LOCUS       NM_012765               4402 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 2C (Htr2c), mRNA.
ACCESSION   NM_012765
VERSION     NM_012765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4402)
  AUTHORS   Harmson,O., Grima,L.L., Panayi,M.C., Husain,M. and Walton,M.E.
  TITLE     5-HT2C receptor perturbation has bidirectional influence over
            instrumental vigour and restraint
  JOURNAL   Psychopharmacology (Berl) 239 (1), 123-140 (2022)
   PUBMED   34762147
  REMARK    GeneRIF: 5-HT2C receptor perturbation has bidirectional influence
            over instrumental vigour and restraint.
REFERENCE   2  (bases 1 to 4402)
  AUTHORS   Kamo,I., Nagata,H., O'Connell,G., Kato,T., Imanishi,A., Kuno,M.,
            Okanishi,S., Yoshikawa,K. and Nishiyama,Y.
  TITLE     Increasing Effects of Selective 5-Hydroxytryptamine Type 2C
            Receptor Stimulation on Evoked Momentary Urethral Closure in Female
            Rats and Humans
  JOURNAL   J Pharmacol Exp Ther 378 (2), 60-68 (2021)
   PUBMED   33837045
  REMARK    GeneRIF: Increasing Effects of Selective 5-Hydroxytryptamine Type
            2C Receptor Stimulation on Evoked Momentary Urethral Closure in
            Female Rats and Humans.
REFERENCE   3  (bases 1 to 4402)
  AUTHORS   Xu,G.Z., Xue,Y., Wei,S.Q., Li,J.H., Traub,R.J., Wang,M.D. and
            Cao,D.Y.
  TITLE     Valproate reverses stress-induced somatic hyperalgesia and visceral
            hypersensitivity by up-regulating spinal 5-HT2C receptor expression
            in female rats
  JOURNAL   Neuropharmacology 165, 107926 (2020)
   PUBMED   31883927
  REMARK    GeneRIF: Valproate reverses stress-induced somatic hyperalgesia and
            visceral hypersensitivity by up-regulating spinal 5-HT2C receptor
            expression in female rats.
REFERENCE   4  (bases 1 to 4402)
  AUTHORS   Gao,J., Nie,L., Li,Y. and Li,M.
  TITLE     Serotonin 5-HT2A and 5-HT2C receptors regulate rat maternal
            behavior through distinct behavioral and neural mechanisms
  JOURNAL   Neuropharmacology 162, 107848 (2020)
   PUBMED   31706992
  REMARK    GeneRIF: Serotonin 5-HT2A and 5-HT2C receptors regulate rat
            maternal behavior through distinct behavioral and neural
            mechanisms.
REFERENCE   5  (bases 1 to 4402)
  AUTHORS   Price,A.E., Sholler,D.J., Stutz,S.J., Anastasio,N.C. and
            Cunningham,K.A.
  TITLE     Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the
            Medial Prefrontal Cortex
  JOURNAL   ACS Chem Neurosci 10 (7), 3241-3248 (2019)
   PUBMED   30645940
  REMARK    GeneRIF: Our results demonstrate subregion- and layer-specific
            expression of the 5-HT2AR and 5-HT2CR proteins using
            immunofluorescence and single recognition PLA, and a spatially
            close (within 40 nm) interaction between the 5-HT2AR and 5-HT2CR
            that occurs along a dorsal-ventral gradient in the rat medial
            prefrontal cortex.
REFERENCE   6  (bases 1 to 4402)
  AUTHORS   Burns,C.M., Chu,H., Rueter,S.M., Hutchinson,L.K., Canton,H.,
            Sanders-Bush,E. and Emeson,R.B.
  TITLE     Regulation of serotonin-2C receptor G-protein coupling by RNA
            editing
  JOURNAL   Nature 387 (6630), 303-308 (1997)
   PUBMED   9153397
REFERENCE   7  (bases 1 to 4402)
  AUTHORS   Bonhaus,D.W., Bach,C., DeSouza,A., Salazar,F.H., Matsuoka,B.D.,
            Zuppan,P., Chan,H.W. and Eglen,R.M.
  TITLE     The pharmacology and distribution of human 5-hydroxytryptamine2B
            (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C
            receptors
  JOURNAL   Br J Pharmacol 115 (4), 622-628 (1995)
   PUBMED   7582481
REFERENCE   8  (bases 1 to 4402)
  AUTHORS   Tecott,L.H., Sun,L.M., Akana,S.F., Strack,A.M., Lowenstein,D.H.,
            Dallman,M.F. and Julius,D.
  TITLE     Eating disorder and epilepsy in mice lacking 5-HT2c serotonin
            receptors
  JOURNAL   Nature 374 (6522), 542-546 (1995)
   PUBMED   7700379
REFERENCE   9  (bases 1 to 4402)
  AUTHORS   Matsuuchi,L., Gold,M.R., Travis,A., Grosschedl,R., DeFranco,A.L.
            and Kelly,R.B.
  TITLE     The membrane IgM-associated proteins MB-1 and Ig-beta are
            sufficient to promote surface expression of a partially functional
            B-cell antigen receptor in a nonlymphoid cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3404-3408 (1992)
   PUBMED   1373499
REFERENCE   10 (bases 1 to 4402)
  AUTHORS   Julius,D., MacDermott,A.B., Axel,R. and Jessell,T.M.
  TITLE     Molecular characterization of a functional cDNA encoding the
            serotonin 1c receptor
  JOURNAL   Science 241 (4865), 558-564 (1988)
   PUBMED   3399891
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U35315.1, JAXUCZ010000021.1,
            CB613191.1, CB784937.1, CB557712.1, BF285550.1, BF415855.1 and
            BF409467.1.
            
            On Jan 2, 2008 this sequence version replaced NM_012765.2.
            
            Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,
            elicits a wide array of physiological effects by binding to several
            receptor subtypes, including the 5-HT2 family of
            seven-transmembrane-spanning, G-protein-coupled receptors, which
            activate phospholipase C and D signaling pathways. This gene
            encodes the 2C subtype of serotonin receptor and its mRNA is
            subject to multiple RNA editing events, where genomically encoded
            adenosine residues are converted to inosines. RNA editing is
            predicted to alter amino acids within the second intracellular loop
            of the 5-HT2C receptor and generate receptor isoforms that differ
            in their ability to interact with G proteins and the activation of
            phospholipase C and D signaling cascades, thus modulating
            serotonergic neurotransmission in the central nervous system.
            Studies in rodents show altered patterns of RNA editing in response
            to drug treatments and stressful situations. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.32854.1,
                                           SRR26643297.55132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 9153397
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               U35315.1           1-101
            102-103             JAXUCZ010000021.1  115453291-115453292
            104-801             U35315.1           103-800
            802-896             JAXUCZ010000021.1  115653723-115653817
            897-1730            JAXUCZ010000021.1  115678837-115679670
            1731-1863           U35315.1           1636-1768
            1864-1979           CB613191.1         377-492
            1980-2063           JAXUCZ010000021.1  115679920-115680003
            2064-2427           CB784937.1         15-378
            2428-2505           JAXUCZ010000021.1  115680368-115680445
            2506-3143           CB557712.1         14-651
            3144-3421           BF285550.1         243-520
            3422-3813           JAXUCZ010000021.1  115681362-115681753
            3814-4219           BF415855.1         184-589             c
            4220-4402           BF409467.1         1-183               c
FEATURES             Location/Qualifiers
     source          1..4402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..4402
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /note="5-hydroxytryptamine receptor 2C"
                     /db_xref="GeneID:25187"
                     /db_xref="RGD:2848"
     exon            1..215
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
     exon            216..273
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
     exon            274..378
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1726
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /note="serotonin receptor 2C; serotonin 1c receptor;
                     5-HT1C; 5-HT-1C; 5-hydroxytryptamine receptor 1C;
                     5-hydroxytryptamine (serotonin) receptor 2C, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2C precursor"
                     /protein_id="NP_036897.2"
                     /db_xref="GeneID:25187"
                     /db_xref="RGD:2848"
                     /translation="MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGG
                     RLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADML
                     VGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNP
                     IEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLI
                     GSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGE
                     EENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNI
                     LSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPD
                     KKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPS
                     NVVSERISSV"
     exon            379..695
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
     exon            696..896
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
     exon            897..4385
                     /gene="Htr2c"
                     /gene_synonym="5-HT2C; 5-HTR2C; 5HT-1C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaggttgc ccacaggagg tcgacttgcc ggcgctgtcc ttcgcgccga gctccctcca
       61 tccttctttc cgtctgctga gacgcaaggt tgcggcgcgc agcgctgagc agcgcactga
      121 ctgccgcggg ctccgctggg cgattgcagc cgagtccgtt tctcgtctag ctgccgccgc
      181 ggcgacctgc ctggtcttcc tcccggacgc tagcgggttg tcaactatta cctgcaagca
      241 taggccaacg aacaccttct ttccaaatta attggaatga aacaattctg ttaacttcct
      301 aattctcagt ttgaaactct ggttgcttaa gcctgaagca atcatggtga accttggcaa
      361 cgcggtgcgc tcgctcctga tgcacctaat cggcctattg gtttggcaat tcgatatttc
      421 cataagtcca gtagcagcta tagtaactga cacttttaat tcctccgatg gtggacgctt
      481 gtttcaattc ccggacgggg tacaaaactg gccagcactt tcaatcgtcg tgattataat
      541 catgacaata gggggcaaca ttcttgttat catggcagta agcatggaga agaaactgca
      601 caatgcaacc aattacttct taatgtccct agccattgct gatatgctgg tgggactact
      661 tgtcatgccc ctgtccctgc ttgctattct ttatgattat gtctggcctt tacctagata
      721 tttgtgcccc gtctggattt cactagatgt gctattttca actgcgtcca tcatgcacct
      781 ctgcgccata tcgctggacc ggtatgtagc aatacgtaat cctattgagc atagccggtt
      841 caattcgcgg actaaggcca tcatgaagat tgccatcgtt tgggcaatat caataggagt
      901 ttcagttcct atccctgtga ttggactgag ggacgaaagc aaagtgttcg tgaataacac
      961 cacgtgcgtg ctcaatgacc ccaacttcgt tctcatcggg tccttcgtgg cattcttcat
     1021 cccgttgacg attatggtga tcacctactt cttaacgatc tacgtcctgc gccgtcaaac
     1081 tctgatgtta cttcgaggtc acaccgagga ggaactggct aatatgagcc tgaactttct
     1141 gaactgctgc tgcaagaaga atggtggtga ggaagagaac gctccgaacc ctaatccaga
     1201 tcagaaacca cgtcgaaaga agaaagaaaa gcgtcccaga ggcaccatgc aagctatcaa
     1261 caacgaaaag aaagcttcca aagtccttgg cattgtattc tttgtgtttc tgatcatgtg
     1321 gtgcccgttt ttcatcacca atatcctgtc ggttctttgt gggaaggcct gtaaccaaaa
     1381 gctaatggag aagcttctca atgtgtttgt gtggattggc tatgtgtgtt caggcatcaa
     1441 tcctctggtg tacactctct ttaataaaat ttaccgaagg gctttctcta aatatttgcg
     1501 ctgcgattat aagccagaca aaaagcctcc tgttcgacag attcctaggg ttgctgccac
     1561 tgctttgtct gggagggagc tcaatgttaa catttatcgg cataccaatg aacgtgtggc
     1621 taggaaagct aatgaccctg agcctggcat agagatgcag gtggagaact tagagctgcc
     1681 agtcaacccc tctaatgtgg tcagcgagag gattagtagt gtgtaagcga gagcagcgca
     1741 gacttcctac aggaaagttc ctgtaggaaa gtcctcccca ccccccgtga ttttcctgtg
     1801 aatcataact aatgtaaata ttgctgtgtg acaagacagt gtttttataa atagctttgc
     1861 aaccctgtac tttacaatca tgcgttaata gtgagattcg gggttctata tttactgttt
     1921 atgatagacg gggactaatt tattttgatt ccttgatgca taatagtgtt tgtggttttt
     1981 ctcttccttc cttccctatt tcctccctcc cttgcccctt ctttgctttc ttccttccta
     2041 tctcgattct ttttgtgaat gaggaaatgt tgatgttcat ctcaggtggc atttgcaaga
     2101 gaccagaatg atgcacggga ctgtgatgtt atttcaaacc acacctaaat ggacagattc
     2161 agtggcatct tttccgggtt aacagtaaat atgtacttta gattctcgct ctgctcatct
     2221 acacgcataa acacagtaag ataggttctg cccattgtga aaaatattca tcagtgagtc
     2281 agagtcagac ttcaactttg ttgttataca tcggggtgca attggacatt gtcagaacgt
     2341 cgtgtcagat ttttgctgca atgtctatcc ccaatcatag tggtctttta acatagcagc
     2401 tggttaacca ggactacaga agtggaagga tgcgaaagag atatacacac gaaacagctt
     2461 ttcacttctt aaggacaatg ttcaaattct gattattacg acaagcaaac taaaattagt
     2521 gtcgtcattc tggtccttag taaataccta attccaagag taaactggga aagcaaatcc
     2581 cagagttatt tcccaatcca ggattcaaca tcaattggat tttgatctca gaattctgga
     2641 aatttgtgtg ctccacacaa aatgaaattt gcatttcgag ccttattaaa atatcttctt
     2701 aattatggta cctctatcta taggacccaa tttggcagtc catttttaag taaaactagt
     2761 ctgagaaggg tagagaacca tgaccttgaa agttttgctt gattaaggac tactgaatta
     2821 ggcccttaga atgtgaaaaa agtaatttaa aaagacgctt tcattgaact ctgggaagaa
     2881 tagaaataca gagtttccat ttgaatttta aacaaaattt atctcattgt cagatccttc
     2941 caagctctct agtgcaggaa aaggctgcag ctaaattgtg accgtggaag ctccccattg
     3001 tgctgcaatt atgtacctga actttaaatc tttgttcaaa tataatgctg tgttccaatt
     3061 aatgtcagcc attgtttcat tcgtgggcct gctgctccct aagaattaag taccatttta
     3121 gtgaaattga aaactatgaa aagttttcaa acattgctca agtcagatta ttaagtctat
     3181 gctgtgtaca gagtatacac ccgttcccag taactgtgtt tccctgtgtg gacatttgta
     3241 cacaactgtg aataaatttc tgaagaattc atgacactgt ttcttatgcc caagagctgc
     3301 ttgcacacct tggaatggga ctcttaggct cttgaagtca gcaaggaagg atttgaattt
     3361 caaaaactcc tggagtgtgt tcttaacaca cagcatagat aaattgaaca gtctgccacg
     3421 ggggcagtgg gagagcggct gtatttgagg aaactcaagc agtctctatt tgatttccaa
     3481 cactgccaaa tgtcactcaa ttgcttgagc atgcccaaac atgacaggaa agtaaagtct
     3541 acctgccttt taggtcagtt gaactgcatg taaaaacaat tacctgaaat tgaatgagat
     3601 gacctacttc ttaatgaaat gaaaatgact gaagaaacac agcatgcatt gagcatgagt
     3661 tctgcacata cagatggtga tgtgcatgta cgccatgtat gttgcatcaa tccactgatc
     3721 cgtatcaacg caaggcagag gagctgatat agaaagcgct ggagaaaact tcttcggcag
     3781 tccctaagag acattcagat ctgaagtatt gtattagaga aaattggaaa catctgattt
     3841 ctttcttaag tatcagggca agctcatagc atatgtttta cagagacata gactataaac
     3901 catggagttc ctaaagcact agcaataagt tgaatgataa tcgcttatag cacatttgtt
     3961 aataattctt atgtcatcaa gtagtagtac gtaatagtac ccaacacagc aattattctc
     4021 aacttgtgtg ctattcgtaa gttccgtgca gtttggtatg aagtatatct atataaaaac
     4081 aaccatttgg aaataaatct tacagttcag tgttaaatct acaaactttt ataaatgttt
     4141 taaaacagtt catgtgacaa ctgtaaacgt ggtgaattta ctgtcaaatc attttgatgt
     4201 gctattatgt atgtatactc tttaagactg ccttatatta ttatttcctg tgattttcct
     4261 cctttgtcaa acggtacttt ttgtgaatgg ttgcaaactg gtgtcatatt ccttattccc
     4321 gtgtgttaca ttcttctgag ttttgtgaga cttcctctta atttattaaa tttattaagt
     4381 gatgaaaaaa aaaaaaaaaa aa
//
