LOCUS       NM_022225               4738 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 1B (Htr1b), mRNA.
ACCESSION   NM_022225 XM_039080866
VERSION     NM_022225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4738)
  AUTHORS   Gharishvandi,F., Shafaroodi,H., Mohammad Jafari,R., Abdollahi,A.,
            Pasalar,P. and Dehpour,A.R.
  TITLE     The protective effect of alpha7-nACh receptor and its interaction
            with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion
            injury in rats
  JOURNAL   Fundam Clin Pharmacol 36 (1), 100-113 (2022)
   PUBMED   34061415
  REMARK    GeneRIF: The protective effect of alpha7-nACh receptor and its
            interaction with 5-HT1B/1D receptors in acute intestinal
            ischemia-reperfusion injury in rats.
REFERENCE   2  (bases 1 to 4738)
  AUTHORS   Gharishvandi,F., Abdollahi,A., Shafaroodi,H., Mohammad Jafari,R.,
            Pasalar,P. and Dehpour,A.R.
  TITLE     Involvement of 5-HT1B/1D receptors in the inflammatory response and
            oxidative stress in intestinal ischemia/reperfusion in rats
  JOURNAL   Eur J Pharmacol 882, 173265 (2020)
   PUBMED   32574671
  REMARK    GeneRIF: Involvement of 5-HT1B/1D receptors in the inflammatory
            response and oxidative stress in intestinal ischemia/reperfusion in
            rats.
REFERENCE   3  (bases 1 to 4738)
  AUTHORS   Padovan-Neto,F.E., Patterson,S., F Voelkner,N.M., Altwal,F.,
            Beverley,J.A., West,A.R. and Steiner,H.
  TITLE     Selective Regulation of 5-HT1B Serotonin Receptor Expression in the
            Striatum by Dopamine Depletion and Repeated L-DOPA Treatment:
            Relationship to L-DOPA-Induced Dyskinesias
  JOURNAL   Mol Neurobiol 57 (2), 736-751 (2020)
   PUBMED   31468338
  REMARK    GeneRIF: Selective Regulation of 5-HT1B Serotonin Receptor
            Expression in the Striatum by Dopamine Depletion and Repeated
            L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias.
REFERENCE   4  (bases 1 to 4738)
  AUTHORS   Cruz-Martinez,A.M., Tejas-Juarez,J.G., Mancilla-Diaz,J.M.,
            Floran-Garduno,B., Lopez-Alonso,V.E. and Escartin-Perez,R.E.
  TITLE     CB1 receptors in the paraventricular nucleus of the hypothalamus
            modulate the release of 5-HT and GABA to stimulate food intake in
            rats
  JOURNAL   Eur Neuropsychopharmacol 28 (11), 1247-1259 (2018)
   PUBMED   30217553
REFERENCE   5  (bases 1 to 4738)
  AUTHORS   Alter,D., Beverley,J.A., Patel,R., Bolanos-Guzman,C.A. and
            Steiner,H.
  TITLE     The 5-HT1B serotonin receptor regulates methylphenidate-induced
            gene expression in the striatum: Differential effects on
            immediate-early genes
  JOURNAL   J Psychopharmacol 31 (8), 1078-1087 (2017)
   PUBMED   28720013
  REMARK    GeneRIF: findings indicate that stimulation of the 5-HT1B receptor
            can enhance methylphenidate-induced gene regulation.
REFERENCE   6  (bases 1 to 4738)
  AUTHORS   Trillat,A.C., Malagie,I., Scearce,K., Pons,D., Anmella,M.C.,
            Jacquot,C., Hen,R. and Gardier,A.M.
  TITLE     Regulation of serotonin release in the frontal cortex and ventral
            hippocampus of homozygous mice lacking 5-HT1B receptors: in vivo
            microdialysis studies
  JOURNAL   J Neurochem 69 (5), 2019-2025 (1997)
   PUBMED   9349547
REFERENCE   7  (bases 1 to 4738)
  AUTHORS   Ullmer,C., Boddeke,H.G., Schmuck,K. and Lubbert,H.
  TITLE     5-HT2B receptor-mediated calcium release from ryanodine-sensitive
            intracellular stores in human pulmonary artery endothelial cells
  JOURNAL   Br J Pharmacol 117 (6), 1081-1088 (1996)
   PUBMED   8882600
REFERENCE   8  (bases 1 to 4738)
  AUTHORS   Hamblin,M.W., Metcalf,M.A., McGuffin,R.W. and Karpells,S.
  TITLE     Molecular cloning and functional characterization of a human 5-HT1B
            serotonin receptor: a homologue of the rat 5-HT1B receptor with
            5-HT1D-like pharmacological specificity
  JOURNAL   Biochem Biophys Res Commun 184 (2), 752-759 (1992)
   PUBMED   1315531
REFERENCE   9  (bases 1 to 4738)
  AUTHORS   Voigt,M.M., Laurie,D.J., Seeburg,P.H. and Bach,A.
  TITLE     Molecular cloning and characterization of a rat brain cDNA encoding
            a 5-hydroxytryptamine1B receptor
  JOURNAL   EMBO J 10 (13), 4017-4023 (1991)
   PUBMED   1836757
REFERENCE   10 (bases 1 to 4738)
  AUTHORS   Verge,D., Daval,G., Marcinkiewicz,M., Patey,A., el Mestikawy,S.,
            Gozlan,H. and Hamon,M.
  TITLE     Quantitative autoradiography of multiple 5-HT1 receptor subtypes in
            the brain of control or 5,7-dihydroxytryptamine-treated rats
  JOURNAL   J Neurosci 6 (12), 3474-3482 (1986)
   PUBMED   2947981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000199.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022225.3.
            
            On or before Sep 22, 2022 this sequence version replaced
            XM_039080866.1, NM_022225.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132302,
                              SAMD00132304 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JACYVU010000199.1  15149340-15149486   c
            148-4738            JACYVU010000199.1  15143960-15148550   c
FEATURES             Location/Qualifiers
     source          1..4738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4738
                     /gene="Htr1b"
                     /note="5-hydroxytryptamine receptor 1B"
                     /db_xref="GeneID:25075"
                     /db_xref="RGD:2846"
     exon            1..147
                     /gene="Htr1b"
                     /inference="alignment:Splign:2.1.0"
     exon            148..4738
                     /gene="Htr1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..1628
                     /gene="Htr1b"
                     /note="5-HT-1B; serotonin receptor 1B; serotonin
                     (5-hydroxytryptamine (5HT)) receptor type 1B;
                     5-hydroxytryptamine (serotonin) receptor 1B; 5-HT1B
                     serotonin receptor; 5-hydroxytryptamine (serotonin)
                     receptor 1B, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1B"
                     /protein_id="NP_071561.1"
                     /db_xref="GeneID:25075"
                     /db_xref="RGD:2846"
                     /translation="MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPW
                     KVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIS
                     TMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPK
                     RAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTL
                     LLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSE
                     SGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMP
                     ICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG"
ORIGIN      
        1 tcactaagtc tgtggcagcg actaagggcg tgggttgact gcggagcgca gactctcaaa
       61 cctctcagag gcaagaacag gacgtcccat ttcccgttcc ccgcttgaaa ggcgactcca
      121 agtttcaggg tcgggagaaa ggacaaggga acctgagaga agctggactg ggtgggccag
      181 tgctttaatc accggggcga agacggggcg tggagaggag ctagcagacg cggtggcagc
      241 gcctggcgca ctggaagtgc aggggacgcg cccgcaggct tggtggccgc gcctgtgacc
      301 tctcctttcg gctgagaaca caggcggagg agtttactga ggaacccacg gaactggcta
      361 gccaaaggag acaagcctat agtctccatg atcctcccgt cctctgttct ttccctggtc
      421 cgctccatgt tcaagagctg cgctccgcag ccaggacgag gagagctatg gaggagcagg
      481 gtattcagtg cgctccgccg cctcccgcca cctcccagac aggggtacct ctcgccaacc
      541 tctcccacaa ctgcagcgcc gacgactaca tttaccagga ctccatcgcc ctgccctgga
      601 aagtcctgct ggttgctttg ttagcgctca tcaccttggc caccacgctc tccaacgcct
      661 ttgtaatcgc tacggtgtat cggacccgga agctgcacac cccggctaac tacctgatcg
      721 cctcgctggc agtcactgac ctgctcgtgt ccatcctggt gatgcccatc agcaccatgt
      781 acacggtcac tggacgctgg acactaggcc aggtggtctg cgacttctgg ctgtcgtcgg
      841 atatcacctg ttgcactgct tccatcatgc atctctgtgt catcgccctg gaccgctact
      901 gggccatcac tgatgcggtg gactattctg ctaaaagaac tcccaaaagg gcggccatca
      961 tgatcgtgct ggtgtgggtc ttctccatct cgatttcgct gccacccttc ttctggcgtc
     1021 aagccaaagc ggaggaggag gtgctggact gctttgtgaa caccgaccac gtcctctaca
     1081 cggtctactc cacggtgggg gctttctatt tacccaccct gctcctcatc gccctctatg
     1141 gccgtatcta tgtggaagcc cgctctcgga ttttgaaaca gacacccaac aagaccggca
     1201 agcgcttgac ccgagcccag ttgataacag actctccagg atccacgtcc tcggtcacct
     1261 ccattaactc ccgggttccg gaggtgccca gtgagtccgg gtctcctgtg tacgtgaacc
     1321 aagtcaaagt gcgagtctca gacgccctgc tggaaaagaa gaaactcatg gccgctaggg
     1381 agcgcaaagc caccaagacc ctagggatca ttttaggagc atttattgtg tgctggctcc
     1441 ccttcttcat catctccctg gtgatgccta tctgcaagga tgcctgctgg tttcacatgg
     1501 ccatttttga ctttttcaat tggctaggct atcttaactc tctcatcaac cccatcatct
     1561 acaccatgtc caatgaggac ttcaaacaag cattccataa actgatacgc tttaagtgca
     1621 caggttgact tgtcaatggc attggggtcg cctaagcgac ctttggggac caagttgggt
     1681 cttttcacag gtaggtcaaa tcttctttgc ctgttactgg gtggaagcaa ggctctctca
     1741 actgggcaag ggcagtggat cctcagaggc cagggcagaa gcctggctgc tctgagagag
     1801 cactctggaa tgtgaactga agcaaactat tgtaaagctt ccaagctgag gagcttagct
     1861 tcctccattc aaagtccggg ctcagcaccg atcctccagc agccaatcac acgaaaggtt
     1921 gcaacttttt aacattgatg acggatgggt atccctgccc cgttttgtat catggatgtt
     1981 gccctctcag ccagtagcac ttgtgggtgc tgtctgaagc ctgtctgaga cagctctcca
     2041 cacagcctgg cagtacttga accagacaat taataccctg tgctctgggg gagaactctg
     2101 tgttacagtt taattttaaa acactctggc atccttcagt cttcatttgt ttatttcaat
     2161 ttggttggag aaactttgtg gacttggtgc ttcaaacact gaatgtggtt tggatggcgc
     2221 agagcaacct tgaagagtta acagcaaaat tccgatgcta agagatctat ttttattaca
     2281 atcgaaaatt atatgggggt ggtgggtggg catgggagaa ggggagtgtt acactgagaa
     2341 tcaacaccta agattgtttg ttttccgaag atttctaatt tttttttcaa ttcctgttta
     2401 gtgatcgtca aaccacactc taacaactca aaacacgatg tgtgctagtg ccaaagtctg
     2461 caggctgctt tgtttcctca tctcatgtct cagtcatttc acacacttaa atccccacca
     2521 tggaggatac gcagggttac tcagcccaac ctgctgctat cagaggagtt cagcaagtgg
     2581 attagagttg tatacagttc cttaacgaga aagtctcctt attccttatc cagttccgtg
     2641 gtgtgcggag gagaccgaag aaacacgagt gatttcttat gtaattaagg agtgaagggg
     2701 gaaataggag gatgtatatt tttgacttgt aaaaaaaatc ttaaaattgc atgagacaat
     2761 ttttgataat catttgcact cttgcccatc tgtgattccg ttgtgtgcaa acttagaaag
     2821 taaccaagag aactggtttc cctgtccaga aatcttcaaa atgcagccag agtccccaat
     2881 actattaaag tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgag agagagagag
     2941 agagagagag agagagagag agagagagag agagagagag agagtttgag attatagctt
     3001 gttttgtctt tactattgaa gtttggacag aaacaggaaa attacacatt agaaatttag
     3061 aaaagccgag agagcctgaa aaacaagcct attttcttta taacttatag acccaaacct
     3121 cagtcttgag aaacaaccag gaaactggca aaccttctag ccttggaaat gtgttagtga
     3181 cctgccactt cagcgactgt aacatctgaa ataatttaag cgtatctctt tttctaagtt
     3241 tcaatcacac gtagctattt tggattcact ttgcagggta caccctatag taaaatcaca
     3301 tgctagaaga tgaaaaaaat gcactttctt aataaaaaga aacagtcctg aagggttaac
     3361 tgtaagaaca aatgtgtatg tggaatgttt aatatgccaa agaagattca cagtccttgc
     3421 ttcagaggct gtctgcactg gagacctttt gtctgcagaa ggaagttctt tataaaatgg
     3481 atccactccc tgcgtgaagc tgccagtcca gatcaccaga caatagatgt agtgagctga
     3541 attacactgc ttgtctactg tgcagacctt cacattgggt aatgactctt gaaaagatgc
     3601 tattcaaaag ttcacatgta ctgtagggaa aaaaagggaa tttcaaccaa cattatacct
     3661 gacactggag taggatgaaa tcttaggcat tagataatcc tatagactgg gatctatagt
     3721 ttcttctgct ggatcccgag cttctttgtg ctttgtgaca tttctcctat ggagggatgc
     3781 acatagagca tggcatttct tttttttttt aatattgtta atatgttggt cttctgttta
     3841 tgtagctgtg ttttcttgag gccgaagagg caattaagtc aacttctaag agccttaggg
     3901 gaaaattaat ggaaacaaat agccacttgc aaatgatttc tttatagggc acctacaagg
     3961 attgtgtcgt catgttgacc aaacgtggtc gatttagtca aatggtttgt ttgccatttt
     4021 gtaaatcacc caccttaatt attgcttgag tatttggctg aactgactga attgtgtatc
     4081 aaatagaagc ttgcaaacct ttgtagtgtt aagagatcta ggatcatcgt ccagcattgc
     4141 acatgattat gcaaggtgta tattcatccc aggggtatgc agttaggact gtttatctcc
     4201 ttttcagttc ctactgcata taaacatagt ttgtttcata aactggacat atgtctacgt
     4261 tggagaccat gagatgggag atggaaatgt ttaacttaca tagaaatgaa actatatttt
     4321 cattgactat ggtaacaaat accattttcc atatcgttta attgcacaaa atttcactca
     4381 agtatatgaa tgtatactca tctaaaattg cgaatattgt cttgtgtttg taggaacttt
     4441 agagtttcct ttaaaaaaaa aaaagaaccc tgcacccatg gaatgaatgt ttgaggaatt
     4501 taacaaattt cctatagaac aatattgttc acttttcctc tctgttatcc tagttttatc
     4561 ttctttaagc aggtagcact gagaggactc taactcactc aagcagtaac gtctcagact
     4621 gtgtatttgt tggagttctg tgtctgaaat cgcctttgaa tcacctctca gaaaacgtgt
     4681 aattggaaag taaatttaag gaaatgatga aataaaagtc ctttttgtgt tctaaaaa
//
