LOCUS       NM_012585               4565 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Rattus norvegicus 5-hydroxytryptamine receptor 1A (Htr1a), mRNA.
ACCESSION   NM_012585
VERSION     NM_012585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4565)
  AUTHORS   Zhu,C.P., Liu,S.Q., Wang,K.Q., Xiong,H.L., Aristu-Zabalza,P.,
            Boyer-Diaz,Z., Feng,J.F., Song,S.H., Luo,C., Chen,W.S., Zhang,X.,
            Dong,W.H., Gracia-Sancho,J. and Xie,W.F.
  TITLE     Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to
            Decrease Portal Hypertension
  JOURNAL   Gastroenterology 167 (5), 993-1007 (2024)
   PUBMED   38906512
  REMARK    GeneRIF: Targeting 5-Hydroxytryptamine Receptor 1A in the Portal
            Vein to Decrease Portal Hypertension.
REFERENCE   2  (bases 1 to 4565)
  AUTHORS   Nikolaus,S., Chao,O.Y., Henke,J., Beu,M., Fazari,B., Almeida,F.R.,
            Abdel-Hafiz,L., Antke,C., Hautzel,H., Mamlins,E., Muller,H.W.,
            Huston,J.P., von Gall,C. and Giesel,F.L.
  TITLE     5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat
  JOURNAL   Behav Brain Res 469, 115051 (2024)
   PUBMED   38777263
  REMARK    GeneRIF: 5-HT1A and 5-HT2A receptor effects on recognition memory,
            motor/exploratory behaviors, emotionality and regional dopamine
            transporter binding in the rat.
REFERENCE   3  (bases 1 to 4565)
  AUTHORS   Malheiros,J., Amaral,C., da Silva,L.S., Guinsburg,R. and Covolan,L.
  TITLE     Neonatal nociceptive stimulation results in pain sensitization,
            reduction of hippocampal 5-HT1A receptor, and p-CREB expression in
            adult female rats
  JOURNAL   Behav Brain Res 466, 114975 (2024)
   PUBMED   38552745
  REMARK    GeneRIF: Neonatal nociceptive stimulation results in pain
            sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB
            expression in adult female rats.
REFERENCE   4  (bases 1 to 4565)
  AUTHORS   Valipour,H., Jahromi,G.P., Mohammadi,A. and Meftahi,G.H.
  TITLE     Effects of the suppression of 5-HT1A receptors in the left, right,
            or bilateral basolateral amygdala on memory consolidation in
            chronic stress in male rats
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (5), 3049-3064 (2024)
   PUBMED   37874340
  REMARK    GeneRIF: Effects of the suppression of 5-HT1A receptors in the
            left, right, or bilateral basolateral amygdala on memory
            consolidation in chronic stress in male rats.
REFERENCE   5  (bases 1 to 4565)
  AUTHORS   Munawar,N., Bitar,M.S. and Masocha,W.
  TITLE     Activation of 5-HT1A Receptors Normalizes the Overexpression of
            Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic
            Pain
  JOURNAL   Int J Mol Sci 24 (18), 14334 (2023)
   PUBMED   37762636
  REMARK    GeneRIF: Activation of 5-HT1A Receptors Normalizes the
            Overexpression of Presynaptic 5-HT1A Receptors and Alleviates
            Diabetic Neuropathic Pain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4565)
  AUTHORS   Charest,A., Wainer,B.H. and Albert,P.R.
  TITLE     Cloning and differentiation-induced expression of a murine
            serotonin1A receptor in a septal cell line
  JOURNAL   J Neurosci 13 (12), 5164-5171 (1993)
   PUBMED   8254366
REFERENCE   7  (bases 1 to 4565)
  AUTHORS   Penington,N.J., Kelly,J.S. and Fox,A.P.
  TITLE     Whole-cell recordings of inwardly rectifying K+ currents activated
            by 5-HT1A receptors on dorsal raphe neurones of the adult rat
  JOURNAL   J Physiol 469, 387-405 (1993)
   PUBMED   8271204
REFERENCE   8  (bases 1 to 4565)
  AUTHORS   Aune,T.M., McGrath,K.M., Sarr,T., Bombara,M.P. and Kelley,K.A.
  TITLE     Expression of 5HT1a receptors on activated human T cells.
            Regulation of cyclic AMP levels and T cell proliferation by
            5-hydroxytryptamine
  JOURNAL   J Immunol 151 (3), 1175-1183 (1993)
   PUBMED   8393041
REFERENCE   9  (bases 1 to 4565)
  AUTHORS   Albert,P.R., Zhou,Q.Y., Van Tol,H.H., Bunzow,J.R. and Civelli,O.
  TITLE     Cloning, functional expression, and mRNA tissue distribution of the
            rat 5-hydroxytryptamine1A receptor gene
  JOURNAL   J Biol Chem 265 (10), 5825-5832 (1990)
   PUBMED   2156831
REFERENCE   10 (bases 1 to 4565)
  AUTHORS   Verge,D., Daval,G., Marcinkiewicz,M., Patey,A., el Mestikawy,S.,
            Gozlan,H. and Hamon,M.
  TITLE     Quantitative autoradiography of multiple 5-HT1 receptor subtypes in
            the brain of control or 5,7-dihydroxytryptamine-treated rats
  JOURNAL   J Neurosci 6 (12), 3474-3482 (1986)
   PUBMED   2947981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_012585.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360194.1822363.1,
                                        SRR26643298.9522.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4565              JAXUCZ010000002.1  38427169-38431733
FEATURES             Location/Qualifiers
     source          1..4565
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..4565
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="5-hydroxytryptamine receptor 1A"
                     /db_xref="GeneID:24473"
                     /db_xref="RGD:2845"
     exon            1..4565
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..1981
                     /gene="Htr1a"
                     /gene_synonym="5HT1A; RAT5HT1A"
                     /note="5-HT1A; 5-HT-1A; serotonin receptor 1A;
                     5-hydroxytryptamine (serotonin) receptor 1A, G
                     protein-coupled; serotonin 1A receptor; serotonin 5-HT1A
                     receptor"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1A"
                     /protein_id="NP_036717.2"
                     /db_xref="GeneID:24473"
                     /db_xref="RGD:2845"
                     /translation="MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLG
                     TLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKW
                     TLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT
                     WLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRI
                     FRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPC
                     TNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRK
                     MALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCENSCHMPALLGAIINWLGYSN
                     SLLNPVIYAYFNKDFQNAFKKIIKCKFCRR"
ORIGIN      
        1 actggaatgt aaagacgcct ggctagaggg agaggagggc ggggacccag aagaaggagg
       61 cactcgggac tgtggaagtg ttagatggtg gtgggggtta gcgtgggagg aagggagact
      121 agctgtctga gcgacataca agactaaaga aagagaggtg agaaggaaag gggaactgga
      181 agggaaggcc agtgagagga agccgggaga aggaggctgg aaaaaagaaa aacagtagag
      241 aaggcaggag agtctgagag aagcaaccag gagatgaggg tcacagagtg accccggaag
      301 atggggtttc tggaatccag agacttctga gtctgtttgt taggcgggag aatccggctc
      361 ccgcagtcag ttgggcagcg acgacaaagt gaaatggaca gtgagagaca gatattgcag
      421 ccatctcacc agcacccaga gatttggaag ctgcttccag cccaactaca gtttcctagc
      481 tggagcctct gagtgcttag gacccgcggg agccaagcaa gagagcgccg gtgagtgctc
      541 ttctcagatg ccttcgcccg agcaagtaag aacttcccgc tccagtctct ggatcccctc
      601 cctctgaaac tccccagaaa agaaggaaga ccctaggggg aggggcgagg gagatcccct
      661 tgcagttctt tcccccctcc cttcccccac cccagcggga gtgcaggcag gcatggatgt
      721 gttcagtttt ggccagggca acaacaccac agcgtcccag gagccctttg ggaccggcgg
      781 caacgttact agcatctccg acgtgacctt cagctaccaa gtgatcacct ctctgttgct
      841 gggtactctc attttctgcg cggtgctcgg caatgcctgc gtggttgctg ccatcgccct
      901 ggagcgctcc ctccagaatg tggccaacta tctcatcggc tccttggcgg ttactgatct
      961 catggtatca gtgctggtgc tgcccatggc tgctctgtac caggtgctca acaagtggac
     1021 cctgggccag gtcacctgcg acctgtttat cgccctggat gtactgtgct gcacctcgtc
     1081 catcctgcac ctgtgcgcca tcgcgctaga caggtactgg gctatcaccg accctataga
     1141 ctatgtgaac aagaggacgc cccggcgcgc cgctgcgctg atctcgctca cttggctcat
     1201 tggctttctc atctccatcc cgcccatgct gggctggcgc accccggaag accgatcgga
     1261 ccccgacgcg tgcaccatca gcaaggacca cggctacacc atctactcca ctttcggcgc
     1321 tttctatatc ccgctgttgc tcatgctggt tctctacggg cgcatcttca gagccgcacg
     1381 cttccgaatc cgcaagactg tcaggaaggt ggaaaagaag ggagcaggca ccagcttagg
     1441 aacttcgtcg gcaccgcccc ccaagaagag cctgaacgga cagccaggta gtggggactg
     1501 gaggcgctgt gctgagaaca gggcggtggg gactccgtgc actaatgggg cagtgaggca
     1561 gggtgacgac gaggccaccc tggaggtgat cgaggtgcac cgagtgggca actccaaaga
     1621 gcaccttcct ctgcccagcg agtcaggatc taactcctat gcccccgcct gcttggagag
     1681 aaaaaatgag cgcaatgctg aagcaaagcg caagatggcc ttggcccgtg aaaggaagac
     1741 ggtgaagact ctgggcatca tcatgggcac cttcatcctc tgctggctgc cgtttttcat
     1801 tgtggctctg gtcctgcctt tctgtgaaaa cagctgccac atgcctgcgt tgttgggtgc
     1861 cataattaac tggctaggct actccaactc cctgctcaat ccggttattt atgcttattt
     1921 caacaaagac tttcaaaacg cttttaagaa gataatcaag tgcaagttct gccgccgatg
     1981 atgatgatga tggtggtggt aatagtggtg actatggaga aggaggagga ggaggaagag
     2041 gaggaggaag aagaggaaga ggaggaagag tgtagggttt acaggaccct ccccattcac
     2101 tcagtaccct agccctggaa gcaacaccta agataacttg cttttcctag aacatgcagc
     2161 ttctcagcac atggctttca gtccttgttc tctctatatc tcatttcaag gggacagtac
     2221 tctttgcaga aatcttagag aaccactagt atctgtgtga aaagttattg gcttggtctt
     2281 tggccctagg atcagttttg gtagttgtaa taacatcctc cctattcaaa atcccaattc
     2341 ttcacgatgg aattttaaac cttggtgatt caaggtagaa aaccgaaaca gaaaatctaa
     2401 actgtcctga catctgccag gcccactaga actgtcactc tctgccctac ttctggaact
     2461 ttgaggatca agactgctct gtctctcact ccctcttgct ctagaaacat ctgttccctt
     2521 tgggtgtcaa tctacactgt tgaactggtc tccatgctgg tctggaaaag cagttggaag
     2581 taactactct gggttatgtg ctctggaaat ttttgaatag caaaagatcc cccccacccc
     2641 tgcacaacac ccactttctg tatttttttt aaattttttt ttaatttttg aactcaaaat
     2701 caagtggcaa aagtgtctgt tggagtggac ttataagtag gtctggctcg taggaagagc
     2761 caggaaggtc tgtggatggt ttcttgtcct ggtgttaaca ctcaccaaag aaactgacaa
     2821 tcagactatt tggaaggaag agttttattc ctacagtttg ttggcctttc tgtaagttct
     2881 ggcaaggctc tgtgtcgtct gcaggaggcg cccactgctg gccagggagg gcgcactgag
     2941 ggcgctgaga tgcccaggat ggctcgcccc acccacagtt ttctttctag cagtgagctc
     3001 tgccaaagca tcacgcctcc ggtttgcagc atgcagattc cttcacctca cctctcacag
     3061 catccaggag ctaataagag aagtttgagt ttgtgcagga ggatggggac ttagaaactt
     3121 ctaaggatgt gtgagtgtgg ggcacgtaga ggaggcagaa agcaaaaaaa aaaaaaaaaa
     3181 aaaaaaagct cctaagtgct ttcaactcct gcggtgcatc ccagggaggg aggtgttggg
     3241 ggtggggcac caaaaaggga gattttaagc acaggatgca aattttctca attcacccct
     3301 tccctcttta gaccaaggaa cagctttgtt tatcaaatcc taacaatgcc cagatttatt
     3361 ctctgggaca ttgtgtgcgc acaagaaatt tgcagagctc tgggctctca ttgccaaggg
     3421 tctcagcacc tcaccactac ctacctagga tcttgatctc agagacatac ctaaaggagg
     3481 gcgatctctg tggactctca gaatctagag aattaatttg ttccagccta gtcagcccca
     3541 gaattctgag ggtaaaatct cgatttttag agcatttccc ctcctaggtg ttctttccct
     3601 gcagttattt ttgctgccct acccccaccc caaagaagga aattattttg gtgcttcgtt
     3661 tgaatgtacg tttctagcta tgtgagaagg catcaagacg tttgcgttat atctgaactt
     3721 cgagttttct gttgaataat ggtttccttt tcaagcaatt acacggagat ttttcacttc
     3781 ccccatcccc ttcagctgtg tctttccaat gtctgcacat gctgttttga aaatctgagc
     3841 tgcatctttt ttattgccaa agttcccggt gagatttccc ctttatgatt ataaaccggg
     3901 agaaaggact gccctgtcac atgaagccat tgtttcattt gctaaactaa acaaagtgtc
     3961 tatttggttt cttttgctct aaagcggctt atagcccatt gcaacagagc catttcagaa
     4021 tgtaagcctg tggggtatcc acatctgaaa ggctaatgaa ggctctgtgg agaaaatgta
     4081 cagggcttct ccaatacaaa tagtacttgt ttgtaaatat agctgtgttg attgattgat
     4141 taccaaattt tttctatatc ttttactgtt ttttttttag aacagatcat ttatttgaaa
     4201 taaatcaatc cctaagtttc agatgtcaca ttggaaacca agacttctaa ctttttttta
     4261 tatatctttt tttccattag gattgtttga gtatgatggg ggagggacac cgctcctgct
     4321 attttgagga aagactttaa acaagactgg gaagggggca cccaactgga ctataattgc
     4381 taagtaatag agcagtcaga gaaataagtg caacatgcac taaataaccc ctgatgcttg
     4441 ttttatttta aaatacttgt actacagtaa aatactaatg catcaaaatt ggccttcact
     4501 tttccttgtg ataataaagg acttcaataa tggcgatgct gtaataaacc aagaccagta
     4561 atcta
//
