LOCUS       NM_022189               1346 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 3B (Htr3b), mRNA.
ACCESSION   NM_022189
VERSION     NM_022189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Enoch,M.A., Gorodetsky,E., Hodgkinson,C., Roy,A. and Goldman,D.
  TITLE     Functional genetic variants that increase synaptic serotonin and
            5-HT3 receptor sensitivity predict alcohol and drug dependence
  JOURNAL   Mol Psychiatry 16 (11), 1139-1146 (2011)
   PUBMED   20838391
REFERENCE   2  (bases 1 to 1346)
  AUTHORS   Ge,Q.F. and Zhang,H.Y.
  TITLE     [Effects of Chinese herbal medicines for regulating liver qi on
            expression of 5-hydroxytryptamine 3B receptor in hypothalamic
            tissues of rats with anger emotion]
  JOURNAL   Zhong Xi Yi Jie He Xue Bao 9 (8), 871-877 (2011)
   PUBMED   21849148
  REMARK    GeneRIF: Chinese herbal medicines for regulating liver qi may treat
            anger emotion in rats by improving the hypothalamic 5-HT3BR protein
            and gene expression levels.
REFERENCE   3  (bases 1 to 1346)
  AUTHORS   Doucet,E., Latremoliere,A., Darmon,M., Hamon,M. and Emerit,M.B.
  TITLE     Immunolabelling of the 5-HT 3B receptor subunit in the central and
            peripheral nervous systems in rodents
  JOURNAL   Eur J Neurosci 26 (2), 355-366 (2007)
   PUBMED   17650111
REFERENCE   4  (bases 1 to 1346)
  AUTHORS   Yamada,K., Hattori,E., Iwayama,Y., Ohnishi,T., Ohba,H., Toyota,T.,
            Takao,H., Minabe,Y., Nakatani,N., Higuchi,T., Detera-Wadleigh,S.D.
            and Yoshikawa,T.
  TITLE     Distinguishable haplotype blocks in the HTR3A and HTR3B region in
            the Japanese reveal evidence of association of HTR3B with female
            major depression
  JOURNAL   Biol Psychiatry 60 (2), 192-201 (2006)
   PUBMED   16487942
REFERENCE   5  (bases 1 to 1346)
  AUTHORS   Reeves,D.C. and Lummis,S.C.
  TITLE     Detection of human and rodent 5-HT3B receptor subunits by
            anti-peptide polyclonal antibodies
  JOURNAL   BMC Neurosci 7, 27 (2006)
   PUBMED   16571125
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1346)
  AUTHORS   Morales,M. and Wang,S.D.
  TITLE     Differential composition of 5-hydroxytryptamine3 receptors
            synthesized in the rat CNS and peripheral nervous system
  JOURNAL   J Neurosci 22 (15), 6732-6741 (2002)
   PUBMED   12151552
REFERENCE   7  (bases 1 to 1346)
  AUTHORS   Hanna,M.C., Davies,P.A., Hales,T.G. and Kirkness,E.F.
  TITLE     Evidence for expression of heteromeric serotonin 5-HT(3) receptors
            in rodents
  JOURNAL   J Neurochem 75 (1), 240-247 (2000)
   PUBMED   10854267
REFERENCE   8  (bases 1 to 1346)
  AUTHORS   Davies,P.A., Pistis,M., Hanna,M.C., Peters,J.A., Lambert,J.J.,
            Hales,T.G. and Kirkness,E.F.
  TITLE     The 5-HT3B subunit is a major determinant of serotonin-receptor
            function
  JOURNAL   Nature 397 (6717), 359-363 (1999)
   PUBMED   9950429
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF155044.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132271 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1346
                     /gene="Htr3b"
                     /note="5-hydroxytryptamine receptor 3B"
                     /db_xref="GeneID:58963"
                     /db_xref="RGD:61820"
     exon            1..72
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1346
                     /gene="Htr3b"
                     /note="serotonin-gated ion channel subunit; 5-HT3B;
                     5-HT-3B; serotonin receptor 3B; 5-HT3-B;
                     5-hydroxytryptamine (serotonin) receptor 3B, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3B precursor"
                     /protein_id="NP_071525.1"
                     /db_xref="GeneID:58963"
                     /db_xref="RGD:61820"
                     /translation="MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVR
                     PVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEI
                     SLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPF
                     DIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSS
                     AGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVG
                     YTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERP
                     LMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRD
                     QVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM"
     exon            73..233
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            234..278
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            279..388
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            389..558
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            559..716
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            717..927
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1110
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1346
                     /gene="Htr3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtacctgc cccagaacaa taggcaagtg cgatgattct tctgtggtcc tgcctcctgg
       61 tggctgtcgt aggtattcta ggcacagcga cacctcagcc tgggaattcc tctctgcatc
      121 gcctcaccag gcagctgcta cagcagtacc acaaggaggt cagaccagtt tacaactggg
      181 ctgaggccac cactgtctac ctggaccttt gcgtccatgc tgtattggat gtggatgtac
      241 agaatcaaaa attaaagaca agcatgtggt accgagaggt ttggaatgat gagtttctgt
      301 cctggaactc tagtctgttc gatgatattc aagagatctc tctccctctc agtgccatct
      361 gggcccctga tatcatcatt aatgagtttg tggatgtcga aaggtctcct gacctgccct
      421 atgtatacgt gaactcttcc ggaacgatta gaaaccacaa gcccatccag gtggtctccg
      481 catgcagttt gcagacatac gctttcccct ttgatatcca gaactgcagt ctcaccttca
      541 atagcatcct gcatacagtg gaagacatag acctgggctt cctgaggaac caagaagaca
      601 ttgagaacga caaaaggtct tttctgaatg acagcgagtg gcagcttctt tctgtgacct
      661 ccacttacca catccggcag agcagcgctg gtgacttcgc acagattcgg tttaatgtag
      721 tgattcgcag atgtccattg gcctatgttg tgagcctctt gattcctagc atcttcctga
      781 tgctcgtgga cctgggaagc ttctacttgc cccccaactg tcgtgccaga attgtgttca
      841 agaccaatgt gctggtgggc tatacagtct tcagggtcaa catgtctgat gaggtgccaa
      901 gaagcgcagg gtgcacatct ctgattgggg tcttctttac cgtctgcatg gccctcttgg
      961 ttctcagttt atccaaatcc atcttgttga tcaaattcct ctatgaggag cggcacagtg
     1021 agcaagaacg gcctcttatg tgccttcgag gggactctga tgccaatgag tctagattgt
     1081 acctcagagc tccatgtgct gaggacacag agtccccggt tcgtcaggag caccaggtcc
     1141 catcagatac tctgaaggat ttctggttcc agctccaatc catcaacaac tctctccgaa
     1201 ctcgggatca ggtttaccag aaggaggtgg agtggctcgc catcctgtgc cactttgatc
     1261 agctgctctt ccgaatctac cttgccgtgc tggggctcta tactgtcacc ttatgctctc
     1321 tctgggcact gtggagcagg atgtga
//
