LOCUS       NM_017254               1566 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 2A (Htr2a), mRNA.
ACCESSION   NM_017254 NM_021862
VERSION     NM_017254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Chen,X., Lv,R., Li,M., Zhang,L., Sun,Y., Cao,N. and Gu,B.
  TITLE     The serotonin(5-HT)2A receptor is involved in the hypersensitivity
            of bladder afferent neurons in cyclophosphamide-induced cystitis
  JOURNAL   Eur J Pharmacol 982, 176909 (2024)
   PUBMED   39154826
  REMARK    GeneRIF: The serotonin(5-HT)2A receptor is involved in the
            hypersensitivity of bladder afferent neurons in
            cyclophosphamide-induced cystitis.
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Nikolaus,S., Chao,O.Y., Henke,J., Beu,M., Fazari,B., Almeida,F.R.,
            Abdel-Hafiz,L., Antke,C., Hautzel,H., Mamlins,E., Muller,H.W.,
            Huston,J.P., von Gall,C. and Giesel,F.L.
  TITLE     5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat
  JOURNAL   Behav Brain Res 469, 115051 (2024)
   PUBMED   38777263
  REMARK    GeneRIF: 5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat.
REFERENCE   3  (bases 1 to 1566)
  AUTHORS   Farias,C.P., Leite,A.K.O., Schmidt,B.E., de Carvalho Myskiw,J. and
            Wyse,A.T.S.
  TITLE     The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial
            prefrontal cortex behave differently in extinction learning: Does
            social support play a role?
  JOURNAL   Behav Brain Res 463, 114922 (2024)
   PUBMED   38408524
  REMARK    GeneRIF: The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in
            the medial prefrontal cortex behave differently in extinction
            learning: Does social support play a role?
REFERENCE   4  (bases 1 to 1566)
  AUTHORS   Rohn,T.T., Radin,D., Brandmeyer,T., Seidler,P.G., Linder,B.J.,
            Lytle,T., Mee,J.L. and Macciardi,F.
  TITLE     Intranasal delivery of shRNA to knockdown the 5HT-2A receptor
            enhances memory and alleviates anxiety
  JOURNAL   Transl Psychiatry 14 (1), 154 (2024)
   PUBMED   38509093
  REMARK    GeneRIF: Intranasal delivery of shRNA to knockdown the 5HT-2A
            receptor enhances memory and alleviates anxiety.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1566)
  AUTHORS   Ercan,Z., Bulmus,O., Kacar,E., Serhatlioglu,I., Zorlu,G. and
            Kelestimur,H.
  TITLE     Treadmill Exercise Improves Behavioral and Neurobiological
            Alterations in Restraint-Stressed Rats
  JOURNAL   J Mol Neurosci 73 (9-10), 831-842 (2023)
   PUBMED   37794307
REFERENCE   6  (bases 1 to 1566)
  AUTHORS   Bonhaus,D.W., Bach,C., DeSouza,A., Salazar,F.H., Matsuoka,B.D.,
            Zuppan,P., Chan,H.W. and Eglen,R.M.
  TITLE     The pharmacology and distribution of human 5-hydroxytryptamine2B
            (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C
            receptors
  JOURNAL   Br J Pharmacol 115 (4), 622-628 (1995)
   PUBMED   7582481
REFERENCE   7  (bases 1 to 1566)
  AUTHORS   Du,Y.L., Wilcox,B.D., Teitler,M. and Jeffrey,J.J.
  TITLE     Isolation and characterization of the rat 5-hydroxytryptamine type
            2 receptor promoter: constitutive and inducible activity in
            myometrial smooth muscle cells
  JOURNAL   Mol Pharmacol 45 (6), 1125-1131 (1994)
   PUBMED   8022406
REFERENCE   8  (bases 1 to 1566)
  AUTHORS   Liu,J., Chen,Y., Kozak,C.A. and Yu,L.
  TITLE     The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10
            on mouse chromosome 14
  JOURNAL   Genomics 11 (1), 231-234 (1991)
   PUBMED   1765383
REFERENCE   9  (bases 1 to 1566)
  AUTHORS   Julius,D., Huang,K.N., Livelli,T.J., Axel,R. and Jessell,T.M.
  TITLE     The 5HT2 receptor defines a family of structurally distinct but
            functionally conserved serotonin receptors
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 928-932 (1990)
   PUBMED   2300586
REFERENCE   10 (bases 1 to 1566)
  AUTHORS   Pritchett,D.B., Bach,A.W., Wozny,M., Taleb,O., Dal Toso,R.,
            Shih,J.C. and Seeburg,P.H.
  TITLE     Structure and functional expression of cloned rat serotonin 5HT-2
            receptor
  JOURNAL   EMBO J 7 (13), 4135-4140 (1988)
   PUBMED   2854054
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M30705.1.
            
            On Oct 1, 2003 this sequence version replaced NM_021862.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M30705.1, M64867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..1566
                     /gene="Htr2a"
                     /gene_synonym="5-HT2A; 5Ht-2"
                     /note="5-hydroxytryptamine receptor 2A"
                     /db_xref="GeneID:29595"
                     /db_xref="RGD:61800"
     exon            1..471
                     /gene="Htr2a"
                     /gene_synonym="5-HT2A; 5Ht-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1475
                     /gene="Htr2a"
                     /gene_synonym="5-HT2A; 5Ht-2"
                     /note="serotonin 5HT-2 receptor; 5-HT-2; 5-HT-2A;
                     serotonin receptor 2A; 5-hydroxytryptamine (serotonin)
                     receptor 2A, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 2A"
                     /protein_id="NP_058950.1"
                     /db_xref="GeneID:29595"
                     /db_xref="RGD:61800"
                     /translation="MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASN
                     WTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLE
                     KKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFST
                     ASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDD
                     SKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRA
                     KLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVV
                     MWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFS
                     RYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGK
                     QQSEENCTDNIETVNEKVSCV"
     exon            472..672
                     /gene="Htr2a"
                     /gene_synonym="5-HT2A; 5Ht-2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..1566
                     /gene="Htr2a"
                     /gene_synonym="5-HT2A; 5Ht-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggctat gaacccctag tctctccaca cttcatctgc tacaacttcc ggcttagaca
       61 tggaaattct ttgtgaagac aatatctctc tgagctcaat tccaaactcc ttaatgcaat
      121 taggtgatgg cccgaggctc taccataatg acttcaactc cagagatgct aacacttcgg
      181 aagcatcgaa ctggacaatt gatgctgaaa acagaaccaa cctctcctgt gaagggtacc
      241 tcccaccgac atgcctctcc attcttcatc tccaggaaaa aaactggtct gctttattga
      301 caactgtcgt gattattctc accattgctg gaaatatact ggtcatcatg gcagtgtccc
      361 tagaaaaaaa gctgcagaat gccaccaact atttcctgat gtcacttgcc atagctgata
      421 tgctgctggg tttccttgtc atgcctgtgt ccatgttaac catcctgtat gggtaccggt
      481 ggcctttgcc tagcaagctc tgtgcgatct ggatttacct ggatgtgctc ttttctacgg
      541 catccatcat gcacctctgc gccatctccc tggaccgcta tgtcgccatc cagaacccca
      601 ttcaccacag ccgcttcaac tccagaacca aagccttcct gaaaatcatt gccgtgtgga
      661 ccatatctgt aggtatatcc atgccaatcc cagtctttgg actacaggat gattcgaagg
      721 tctttaagga ggggagctgc ctgcttgccg atgacaactt tgttctcata ggctcttttg
      781 tggcattttt catcccccta accatcatgg tgatcaccta cttcctgact atcaagtcac
      841 ttcagaaaga agccaccttg tgtgtgagtg acctcagcac tcgagccaaa ctagcctcct
      901 tcagcttcct ccctcagagt tctctgtcat cagaaaagct cttccaacgg tccatccaca
      961 gagagccagg ctcctacgca ggccgaagga cgatgcagtc catcagcaat gagcaaaagg
     1021 cgtgcaaggt gctgggcatc gtgttcttcc tgtttgttgt aatgtggtgc ccattcttca
     1081 tcaccaatat catggccgtc atctgcaaag aatcctgcaa tgaaaatgtc atcggagccc
     1141 tgctcaatgt gtttgtctgg attggttatc tctcctcagc tgtcaatcca ctggtatata
     1201 cgttgttcaa taaaacttat aggtccgcct tctcaaggta cattcagtgt cagtacaagg
     1261 aaaacagaaa gccactgcag ttaattttag tgaacactat accagcattg gcctacaagt
     1321 ctagtcagct ccaggtggga cagaaaaaga actcacagga agatgctgag cagacagttg
     1381 atgactgctc catggttaca ctggggaaac aacagtcgga agagaattgt acagacaata
     1441 ttgaaaccgt gaatgaaaag gttagctgtg tgtgatgaac tggatgctat ggcaattgcc
     1501 cagggcatgt gaacaaggtt atacccatgt gtgtggggcg gggataagga ggctgcaaca
     1561 aattag
//
