LOCUS       NM_031970                890 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus heat shock protein family B (small) member 1
            (Hspb1), mRNA.
ACCESSION   NM_031970
VERSION     NM_031970.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 890)
  AUTHORS   Li,C., Kuang,J., Wang,X., Zhang,G., Hong,M., Cheng,G. and Zhao,T.
  TITLE     Exosomal Hsp27 protein are associated with heart failure in
            STZ-induced type 1 diabetic rats
  JOURNAL   Int J Biol Macromol 277 (Pt 1), 133772 (2024)
   PUBMED   38992522
  REMARK    GeneRIF: Exosomal Hsp27 protein are associated with heart failure
            in STZ-induced type 1 diabetic rats.
REFERENCE   2  (bases 1 to 890)
  AUTHORS   Yan,L., Li,Z., Li,C., Chen,J., Zhou,X., Cui,J., Liu,P., Shen,C.,
            Chen,C., Hong,H., Xu,G. and Cui,Z.
  TITLE     Hspb1 and Lgals3 in spinal neurons are closely associated with
            autophagy following excitotoxicity based on machine learning
            algorithms
  JOURNAL   PLoS One 19 (5), e0303235 (2024)
   PUBMED   38728287
  REMARK    GeneRIF: Hspb1 and Lgals3 in spinal neurons are closely associated
            with autophagy following excitotoxicity based on machine learning
            algorithms.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 890)
  AUTHORS   Lu,Q. and Tang,H.
  TITLE     Overexpression of HSP27 accelerates stress-induced gastric ulcer
            healing via the CXCL12/CXCR4 axis
  JOURNAL   Clin Exp Pharmacol Physiol 51 (5), e13857 (2024)
   PUBMED   38566371
  REMARK    GeneRIF: Overexpression of HSP27 accelerates stress-induced gastric
            ulcer healing via the CXCL12/CXCR4 axis.
REFERENCE   4  (bases 1 to 890)
  AUTHORS   Yeh,T.Y., Chang,M.F., Kan,Y.Y., Chiang,H. and Hsieh,S.T.
  TITLE     HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation
  JOURNAL   Mol Neurobiol 61 (2), 707-724 (2024)
   PUBMED   37656312
  REMARK    GeneRIF: HSP27 Modulates Neuropathic Pain by Inhibiting P2X3
            Degradation.
REFERENCE   5  (bases 1 to 890)
  AUTHORS   Kim,Y.J., Khaleel,Z.H., Jin,M., Lee,J.W.Y., Park,S., Ga,S.,
            Kim,N.H., Sa,D.H., Kang,E.S., Han,S.H., Lee,J.Y., Ku,H.J.,
            Kim,S.W., Kim,K.Y., Park,J.E., Kim,Y.H. and Lee,B.S.
  TITLE     Mechanistic insights into the anti-restenotic effects of HSP27 and
            HO1 modulated by reconstituted HDL on neointimal hyperplasia
  JOURNAL   Sci Rep 13 (1), 22078 (2023)
   PUBMED   38087008
  REMARK    GeneRIF: Mechanistic insights into the anti-restenotic effects of
            HSP27 and HO1 modulated by reconstituted HDL on neointimal
            hyperplasia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 890)
  AUTHORS   Rallu,M., Loones,M., Lallemand,Y., Morimoto,R., Morange,M. and
            Mezger,V.
  TITLE     Function and regulation of heat shock factor 2 during mouse
            embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2392-2397 (1997)
   PUBMED   9122205
REFERENCE   7  (bases 1 to 890)
  AUTHORS   Clifton,A.D., Young,P.R. and Cohen,P.
  TITLE     A comparison of the substrate specificity of MAPKAP kinase-2 and
            MAPKAP kinase-3 and their activation by cytokines and cellular
            stress
  JOURNAL   FEBS Lett 392 (3), 209-214 (1996)
   PUBMED   8774846
REFERENCE   8  (bases 1 to 890)
  AUTHORS   Welsh,M.J., Wu,W., Parvinen,M. and Gilmont,R.R.
  TITLE     Variation in expression of hsp27 messenger ribonucleic acid during
            the cycle of the seminiferous epithelium and co-localization of
            hsp27 and microfilaments in Sertoli cells of the rat
  JOURNAL   Biol Reprod 55 (1), 141-151 (1996)
   PUBMED   8793069
REFERENCE   9  (bases 1 to 890)
  AUTHORS   Uoshima,K., Handelman,B. and Cooper,L.F.
  TITLE     Isolation and characterization of a rat HSP 27 gene
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1388-1395 (1993)
   PUBMED   7916612
REFERENCE   10 (bases 1 to 890)
  AUTHORS   Inaguma,Y., Goto,S., Shinohara,H., Hasegawa,K., Ohshima,K. and
            Kato,K.
  TITLE     Physiological and pathological changes in levels of the two small
            stress proteins, HSP27 and alpha B crystallin, in rat hindlimb
            muscles
  JOURNAL   J Biochem 114 (3), 378-384 (1993)
   PUBMED   8282729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1 and FM035762.1.
            
            On Feb 5, 2015 this sequence version replaced NM_031970.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF109657.1, CB577787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000012.1  26432216-26432301   c
            87-666              FM035762.1         1-580
            667-890             JAXUCZ010000012.1  26430640-26430863   c
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..890
                     /gene="Hspb1"
                     /gene_synonym="Hsp25; Hsp27"
                     /note="heat shock protein family B (small) member 1"
                     /db_xref="GeneID:24471"
                     /db_xref="RGD:61306"
     exon            1..510
                     /gene="Hspb1"
                     /gene_synonym="Hsp25; Hsp27"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..755
                     /gene="Hspb1"
                     /gene_synonym="Hsp25; Hsp27"
                     /note="heat shock 27 kDa protein 1; HSP 27; heat shock
                     27kDa protein 1; heat shock protein B1"
                     /codon_start=1
                     /product="heat shock protein beta-1"
                     /protein_id="NP_114176.4"
                     /db_xref="GeneID:24471"
                     /db_xref="RGD:61306"
                     /translation="MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRFPDEWS
                     QWFSSAGWPGYVRPLPAATAEGPAAVTLAAPAFSRALNRQLSSGVSEIRQTADRWRVS
                     LDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSS
                     LSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPESEQSGAK"
     exon            511..574
                     /gene="Hspb1"
                     /gene_synonym="Hsp25; Hsp27"
                     /inference="alignment:Splign:2.1.0"
     exon            575..890
                     /gene="Hspb1"
                     /gene_synonym="Hsp25; Hsp27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacctgaagc accgcctgct aaaaataccc ggctggacac ccataaaagc acagttgggg
       61 ctccagctcg gcacttctcg gatcctcagc ccagtgcttc tagatcctca gccctgacca
      121 gctcagccaa gaccatgacc gagcgccgcg tgcccttctc gctactgcgg agccccagct
      181 gggagccgtt ccgggactgg taccctgccc acagccgcct cttcgatcaa gctttcgggg
      241 tgcctcggtt tcccgatgag tggtctcagt ggttcagctc cgctggttgg cccggctatg
      301 tgcgccctct gcccgccgcg accgccgagg gccccgcagc agtgaccctg gccgcgcccg
      361 ccttcagccg ggcgctcaac cggcaactca gcagcggtgt ctcagagatc cgacagacgg
      421 ccgatcgctg gcgcgtgtcc ctggacgtca accacttcgc tcctgaggag ctcacagtta
      481 agaccaagga aggcgtggtg gagatcactg gcaagcacga agaaaggcag gatgaacatg
      541 gctacatctc tcggtgcttc acccggaaat acacgctccc tccaggtgtg gaccccaccc
      601 tggtgtcctc ttccctgtcc cctgagggca cactcaccgt ggaggctccg ctgcccaaag
      661 cagtcacaca atcagcggag atcaccattc cggtcacttt cgaggcccgt gcccaaattg
      721 gaggcccaga gtcggaacag tctggagcca agtagaagcc ttcagcttgc tacccatccc
      781 cagtagccgt caccagccct ccctctctgt caatctgaat gctcttttga tacatgtact
      841 ttctgttttt ctcaaataaa agttggaaac tactgctcac caccctctca
//
