LOCUS       NM_021857               1400 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 1F (Htr1f), mRNA.
ACCESSION   NM_021857
VERSION     NM_021857.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Zhang,C., Meng,X., Chen,L., Zhang,X., Hans,H. and Ren,L.
  TITLE     Changes in 5-HT1F receptor expression in rats with spasticity
            following spinal cord injury
  JOURNAL   Neurosci Lett 793, 136988 (2023)
   PUBMED   36471527
  REMARK    GeneRIF: Changes in 5-HT1F receptor expression in rats with
            spasticity following spinal cord injury.
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Murray,K.C., Stephens,M.J., Rank,M., D'Amico,J., Gorassini,M.A. and
            Bennett,D.J.
  TITLE     Polysynaptic excitatory postsynaptic potentials that trigger spasms
            after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F
            receptors
  JOURNAL   J Neurophysiol 106 (2), 925-943 (2011)
   PUBMED   21653728
  REMARK    GeneRIF: Polysynaptic excitatory postsynaptic potentials that
            trigger spasms after spinal cord injury are regulated by 5-HT1F and
            5-HT1B receptors.
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Klein,M.T., Dukat,M., Glennon,R.A. and Teitler,M.
  TITLE     Toward selective drug development for the human 5-hydroxytryptamine
            1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor
            structure-affinity relationships
  JOURNAL   J Pharmacol Exp Ther 337 (3), 860-867 (2011)
   PUBMED   21422162
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Classey,J.D., Bartsch,T. and Goadsby,P.J.
  TITLE     Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression
            in rat trigeminal and dorsal root ganglia neurons: relevance to the
            selective anti-migraine effect of triptans
  JOURNAL   Brain Res 1361, 76-85 (2010)
   PUBMED   20833155
  REMARK    GeneRIF: 5-HT(1B), 5-HT(1D)and 5-HT(1F) receptor expression are
            equally represented in trigeminal ganglia and the dorsal root
            ganglia.
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Ahn,S.K., Khalmuratova,R., Jeon,S.Y., Kim,J.P., Park,J.J., Hur,D.G.
            and Balaban,C.D.
  TITLE     Colocalization of 5-HT1F receptor and calcitonin gene-related
            peptide in rat vestibular nuclei
  JOURNAL   Neurosci Lett 465 (2), 151-156 (2009)
   PUBMED   19735698
  REMARK    GeneRIF: This study demonstrates the colocalization of 5-HT(1F)
            receptor and CGRP in the rat vestibular nuclei, indicates that
            5-HT(1F) receptor agonists may ameliorate migrainous vertigo by
            attenuating elevated levels of CGRP release from vestibular nuclei.
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Ahn,S.K., Khalmuratova,R., Jeon,S.Y., Kim,J.P., Park,J.J.,
            Hur,D.G., Kim,D.W. and Balaban,C.D.
  TITLE     Colocalization of 5-HT1F receptor and glutamate in neurons of the
            vestibular nuclei in rats
  JOURNAL   Neuroreport 20 (2), 111-115 (2009)
   PUBMED   19077678
  REMARK    GeneRIF: colocalization of 5-HT1F receptor and glutamate in the
            vestibular nuclei wsas observed; this suggests that 5-HT1F receptor
            might modulate glutamate release from the vestibular nuclei
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Lovenberg,T.W., Erlander,M.G., Baron,B.M., Racke,M., Slone,A.L.,
            Siegel,B.W., Craft,C.M., Burns,J.E., Danielson,P.E. and
            Sutcliffe,J.G.
  TITLE     Molecular cloning and functional expression of 5-HT1E-like rat and
            human 5-hydroxytryptamine receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2184-2188 (1993)
   PUBMED   8384716
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Adham,N., Kao,H.T., Schecter,L.E., Bard,J., Olsen,M., Urquhart,D.,
            Durkin,M., Hartig,P.R., Weinshank,R.L. and Branchek,T.A.
  TITLE     Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1
            receptor subtype coupled to the inhibition of adenylate cyclase
  JOURNAL   Proc Natl Acad Sci U S A 90 (2), 408-412 (1993)
   PUBMED   8380639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Feb 10, 2021 this sequence version replaced NM_021857.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1400              JAXUCZ010000011.1  16089266-16090665   c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..1400
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="5-hydroxytryptamine receptor 1F"
                     /db_xref="GeneID:60448"
                     /db_xref="RGD:71083"
     exon            1..1400
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1142
                     /gene="Htr1f"
                     /gene_synonym="Htr1eb"
                     /note="5-HT-1F; serotonin receptor 1F; 5-HT1F; serotonin
                     receptor gene (similar to Mm Htr1eb); 5-hydroxytryptamine
                     (serotonin) receptor 1F, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1F"
                     /protein_id="NP_068629.2"
                     /db_xref="GeneID:60448"
                     /db_xref="RGD:71083"
                     /translation="MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLV
                     ITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVSESWIMGQGLCDLWLSV
                     DIICCSCSILHLSAIALDRYRAITDAVEYARKRTPRHAGITITTVWVISVFISMPPLF
                     WRHQGNSRDDQCIIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQAS
                     RMIKEELNGQVLLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEK
                     SWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKISEEMSNFLAW
                     LGYLNSLINPLIYTIFNEDFKKAFQKLVRCRN"
ORIGIN      
        1 gtattcattt cttcaactat gtaaaccttt taaacaaaaa aatggatttt ctaaactcat
       61 cagaccaaaa tttaacctca gaggaactgt taaaccgaat gccatccaaa attctggtat
      121 ccctcactct gtctggcctg gccttgatga caaccaccat caactccctc gtgatcactg
      181 caatcattgt gactcggaag ctgcaccacc cagccaacta tttaatctgt tccttggcag
      241 ttacagactt tcttgttgct gtcctggtta tgccctttag catcgtgtac attgtgagcg
      301 agagttggat tatgggacaa ggactctgtg acctttggct gagtgttgac atcatctgct
      361 gtagctgctc catcttgcac ctgtcggcta tagcgttgga taggtaccga gcaatcacag
      421 acgcagtcga gtatgccagg aagaggactc ccaggcatgc tggcatcacg attacaacag
      481 tgtgggttat atctgtgttc atctccatgc ctcctctctt ctggaggcac caaggaaata
      541 gccgtgatga tcagtgtatc atcaaacatg accatattgt ttccacaatt tactccacgt
      601 ttggagcctt ctacatccca cttgtgttga tattgatcct ctactacaaa atatacagag
      661 cagcaaggac actataccac aagagacaag caagtcggat gataaaggag gaactgaatg
      721 gccaagtcct tttggagagt ggtgagaaga gcattaaact ggtctccaca tcctacatgt
      781 tagaaaaatc cttatctgat ccatcaacag actttgatag aattcacagc acagtgaaaa
      841 gtcccagatc tgagctgaag cacgagaaat cttggagaag acagaaaatc tcaggcactc
      901 gagaacgcaa agcagccact accctgggat tgatcttggg cgcatttgta atatgttggt
      961 tgcccttttt tgtaaaggaa ttggttgtta atatctgtga aaaatgtaaa atttctgaag
     1021 aaatgtcaaa ttttttggca tggcttggtt acctgaattc tcttataaac ccactgattt
     1081 ataccatctt taatgaagac tttaagaaag ccttccaaaa acttgtacga tgtcgaaatt
     1141 aggatttaaa aaaaagccta tttttaaagg gtagaggctg tatttcttgg gggggggagg
     1201 gataactaaa tgaatgtaaa gtaataaaag attgaaattt ttagagaaaa tatataaaga
     1261 ctgctaaaat tataagagga taaatttatt tttaatagta ccaagaaaat aagatatact
     1321 aatttggcca tcattttaat gttctcaaaa ttaggaaata atttaggcag ctcagctcat
     1381 aatatttttt ctatgcaata
//
