LOCUS       NM_139261               1465 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus HSPA (Hsp70) binding protein 1 (Hspbp1), mRNA.
ACCESSION   NM_139261
VERSION     NM_139261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1465)
  AUTHORS   Al-Ramahi,I., Lam,Y.C., Chen,H.K., de Gouyon,B., Zhang,M.,
            Perez,A.M., Branco,J., de Haro,M., Patterson,C., Zoghbi,H.Y. and
            Botas,J.
  TITLE     CHIP protects from the neurotoxicity of expanded and wild-type
            ataxin-1 and promotes their ubiquitination and degradation
  JOURNAL   J Biol Chem 281 (36), 26714-26724 (2006)
   PUBMED   16831871
REFERENCE   2  (bases 1 to 1465)
  AUTHORS   Arndt,V., Daniel,C., Nastainczyk,W., Alberti,S. and Hohfeld,J.
  TITLE     BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin
            ligase CHIP
  JOURNAL   Mol Biol Cell 16 (12), 5891-5900 (2005)
   PUBMED   16207813
REFERENCE   3  (bases 1 to 1465)
  AUTHORS   Raynes,D.A. and Guerriero,V.
  TITLE     Isolation and characterization of isoforms of HspBP1, inhibitors of
            Hsp70
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 203-207 (2000)
   PUBMED   10786638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF187860.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF187860.1, BC072541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1465
                     /gene="Hspbp1"
                     /note="HSPA (Hsp70) binding protein 1"
                     /db_xref="GeneID:246146"
                     /db_xref="RGD:628677"
     exon            1..29
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            30..327
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1197
                     /gene="Hspbp1"
                     /function="Hsp70 inhibitor"
                     /note="hsp70-interacting protein 1; HSPA binding protein,
                     cytoplasmic cochaperone 1; heat shock protein-binding
                     protein 1; HSPA (heat shock 70kDa) binding protein,
                     cytoplasmic cochaperone 1; HSPA (heat shock 70) binding
                     protein, cytoplasmic cochaperone 1"
                     /codon_start=1
                     /product="hsp70-binding protein 1"
                     /protein_id="NP_640354.1"
                     /db_xref="GeneID:246146"
                     /db_xref="RGD:628677"
                     /translation="MADKGSGGSRLPLALPPASQGCSSGSSGSSAGGSGNPRLPRNLQ
                     GLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKNCLRVLSQAT
                     PPTAGEAELATDQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLR
                     WRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDSCDTVRVNALFAISCLVREQE
                     AGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLV
                     ALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEYQE
                     ELEFCEKLLQTCFSSPTDDSMDR"
     exon            328..532
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..757
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..913
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1010
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1122
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1440
                     /gene="Hspbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtggtgg ccgctctaga ccgggcaagc agaccttaag gaatcgaccc atcccgacgc
       61 cagagctgcc tcaccggtga ccatcaattt cttttcaaca cattcttcct tcacagacag
      121 tccatggcag acaaaggctc agggggcagt cgcctccccc tcgcactgcc tccggcctcc
      181 cagggttgct cgtcagggag cagtggctcc tcggcggggg gctcaggcaa ccctcgcctt
      241 ccacggaacc tccaaggcct gctgcagatg gctattactg cgggctctga ggaaccagac
      301 cctcctccag aacccatgag cgaggagaga cgccaatggc tgcaggaagc catgtcagct
      361 gccttccgag gccagcggga agaggtagag cagatgaaga actgcctccg ggtcttgtcc
      421 caggccacac ccccaactgc tggtgaagct gaactggcca ctgaccagca ggagcgtgaa
      481 ggggcactag agctgctggc agacctgtgc gagaacatgg acaatgcggc agatttctgc
      541 cagctgtcag gcatgcacct gctggtgggt cgatacctgg aggcaggagc tgcagggctg
      601 cgttggaggg cagcacagct catcggcacg tgcagtcaga atgttgcagc catccaggag
      661 caggtgttgg gcttgggtgc cctgcgtaag ctacttcggc tgctcgaccg ggactcctgc
      721 gacacggtac gagtcaatgc tctcttcgcc atctcctgtc ttgtccgaga gcaggaggct
      781 ggattgctgc agttcctccg cctggatgga ttctcagtgc tgatgcgggc catgcagcag
      841 caagtgcaga agctcaaggt caagtcagca ttcctgctgc agaacctgct ggtgggccac
      901 cctgagcaca aaggaaccct ttgctccatg gggatggtcc agcagctggt ggcccttgtg
      961 aggacagaac acagtccttt ccatgagcat gtgcttggag ccctgtgcag ccttgtgaca
     1021 gacttccctc agggtgttcg agaatgccgg gagcctgagc tgggcctgga ggaactgctc
     1081 cgtcatcgct gccagctgct gcagcagcat gaggagtacc aggaggagct ggagttctgt
     1141 gaaaagctgt tacagacctg tttctccagc cctacggatg acagcatgga tcggtgagac
     1201 caggcggctt cttgcattct ctccgtggga accccaggcc tcctgcctcc ctccttccca
     1261 ggcaccctct cccaagggat tgccaggcct tgtttgggcc tgcgcctggg cctgccagcc
     1321 catctctagg cagccccctg gaggggttgc tgagaaaggt gctggtccct tggaacccct
     1381 tccttgcttt ctgtctttca tgtccacact gctcttcaaa taaaaacatt tctcctgctc
     1441 aaaaaaaaaa aaaaaaaaaa aaaaa
//
