LOCUS       NM_138887               1310 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus heat shock protein family B (small) member 6
            (Hspb6), mRNA.
ACCESSION   NM_138887
VERSION     NM_138887.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Qi,A.Q., Zhang,Y.H., Qi,Q.D., Liu,Y.H. and Zhu,J.L.
  TITLE     Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic
            Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA
            Pathway
  JOURNAL   Cell Mol Neurobiol 39 (1), 111-122 (2019)
   PUBMED   30511325
  REMARK    GeneRIF: activation of the cAMP-PKA pathway induces overexpression
            and partial phosphorylation of HspB6 lead to the inhibition of ASK1
            expression.
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Shimizu,M., Tanaka,M. and Atomi,Y.
  TITLE     Small Heat Shock Protein alphaB-Crystallin Controls Shape and
            Adhesion of Glioma and Myoblast Cells in the Absence of Stress
  JOURNAL   PLoS One 11 (12), e0168136 (2016)
   PUBMED   27977738
  REMARK    GeneRIF: we show for the first time that alphaB-crystallin, a
            molecular chaperon for tubulin/microtubules, is involved in cell
            shape determination. knockdown of this molecule caused myoblasts
            and glioma cells to lose their ability for adhesion as they tended
            to behave like migratory cells. knockdown in both C6 glial cells
            and L6 myoblast permitted cells to migrate more rapidly than dermal
            fibroblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Sin,Y.Y. and Baillie,G.S.
  TITLE     Heat shock protein 20 (HSP20) is a novel substrate for protein
            kinase D1 (PKD1)
  JOURNAL   Cell Biochem Funct 33 (7), 421-426 (2015)
   PUBMED   26443497
  REMARK    GeneRIF: Study delineates the protein kinase D1 binding sites on
            HSP20 and shows that HSP20 is a substrate for protein kinase D1.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Sin,Y.Y., Martin,T.P., Wills,L., Currie,S. and Baillie,G.S.
  TITLE     Small heat shock protein 20 (Hsp20) facilitates nuclear import of
            protein kinase D 1 (PKD1) during cardiac hypertrophy
  JOURNAL   Cell Commun Signal 13, 16 (2015)
   PUBMED   25889640
  REMARK    GeneRIF: formation of the Hsp20-PKD1 complex is essential for PKD1
            nuclear translocation, signaling mechanisms leading to hypertrophy
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   Nefedova,V.V., Sudnitsyna,M.V., Strelkov,S.V. and Gusev,N.B.
  TITLE     Structure and properties of G84R and L99M mutants of human small
            heat shock protein HspB1 correlating with motor neuropathy
  JOURNAL   Arch Biochem Biophys 538 (1), 16-24 (2013)
   PUBMED   23948568
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Bukach,O.V., Seit-Nebi,A.S., Marston,S.B. and Gusev,N.B.
  TITLE     Some properties of human small heat shock protein Hsp20 (HspB6)
  JOURNAL   Eur J Biochem 271 (2), 291-302 (2004)
   PUBMED   14717697
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Pipkin,W., Johnson,J.A., Creazzo,T.L., Burch,J., Komalavilas,P. and
            Brophy,C.
  TITLE     Localization, macromolecular associations, and function of the
            small heat shock-related protein HSP20 in rat heart
  JOURNAL   Circulation 107 (3), 469-476 (2003)
   PUBMED   12551873
  REMARK    GeneRIF: Localization, macromolecular associations, and function of
            HSP20 in the heart.
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Sugiyama,Y., Suzuki,A., Kishikawa,M., Akutsu,R., Hirose,T.,
            Waye,M.M., Tsui,S.K., Yoshida,S. and Ohno,S.
  TITLE     Muscle develops a specific form of small heat shock protein complex
            composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
  JOURNAL   J Biol Chem 275 (2), 1095-1104 (2000)
   PUBMED   10625651
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Inaguma,Y., Hasegawa,K., Kato,K. and Nishida,Y.
  TITLE     cDNA cloning of a 20-kDa protein (p20) highly homologous to small
            heat shock proteins: developmental and physiological changes in rat
            hindlimb muscles
  JOURNAL   Gene 178 (1-2), 145-150 (1996)
   PUBMED   8921906
REFERENCE   10 (bases 1 to 1310)
  AUTHORS   Kato,K., Goto,S., Inaguma,Y., Hasegawa,K., Morishita,R. and
            Asano,T.
  TITLE     Purification and characterization of a 20-kDa protein that is
            highly homologous to alpha B crystallin
  JOURNAL   J Biol Chem 269 (21), 15302-15309 (1994)
   PUBMED   8195168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D29960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D29960.1, FQ217608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1310
                     /gene="Hspb6"
                     /gene_synonym="Hsp20; p20"
                     /note="heat shock protein family B (small) member 6"
                     /db_xref="GeneID:192245"
                     /db_xref="RGD:621554"
     exon            1..203
                     /gene="Hspb6"
                     /gene_synonym="Hsp20; p20"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..494
                     /gene="Hspb6"
                     /gene_synonym="Hsp20; p20"
                     /note="heat shock 20 kDa-like protein p20; heat shock
                     20-kDa protein; heat shock protein,
                     alpha-crystallin-related, B6; heat shock protein family B
                     (small) member B6"
                     /codon_start=1
                     /product="heat shock protein beta-6"
                     /protein_id="NP_620242.1"
                     /db_xref="GeneID:192245"
                     /db_xref="RGD:621554"
                     /translation="MEIRVPVQPSWLRRASAPLPGFSTPGRLFDQRFGEGLLEAELAS
                     LCPAAIAPYYLRAPSVALPTAQVPTDPGYFSVLLDVKHFSPEEISVKVVGDHVEVHAR
                     HEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQASLPSPPA
                     AK"
     exon            204..326
                     /gene="Hspb6"
                     /gene_synonym="Hsp20; p20"
                     /inference="alignment:Splign:2.1.0"
     exon            327..1310
                     /gene="Hspb6"
                     /gene_synonym="Hsp20; p20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggatgga gatccgggtg cctgtgcagc cttcttggct gcgccgtgct tcagctcctt
       61 taccgggttt ttccactccg ggacgcctct ttgaccagcg tttcggcgaa gggctgcttg
      121 aggcagagct ggcttcactg tgccctgctg cgatcgcgcc ctactatctg cgcgccccca
      181 gtgtggcgtt acccacagcc caggtgccca cggaccctgg gtatttttct gtgctgctgg
      241 atgtgaagca cttctcgcca gaggaaatct ctgtcaaggt ggttggtgac catgtggagg
      301 tccatgctcg gcatgaggag cgcccagatg aacatggatt cattgctcga gagttccacc
      361 gccgataccg cctgcctcct ggcgtggacc ctgctgcagt gacctctgca ctgtctcctg
      421 agggtgttct gtctatccag gccacaccag cgtcggccca ggcctcactt ccgtcaccac
      481 ctgctgccaa gtaggggtcc cagcattaca ggaccgaacc gggaagcctc tttaggctcc
      541 cttttaaaat gccgatctga ctccactgcc cagccagatg tcccaatcgc tgtcaagaca
      601 gcctttccca accacaacta gatgtcctcc cctgagacct tcccaaccca aaccctacct
      661 gagccttagt gacctagaca cccttcctaa gccctctccc agctttcagg ccccacccat
      721 gacatctctc tagaggcaac acaaacacta ctgtcaggag ccaaggctcc catcagactg
      781 accccacttt gggcttctct cacactcagg ctgcatttgt gagctgtaga acaccccacc
      841 gtgacagcag agtacaatgt agtcagcgct cccctccttc caatcctgtc acctaattcc
      901 ccacagtgat gtagactgca taggctttcc acaccagaac gctcaagcct ggtccaccag
      961 actccagtct ctgtaaccta acactcctct gccccagccc actgtctgac ttaaaactcc
     1021 aggcaccgaa attcttgaat actattctga cctccaattc ttgggactcc tattcctgac
     1081 aaaccaggaa ccccaaactc aaattgtatg gacactccac cttctccaga tgtgctagac
     1141 caatgaacaa gaacctgtga gctctctgtc ctggctcccc atctgcagtc agatgtctta
     1201 gggagcccgc tccacatctg ccatcctcta aggttgcacc ttcactctga acatttcctg
     1261 tctccccagg ccttcctgcc attagttccc aataaatgca cttgagattt
//
