361 tggggtcccg ggccaccgcc tgctccgggg ggcagcggct gggtggctgc cgcgctgtgc
      421 gtggtcatcg tgctgacagc agccgccaat tcgctgctga tcgtgctcat ttgcacgcag
      481 cccgcgctgc gcaacacgtc taacttcttt ctggtgtcgc tcttcacgtc ggacttgatg
      541 gtggggttgg tggtgatgcc cccagccatg ctgaacgcgc tgtatgggcg ctgggtgtta
      601 gctcgaggcc tctgtctgct ttggactgcc ttcgacgtga tgtgctgcag cgcctccatc
      661 ctcaacctct gcctcatcag cctggaccgc tacctgctca tcctctcgcc gctgcgctac
      721 aagctgcgca tgacagcccc gcgagccctg gcgctcatcc tgggtgcctg gagcctcgcg
      781 gcgcttgcct ccttcctacc cctcttgctg ggctggcacg aactgggcaa agctcgaaca
      841 cctgcccctg gccagtgccg cctattggcc agcctgcctt ttgtcctcgt ggcgtccggc
      901 gtcacctttt tcctgccttc gggtgccatc tgcttcacct actgcaggat ccttctggct
      961 gcccgcaagc aggcggtgca agtggcctcg ctcaccacgg gcacggctgg ccaggccttg
     1021 gaaaccttgc aggtgcccag gacaccacgc ccagggatgg agtccgctga cagtaggcgt
     1081 ctggccacca agcatagcag gaaggccttg aaggccagcc tgaccctggg catcctgctg
     1141 ggaatgttct ttgtcacctg gctgcccttc tttgtggcca acatagctca ggccgtgtgt
     1201 gactgcatct ccccaggcct cttcgatgtc ctcacatggc tggggtactg taatagcacc
     1261 atgaacccta tcatctaccc gctctttatg cgggacttca agagggccct gggcaggttc
     1321 ctgccatgcg tccactgtcc cccggagcac cgggccagcc ctgcctcccc ctccatgtgg
     1381 acctctcaca gcggtgccag accaggcctc agcctgcagc aggtgctgcc tctgcctctg
     1441 ccgccaaact cagattcaga ctccgcttca gggggcacct cgggcctgca gctcacagcc
     1501 cagcttctgc tgcctggaga ggccacccgg gaccccccgc cacccaccag ggccaccact
     1561 gtggtcaact tctttgtcac agactctgtg gagcctgaga tacggccgca tccactcagt
     1621 tcccccgtga actgaccagg tcaagagctg gccattggag gccacattcc cggagctctc
     1681 agcccactct ccctgagact aggaggtggt aggtctcctg agagtgtgct gaattgaggt
     1741 atcctcagct agccccatct tctgctgcag gctccttgac ctgaggggta gccagaaaca
     1801 tctctgtggg gtactccagt gcaatgttgc ttgtgtagtg aggctggggg cagtctcaga
     1861 gctgggccat ttggttcagg tcagtaggaa agcaatctgt cctcatccct ttctctcatg
     1921 gtggg
//
