LOCUS       NM_012966                680 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus heat shock protein family E (Hsp10) member 1
            (Hspe1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012966
VERSION     NM_012966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 680)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 680)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 680)
  AUTHORS   Yagi,H., Sato,A., Yoshida,A., Hattori,Y., Hara,M., Shimamura,J.,
            Sakane,I., Hongo,K., Mizobata,T. and Kawata,Y.
  TITLE     Fibril formation of hsp10 homologue proteins and determination of
            fibril core regions: differences in fibril core regions dependent
            on subtle differences in amino acid sequence
  JOURNAL   J Mol Biol 377 (5), 1593-1606 (2008)
   PUBMED   18329043
  REMARK    GeneRIF: Data show that Rhsp10 formed fibrils from only the acidic
            unfolded state and Core peptide regions of these protein fibrils
            were determined by proteolysis followed by a combination of Edman
            degradation and mass spectroscopy analyses.
REFERENCE   4  (bases 1 to 680)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   5  (bases 1 to 680)
  AUTHORS   Sakane,I., Ikeda,M., Matsumoto,C., Higurashi,T., Inoue,K.,
            Hongo,K., Mizobata,T. and Kawata,Y.
  TITLE     Structural stability of oligomeric chaperonin 10: the role of two
            beta-strands at the N and C termini in structural stabilization
  JOURNAL   J Mol Biol 344 (4), 1123-1133 (2004)
   PUBMED   15544816
  REMARK    GeneRIF: Data describe the structural stabilities of chaperonin 10
            from rat mitochondria and from hyperthermophilic eubacteria
            Thermotoga maritima, and compare the values to those of Escherichia
            coli GroES.
REFERENCE   6  (bases 1 to 680)
  AUTHORS   Samali,A., Cai,J., Zhivotovsky,B., Jones,D.P. and Orrenius,S.
  TITLE     Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and
            Hsp10 in the mitochondrial fraction of jurkat cells
  JOURNAL   EMBO J 18 (8), 2040-2048 (1999)
   PUBMED   10205158
REFERENCE   7  (bases 1 to 680)
  AUTHORS   Ryan,M.T., Herd,S.M., Sberna,G., Samuel,M.M., Hoogenraad,N.J. and
            Hoj,P.B.
  TITLE     The genes encoding mammalian chaperonin 60 and chaperonin 10 are
            linked head-to-head and share a bidirectional promoter
  JOURNAL   Gene 196 (1-2), 9-17 (1997)
   PUBMED   9322735
REFERENCE   8  (bases 1 to 680)
  AUTHORS   Ryan,M.T., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Isolation of a cDNA clone specifying rat chaperonin 10, a
            stress-inducible mitochondrial matrix protein synthesised without a
            cleavable presequence
  JOURNAL   FEBS Lett 337 (2), 152-156 (1994)
   PUBMED   7904573
REFERENCE   9  (bases 1 to 680)
  AUTHORS   Hartman,D.J., Hoogenraad,N.J., Condron,R. and Hoj,P.B.
  TITLE     The complete primary structure of rat chaperonin 10 reveals a
            putative beta alpha beta nucleotide-binding domain with homology to
            p21ras
  JOURNAL   Biochim Biophys Acta 1164 (2), 219-222 (1993)
   PUBMED   8101099
REFERENCE   10 (bases 1 to 680)
  AUTHORS   Hartman,D.J., Hoogenraad,N.J., Condron,R. and Hoj,P.B.
  TITLE     Identification of a mammalian 10-kDa heat shock protein, a
            mitochondrial chaperonin 10 homologue essential for assisted
            folding of trimeric ornithine transcarbamoylase in vitro
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3394-3398 (1992)
   PUBMED   1348860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U68562.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220992.1, CF977228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W x SD"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..680
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /note="heat shock protein family E (Hsp10) member 1"
                     /db_xref="GeneID:25462"
                     /db_xref="RGD:2844"
     exon            1..274
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..580
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /note="hsp10; 10 kDa chaperonin; chaperonin 10; Heat shock
                     10 kD protein 1 (chaperonin 10); heat shock 10 kDa protein
                     1 (chaperonin 10); heat shock protein 1 (chaperonin 10);
                     heat shock protein family E member 1"
                     /codon_start=1
                     /product="10 kDa heat shock protein, mitochondrial"
                     /protein_id="NP_037098.1"
                     /db_xref="GeneID:25462"
                     /db_xref="RGD:2844"
                     /translation="MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQA
                     TVVAVGSGGKGKGGEIQPVSVKVGDKVLLPEHGGTKVVLDDKDYFLFRDGDILGKYVD
                     "
     exon            275..439
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /inference="alignment:Splign:2.1.0"
     exon            440..529
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /inference="alignment:Splign:2.1.0"
     exon            530..680
                     /gene="Hspe1"
                     /gene_synonym="Cpn10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggggcttg ttctttcacc tcagcggccg acctggaaaa gcctagaaag tgctcccctt
       61 ttcttccgcc tccggctacc cgcatcggcc gcctgcgcgg agtcctggcc accaatcggc
      121 gcgcgcgctg gagtggccgc cttctctcac gctaaggggc tgagtgcgcc tgcgcgctgc
      181 gctgtctttt cacgtgtcct gagccggccc acgggagtct ccttgcagca ggagtccgag
      241 tgcagagtcc ggagctgcgg cggcgtaagt catggctgga caagctttta ggaagtttct
      301 tccgctattt gacagagtat tggttgaaag gagtgccgct gaaactgtga ccaaaggtgg
      361 cattatgctt ccagaaaagt ctcaaggaaa agtattgcaa gcaacggtcg tggctgtggg
      421 atcaggcggg aaaggaaagg gtggagagat tcagcctgtc agtgtgaaag ttggagataa
      481 agttcttctc ccagaacacg gaggcaccaa agtagtacta gacgacaagg attacttctt
      541 atttagagat ggcgacattc ttggaaagta tgtcgactga aatcactgtt gaaatggtgt
      601 cacatgaagc tgcccattcc actgatattc tgaactattt catcatgtaa ataatttcca
      661 tgcctccctt ttataataaa
//
