LOCUS       NM_022229               2255 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family D (Hsp60) member 1
            (Hspd1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022229 XM_212759
VERSION     NM_022229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Cheng,L., Yi,X., Shi,Y., Yu,S., Zhang,L., Wang,J. and Su,P.
  TITLE     Abnormal lipid metabolism induced apoptosis of spermatogenic cells
            by increasing testicular HSP60 protein expression
  JOURNAL   Andrologia 52 (11), e13781 (2020)
   PUBMED   32892424
  REMARK    GeneRIF: Abnormal lipid metabolism induced apoptosis of
            spermatogenic cells by increasing testicular HSP60 protein
            expression.
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Blagonravov,M.L., Sklifasovskaya,A.P., Korshunova,A.Y., Azova,M.M.
            and Kurlaeva,A.O.
  TITLE     Heat Shock Protein HSP60 in Left Ventricular Cardiomyocytes of
            Hypertensive Rats with and without Insulin-Dependent Diabetes
            Mellitus
  JOURNAL   Bull Exp Biol Med 170 (1), 10-14 (2020)
   PUBMED   33219889
  REMARK    GeneRIF: Heat Shock Protein HSP60 in Left Ventricular
            Cardiomyocytes of Hypertensive Rats with and without
            Insulin-Dependent Diabetes Mellitus.
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Del Carmen Dominguez,M., Cabrales,A., Lorenzo,N., Padron,G. and
            Gonzalez,L.J.
  TITLE     Biodistribution and pharmacokinetic profiles of an altered peptide
            ligand derived from heat-shock proteins 60 in Lewis rats
  JOURNAL   Cell Stress Chaperones 25 (1), 133-140 (2020)
   PUBMED   31802366
  REMARK    GeneRIF: Biodistribution and pharmacokinetic profiles of an altered
            peptide ligand derived from heat-shock proteins 60 in Lewis rats.
REFERENCE   4  (bases 1 to 2255)
  AUTHORS   Hu,Y., Chen,X., Li,X., Li,Z., Diao,H., Liu,L., Zhang,J., Ju,J.,
            Wen,L., Liu,X., Pan,Z., Xu,C., Hai,X. and Zhang,Y.
  TITLE     MicroRNA-1 downregulation induced by carvedilol protects
            cardiomyocytes against apoptosis by targeting heat shock protein 60
  JOURNAL   Mol Med Rep 19 (5), 3527-3536 (2019)
   PUBMED   30896796
  REMARK    GeneRIF: the present study revealed that carvedilol protected
            cardiomyocytes from apoptosis by inhibiting miR-1 expression in
            cardiomyocytes; this cardioprotective effect was associated with
            increased HSP60 expression within cardiomyocytes in ischemia.
REFERENCE   5  (bases 1 to 2255)
  AUTHORS   Tian,K., Song,Y., Zhou,K., Yue,B., Qiu,Y., Sun,F., Wang,R., Zha,D.
            and Qiu,J.
  TITLE     Upregulation of HSP60 expression in the postnatal rat cochlea and
            rats with drug-induced hearing loss
  JOURNAL   Cell Stress Chaperones 23 (6), 1311-1317 (2018)
   PUBMED   30196524
  REMARK    GeneRIF: this research suggests that HSP60 may play an important
            role in auditory function.
REFERENCE   6  (bases 1 to 2255)
  AUTHORS   Xu,Q., Schett,G., Seitz,C.S., Hu,Y., Gupta,R.S. and Wick,G.
  TITLE     Surface staining and cytotoxic activity of heat-shock protein 60
            antibody in stressed aortic endothelial cells
  JOURNAL   Circ Res 75 (6), 1078-1085 (1994)
   PUBMED   7525102
REFERENCE   7  (bases 1 to 2255)
  AUTHORS   Hartman,D.J., Hoogenraad,N.J., Condron,R. and Hoj,P.B.
  TITLE     Identification of a mammalian 10-kDa heat shock protein, a
            mitochondrial chaperonin 10 homologue essential for assisted
            folding of trimeric ornithine transcarbamoylase in vitro
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3394-3398 (1992)
   PUBMED   1348860
REFERENCE   8  (bases 1 to 2255)
  AUTHORS   Brudzynski,K., Martinez,V. and Gupta,R.S.
  TITLE     Immunocytochemical localization of heat-shock protein 60-related
            protein in beta-cell secretory granules and its altered
            distribution in non-obese diabetic mice
  JOURNAL   Diabetologia 35 (4), 316-324 (1992)
   PUBMED   1516759
REFERENCE   9  (bases 1 to 2255)
  AUTHORS   Peralta,D., Hartman,D.J., McIntosh,A.M., Hoogenraad,N.J. and
            Hoj,P.B.
  TITLE     cDNA and deduced amino acid sequence of rat liver prehsp60
            (chaperonin-60)
  JOURNAL   Nucleic Acids Res 18 (23), 7162 (1990)
   PUBMED   1979858
REFERENCE   10 (bases 1 to 2255)
  AUTHORS   Venner,T.J. and Gupta,R.S.
  TITLE     Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA
  JOURNAL   Nucleic Acids Res 18 (17), 5309 (1990)
   PUBMED   1976241
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086507.1.
            
            On Sep 25, 2008 this sequence version replaced NM_022229.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086507.1, SRR8487231.145504.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2255
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /note="heat shock protein family D (Hsp60) member 1"
                     /db_xref="GeneID:63868"
                     /db_xref="RGD:621314"
     exon            1..56
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            57..232
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1780
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /EC_number="5.6.1.7"
                     /note="CPN60; HSP-60; HSP-65; heat shock protein family D
                     member 1; chaperonin 60; 60 kDa chaperonin; mitochondrial
                     matrix protein P1; heat shock 60kDa protein 1; heat shock
                     60kD protein 1 (chaperonin); heat shock protein 60
                     (liver); heat shock protein 1 (chaperonin)"
                     /codon_start=1
                     /product="60 kDa heat shock protein, mitochondrial"
                     /protein_id="NP_071565.2"
                     /db_xref="GeneID:63868"
                     /db_xref="RGD:621314"
                     /translation="MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGV
                     DLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVA
                     NNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSK
                     PVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMK
                     FDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAE
                     DVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNL
                     EDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNE
                     RLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPA
                     LDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLG
                     DFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGG
                     GMGGGMF"
     exon            233..485
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            486..568
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            569..664
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            665..758
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            759..927
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1027
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1273
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1448
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1627
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..2227
                     /gene="Hspd1"
                     /gene_synonym="Hsp60; Hspd1-30p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcactcgcc gcagacggcc tgcctcgcct cgtgctcttc cgccgccgcc ccgcagaaat
       61 gcttcgacta cccacagtcc ttcgccagat gagaccagtg tctcgggcac tggctcctca
      121 tctcactcgg gcctatgcca aagatgtaaa atttggtgcg gatgctcgag ccttaatgct
      181 tcaaggtgta gaccttttag ccgatgctgt agctgttaca atggggccaa agggaagaac
      241 agtgattatt gaacagagtt ggggaagtcc caaagtaaca aaagatgggg tcactgttgc
      301 aaagtcaatt gatttaaagg ataaatacaa aaatatcgga gctaagcttg ttcaggatgt
      361 tgccaataac acaaatgaag aggctgggga tggcaccacc actgccactg ttctggcacg
      421 gtctattgcc aaggagggct ttgagaagat cagcaaaggg gctaatccag tggaaatccg
      481 gagaggtgtg atgttggctg ttgatgctgt aattgctgaa cttaagaaac aatctaaacc
      541 tgtgacaacc cctgaagaaa ttgctcaggt tgctacaatt tctgcaaacg gagacaaaga
      601 cattgggaac atcatttctg atgcaatgaa gaaggttgga agaaagggtg tcatcacagt
      661 gaaggatgga aaaaccctga atgatgagct agaaattatt gaaggcatga agtttgatag
      721 aggatatatt tccccatatt ttattaacac atcaaaaggt caaaaatgtg aattccaaga
      781 tgcctatgtt ttgttgagtg aaaagaaaat ttctagtgtt cagtccattg tacctgctct
      841 tgaaattgcc aatgctcacc ggaagccctt ggtcataatt gctgaagatg ttgatggaga
      901 agctcttagc acactggttt tgaacaggct aaaagttggt cttcaggttg tagcagtcaa
      961 agctccaggg tttggggaca acaggaagaa ccagcttaaa gatatggcta tcgctactgg
     1021 tggtgcggtg tttggagaag agggtttgaa tctaaatctt gaagatgttc aagctcatga
     1081 tttagggaaa gttggagagg tcatcgtcac caaagatgat gccatgcttt tgaaaggaaa
     1141 aggtgacaaa gctcacattg aaaaacgtat tcaagaaatc actgagcagc tagacatcac
     1201 aactagtgaa tatgagaagg aaaagctgaa cgagcgactt gctaaactct cagatggagt
     1261 agctgtgttg aaggttggag ggacaagtga tgttgaagtg aatgagaaga aagacagagt
     1321 tacagatgct ctcaatgcta caagagcagc tgttgaagaa ggcattgttc taggaggggg
     1381 ctgtgctcta cttcggtgca tcccagcctt ggattcatta aagcctgcta atgaagatca
     1441 gaagataggt atagaaatta ttaaaagagc acttaaaatt cctgcaatga caattgctaa
     1501 gaatgcaggt gttgaaggat ctttgatagt tgaaaaaatt ctgcagagtt cctcagaggt
     1561 tggctatgat gccatgcttg gagattttgt gaacatggtg gaaaagggaa tcattgatcc
     1621 aacaaaggtt gtaagaactg ctttactgga tgctgctggg gtggcctccc tgctaactac
     1681 agccgaagct gtagtgacag aaattcctaa agaagagaag gaccctggaa tgggtgcaat
     1741 gggtggaatg ggagggggta tgggaggtgg catgttctaa ctcctagaat agtgctttgc
     1801 ccttatcaat gaactgtggc aggaagctca aggcaggttc ctcaccaata acttcagaga
     1861 agtcacctga agaaaatgac tgaagagaag gctggctgat cactgtaacc atcagttact
     1921 ggtttccttt gacaatacat aatggtttac tgctgtcatt gtccatgcct acagataatt
     1981 tattttgtat ttttgaataa agacatttgt acattcctga tgctgggtgc aagagccagt
     2041 gtcctgcttt caacttaaat cactgaggca tctctactgt tctgttagca tcaggactgt
     2101 agcgctgtgt caccacatga gaagttcaga agcagccttt ctgtggaggg tgagaatgat
     2161 tgtgtacaga gtagagaagt atccaattat gtgacaacct ttgtgtaata aaattttgtt
     2221 taaagttaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
