LOCUS       NM_024394               2002 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 3A (Htr3a), mRNA.
ACCESSION   NM_024394
VERSION     NM_024394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Huang,Z., Zhang,Y., Wang,S., Qi,R., Tao,Y., Sun,Y., Jiang,D.,
            Jiang,X. and Tao,J.
  TITLE     FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain
            via m6A-dependent stabilization of 5-HT3A mRNA in sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2312861121 (2024)
   PUBMED   38285939
  REMARK    GeneRIF: FOXD3-mediated transactivation of ALKBH5 promotes
            neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA
            in sensory neurons.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Suchanecka,A., Chmielowiec,J., Chmielowiec,K., Trybek,G., Jaron,A.,
            Czarny,W., Krol,P., Masiak,J. and Grzywacz,A.
  TITLE     Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and
            rs1062613, E-Cigarette Use and Personality
  JOURNAL   Int J Environ Res Public Health 19 (8), 4746 (2022)
   PUBMED   35457612
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Belliveau,S., Kang,W., Bovaird,S., Hamadjida,A., Bedard,D.,
            Dancause,N., Stroh,T. and Huot,P.
  TITLE     Stereological investigation of 5-HT3 receptors in the substantia
            nigra and dorsal raphe nucleus in the rat
  JOURNAL   J Chem Neuroanat 111, 101881 (2021)
   PUBMED   33160048
  REMARK    GeneRIF: Stereological investigation of 5-HT3 receptors in the
            substantia nigra and dorsal raphe nucleus in the rat.
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Domocos,D., Selescu,T., Ceafalan,L.C., Iodi Carstens,M.,
            Carstens,E. and Babes,A.
  TITLE     Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of
            sensory neurons in relation to itch and pain behavior in the rat
  JOURNAL   J Neurosci Res 98 (10), 1999-2017 (2020)
   PUBMED   32537854
  REMARK    GeneRIF: Role of 5-HT1A and 5-HT3 receptors in serotonergic
            activation of sensory neurons in relation to itch and pain behavior
            in the rat.
            Erratum:[J Neurosci Res. 2023 Jan;101(1):196. doi:
            10.1002/jnr.25137.. PMID: 36250251]
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Han,H., Liu,Q., Yang,Z., Wang,M., Ma,Y., Cao,L., Cui,W., Yuan,W.,
            Payne,T.J., Li,L. and Li,M.D.
  TITLE     Association and cis-mQTL analysis of variants in serotonergic genes
            associated with nicotine dependence in Chinese Han smokers
  JOURNAL   Transl Psychiatry 8 (1), 243 (2018)
   PUBMED   30405098
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Hanna,M.C., Davies,P.A., Hales,T.G. and Kirkness,E.F.
  TITLE     Evidence for expression of heteromeric serotonin 5-HT(3) receptors
            in rodents
  JOURNAL   J Neurochem 75 (1), 240-247 (2000)
   PUBMED   10854267
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Davies,P.A., Pistis,M., Hanna,M.C., Peters,J.A., Lambert,J.J.,
            Hales,T.G. and Kirkness,E.F.
  TITLE     The 5-HT3B subunit is a major determinant of serotonin-receptor
            function
  JOURNAL   Nature 397 (6717), 359-363 (1999)
   PUBMED   9950429
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Miyake,A., Mochizuki,S., Takemoto,Y. and Akuzawa,S.
  TITLE     Molecular cloning of human 5-hydroxytryptamine3 receptor:
            heterogeneity in distribution and function among species
  JOURNAL   Mol Pharmacol 48 (3), 407-416 (1995)
   PUBMED   7565620
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Miquel,M.C., Emerit,M.B., Gingrich,J.A., Nosjean,A., Hamon,M. and
            el Mestikawy,S.
  TITLE     Developmental changes in the differential expression of two
            serotonin 5-HT3 receptor splice variants in the rat
  JOURNAL   J Neurochem 65 (2), 475-483 (1995)
   PUBMED   7616200
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Isenberg,K.E., Ukhun,I.A., Holstad,S.G., Jafri,S., Uchida,U.,
            Zorumski,C.F. and Yang,J.
  TITLE     Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor
            subunit
  JOURNAL   Neuroreport 5 (2), 121-124 (1993)
   PUBMED   7509203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_024394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.33656.1,
                                           SRR26643291.22947.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000008.1  58150709-58150884   c
            177-343             JAXUCZ010000008.1  58148348-58148514   c
            344-388             JAXUCZ010000008.1  58147137-58147181   c
            389-498             JAXUCZ010000008.1  58146064-58146173   c
            499-668             JAXUCZ010000008.1  58144193-58144362   c
            669-829             JAXUCZ010000008.1  58141007-58141167   c
            830-1040            JAXUCZ010000008.1  58140470-58140680   c
            1041-1262           JAXUCZ010000008.1  58139797-58140018   c
            1263-2002           JAXUCZ010000008.1  58138516-58139255   c
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2002
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /note="5-hydroxytryptamine receptor 3A"
                     /db_xref="GeneID:79246"
                     /db_xref="RGD:61818"
     exon            1..176
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1561
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /note="5-HT3 receptor; 5-HT-3; 5-HT3R; serotonin receptor
                     3A; serotonin-gated ion channel receptor; 5-HT3-A;
                     5-hydroxytryptamine receptor 3; 5-hydroxytryptamine
                     (serotonin) receptor 3A, ionotropic"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 3A precursor"
                     /protein_id="NP_077370.2"
                     /db_xref="GeneID:79246"
                     /db_xref="RGD:61818"
                     /translation="MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSD
                     HLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQW
                     TPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVT
                     ACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLG
                     VFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSG
                     ERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQL
                     VHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSH
                     VGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRV
                     GYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS"
     exon            177..343
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..388
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            389..498
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            499..668
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..829
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1040
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1262
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2002
                     /gene="Htr3a"
                     /gene_synonym="5-HT3; 5-HT3A; 5HT3; Htr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagcctg cctgggacat gaggttggca gcgggtgtgc aggctggcag tctgggggac
       61 tcatcctgag tggctgctcc gaggccctcc cacatccggg aagcttgcca tgccgctctg
      121 catcccgcag gtgctgttgg ccttgttcct ttccgtgctg atagcccagg gagaaggcag
      181 ccggaggagg gccacccagg cccacagcac cacccagcct gctctgctga ggctgtcaga
      241 tcacctcctg gctaactaca agaagggggt gcggcctgtg cgggactgga ggaagcccac
      301 cctggtctcc atcgatgtca tcatgtatgc catcctcaac gtggatgaga agaaccaggt
      361 tctgacaacc tacatatggt accggcagtt ctggaccgac gagtttctac agtggactcc
      421 tgaggacttc gacaatgtca ccaaattgtc catccccacc gacagcatct gggtccctga
      481 catcctcatc aatgagtttg tggacgtggg gaagtctcca agcattcctt atgtgtatgt
      541 gcaccatcaa ggtgaagtcc agaactacaa gcccctacag ctggtgaccg cctgtagcct
      601 tgacatctat aacttcccgt tcgatgtgca gaactgctct ctgaccttca ccagctggct
      661 gcataccatc caggacatca acatttccct gtggcgaaca ccagaagaag tgaggtcgga
      721 caagagcatc ttcataaatc agggcgagtg ggagctgctg ggggtgttca ccaaatttca
      781 ggagttcagt atagaaacca gtaacagcta tgcggaaatg aagttctacg tggtcatccg
      841 ccggcggcct ttattctacg cagtcagcct cttgctgccc agtatcttcc tcatggttgt
      901 ggacattgtg ggcttttgtc tgcccccgga cagtggtgag agagtgtctt tcaagatcac
      961 gctccttctg ggatactcag tctttctcat catcgtgtca gacacactgc ctgcaacggc
     1021 catcggcact cccctcattg gtgtctactt tgtagtgtgc atggctctgc tggtgataag
     1081 cctcgctgag accatcttca ttgtgcagct ggtgcataag caggatttac agcgccctgt
     1141 acctgactgg ctgaggcacc tggtcctaga cagaatagcc tggctgctct gcctagggga
     1201 gcagcccatg gcccataggc ccccagccac cttccaagcc aacaagactg atgactgctc
     1261 agccatggga aaccactgca gccatgtcgg aagccctcag gacttggaga agacctcgag
     1321 gagcagagat agccctcttc caccaccaag ggaggcctcg ctggctgtgc gtggcctctt
     1381 gcaagagctg tcctccatcc gccactccct ggagaagcgg gatgagatgc gggaggtggc
     1441 aagggactgg ttgcgggtgg gatatgtgct ggacaggctg ctgtttcgca tctacctgct
     1501 ggccgtgctg gcttacagca tcaccctggt cacgctctgg tccatttggc attattcctg
     1561 agtgggtaca gcctggcagg gaggggatgt gagtcctgca tcctgtttcc aacaccaatt
     1621 catctgagca accccagtcc ccttgtcccc taaacttagc actgaagacc cggtcagacc
     1681 ccccgacttc gctatcatga ctttaaagca tgatatccta gatcaagagg aaccaagact
     1741 cctctaactt attaagacat caagccctgg ttccttttcc agtacttctg tgattatggc
     1801 ccttgggatg gctcatttcc acagtttttt ttttcctttt tgatcagagg aaagcaaatt
     1861 ctcttgccta ggtgcctgag acgtctgtgc ctgttttatc caggccccag tggcttcttc
     1921 ttcagctcac ttgtgggtac ttccctagcg ctcagcctca tcaaccaacg gggggaggga
     1981 ataataaaat gctatgatat cc
//
