LOCUS       NM_017250               2102 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 2B (Htr2b), mRNA.
ACCESSION   NM_017250 XM_017596306
VERSION     NM_017250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2102)
  AUTHORS   Li,Z.Y., Mao,Y.Q., Hua,Q., Sun,Y.H., Wang,H.Y., Ye,X.G., Hu,J.X.,
            Wang,Y.J. and Jiang,M.
  TITLE     Serotonin receptor 2B induces visceral hyperalgesia in rat model
            and patients with diarrhea-predominant irritable bowel syndrome
  JOURNAL   World J Gastroenterol 30 (10), 1431-1449 (2024)
   PUBMED   38596485
  REMARK    GeneRIF: Serotonin receptor 2B induces visceral hyperalgesia in rat
            model and patients with diarrhea-predominant irritable bowel
            syndrome.
REFERENCE   2  (bases 1 to 2102)
  AUTHORS   Chen,W., Gao,X., Yang,W., Xiao,X., Pan,X. and Li,H.
  TITLE     Htr2b Promotes M1 Microglia Polarization and Neuroinflammation
            after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB
            Signaling
  JOURNAL   Mol Neurobiol 61 (3), 1643-1654 (2024)
   PUBMED   37747614
  REMARK    GeneRIF: Htr2b Promotes M1 Microglia Polarization and
            Neuroinflammation after Spinal Cord Injury via Inhibition of
            Neuregulin-1/ErbB Signaling.
REFERENCE   3  (bases 1 to 2102)
  AUTHORS   Binetti,J., Bertran,L., Riesco,D., Aguilar,C., Martinez,S.,
            Sabench,F., Porras,J.A., Camaron,J., Castillo,D.D., Richart,C. and
            Auguet,T.
  TITLE     Deregulated Serotonin Pathway in Women with Morbid Obesity and
            NAFLD
  JOURNAL   Life (Basel) 10 (10), 245 (2020)
   PUBMED   33081272
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2102)
  AUTHORS   Borkowski,L.F., Craig,T.A., Stricklin,O.E., Johnson,K.A. and
            Nichols,N.L.
  TITLE     5-HT2A/B receptor expression in the phrenic motor nucleus in a rat
            model of ALS (SOD1G93A)
  JOURNAL   Respir Physiol Neurobiol 279, 103471 (2020)
   PUBMED   32504811
  REMARK    GeneRIF: 5-HT2A/B receptor expression in the phrenic motor nucleus
            in a rat model of ALS (SOD1(G93A)).
REFERENCE   5  (bases 1 to 2102)
  AUTHORS   Perim,R.R., Fields,D.P. and Mitchell,G.S.
  TITLE     Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic
            motor facilitation via NADPH oxidase and PKA
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 314 (5), R709-R715 (2018)
   PUBMED   29384698
  REMARK    GeneRIF: Cross-talk inhibition occurs between 5-HT2B and 5-HT7
            receptors in phrenic motor facilitation via NADPH oxidase and PKA
            pathway.
REFERENCE   6  (bases 1 to 2102)
  AUTHORS   Bonhaus,D.W., Bach,C., DeSouza,A., Salazar,F.H., Matsuoka,B.D.,
            Zuppan,P., Chan,H.W. and Eglen,R.M.
  TITLE     The pharmacology and distribution of human 5-hydroxytryptamine2B
            (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C
            receptors
  JOURNAL   Br J Pharmacol 115 (4), 622-628 (1995)
   PUBMED   7582481
REFERENCE   7  (bases 1 to 2102)
  AUTHORS   Borman,R.A. and Burleigh,D.E.
  TITLE     Functional evidence for a 5-HT2B receptor mediating contraction of
            longitudinal muscle in human small intestine
  JOURNAL   Br J Pharmacol 114 (8), 1525-1527 (1995)
   PUBMED   7599919
REFERENCE   8  (bases 1 to 2102)
  AUTHORS   Choi,D.S., Birraux,G., Launay,J.M. and Maroteaux,L.
  TITLE     The human serotonin 5-HT2B receptor: pharmacological link between
            5-HT2 and 5-HT1D receptors
  JOURNAL   FEBS Lett 352 (3), 393-399 (1994)
   PUBMED   7926008
REFERENCE   9  (bases 1 to 2102)
  AUTHORS   Kursar,J.D., Nelson,D.L., Wainscott,D.B., Cohen,M.L. and Baez,M.
  TITLE     Molecular cloning, functional expression, and pharmacological
            characterization of a novel serotonin receptor
            (5-hydroxytryptamine2F) from rat stomach fundus
  JOURNAL   Mol Pharmacol 42 (4), 549-557 (1992)
   PUBMED   1331748
REFERENCE   10 (bases 1 to 2102)
  AUTHORS   Foguet,M., Hoyer,D., Pardo,L.A., Parekh,A., Kluxen,F.W.,
            Kalkman,H.O., Stuhmer,W. and Lubbert,H.
  TITLE     Cloning and functional characterization of the rat stomach fundus
            serotonin receptor
  JOURNAL   EMBO J 11 (9), 3481-3487 (1992)
   PUBMED   1505525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_017596306.2, NM_017250.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.35299.1,
                                           SRR26643294.37202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000009.1  94203987-94204087   c
            102-680             JAXUCZ010000009.1  94202540-94203118   c
            681-881             JAXUCZ010000009.1  94193489-94193689   c
            882-2102            JAXUCZ010000009.1  94190083-94191303   c
FEATURES             Location/Qualifiers
     source          1..2102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2102
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /note="5-hydroxytryptamine receptor 2B"
                     /db_xref="GeneID:29581"
                     /db_xref="RGD:61801"
     exon            1..101
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            102..680
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1771
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /note="serotonin receptor 2B; stomach fundus serotonin
                     receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2B"
                     /protein_id="NP_058946.2"
                     /db_xref="GeneID:29581"
                     /db_xref="RGD:61801"
                     /translation="MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQ
                     TAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLV
                     GLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPI
                     QANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFML
                     FGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSS
                     PEKMAMLDGSHKDKILPNSIDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLL
                     MWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGR
                     YITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSS
                     TIQSSSIILLNTFLTENDGDKVEDQVSYI"
     exon            681..881
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
     exon            882..2102
                     /gene="Htr2b"
                     /gene_synonym="5-HT-2B; 5-HT-2F; 5-HT2B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaggctc cgagaagtca ggaggaggat ctgtcagggg agggagtcca gctgaacaga
       61 cacaggacag caggcttagg aaagccagaa gcagacaagc atcttctgaa atctaagcct
      121 ctagaaggac tagaatctgg atgtcttacc tgcaaacatg gacagatatg tacacagtcc
      181 catcttggag aacctgaatc tttttagaag aaagaaggcc accttggctg ggagtgtctg
      241 gaggatacca tgctttgcaa aagcagatga cctgctagca actgaccatg ctgaccactg
      301 tctggaactg gactgagtca cagaaaggcg aatggcttca tcttataaaa tgtctgaaca
      361 aagcacaatt tctgagcaca ttttgcagaa aacatgtgat cacctgatct tgactgaccg
      421 ttctggatta aaggcagaat cagcagcaga ggaaatgaag cagactgccg agaaccaggg
      481 gaatacagtg cactgggcag ctctcctgat cttcgcggta ataatcccca ccattggcgg
      541 gaacatcctg gttattctgg ctgtttcact ggagaaaagg ctgcagtacg ctaccaacta
      601 ctttctaatg tccttggcgg tggctgattt gctggttgga ttgtttgtga tgccgattgc
      661 tctcttaaca atcatgtttg aggctacatg gcccctccca ctggccctgt gtcctgcctg
      721 gttattcctt gatgttctct tttcaactgc ctccatcatg catctctgtg ccatttccct
      781 ggatcgctat atagccatca aaaagccaat tcaggccaat cagtgcaatt cccggactac
      841 tgcattcgtc aagattacgg tggtatggtt aatttcaata ggcatcgcca tcccagtccc
      901 tattaaagga atagaggctg atgtggtcaa cgcacacaac atcacctgtg agctgacaaa
      961 ggaccgcttt ggcagtttca tgctctttgg gtcactggct gctttctttg cacctctcac
     1021 catcatgata gtcacctact ttctcaccat tcacgctttg cggaagaaag cttacttggt
     1081 cagaaacagg ccacctcaac gcctaacacg gtggactgtg tccacagttc tccaaaggga
     1141 agactcatcc ttttcatcac cagaaaagat ggcgatgctg gatggctctc acaaggataa
     1201 aattctacct aactcaattg atgagacact gatgagaaga atgtcctcag caggaaaaaa
     1261 accagcccag accatttcta atgaacagag agcctcaaag gtccttggaa ttgtgtttct
     1321 cttctttctg cttatgtggt gccccttttt cattacaaac gtaactttag ctctgtgtga
     1381 ttcctgcaac cagactactc tcaaaacact cctgcagata tttgtgtggg taggctacgt
     1441 ttcctcggga gtgaatcctt tgatctatac cctcttcaat aagacatttc gggaagcatt
     1501 tggcaggtac atcacctgca attaccaggc cacaaagtca gtaaaagtgc ttagaaagtg
     1561 ttctagtaca ctctattttg ggaattcaat ggtagaaaac tctaaatttt tcacaaaaca
     1621 tggaattcga aatgggatca accctgccat gtaccagagc ccagtaaggc tccgaagttc
     1681 aaccattcag tcttcatcca tcattctcct caatacattt ctcactgaaa acgatggtga
     1741 caaagtagaa gaccaagtca gctacatata gtggaatggg gcagccctca tctgactgag
     1801 ggaggggatg aggaggacgc aagcaaacca aggaaaaggc aagagtgaag cactaaggtt
     1861 gtccagtttc cttatctaaa caaactcaac gcacgggtat agtagttccg tatggctaca
     1921 aacaaaagca ttccctactc tggtattcaa atggaacaaa attaaataag tggatatact
     1981 tcagtcttta aaaagaaaag aaggggttgg ggatttagct cagtggtaga gagtttgcct
     2041 agtaagtgca aggccctggg ttcggttctc agctccagaa aaaaagaaaa taaaaaaaaa
     2101 aa
//
