LOCUS       NM_130431                839 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus heat shock protein family B (small) member 2
            (Hspb2), transcript variant 1, mRNA.
ACCESSION   NM_130431
VERSION     NM_130431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 839)
  AUTHORS   den Engelsman,J., Boros,S., Dankers,P.Y., Kamps,B., Vree
            Egberts,W.T., Bode,C.S., Lane,L.A., Aquilina,J.A., Benesch,J.L.,
            Robinson,C.V., de Jong,W.W. and Boelens,W.C.
  TITLE     The small heat-shock proteins HSPB2 and HSPB3 form well-defined
            heterooligomers in a unique 3 to 1 subunit ratio
  JOURNAL   J Mol Biol 393 (5), 1022-1032 (2009)
   PUBMED   19715703
  REMARK    GeneRIF: Despite the high level of sequence homology within the
            small heat-shock proteins (sHSPs) family the biochemical properties
            of the HSPB2/B3 complex are distinctly different from those of
            other sHSPs.
REFERENCE   2  (bases 1 to 839)
  AUTHORS   Vos,M.J., Kanon,B. and Kampinga,H.H.
  TITLE     HSPB7 is a SC35 speckle resident small heat shock protein
  JOURNAL   Biochim Biophys Acta 1793 (8), 1343-1353 (2009)
   PUBMED   19464326
  REMARK    Erratum:[Biochim Biophys Acta. 2009 Dec;1793(12):1929-30]
REFERENCE   3  (bases 1 to 839)
  AUTHORS   Schmeer,C., Gamez,A., Tausch,S., Witte,O.W. and Isenmann,S.
  TITLE     Statins modulate heat shock protein expression and enhance retinal
            ganglion cell survival after transient retinal ischemia/reperfusion
            in vivo
  JOURNAL   Invest Ophthalmol Vis Sci 49 (11), 4971-4981 (2008)
   PUBMED   18566458
  REMARK    GeneRIF: Systemic delivery of statins after a transient period of
            retinal ischemia significantly modulated HSP expression in the
            retina and enhanced RGC survival.
REFERENCE   4  (bases 1 to 839)
  AUTHORS   Brady,J.P., Garland,D.L., Green,D.E., Tamm,E.R., Giblin,F.J. and
            Wawrousek,E.F.
  TITLE     AlphaB-crystallin in lens development and muscle integrity: a gene
            knockout approach
  JOURNAL   Invest Ophthalmol Vis Sci 42 (12), 2924-2934 (2001)
   PUBMED   11687538
REFERENCE   5  (bases 1 to 839)
  AUTHORS   Sugiyama,Y., Suzuki,A., Kishikawa,M., Akutsu,R., Hirose,T.,
            Waye,M.M., Tsui,S.K., Yoshida,S. and Ohno,S.
  TITLE     Muscle develops a specific form of small heat shock protein complex
            composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
  JOURNAL   J Biol Chem 275 (2), 1095-1104 (2000)
   PUBMED   10625651
REFERENCE   6  (bases 1 to 839)
  AUTHORS   Iwaki,A., Nagano,T., Nakagawa,M., Iwaki,T. and Fukumaki,Y.
  TITLE     Identification and characterization of the gene encoding a new
            member of the alpha-crystallin/small hsp family, closely linked to
            the alphaB-crystallin gene in a head-to-head manner
  JOURNAL   Genomics 45 (2), 386-394 (1997)
   PUBMED   9344664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 23, 2022 this sequence version replaced NM_130431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.21720.1,
                                           SRR26360194.1296995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000008.1  59990713-59990901   c
            190-839             JAXUCZ010000008.1  59989640-59990289   c
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..839
                     /gene="Hspb2"
                     /note="heat shock protein family B (small) member 2"
                     /db_xref="GeneID:161476"
                     /db_xref="RGD:70914"
     exon            1..189
                     /gene="Hspb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..644
                     /gene="Hspb2"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock 27kD protein 2; heat shock protein beta-2; heat
                     shock 27kDa protein 2; heat shock protein 2; heat shock
                     protein B2"
                     /codon_start=1
                     /product="heat shock protein beta-2 isoform 1"
                     /protein_id="NP_569115.1"
                     /db_xref="GeneID:161476"
                     /db_xref="RGD:70914"
                     /translation="MSGRTVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLY
                     HGYYVRPRAARAGEGGRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSAR
                     HPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEV
                     YISLLPAPPDPEEEEEVARVEP"
     exon            190..839
                     /gene="Hspb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgagtcc tggctctccc tctgaagctg gaggggtcgc cttgatcttg ttggggctac
       61 acttgggatc agggctacta gtcgcaacag cagtcatgtc gggccgcaca gtgccacacg
      121 cccacccagc cactgccgag tacgaatttg ccaaccctag ccgcctgggc gagcagcgct
      181 tcggagaagg cctcctgcca gaagagatcc tgacccccac cctctaccat ggctactatg
      241 ttcggccccg ggccgccaga gctggggagg gcggcagggc aggggcctca gagctcaggc
      301 tcagtgaagg caagttccag gcatttctgg atgtgagcca ctttacccca gatgaggtga
      361 ccgtgaggac tgtggacaac ctgctagagg tgtctgcccg acacccccaa cgtctggacc
      421 gccacggctt cgtgtcccga gagttctgtc gcacctatgt cctgcctgca gatgtggacc
      481 cctggcgggt cagagctgct ctctcccatg atggcatcct taacttggag gcaccgcggg
      541 gtggccggca tctggacacg gaagtcaatg aggtctacat ctccctgctt cctgcacctc
      601 ctgaccccga ggaagaggaa gaggtagcca gagttgaacc ctgactgcca gacccagaac
      661 ccggtgaatc ccctgtctac ctcccgtggt gattccagaa atccaccaca ccccagaggg
      721 agcagcattc ctgggagatg ggataggtgc atggtccaca gtgtatggtt tggtcccttg
      781 atgaatcgta gccttcgatt taattctggg tgaggctaaa taaaccaaaa tctaggggc
//
