LOCUS       NM_053612               1795 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family B (small) member 8
            (Hspb8), mRNA.
ACCESSION   NM_053612
VERSION     NM_053612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Zhang,L., Liu,L., Li,D., Wu,J., Gao,S., Song,F., Zhou,Y., Liu,D.
            and Mei,W.
  TITLE     Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic
            Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative
            Stress Mediated By Spinal AMPK/PGC-1alpha Pathway in Male Rats
  JOURNAL   J Neuroimmune Pharmacol 19 (1), 5 (2024)
   PUBMED   38319409
  REMARK    GeneRIF: Heat Shock Protein 22 Attenuates Nerve Injury-induced
            Neuropathic Pain Via Improving Mitochondrial Biogenesis and
            Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1alpha
            Pathway in Male Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Cheng,J., Ji,M., Jing,H. and Lin,H.
  TITLE     DUSP12 ameliorates myocardial ischemia-reperfusion injury through
            HSPB8-induced mitophagy
  JOURNAL   J Biochem Mol Toxicol 37 (5), e23310 (2023)
   PUBMED   36644958
  REMARK    GeneRIF: DUSP12 ameliorates myocardial ischemia-reperfusion injury
            through HSPB8-induced mitophagy.
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Fan,H., Ding,R., Liu,W., Zhang,X., Li,R., Wei,B., Su,S., Jin,F.,
            Wei,C., He,X., Li,X. and Duan,C.
  TITLE     Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial
            biogenesis and DRP1-sparked mitochondrial apoptosis through
            AMPK-PGC1alpha signaling pathway to alleviate the early brain
            injury of subarachnoid hemorrhage in rats
  JOURNAL   Redox Biol 40, 101856 (2021)
   PUBMED   33472123
  REMARK    GeneRIF: Heat shock protein 22 modulates NRF1/TFAM-dependent
            mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis
            through AMPK-PGC1alpha signaling pathway to alleviate the early
            brain injury of subarachnoid hemorrhage in rats.
REFERENCE   4  (bases 1 to 1795)
  AUTHORS   Kuroyanagi,G., Sakai,G., Otsuka,T., Yamamoto,N., Fujita,K.,
            Kawabata,T., Matsushima-Nishiwaki,R., Kozawa,O. and Tokuda,H.
  TITLE     HSP22 (HSPB8) positively regulates PGF2alpha-induced synthesis of
            interleukin-6 and vascular endothelial growth factor in osteoblasts
  JOURNAL   J Orthop Surg Res 16 (1), 72 (2021)
   PUBMED   33478532
  REMARK    GeneRIF: HSP22 (HSPB8) positively regulates PGF2alpha-induced
            synthesis of interleukin-6 and vascular endothelial growth factor
            in osteoblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1795)
  AUTHORS   Li,F., Yang,B., Li,T., Gong,X., Zhou,F. and Hu,Z.
  TITLE     HSPB8 over-expression prevents disruption of blood-brain barrier by
            promoting autophagic flux after cerebral ischemia/reperfusion
            injury
  JOURNAL   J Neurochem 148 (1), 97-113 (2019)
   PUBMED   30422312
  REMARK    GeneRIF: HSPB8 over-expression noticeably prevented blood-brain
            barrier disruption after cerebral ischemia/reperfusion injury...
            and this protective role was, at least in part, mediated through
            autophagy
REFERENCE   6  (bases 1 to 1795)
  AUTHORS   Chowdary,T.K., Raman,B., Ramakrishna,T. and Rao,C.M.
  TITLE     Mammalian Hsp22 is a heat-inducible small heat-shock protein with
            chaperone-like activity
  JOURNAL   Biochem J 381 (Pt 2), 379-387 (2004)
   PUBMED   15030316
REFERENCE   7  (bases 1 to 1795)
  AUTHORS   Irobi,J., Van Impe,K., Seeman,P., Jordanova,A., Dierick,I.,
            Verpoorten,N., Michalik,A., De Vriendt,E., Jacobs,A., Van
            Gerwen,V., Vennekens,K., Mazanec,R., Tournev,I., Hilton-Jones,D.,
            Talbot,K., Kremensky,I., Van Den Bosch,L., Robberecht,W., Van
            Vandekerckhove,J., Van Broeckhoven,C., Gettemans,J., De Jonghe,P.
            and Timmerman,V.
  TITLE     Hot-spot residue in small heat-shock protein 22 causes distal motor
            neuropathy
  JOURNAL   Nat Genet 36 (6), 597-601 (2004)
   PUBMED   15122253
REFERENCE   8  (bases 1 to 1795)
  AUTHORS   Kim,M.V., Seit-Nebi,A.S., Marston,S.B. and Gusev,N.B.
  TITLE     Some properties of human small heat shock protein Hsp22 (H11 or
            HspB8)
  JOURNAL   Biochem Biophys Res Commun 315 (4), 796-801 (2004)
   PUBMED   14985082
REFERENCE   9  (bases 1 to 1795)
  AUTHORS   Sun,X., Fontaine,J.M., Rest,J.S., Shelden,E.A., Welsh,M.J. and
            Benndorf,R.
  TITLE     Interaction of human HSP22 (HSPB8) with other small heat shock
            proteins
  JOURNAL   J Biol Chem 279 (4), 2394-2402 (2004)
   PUBMED   14594798
REFERENCE   10 (bases 1 to 1795)
  AUTHORS   Benndorf,R., Sun,X., Gilmont,R.R., Biederman,K.J., Molloy,M.P.,
            Goodmurphy,C.W., Cheng,H., Andrews,P.C. and Welsh,M.J.
  TITLE     HSP22, a new member of the small heat shock protein superfamily,
            interacts with mimic of phosphorylated HSP27 ((3D)HSP27)
  JOURNAL   J Biol Chem 276 (29), 26753-26761 (2001)
   PUBMED   11342557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061748.1.
            
            On Oct 17, 2004 this sequence version replaced NM_053612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061748.1, FQ148790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1795
                     /gene="Hspb8"
                     /gene_synonym="Cryac; Hsp22"
                     /note="heat shock protein family B (small) member 8"
                     /db_xref="GeneID:113906"
                     /db_xref="RGD:71003"
     exon            1..727
                     /gene="Hspb8"
                     /gene_synonym="Cryac; Hsp22"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..951
                     /gene="Hspb8"
                     /gene_synonym="Cryac; Hsp22"
                     /note="alpha-crystallin C chain; small stress protein-like
                     protein HSP22; crystallin, alpha C; heat shock 22kDa
                     protein 8; heat shock protein 8; heat shock protein B8"
                     /codon_start=1
                     /product="heat shock protein beta-8"
                     /protein_id="NP_446064.1"
                     /db_xref="GeneID:113906"
                     /db_xref="RGD:71003"
                     /translation="MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDL
                     TAPWPEWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRNPPPFPGEPWKVCVNV
                     HSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSP
                     EGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS"
     exon            728..791
                     /gene="Hspb8"
                     /gene_synonym="Cryac; Hsp22"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1774
                     /gene="Hspb8"
                     /gene_synonym="Cryac; Hsp22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagctttt attaaactcc tggctgcgct caagacctca gcaggctttg gctgggagcc
       61 ggggcagcct gggaggaggg cagtcggtgg cttgctgata gcctggtgag gtgggactga
      121 gagaggccct ctgggattct gctgggcccg attaggtggt cacctttgtg agccaggacc
      181 ccagtgcaat tctgggcagc ggatgtttgg gcttgtggct aaaggaagat cagcattttc
      241 tgaagtggag aattaaactc tgaaagccat ctcaagccac atcaccttgc tgtgtgacct
      301 ttgggtaggt ggctccgtct ctctgagcct ctgtttcccc ctctaagctc aacaaacacc
      361 atggctgacg ggcaattgcc tttcccgtgc tcctacccaa gccgcttgcg ccgagacccc
      421 tttcgggact caccgctctc ttcccgcctg ctggacgatg gctttggcat ggaccccttc
      481 ccagacgact tgacagcccc ttggcccgag tgggctttgc ctcggctctc ctctgcctgg
      541 cctggaaccc taaggtctgg catggtaccc cgagggccta cagccacagc caggtttggg
      601 gtacctgctg agggtaggaa ccccccaccc ttccctgggg agccctggaa agtgtgtgtc
      661 aatgtgcaca gcttcaagcc ggaagaactg atggtaaaga ccaaggatgg atacgtggaa
      721 gtgtcaggga agcacgaaga gaagcagcaa gaaggtggga ttgtctccaa gaacttcacc
      781 aagaaaatac agcttcctgc agaagtggat ccagtgactg tatttgcctc actttctcca
      841 gagggtctgc tcatcattga ggctccccag gtccctcctt actcaccctt tggagagagc
      901 agctttaaca acgagcttcc tcaagacaac caggaagtca cctgctccta agacgtcagc
      961 cttggtcctt ctttgctcca ggcccctgcc ccagggactc tctgatttga gggtagacga
     1021 ctttagcagc actcagattt aaggcaactc agatgttggg ggatgggagg gagaaccaaa
     1081 tgaccatccc tggataatgt agtagtagat ttctccacag ggtgacacaa tgggcccgcc
     1141 tcgcttggtt gccttaggtc aaagtattgg gaggtttttc ttcaccttgt ctgggtgaag
     1201 acaccacacg gtctatagtt gcaaaacaag caaatgggga ctgaagattt catgttacat
     1261 ttttaccttg cagctaacgc aagacttgct tttctctggg gaccttccca ccacccagat
     1321 cccctgctct gggccctcct tatatgtggc ttggttgatg ggactcattg gcttacctca
     1381 gtgtgtttct aaactctctg tctagaagag gttatagata ggtcttatat ccccatatgg
     1441 gatttatcca cataaaacac agtctggatt tttcacagca tgaccccatg gctctcaaac
     1501 catcaccacc aaggactctg ggagcccctc agttaattct ccggctaagg tcccctttat
     1561 tgtgtcccct gtgtccaagt caggttttta cagagagctg tcttcaggca gctccaccag
     1621 gaaccaagca aaggtcagac agcctggcac gcaggctagt ggtattgtgt atgtgggggt
     1681 gggggtgtct tcattgtgtg aattgagctg ttgtttaggg ggaagataag agtaaataat
     1741 aatgttcata ataaaggagc tgatgttctt agcaaaaaaa aaaaaaaaaa aaaaa
//
