LOCUS       NM_001011901            3425 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus heat shock protein family H (Hsp110) member 1
            (Hsph1), mRNA.
ACCESSION   NM_001011901 XM_213699
VERSION     NM_001011901.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3425)
  AUTHORS   Rauch,J.N. and Gestwicki,J.E.
  TITLE     Binding of human nucleotide exchange factors to heat shock protein
            70 (Hsp70) generates functionally distinct complexes in vitro
  JOURNAL   J Biol Chem 289 (3), 1402-1414 (2014)
   PUBMED   24318877
REFERENCE   2  (bases 1 to 3425)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   3  (bases 1 to 3425)
  AUTHORS   Hageman,J., van Waarde,M.A., Zylicz,A., Walerych,D. and
            Kampinga,H.H.
  TITLE     The diverse members of the mammalian HSP70 machine show distinct
            chaperone-like activities
  JOURNAL   Biochem J 435 (1), 127-142 (2011)
   PUBMED   21231916
REFERENCE   4  (bases 1 to 3425)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 3425)
  AUTHORS   Yamagishi,N., Fujii,H., Saito,Y. and Hatayama,T.
  TITLE     Hsp105beta upregulates hsp70 gene expression through signal
            transducer and activator of transcription-3
  JOURNAL   FEBS J 276 (20), 5870-5880 (2009)
   PUBMED   19754877
REFERENCE   6  (bases 1 to 3425)
  AUTHORS   Yamagishi,N., Ishihara,K., Saito,Y. and Hatayama,T.
  TITLE     Hsp105 family proteins suppress staurosporine-induced apoptosis by
            inhibiting the translocation of Bax to mitochondria in HeLa cells
  JOURNAL   Exp Cell Res 312 (17), 3215-3223 (2006)
   PUBMED   16857185
REFERENCE   7  (bases 1 to 3425)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 3425)
  AUTHORS   Yamagishi,N., Ishihara,K., Saito,Y. and Hatayama,T.
  TITLE     Hsp105 but not Hsp70 family proteins suppress the aggregation of
            heat-denatured protein in the presence of ADP
  JOURNAL   FEBS Lett 555 (2), 390-396 (2003)
   PUBMED   14644449
REFERENCE   9  (bases 1 to 3425)
  AUTHORS   Saito,Y., Yamagishi,N., Ishihara,K. and Hatayama,T.
  TITLE     Identification of alpha-tubulin as an hsp105alpha-binding protein
            by the yeast two-hybrid system
  JOURNAL   Exp Cell Res 286 (2), 233-240 (2003)
   PUBMED   12749852
REFERENCE   10 (bases 1 to 3425)
  AUTHORS   Ishihara,K., Yasuda,K. and Hatayama,T.
  TITLE     Molecular cloning, expression and localization of human 105 kDa
            heat shock protein, hsp105
  JOURNAL   Biochim Biophys Acta 1444 (1), 138-142 (1999)
   PUBMED   9931472
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001011901.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081945.1, SRR26360186.1940766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               JAXUCZ010000012.1  10427368-10427668
            302-359             JAXUCZ010000012.1  10429755-10429812
            360-500             JAXUCZ010000012.1  10431719-10431859
            501-623             JAXUCZ010000012.1  10432370-10432492
            624-723             JAXUCZ010000012.1  10432954-10433053
            724-857             JAXUCZ010000012.1  10433347-10433480
            858-1102            JAXUCZ010000012.1  10433843-10434087
            1103-1331           JAXUCZ010000012.1  10434415-10434643
            1332-1438           JAXUCZ010000012.1  10436211-10436317
            1439-1572           JAXUCZ010000012.1  10436463-10436596
            1573-1781           JAXUCZ010000012.1  10438182-10438390
            1782-1913           JAXUCZ010000012.1  10439747-10439878
            1914-2051           JAXUCZ010000012.1  10442797-10442934
            2052-2177           JAXUCZ010000012.1  10443560-10443685
            2178-2285           JAXUCZ010000012.1  10444347-10444454
            2286-2405           JAXUCZ010000012.1  10444555-10444674
            2406-2567           JAXUCZ010000012.1  10444876-10445037
            2568-3425           JAXUCZ010000012.1  10445745-10446602
FEATURES             Location/Qualifiers
     source          1..3425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3425
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /note="heat shock protein family H (Hsp110) member 1"
                     /db_xref="GeneID:288444"
                     /db_xref="RGD:1311609"
     exon            1..301
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2771
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /note="heat shock 105kDa; heat shock 110 kDa protein; heat
                     shock 105kDa/110kDa protein 1; heat shock 105/110 protein
                     1"
                     /codon_start=1
                     /product="heat shock protein 105 kDa"
                     /protein_id="NP_001011901.1"
                     /db_xref="GeneID:288444"
                     /db_xref="RGD:1311609"
                     /translation="MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPK
                     NRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIK
                     VMYMDEDHLFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAA
                     QIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKPRVVVFVDMGHSSFQVSACAFNKG
                     KLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKL
                     MSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLMEQTHLKTEE
                     VSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREF
                     SVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQ
                     AVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDG
                     SSVEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEEN
                     KIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIM
                     QDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGE
                     DQAKQAYIDKLEELMKMGTPVKVRFQEAEERPRVLEELGQRLQHYAKIAADFRGKDEK
                     YNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQDPVVRTHEISAKVKELNNVCE
                     PVVTQPKPKIESPKLERTPNGPNMDKKEDLEGKSNLGADAPHQNGECHPNEKGSVSMD
                     LD"
     exon            302..359
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            360..500
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            501..623
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            624..723
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            724..857
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1102
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1331
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1438
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1572
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1781
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1913
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2051
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2177
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2285
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2405
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2567
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..3425
                     /gene="Hsph1"
                     /gene_synonym="Hsp105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgattgg gacctcccct tttggattgg tagctgagcg gcagtggcgg cggctgcgtg
       61 agagaggcga gcggcggaga gcggtggcaa atactgaacg cagtctcgca gggtaagccc
      121 gaggcatctt cccggccggt cgggagcagg aggagcacgc agcggatccc aggcagaggc
      181 ggaccgggcc agccatgtcg gtggttgggc tagacgtggg ctcgcagagc tgctacattg
      241 cagtggcacg ggccgggggc atcgagacca tcgccaacga gttcagcgac cgctgcaccc
      301 cgtcagtcat atcatttgga ccaaaaaaca gaacaattgg agttgcagcc aaaaaccagc
      361 aaatcactca tgcaaacaat acggtgtcta gctttaagag atttcatggc agagcattca
      421 atgatccctt cattcaaaag gaaaaggaaa acttgagcta tgatttggtc ccaatgaaga
      481 atggtggtgt tggaataaag gtcatgtaca tggacgaaga ccatctcttt agcgtggagc
      541 agataacagc catgctgctg actaagttga aggaaactgc ggaaaacaac ctcaagaagc
      601 cggtgacaga ctgtgtcatc tcggtcccgt ccttcttcac agatgctgag aggaggtctg
      661 ttctggatgc cgcacagatt gtgggcttga actgcttgcg gctcatgaat gacatgacgg
      721 ctgttgcttt gaattatgga atttataagc aggatctccc gaatgcagac gagaaacccc
      781 gagtcgtggt gtttgtggac atgggacact cctctttcca agtgtctgcc tgtgctttta
      841 acaaagggaa actgaaggtt ctaggcacag cttttgatcc cttcttggga ggaaagaact
      901 ttgacgagaa gctcgtagag catttttgtg ctgaatttaa aaccaagtac aaattagatg
      961 caaaatccaa aattcgagcc ctccttcgtc tccatcagga gtgtgaaaag ttaaagaagc
     1021 tcatgagttc taacagcaca gacctgccgc tgaacattga gtgctttatg aatgacaagg
     1081 acgtctctgc aaagatgaac aggtcacagt ttgaagaact gtgtgctgag ctcctacaaa
     1141 aaatagaggt cccccttcac ttgttgatgg aacaaactca cctcaagact gaagaagtga
     1201 gcgccattga gatagttgga ggagccacaa gaatcccagc tgtgaaggaa agaattgcca
     1261 gattctttgg gaaagacgtc agtaccacgc tcaacgcaga cgaggctgtg gctagagggt
     1321 gcgcactgca gtgtgcaatt ctttctccgg catttaaagt tagagagttc tccgtcaccg
     1381 atgcagttcc tttcccaata tctctggtct ggaaccatga ctcagaagaa actgaaggtg
     1441 ttcacgaggt gttcagtcgg aaccatgctg ctcctttctc caaagtgctc accttcctga
     1501 gaaggggacc ctttgaacta gaagctttct attctgaccc tcaagcagtt ccatatccag
     1561 aagcaaaaat cggccgtttt gtcgttcaga atgtttctgc acagaaagat ggagaaaaat
     1621 ctaaagtgaa agtcaaagtg cgtgtgaaca cacatggcat tttcaccata tccacggcat
     1681 ccatggtgga aaaagtcccg actgaggagg aggatgggtc ctctgtcgag gcagacatgg
     1741 agtgtccaaa ccagaaacca gcagaaagct cggatgtgga taaaaatatc cagcaagaca
     1801 acagtgaagc tggaacacag ccccaggtac aaactgatgg tcaacaaacc tcacagtctc
     1861 ccccttcacc tgaacttacc tcagaagaaa acaaaatccc agatgctgac aaagcaaatg
     1921 aaaagaaagt tgatcagcct ccagaagcca aaaaacctaa aataaaggtg gtaaacgttg
     1981 agctgcctgt tgaagccaac ttggtgtggc agctagggag ggaccttctg aacatgtaca
     2041 tcgagacgga gggcaagatg atcatgcagg acaagctgga gaaggagagg aacgatgcta
     2101 agaacgccgt ggaggagtgt gtgtatgagt tcagagacaa gctgtgtgga ccgtatgaga
     2161 aatttatatg tgagcaggaa cacgagaagt ttctgaggct tctcacagag acagaagact
     2221 ggctgtatga ggaaggagag gaccaagcca agcaggccta tattgacaag ttggaagaat
     2281 tgatgaaaat gggcactcct gtaaaagtca gatttcaaga agccgaggag cgaccgagag
     2341 tgttggagga gctaggccag cgcctacagc actatgccaa gatcgcagca gacttcagag
     2401 gcaaggatga gaaatacaac cacatagatg aatctgaaat gaagaaggtt gagaagtctg
     2461 ttaacgaggt gatggagtgg atgaataatg tcatgaatgc tcaggctaaa cggagtctcc
     2521 atcaggaccc tgttgtgcgc actcatgaga tcagcgctaa ggtcaaggaa ctgaacaatg
     2581 tttgtgaacc tgttgtaact caacccaaac caaaaattga gtcacctaaa ctggagagaa
     2641 ctccaaatgg cccaaatatg gacaagaaag aagatctaga aggcaagagt aatctcggtg
     2701 ctgacgctcc acatcagaac ggtgaatgcc accctaatga gaagggctct gtcagcatgg
     2761 acctggacta ggctctgccc tggctccctc ctccgactca tgaaatgtgt ttgccattgt
     2821 atgtgattct gtatgacaga ctgagtctat ttatattttc tttcttcctt tttttttttt
     2881 ttaaagactg tctagacatt ttgtgtatta tgagggaaaa aagaaaaagc ttgagtctgt
     2941 agtctctgac cctaaatgag agtgactttg gtgacaggct cctgtggagt tgggacccca
     3001 ctgagctctg tacagtattg ctgctcatat gctgaggagg gaggtcgttt gtcttctgag
     3061 gacgtgaact gcactgacag cgctgggctc agtctgcagc agctgttctt gccaaggggt
     3121 tttctgtgtt cttctgcatt tgctcttcat ttccgcatgt gtggccgggg ttgttcataa
     3181 atgagactga gtctgatctg cataagggct ttccaaatta agtctgtcca gtagagtgat
     3241 ttgctttatt attaccaaga atacaacagc tagtgaaccg tagcagcatg cgaagcaggg
     3301 ctgtaactat caccatacat gcactgtccc gtggaggtgt gacacgggag acgtgtggat
     3361 catgtgatca ttgtgaacac cttgtgagct ttaaaataaa gtccaccctg tggtgtcatt
     3421 tctaa
//
