LOCUS       NM_031607               1794 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus heat shock protein family B (small) member 7
            (Hspb7), mRNA.
ACCESSION   NM_031607 XM_001072790 XM_342966
VERSION     NM_031607.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Lin W, Yang Z, Lu Y and Zhao X.
  TITLE     Refined purification of large amounts of rat cvHsp/HspB7 and
            partial biological characterization in vitro
  JOURNAL   Protein Pept Lett 21 (5), 503-510 (2014)
   PUBMED   24555434
  REMARK    GeneRIF: The circular dichroism analyzed urea induced unfolding
            processes. Multiple sequence alignment and an automated protein
            modeling were used to describe the three-dimensional structural
            model of the Hspb7 monomer and dimer.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Yang Z, Wang Y, Lu Y and Zhao X.
  TITLE     Molecular characterization of rat cvHsp/HspB7 in vitro and its
            dynamic molecular architecture
  JOURNAL   Mol Med Rep 4 (1), 105-111 (2011)
   PUBMED   21461572
  REMARK    GeneRIF: The cvHsp mainly consisted of beta-sheets and randomly
            coiled secondary structural elements, and in addition possessed
            variable tertiary structures and several solvent-exposed
            hydrophobic patches on its molecular surface.
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Vos MJ, Kanon B and Kampinga HH.
  TITLE     HSPB7 is a SC35 speckle resident small heat shock protein
  JOURNAL   Biochim Biophys Acta 1793 (8), 1343-1353 (2009)
   PUBMED   19464326
  REMARK    Erratum:[Biochim Biophys Acta. 2009 Dec;1793(12):1929-30]
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Doran P, Gannon J, O'Connell K and Ohlendieck K.
  TITLE     Aging skeletal muscle shows a drastic increase in the small heat
            shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7
  JOURNAL   Eur J Cell Biol 86 (10), 629-640 (2007)
   PUBMED   17761354
  REMARK    GeneRIF: Increase in the HspB7 is associated with sarcopenia
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Krief S, Faivre JF, Robert P, Le Douarin B, Brument-Larignon N,
            Lefrere I, Bouzyk MM, Anderson KM, Greller LD, Tobin FL, Souchet M
            and Bril A.
  TITLE     Identification and characterization of cvHsp. A novel human small
            stress protein selectively expressed in cardiovascular and
            insulin-sensitive tissues
  JOURNAL   J Biol Chem 274 (51), 36592-36600 (1999)
   PUBMED   10593960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF525257.1, CK358485.1 and BC089930.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_342966.3, XM_001072790.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF525257.1, BC169050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               BF525257.1         4-328
            326-974             CK358485.1         64-712
            975-1794            BC089930.1         427-1246
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1794
                     /gene="Hspb7"
                     /gene_synonym="Hsp25-2"
                     /note="heat shock protein family B (small) member 7"
                     /db_xref="GeneID:50565"
                     /db_xref="RGD:62021"
     exon            1..265
                     /gene="Hspb7"
                     /gene_synonym="Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..579
                     /gene="Hspb7"
                     /gene_synonym="Hsp25-2"
                     /note="cvHsp; cardiovascular heat shock protein; heat
                     shock protein 25 kDa 2 (cardiovascular); heat shock 27kD
                     protein family, member 7 (cardiovascular); heat shock
                     protein B7; heat shock 27kD protein family member 7; heat
                     shock protein family, member 7 (cardiovascular)"
                     /codon_start=1
                     /product="heat shock protein beta-7"
                     /protein_id="NP_113795.1"
                     /db_xref="GeneID:50565"
                     /db_xref="RGD:62021"
                     /translation="MSHRTSSAFRAERSFRSSSSSSSSSSSSASRALPAQDPPMEKAL
                     SMFSEDFGSFMLPHSEPLTFPARPGGQGNIKTLGDAYEFTVDMRDFSPEDIIVTTSNN
                     HIEVRAEKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQ
                     QTFRTEIKI"
     exon            266..399
                     /gene="Hspb7"
                     /gene_synonym="Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..1769
                     /gene="Hspb7"
                     /gene_synonym="Hsp25-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcctgca cccacacgtt tctccagccc agcccctgcc cgcccggaca gggcccctgc
       61 tgcctgtgga tgagccatcg gacctcctcc gccttcagag cggagaggag cttccgttcc
      121 tcctcttctt cctcctcctc ctcctcttct tcggcctccc gtgcccttcc agcccaggac
      181 ccacccatgg agaaggcctt gagcatgttt tcagaggact ttggcagttt catgctgccc
      241 cactcggagc ccctgacctt cccagcccgt cccgggggac aaggaaacat caagactctc
      301 ggggatgcct acgagtttac tgtggacatg agagacttct cccctgaaga catcattgtc
      361 accacctcca acaaccacat cgaggtgcgg gctgagaagc tggcagctga tggcacagtc
      421 atgaacacct ttgctcacaa gtgccagcta ccagaggatg tggaccctac gtcggtgacc
      481 tcggccctga gggaggatgg cagcctcacc attcgagcac gtcgtcaccc acacacagaa
      541 catgtccagc agaccttccg gacggagata aaaatctgag ggtctcccca cccctggcct
      601 tccccccatc tcctccccca ctggcctgct ggtgaggtcg ccatgacccc tgacaatgcc
      661 ccccccagaa catctcagcc taggccccag tcactccaca cactcttagg ccccaggtgg
      721 gtcacccctg tcctctctac ccaaggcaat ccagggaccc gcttaccctc acccagatag
      781 gccctcccta tcttagttta caatagaggg gctgaggtag ccacttgggg agcaacatga
      841 agacggagtc cgtaacacag ggtggcatca atggcatttc tgcagggcag gggaccaggg
      901 gccctcccag caaggggaat atgagagact ggccacaagc agtgcttctg gcccatgcag
      961 actgcctcag ggaaggcaga gagacagcca tgactgtcac ctcccttgta actctggaag
     1021 cctcaaaccc agggctacct gtcaccctga gcctctaaca actacttgta ccagcaggga
     1081 cacctgtacc tagatggggt ttattagaat gacacgaggt tcctatctcc agctgctggt
     1141 gcatgaggcc agagccccag cctcctgggt ggctccccct gcagagaggg tcctctgtgg
     1201 aagtgagagg gaaacccagg acttgtacac acaaattcac acccacacca ttgtcctatc
     1261 ccataaatac ccatccccat tggttagagc ctagttcaag gcattctaaa atcacactta
     1321 gttagcatct ccgtttccgt caatggagac gtgtcgtctc tgagccagcc ggatgcccag
     1381 ttttgtctgt gaagccagcg ctgcctcagg cgccctcagc ctctcacctc tgtgcactgg
     1441 ggagacgtcc ctccattctt gagtcacatg ccctgcttca ccctaactgc agacggcggc
     1501 cacagggaga accccaaacc agatcccttc tggcccctaa atccagtgca aaaacccttg
     1561 tcagccttaa ccctggggga cctgggctct gactcagact ccacgtgtaa aagcaggtgt
     1621 aaaaggggga agctcactgt tagttggggt cccaggcgcc tctggctcca gcagtcttgg
     1681 gacccttcag atagggaggg gaggggggag gggttcgtgg gagactagtc tctatcacct
     1741 gtacacaata aaaggacagt atgacagaca aaaaaaaaaa aaaaaaaaaa aaaa
//
