LOCUS       NM_012852               2892 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 1D (Htr1d), mRNA.
ACCESSION   NM_012852 XM_008764208
VERSION     NM_012852.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2892)
  AUTHORS   Gharishvandi,F., Shafaroodi,H., Mohammad Jafari,R., Abdollahi,A.,
            Pasalar,P. and Dehpour,A.R.
  TITLE     The protective effect of alpha7-nACh receptor and its interaction
            with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion
            injury in rats
  JOURNAL   Fundam Clin Pharmacol 36 (1), 100-113 (2022)
   PUBMED   34061415
  REMARK    GeneRIF: The protective effect of alpha7-nACh receptor and its
            interaction with 5-HT1B/1D receptors in acute intestinal
            ischemia-reperfusion injury in rats.
REFERENCE   2  (bases 1 to 2892)
  AUTHORS   Gharishvandi,F., Abdollahi,A., Shafaroodi,H., Mohammad Jafari,R.,
            Pasalar,P. and Dehpour,A.R.
  TITLE     Involvement of 5-HT1B/1D receptors in the inflammatory response and
            oxidative stress in intestinal ischemia/reperfusion in rats
  JOURNAL   Eur J Pharmacol 882, 173265 (2020)
   PUBMED   32574671
  REMARK    GeneRIF: Involvement of 5-HT1B/1D receptors in the inflammatory
            response and oxidative stress in intestinal ischemia/reperfusion in
            rats.
REFERENCE   3  (bases 1 to 2892)
  AUTHORS   Godinez-Chaparro,B., Lopez-Santillan,F.J., Arguelles,C.F.,
            Villalon,C.M. and Granados-Soto,V.
  TITLE     Role of 5-HTB/D receptors in the reduction of formalin-induced
            nociception and secondary allodynia/hyperalgesia produced by
            antimigraine drugs in rats
  JOURNAL   Life Sci 92 (22), 1046-1054 (2013)
   PUBMED   23583574
  REMARK    GeneRIF: 5-HTB/D receptors have a role in the reduction of
            formalin-induced nociception and secondary allodynia/hyperalgesia
            produced by antimigraine drugs in rats.
REFERENCE   4  (bases 1 to 2892)
  AUTHORS   Bhatt,D.K., Gupta,S., Jansen-Olesen,I., Andrews,J.S. and Olesen,J.
  TITLE     NXN-188, a selective nNOS inhibitor and a 5-HT1B/1D receptor
            agonist, inhibits CGRP release in preclinical migraine models
  JOURNAL   Cephalalgia 33 (2), 87-100 (2013)
   PUBMED   23155193
  REMARK    GeneRIF: NXN-188 inhibits CGRP release from migraine-relevant
            cephalic tissues.
REFERENCE   5  (bases 1 to 2892)
  AUTHORS   Wei,C., Han,J.K., Wang,H.T., Jia,Z.H., Chang,L.P. and Wu,Y.L.
  TITLE     [Effects of fatigue and restraint stress on the expression of
            carnitine palmitoyltransferase-I and 5-hydroxytryptamine receptors
            in aorta of rats]
  JOURNAL   Zhonghua Yi Xue Za Zhi 91 (13), 915-919 (2011)
   PUBMED   21600121
  REMARK    GeneRIF: The mRNA and protein expressions of 5-HT1D receptor
            decreased in excessive fatigue rats and restraint stress rats.
REFERENCE   6  (bases 1 to 2892)
  AUTHORS   Potrebic,S., Ahn,A.H., Skinner,K., Fields,H.L. and Basbaum,A.I.
  TITLE     Peptidergic nociceptors of both trigeminal and dorsal root ganglia
            express serotonin 1D receptors: implications for the selective
            antimigraine action of triptans
  JOURNAL   J Neurosci 23 (34), 10988-10997 (2003)
   PUBMED   14645495
  REMARK    GeneRIF: Our finding, that 5-HT1D receptors are distributed in
            nociceptors throughout the body, raises the possibility that
            triptans can regulate not only headache-associated pain but also
            nociceptive responses in extracranial tissues
REFERENCE   7  (bases 1 to 2892)
  AUTHORS   Borman,R.A. and Burleigh,D.E.
  TITLE     5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in
            human small intestine
  JOURNAL   Ann N Y Acad Sci 812, 222-223 (1997)
   PUBMED   9186750
REFERENCE   8  (bases 1 to 2892)
  AUTHORS   Maura,G. and Raiteri,M.
  TITLE     Serotonin 5-HT1D and 5-HT1A receptors respectively mediate
            inhibition of glutamate release and inhibition of cyclic GMP
            production in rat cerebellum in vitro
  JOURNAL   J Neurochem 66 (1), 203-209 (1996)
   PUBMED   8522955
REFERENCE   9  (bases 1 to 2892)
  AUTHORS   Maroteaux,L., Saudou,F., Amlaiky,N., Boschert,U., Plassat,J.L. and
            Hen,R.
  TITLE     Mouse 5HT1B serotonin receptor: cloning, functional expression, and
            localization in motor control centers
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3020-3024 (1992)
   PUBMED   1557407
REFERENCE   10 (bases 1 to 2892)
  AUTHORS   Hamblin,M.W. and Metcalf,M.A.
  TITLE     Primary structure and functional characterization of a human
            5-HT1D-type serotonin receptor
  JOURNAL   Mol Pharmacol 40 (2), 143-148 (1991)
   PUBMED   1652050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Aug 30, 2022 this sequence version replaced
            XM_008764208.3, NM_012852.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.24990.1,
                                           SRR26360194.2033777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000005.1  153939735-153939900
            167-2892            JAXUCZ010000005.1  153957287-153960012
FEATURES             Location/Qualifiers
     source          1..2892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2892
                     /gene="Htr1d"
                     /gene_synonym="5HT1D"
                     /note="5-hydroxytryptamine receptor 1D"
                     /db_xref="GeneID:25323"
                     /db_xref="RGD:2847"
     exon            1..166
                     /gene="Htr1d"
                     /gene_synonym="5HT1D"
                     /inference="alignment:Splign:2.1.0"
     exon            167..2892
                     /gene="Htr1d"
                     /gene_synonym="5HT1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             855..1979
                     /gene="Htr1d"
                     /gene_synonym="5HT1D"
                     /note="5-HT-1D; serotonin receptor 1D; 5-HT1D; 5 -
                     Hydroxytryptamine (serotonin) receptor 1D;
                     5-hydroxytryptamine (serotonin) receptor 1D, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1D"
                     /protein_id="NP_036984.1"
                     /db_xref="GeneID:25323"
                     /db_xref="RGD:2847"
                     /translation="MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSI
                     ITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWN
                     FGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVW
                     AISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIY
                     VAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKI
                     KLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPAL
                     FDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS"
ORIGIN      
        1 agagcgcgga gcagcggcgg gcgcgggcag gagcgcggag ccggagctgc aggcgcggag
       61 ggcggtggag cccggagctc agcggggtcg tggaggaggc caggctgcag cccgcagggg
      121 tgcggggcgc tcgcaccctt ggcccgtacc tcccggctgg gagccgctca gagcttctga
      181 acacatcccc agctcggtga accagcagtg acccatttgt tttgccttct cctagctcat
      241 gcattctttg agtcttggta actggaatgt tttgtctagt cagacgcaaa gccgtcagcg
      301 ggacagaacc aacgctgagg actcatgacg tgttggcagg atcctgggaa aaaggagctg
      361 ctgggagtgc acctctgaat cagttggttc tttttgtctc tggttttaaa agctctctgg
      421 aagagacctg atgtctagaa tcttctaagt atgaacaggg gaatgctgaa gttttgtagt
      481 taaatatgtc aatgtcttta tgtttcaaaa agcattagaa tgtcgaaggc aagaacccca
      541 gaaccctgcc catcctcctg tgagaccttg ataattatct aacaaatcta tcatgcgtcc
      601 actgggctgg accatctgct gggagaagtt ccagaacccc aagatgcctt gggcttcatc
      661 tgcttccgga agcatctagc tgtggagttg gtgtcctttc ctgggcacgt cttgaggcct
      721 ttctgctgag ctctgtcctg atgtatggct ttcacagttg tgaagctgaa gtatgacttt
      781 gttctctgga tgggatgagg gtgaaggagt gagccgtgtg tgtagaagtc tgtgggaaga
      841 gagaaacact gagcatgtcg ctgccaaacc agtccctaga aggccttcct caggaggcct
      901 ccaacagatc cctgaatgct acaggggctt gggacccaga ggtcctgcag gcactcagaa
      961 tctccctcgt ggtggtccta tccatcatta cactggccac tgtcctctcc aatgccttcg
     1021 tacttaccac catcctgctc accaagaagc tccatacccc agccaactat ctcattggct
     1081 ccttggccac caccgacctc ctggtttcta tcttggtcat gcccatcagc atagcctata
     1141 ccaccacccg tacctggaac tttggccaga tcctgtgtga catctgggtg tcttctgaca
     1201 tcacatgctg tacggcctcc atcctgcatc tctgtgtcat cgctctggac agatactggg
     1261 ccatcaccga tgccctggag tacagcaagc gccggaccgc aggtcacgcg gcggccatga
     1321 ttgcggccgt ctgggccatc tccatctgta tctccatccc accgctcttc tggcggcagg
     1381 ccacggctca cgaggagatg tctgactgcc tggtgaacac atctcagatt tcttacacca
     1441 tctactcgac ctgtggggcc ttctacatcc catccatctt gctcattatc ctgtatggcc
     1501 gcatatacgt ggccgcccgg agtcgaatcc tgaacccacc ctccctctac gggaagcgct
     1561 tcaccacagc acagcttatc acgggctctg cgggctcttc actctgctcg ctcaacccca
     1621 gcctccacga gagccacacg cacacagtcg gttcccctct ttttttcaac caggtgaaaa
     1681 tcaagcttgc tgatagcatc ttagaacgca agaggatctc tgcagcccga gaaaggaaag
     1741 ccactaagac attgggcatc attctggggg cctttatcat ctgctggctg cctttctttg
     1801 tggtatcctt ggtcctcccc atctgcaggg actcctgttg gatccacccg gccctctttg
     1861 acttcttcac gtggctaggt tatttaaact ctctcattaa ccccgtcatc tacactgtgt
     1921 tcaacgaaga ctttcgacaa gcgtttcaga gagtcgtcca tttccgaaag gcctcttagt
     1981 cgaatttggg ggtgactctt gtttatctgt tatgtcctgt aacccagctg gggttgcctt
     2041 ttttaattac tgtcgtttct ctgggacctg ggctgatttg tgctatcttg ggtcttggat
     2101 taaatcaata gatttgttct gtgtttgact gccagcatct tccagacttc tgaattactg
     2161 aaagctaggt gctgtgtaaa aggcgacagg actgaagaca tcccttaaca taatatcctc
     2221 atggttctct ggattggaag aaatttaata tgtaggactt agatgagaaa ctgtcttatt
     2281 ctctagaagg ctcggaggga aggccttctg gtctacctgg gattttacag agggctttgg
     2341 aaaatgggtg tgattattga cttgaattaa aagtgaattt ggagttaaaa cagagggggt
     2401 tgtcatctcc catagcccac tgattagaaa acaacaccca ggaattgttt ctactgggtc
     2461 ctggttgtcc atatggaaag tgaggttggt gacccagggt agatagagag aaattcagaa
     2521 ggtggcagca ggagagaggt atacgtggga ccagatcaac tactctacat ccttcattct
     2581 tccctttgtc tctattatat aatgttctga agttaaaacc cgtcatcctg ctgctcaaga
     2641 agactgacca gtgtcggatg caccaagctt tgaacggata cctcattctg cccgttccga
     2701 tgtttttatt ttgaattact atttttttac aacccttgtc gggctggaga gatggcttag
     2761 cagttaagag cactgactgc tcttccagag gtcctgagtt caaatcccag caactgcatg
     2821 gtggcttacc acccttgtca tcagaattct taagatgttg agtcttacca aataaaatgc
     2881 atgggggaca ca
//
