LOCUS       NM_013148               1956 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 5A (Htr5a), mRNA.
ACCESSION   NM_013148
VERSION     NM_013148.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Farias,C.P., Leite,A.K.O., Schmidt,B.E., de Carvalho Myskiw,J. and
            Wyse,A.T.S.
  TITLE     The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial
            prefrontal cortex behave differently in extinction learning: Does
            social support play a role?
  JOURNAL   Behav Brain Res 463, 114922 (2024)
   PUBMED   38408524
  REMARK    GeneRIF: The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in
            the medial prefrontal cortex behave differently in extinction
            learning: Does social support play a role?
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Garcia-Pedraza,J.A., Hernandez-Abreu,O., Moran,A., Carretero,J.,
            Garcia-Domingo,M. and Villalon,C.M.
  TITLE     Role of peripheral 5-HT5A receptors in 5-HT-induced cardiac
            sympatho-inhibition in type 1 diabetic rats
  JOURNAL   Sci Rep 10 (1), 19358 (2020)
   PUBMED   33168874
  REMARK    GeneRIF: Role of peripheral 5-HT5A receptors in 5-HT-induced
            cardiac sympatho-inhibition in type 1 diabetic rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Farago,N., Kocsis,A.K., Brasko,C., Lovas,S., Rozsa,M., Baka,J.,
            Kovacs,B., Mikite,K., Szemenyei,V., Molnar,G., Ozsvar,A., Olah,G.,
            Piszar,I., Zvara,A., Patocs,A., Barzo,P., Puskas,L.G. and Tamas,G.
  TITLE     Human neuronal changes in brain edema and increased intracranial
            pressure
  JOURNAL   Acta Neuropathol Commun 4 (1), 78 (2016)
   PUBMED   27487831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Avila-Rojas,S.H., Velazquez-Lagunas,I., Salinas-Abarca,A.B.,
            Barragan-Iglesias,P., Pineda-Farias,J.B. and Granados-Soto,V.
  TITLE     Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic
            pain induced by spinal nerve ligation in rats
  JOURNAL   Brain Res 1622, 377-385 (2015)
   PUBMED   26168890
  REMARK    GeneRIF: results suggest that 5-HT5A receptors reduce pain
            processing in the spinal cord
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Garcia-Alcocer,G., Rodriguez,A., Moreno-Layseca,P., Berumen,L.C.,
            Escobar,J. and Miledi,R.
  TITLE     Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin
            treatment
  JOURNAL   Neurosci Lett 486 (3), 171-173 (2010)
   PUBMED   20863873
  REMARK    GeneRIF: Even though 5-HT5A receptor gene expression does not
            change in the hippocampus of any treated group, in rats that are
            treated with leptin and serotonin, immunostaining specific for
            5-HT5A serotonin receptor decreases significantly in the dentate
            gyrus.
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Geurts,F.J., De Schutter,E. and Timmermans,J.P.
  TITLE     Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like
            immunoreactivity in the rat cerebellum
  JOURNAL   J Chem Neuroanat 24 (1), 65-74 (2002)
   PUBMED   12084412
  REMARK    GeneRIF: 5-HT5A receptor-like immunoreactivity has been observed in
            neuronal somata of the cerebellar cortex and deep cerebellar
            nuclei.
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Kohen,R., Fashingbauer,L.A., Heidmann,D.E., Guthrie,C.R. and
            Hamblin,M.W.
  TITLE     Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis
            studies of the third cytoplasmic loop
  JOURNAL   Brain Res Mol Brain Res 90 (2), 110-117 (2001)
   PUBMED   11406289
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Thomas,E.A., Matli,J.R., Hu,J.L., Carson,M.J. and Sutcliffe,J.G.
  TITLE     Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated
            inhibition of cyclic AMP accumulation in rat C6 glioma cells
  JOURNAL   J Neurosci Res 61 (1), 75-81 (2000)
   PUBMED   10861802
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Rees,S., den Daas,I., Foord,S., Goodson,S., Bull,D., Kilpatrick,G.
            and Lee,M.
  TITLE     Cloning and characterisation of the human 5-HT5A serotonin receptor
  JOURNAL   FEBS Lett 355 (3), 242-246 (1994)
   PUBMED   7988681
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Erlander,M.G., Lovenberg,T.W., Baron,B.M., de Lecea,L.,
            Danielson,P.E., Racke,M., Slone,A.L., Siegel,B.W., Foye,P.E.,
            Cannon,K. et al.
  TITLE     Two members of a distinct subfamily of 5-hydroxytryptamine
            receptors differentially expressed in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 90 (8), 3452-3456 (1993)
   PUBMED   7682702
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10072.1, SRR26643298.21058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-885               JAXUCZ010000004.1  8187601-8188485     c
            886-1956            JAXUCZ010000004.1  8178802-8179872     c
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1956
                     /gene="Htr5a"
                     /gene_synonym="5HT5A; MR22"
                     /note="5-hydroxytryptamine receptor 5A"
                     /db_xref="GeneID:25689"
                     /db_xref="RGD:2851"
     exon            1..885
                     /gene="Htr5a"
                     /gene_synonym="5HT5A; MR22"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1218
                     /gene="Htr5a"
                     /gene_synonym="5HT5A; MR22"
                     /note="REC17; 5-HT-5A; serotonin receptor 5A; 5-HT5A;
                     5-hydroxytryptamine (serotonin) receptor 5A, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 5A"
                     /protein_id="NP_037280.1"
                     /db_xref="GeneID:25689"
                     /db_xref="RGD:2851"
                     /translation="MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVL
                     TLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHEL
                     SGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNV
                     MILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLF
                     VYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWR
                     EQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFN
                     PLIYTAFNRSYSSAFKVFFSKQQ"
     exon            886..1956
                     /gene="Htr5a"
                     /gene_synonym="5HT5A; MR22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactctcac tgggtggaga ctgaggtcag gttcttggct cttggcagaa tcctctccac
       61 tggccagcgg ttgcaaacat ctaaattgac ttcagtgaac tcggtgactg cattgagtct
      121 aaacgcaggt gtgctgggcc agcaatggat ctgcctataa acttgacctc cttttctctc
      181 tctactccct ccactttgga acctaaccgc agcttggaca cggaagccct gcgcactagt
      241 cagtcttttc tctcagcttt ccgagtgcta gtcctgactt tgctgggctt tctagctgcc
      301 gccacgttca cttggaacct gctggtgctg gccaccatcc tcagggtacg caccttccac
      361 cgagtaccac acaacctggt agcatccatg gctatctcgg atgtgctagt agctgtgctg
      421 gttatgcctc tgagcctggt acatgaactg tctgggcgcc gctggcagct gggccggcgt
      481 ctatgccagc tgtggattgc gtgtgacgtc ctctgctgta ctgccagcat ctggaatgtg
      541 acagcaatag ctttggaccg ctactggtca ataacgcgcc acctggagta cacactccgt
      601 gcccgcaagc gtgtctccaa cgtgatgatc ctgctcactt gggcactctc cgctgtcatc
      661 tctctggctc cgctgctctt tggctgggga gagacttact cggagctcag tgaagaatgc
      721 caggtcagtc gcgagccttc ctacaccgtg ttctccactg tgggcgcctt ctacctgccg
      781 ctgtgtgtgg tgctctttgt atactggaag atttacaagg ctgcgaagtt ccgcatgggc
      841 tccaggaaga ccaacagcgt ctcccccata cctgaagctg tggaggtgaa ggacgcttca
      901 caacatcccc agatggtgtt cactgtccgt cacgccaccg tcaccttcca gacagaaggg
      961 gacacgtgga gggaacagaa ggagcaaagg gcagccctca tggtgggcat cctcattggg
     1021 gtgtttgtcc tctgctggtt ccccttcttt gttacggagc tcatcagtcc gctgtgctcc
     1081 tgggatatcc ctgccctctg gaagagcatc ttcctgtggc tgggctattc caactccttc
     1141 ttcaacccgc tcatctacac ggcgttcaac aggagctaca gcagtgcttt taaggtcttc
     1201 ttctccaagc agcagtgaga ggccacatgg gagtgccttc ttcccgtagc ttgtagctcg
     1261 gtggactgtc ctgcctcaca aacccctgta gtctgcccag ctgtccagag gaacaagatc
     1321 catctgccaa gggcaccagg gtcacatcag agctcagctc acttcagttc tgtgcccgtg
     1381 tgctggaagg tgtctcctat aggctctggt agcttgtgtc cccagtctgg gcactcttcc
     1441 tcacactgta ccagcagcca caggcctggc ccacaacgtg cccatttctc ctccaactcc
     1501 actccagcgg gaccatgaga agtttgatca gaacgaacag gaggaaggaa gtgagacaat
     1561 aaggcaggca gagagaggca gaaagaacaa ggctgaaagc cagtgggatc acatacctgg
     1621 aaccctcaca ccaaggagac ttaggcaggt agaacaggaa tttggagcca gcctgggcta
     1681 catagtaagt tcataaatca gtctgagctg tctgacacag acttagcaac agcaatgcac
     1741 tggagaggct atttgaaaag cagagaccat aagggcaaac ttcccagaac agccctcact
     1801 tcacagttct gctctgtggt cctgcagtgt atggcccaat tctgggtcct tctgaatatc
     1861 tgatcacaag attctgtccc caaacatatc aaagcaccat cccatttgtg ataacagtga
     1921 ttcctgtctt taccatttgt tcattgtgaa cccaaa
//
